DRSC/TRiP Functional Genomics Resources

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Protein Alignment fw and MRC1

DIOPT Version :10

Sequence 1:NP_511136.2 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_002429.1 Gene:MRC1 / 4360 HGNCID:7228 Length:1456 Species:Homo sapiens


Alignment Length:828 Identity:160/828 - (19%)
Similarity:259/828 - (31%) Gaps:298/828 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   114 VNVAYRKPVNQSSYTRSGPASYAN--DGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVHVVR 176
            :.:.|..|....:::...|.||.|  .|:|.|.. :.:.|.|.:.:|:..|. |:          
Human   715 LGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQ-NVEYCGELKGDPTMSWN-DI---------- 767

  Fly   177 ITTRGCCGHQPLQDLEIRVGNS-----SADLQRNPLCAWYPGTLDEGVV-KTFTCARPLVGQYVA 235
                 .|.|......:|:.|.:     :...|.||     |.|.|..|: |.:        ||. 
Human   768 -----NCEHLNNWICQIQKGQTPKPEPTPAPQDNP-----PVTEDGWVIYKDY--------QYY- 813

  Fly   236 IQLVGVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHITKGESFDKAQAICK 300
                                                     |||        :.|:.|.|:|.||
Human   814 -----------------------------------------FSK--------EKETMDNARAFCK 829

  Fly   301 QTGGDLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITS----------RTWKWVNGD 355
            :..||||.         |.||.|::       .:|....:....::          :.:.|::|.
Human   830 RNFGDLVS---------IQSESEKK-------FLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGS 878

  Fly   356 VVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVM 420
            .|...:|...:||..|.::|||.:.....: |||:.|..... ||||....|..:      ||||
Human   879 KVDYVSWATGEPNFANEDENCVTMYSNSGF-WNDINCGYPNA-FICQRHNSSINA------TTVM 935

  Fly   421 --------GKKFTLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTC-----KYVDCGSLPEL 472
                    |.|    |...:...|...:.|..|.|.:   .|..:...|     ..|...:..|.
Human   936 PTMPSVPSGCK----EGWNFYSNKCFKIFGFMEEERK---NWQEARKACIGFGGNLVSIQNEKEQ 993

  Fly   473 KFGSIHMSEERTSFGVVATYSC-------HENYTLIGNENRTCAMDGWSGKQP------------ 518
            .|.:.||.:        :|:|.       :..:|.:..:.|......|....|            
Human   994 AFLTYHMKD--------STFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDA 1050

  Fly   519 ECLVDWCPDPQPIAGGDV----RFNDKRAGSTATYVCE----------------PGYVLVGEAII 563
            :|:|        |.||..    ::.|....|...|:|:                .|:|..|::..
Human  1051 DCVV--------IIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSY 1107

  Fly   564 S-CGLGGEWSSKTPSCR--------FVDCGAPA-------RPNRGIAILLNGTTTVNSVV---KY 609
            | .....:|......|:        .:|..:.|       ..|..:.|.||...|.|...   |:
Human  1108 SLMRQKFQWHEAETYCKLHNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKW 1172

  Fly   610 ECDEDHWLDGQSEL-----YCTREGKWSGEAPVC------------ELVTCETPSVPS------- 650
            .....:|...:.:|     |...:|.|  :...|            |:...|.|.:|.       
Human  1173 RVRYTNWAADEPKLKSACVYLDLDGYW--KTAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDH 1235

  Fly   651 GSFV--IGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSG------EWSADAPYCEYIDCGTILPI 707
            .:::  .|:.|.:.|....|       .|...||||..|      |.:|::.:..|    .:.|:
Human  1236 TAWIPFHGHCYYIESSYTRN-------WGQASLECLRMGSSLVSIESAAESSFLSY----RVEPL 1289

  Fly   708 P-------------YGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCL----ESAVWSDASPK 755
            .             .|:..::.|     |.|.|....:...||. :..|:    .|..||:.  .
Human  1290 KSKTNFWIGLFRNVEGTWLWINN-----SPVSFVNWNTGDPSGE-RNDCVALHASSGFWSNI--H 1346

  Fly   756 CEEIR---CPEPKL----AAHSLLSVTGNDRMYGRTLIRTSESSQNTA 796
            |...:   |..||:    ..|.||:...:.|.     :..|:.|.|.|
Human  1347 CSSYKGYICKRPKIIDAKPTHELLTTKADTRK-----MDPSKPSSNVA 1389

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_511136.2 CCP 58..112 CDD:153056
FTP 113..261 CDD:128870 28/154 (18%)
CLECT 281..403 CDD:153057 32/131 (24%)
PHA02927 <408..578 CDD:222943 38/222 (17%)
PHA02927 <508..696 CDD:222943 48/270 (18%)
PHA02639 643..>837 CDD:165022 40/193 (21%)
PHA02927 798..1014 CDD:222943
MRC1NP_002429.1 beta-trefoil_Ricin_MRC1 23..145 CDD:467785
FN2 161..209 CDD:128373
CLECT 234..342 CDD:153057
CLECT 362..487 CDD:214480
CLECT 504..626 CDD:214480
CLECT 659..779 CDD:153057 16/80 (20%)
CLECT 802..923 CDD:214480 39/196 (20%)
CLECT 945..1080 CDD:214480 27/157 (17%)
CLECT 1097..1213 CDD:214480 21/117 (18%)
CLECT 1230..1356 CDD:214480 26/144 (18%)
Blue background indicates that the domain is not in the aligned region.

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