Protein Alignment fw and csmd2

DIOPT Version :10

• Sequence 1: NP_511136.2
• Gene: fw / 32162
• FlyBaseID: FBgn0001083
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: XP_693833.6
• Gene: csmd2 / 565460
• ZFINID: ZDB-GENE-030616-39
• Length: 3604
• Species: Danio rerio
• Alignment Length: 1059
• Identity: 255/1059 - (24%)
• Similarity: 390/1059 - (36%)
• Gaps: 264/1059 - (24%)

  Fly    56 QICGPPAVPLNAKVRTITVDSQIAE-AHYECDAGYELFGPSAVKCDRRTG----WDRDLPFCGVN 115
            |.|.||.:..||::...:.:.:|.: ..|.|..||.|.|.|...|  |.|    :|...|.|.:.
Zfish  2289 QFCLPPPIIPNAEILMASKEFKIGDIVRYRCLPGYHLNGNSIQTC--RLGTHLEFDGPPPSCDIT 2351

  Fly   116 VAYRKPVNQSSYTRSGPASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVHVVRITTR 180
            .    |:|:.....:|   ......||:..|..:.||         |   |:...:.:.:..|..
Zfish  2352 C----PMNEVLTASTG---VILSQSPGSSLPHFESCS---------W---LVKVDSGYNITFTVE 2397

  Fly   181 GCCGHQPLQDLEIRVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVGQYVAIQLVGVEGSL 245
            .....:...:|||..|.|    :::||                              |:.:.|:.
Zfish  2398 HFQTSRQFDELEIFDGPS----RQSPL------------------------------LISLSGNY 2428

  Fly   246 SLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCY---DFHIT---KGESFDKAQAICKQTGG 304
            |                  ||     ..:|:.:...|   .|..|   ||.....:.|.|.....
Zfish  2429 S------------------SP-----LSITSSANKVYLHWSFDHTSSHKGFRIRYSAAYCSSPDP 2470

  Fly   305 DLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNN 369
            .:.......|.:.:.|.| |...:....|:        |.|:.|.......:.|   |....|
Zfish  2471 PVNGSLHSQTGTKLGSTL-RFNCDRGFNLI--------GQTTATCYRTPQGIYQ---WNAPVP-- 2521

  Fly   370 YNGEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVMGKKFTLGEKIQYTC 434
                                          :||  .:|||.|.|..|.||:|:.||||.::.::|
Zfish  2522 ------------------------------LCQ--VVSCGMPIAPVNGTVIGQHFTLGSRVTFSC 2554

  Fly   435 ----------------------------PK---------GHSLL--------------------- 441
                                        |:         |||.:
Zfish  2555 NPGFRLANTQPVSTLCQESGRWSPIETRPRCVPVNCPDIGHSAVDHGRWRLIYGMQNKYEAMMML 2619

  Fly   442 ---------GQTERECRLDGTWS--GSSPTCKYVDCGSL---PE-LKFGSIHMSEERTSFGVVAT 491
                     ||....|:.:|||.  ...|:|:.:.||.|   |. .|.|::      |.:|..|.
Zfish  2620 TCDPGYFYKGQRVIRCQANGTWDYPEPRPSCEIISCGDLGTPPNGNKIGTL------TVYGATAI 2678

  Fly   492 YSCHENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGY 555
            :||:..|||:|:..|.|..:| |||.:.:||...|..|:||..|.:...:.....:..|.|.||:
Zfish  2679 FSCNTGYTLVGSRVRECMSNGLWSGAEVQCLAGHCGTPEPIVNGQIIGENYNYRGSVVYQCNPGF 2743

  Fly   556 VLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT-TVNSVVKYECDEDHWLDG 619
            .|:|.::..|.....||.|||.|..:.||.|..|..|:.   .||. .:|.:|::.|:..:.|.|
Zfish  2744 RLIGVSVRICEQDHRWSGKTPVCIPITCGHPGTPANGVT---QGTQFNLNDIVRFACNPGYVLQG 2805

  Fly   620 QSELYCTREGKWSGEAPVCELVTCETPS---------VPSGSFVIGYDYNVHSKIQYNCDPGHIM 675
            ..:..|...|:||...|.|::|.|..|.         :|||.    :.|:..:.:.|||:||:.:
Zfish  2806 ALKSQCQSNGQWSNALPRCKIVNCTDPGHVENGVRQVLPSGP----HRYSFQTAVSYNCNPGYYL 2866

  Fly   676 HGTPVLECLDSGEWSADAPYCEYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLK 740
            .|:.:|.|...|.|....|.|..:.|......||........|  |||.:.|||.....:.|...
Zfish  2867 LGSSILSCQGDGTWDRSLPKCLLVLCDRPSMPPYAQISGDRRT--VGSVIRFSCIGQRSIVGNTT 2929

  Fly   741 RTCLESAVWSDASPKCEEIR---CPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIG 802
            |.|.....||.:.|.|....   |.:|.:..|.               ||..|.       :..|
Zfish  2930 RMCQLDGQWSGSLPHCSGDSAGLCGDPGIPVHG---------------IRLGEE-------FTTG 2972

  Fly   803 ALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVLY 867
            ::.::.||.||::.|.:..||..:|.|.|..|||..|.||.| |.....::...:...:..::.|
Zfish  2973 SVVRFSCEPGYQLKGSSERTCLANGSWVGIQPECHVVSCGNP-GTPRNAMIQFHDGLVFSRSITY 3036

  Fly   868 ECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFKCAKGRI 932
            .|...:...|:..|.||.:|.|:.:.|||..:.|..|.:..|.|............:|:|:.|..
Zfish  3037 SCREGYYSTGLLTRHCTVNGTWTGDMPECTVINCGDPGVPANGIRLGSDFTYSHSVSFQCSPGFT 3101

  Fly   933 MMGN--DTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIPNYNRIG 995
            |..:  .|.:|.|:..|.|..|.|:.:.|..|.:|.||:  ||.....:|.|..|.|...|....
Zfish  3102 MDADRASTLICTKDRTWNGTKPVCKAIVCAAPPSIPNGQ--VVGSDFQWGSSISYSCNQGYQLSL 3164

  Fly   996 QYLRKCTEDGAWSGKQPRC 1014
            ..:..|...|.|||::|:|
Zfish  3165 PTILTCQGSGNWSGERPQC 3183

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_511136.2	CCP	58..112	CDD:153056	18/58 (31%)
		FTP	113..261	CDD:128870	21/147 (14%)
		CLECT	281..403	CDD:153057	19/127 (15%)
		PHA02927	<408..578	CDD:222943	65/243 (27%)
		PHA02927	<508..696	CDD:222943	61/198 (31%)
		PHA02639	643..>837	CDD:165022	54/205 (26%)
		PHA02927	798..1014	CDD:222943	63/217 (29%)
csmd2	XP_693833.6	CUB	65..172	CDD:238001
		CCP	178..236	CDD:153056
		CUB	241..344	CDD:238001
		CCP	382..440	CDD:153056
		CUB	444..553	CDD:238001
		CCP	560..614	CDD:153056
		CUB	617..724	CDD:238001
		CCP	730..788	CDD:153056
		CUB	791..898	CDD:238001
		CCP	906..959	CDD:153056
		CUB	963..1071	CDD:238001
		CCP	1078..1134	CDD:153056
		CUB	1137..1244	CDD:238001
		CCP	1250..1307	CDD:153056
		CUB	1310..1418	CDD:238001
		CCP	1424..1480	CDD:153056
		CUB	1484..1590	CDD:238001
		CCP	1597..1655	CDD:153056
		CUB	1658..1765	CDD:238001
		CCP	1774..1832	CDD:153056
		CUB	1835..1940	CDD:238001
		CCP	1948..2004	CDD:153056
		CUB	2007..2114	CDD:238001
		CCP	2120..2175	CDD:214478
		CUB	2179..2285	CDD:238001
		CCP	2291..2348	CDD:153056	18/58 (31%)
		CUB	2356..2462	CDD:238001	27/177 (15%)
		CCP	2465..2524	CDD:153056	12/102 (12%)
		PHA02927	2523..2767	CDD:222943	68/251 (27%)
		PHA02927	2674..2888	CDD:222943	70/220 (32%)
		Sushi	2892..2945	CDD:459664	16/54 (30%)
		PHA02927	2953..3242	CDD:222943	70/256 (27%)
		PHA02927	3130..3363	CDD:222943	19/56 (34%)