DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Csmd1

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_001032404.2	Gene:	Csmd1 / 364634	RGDID:	1305103	Length:	3564	Species:	Rattus norvegicus

Alignment Length:	1065	Identity:	260/1065 - (24%)
Similarity:	397/1065 - (37%)	Gaps:	280/1065 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CGPPAVPLNAKVRTITVDSQIAE-AHYECDAGYELFGPSAVKCDRRT-----GWDRDLPFCGVNV 116
            |.||.|...|.:.|...|.:|.: ..|:|..||.|.|...:.|...:     |:.   |.|....
  Rat  2258 CPPPPVVPQADLLTEDEDFEIGDFVKYQCHPGYTLLGSDTLTCKLSSQLLFQGFP---PTCEAQC 2319

  Fly   117 AYRKPVNQSSYTRSG-------PASYAN--------------------DGKPGNKNPDGQECSET 154
                |.|:.....||       |.:|.|                    |.....|..|..|..:.
  Rat  2320 ----PANEVRTESSGVILSPGYPGNYFNSQTCAWSIKVEPNFNITLFVDTFQSEKQFDALEVFDG 2380

  Fly   155 QKEPSPW------------------------WRVDLLTPQAVHVVRITTRGCCGHQPLQDLEI-- 193
            ....||.                        |..|..|.:....:|.....|.....|::..:
  Rat  2381 SSGQSPLLVVLSGNHTEQSNFTSRSNHLYLRWSTDHATSKKGFKIRYAAPYCSLTSTLKNGGVLN 2445

  Fly   194 -------------------RVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLVGQYVAIQLV 239
                               .:|:|:|..:|||:          ||.:..:.| ||. |.|:..:.
  Rat  2446 KTAGALGSKVQYFCKPGYRMIGHSNATCRRNPV----------GVYQWDSMA-PLC-QAVSCGIP 2498

  Fly   240 GVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVVTTFSKTCYDFHITKGESFDKAQ---AICKQ 301
            ...|:.|      ||.:||::|                ||..|:  ..:|...|.:|   |:|::
  Rat  2499 EAPGNGS------FTGNEFTLD----------------SKVTYE--CNEGFKLDASQQATAVCQE 2539

  Fly   302 TGGDLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQ 366
            .|                              :|....|.|
  Rat  2540 DG------------------------------LWSNRGKPP------------------------ 2550

  Fly   367 PNNYNGEQNCVVLDGGRNWLWNDVGCNLDYLHFICQHSPLSCGSPDAQQNTTVM-----GKKFTL 426
                    .|                           .|:.|.|.:.|.:..|:     |.....
  Rat  2551 --------TC---------------------------KPVPCPSIEGQLSEHVLWRLVSGSLNEY 2580

  Fly   427 GEKIQYTCPKGHSLLGQTERECRLDGTWSGSS--PTCKYVDCGSL---PE-LKFGSIHMSEERTS 485
            |.::..:|..|:.|.||...:|:.:|||:...  |.||.:.||||   |. .|.|::      |.
  Rat  2581 GAQVLLSCSPGYFLQGQRLLQCQANGTWNTEEDRPRCKVISCGSLSFPPNGNKIGTL------TM 2639

  Fly   486 FGVVATYSCHENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATY 549
            :|..|.::|:..|||:|:..|.|..:| |||.:..||...|..|.||..|.:..:......|..|
  Rat  2640 YGATAIFTCNTGYTLVGSHVRECLANGLWSGSETRCLAGHCGSPDPIVNGHISGDGFSYRDTVVY 2704

  Fly   550 VCEPGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT-TVNSVVKYECDE 613
            .|.||:.|||.::..|....:||.:||.|..:.||.|..|..|   |.||:. .:|.:|.:.|..
  Rat  2705 QCNPGFRLVGTSVRICLQDHKWSGQTPVCVPITCGHPGNPAHG---LTNGSEFNLNDLVNFTCHT 2766

  Fly   614 DHWLDGQSELYCTREGKWSGEAPVCELVTCETP-----SVPSG--SFVIGYDYNVHSKIQYNCDP 671
            .:.|.|.|...|...|:||...|:|.:|.|..|     :|..|  :|...::|.  :.:.|:|..
  Rat  2767 GYLLQGASRAQCRSNGQWSSPLPICRVVNCSDPGFVENAVRHGQQNFPESFEYG--TSVMYHCKK 2829

  Fly   672 GHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILP-IPYGSHKYVTNTTYV-GSEVVFSCSQSHK 734
            |..:.|:..|.|:.||.|....|.|..|.||.  | :|  ::..:|...:. |:.|.:||.....
  Rat  2830 GFYLLGSSALTCMASGLWDRSLPKCLAISCGH--PGVP--ANAVLTGELFTFGATVQYSCKGGQI 2890

  Fly   735 LSGVLKRTCLESAVWSDASPKCEEIR---CPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTA 796
            |:|...|.|.|.:.||.:.|.|....   |.:|...||.  |..|::
  Rat  2891 LTGNSTRVCQEDSHWSGSLPHCSGNSPGFCGDPGTPAHG--SRLGDE------------------ 2935

  Fly   797 QTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYY 861
              :|..:|.::.||.|:::.|.|..||..:|.|||..|.|..|.||.|....|| ::|:::...:
  Rat  2936 --FKTKSLLRFSCEMGHQLRGSAERTCLVNGSWSGVQPVCEAVSCGNPGTPTNG-MILSSDGILF 2997

  Fly   862 GAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVATFK 926
            .::|:|.|...:|.:|:..|.||.:|.|:..||:|..:.|..|....|.|............:::
  Rat  2998 SSSVIYACWEGYKTSGLMTRHCTANGTWTGTAPDCTIISCGDPGTLPNGIQFGTDFTFNKTVSYQ 3062

  Fly   927 CAKGRIM--MGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIP 989
            |..|.:|  ..:.|..|.|:|.|....|.|:.|.|.:|.::.||:  |......:|.|..|.|:.
  Rat  3063 CNPGYLMEPPTSPTIRCTKDGTWNQTRPLCKAVLCSQPPSVPNGK--VEGSDFRWGASISYSCVD 3125

  Fly   990 NYNRIGQYLRKCTEDGAWSGKQPRC 1014
            .|......:..|...|.|.|:.|:|
  Rat  3126 GYQLSHSAILSCEGRGVWKGEVPQC 3150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	17/59 (29%)
		FTP	113..261	CDD:128870	38/219 (17%)
		CLECT	281..403	CDD:153057	11/124 (9%)
		CCP	408..462	CDD:153056	16/60 (27%)
		CCP	466..520	CDD:153056	21/58 (36%)
		CCP	525..579	CDD:153056	18/53 (34%)
		CCP	583..639	CDD:153056	19/56 (34%)
		PHA02927	637..897	CDD:222943	78/271 (29%)
		CCP	643..697	CDD:153056	16/60 (27%)
		CCP	701..757	CDD:153056	17/57 (30%)
		Sushi	<799..836	CDD:278512	14/36 (39%)
		Sushi	841..896	CDD:278512	18/54 (33%)
		CCP	901..955	CDD:153056	13/55 (24%)
		CCP	959..1015	CDD:153056	16/56 (29%)
Csmd1	NP_001032404.2	CUB	32..139	CDD:238001
		CCP	145..202	CDD:214478
		CUB	208..311	CDD:238001
		CCP	349..407	CDD:153056
		CUB	411..520	CDD:238001
		CCP	527..581	CDD:153056
		CUB	584..691	CDD:238001
		CCP	697..755	CDD:153056
		CUB	758..865	CDD:238001
		CCP	873..926	CDD:153056
		CUB	930..1037	CDD:238001
		CCP	1045..1101	CDD:153056
		CUB	1104..1211	CDD:238001
		CCP	1217..1274	CDD:153056
		CUB	1277..1385	CDD:238001
		CCP	1391..1448	CDD:153056
		CUB	1451..1556	CDD:238001
		CCP	1564..1622	CDD:153056
		CUB	1625..1732	CDD:238001
		CCP	1741..1799	CDD:153056
		CUB	1802..1907	CDD:238001
		CCP	1915..1971	CDD:153056
		CUB	1974..2081	CDD:238001
		CCP	2087..2142	CDD:214478
		CUB	2146..2252	CDD:238001
		CCP	2258..2316	CDD:153056	17/60 (28%)
		CUB	2323..2429	CDD:238001	15/105 (14%)
		PHA02927	<2451..2617	CDD:222943	50/290 (17%)
		PHA02927	2619..2855	CDD:222943	79/246 (32%)
		CCP	2859..2912	CDD:153056	17/56 (30%)
		PHA02927	<2940..3092	CDD:222943	47/152 (31%)
		PHA02927	3032..3271	CDD:222943	32/121 (26%)
		CCP	3275..3331	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11141
eggNOG	1	0.900	-	-		E33208_3BCEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2941
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45787
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.860