DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Csmd2

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_011238862.1	Gene:	Csmd2 / 329942	MGIID:	2386401	Length:	3612	Species:	Mus musculus

Alignment Length:	1197	Identity:	282/1197 - (23%)
Similarity:	425/1197 - (35%)	Gaps:	369/1197 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 QICGPPAVPLNAKVR--TITVDSQIAEAHYECDAGYELFGPSAVKCDRRT--GWDRDLPF----C 112
            |.|..|....|..||  ...|...:.   :||..||:|.|...:.|...|  .||..||.    |
Mouse  2124 QECPDPEPFANGIVRGAGYNVGQSVT---FECLPGYQLTGQPVLTCQHGTNRNWDHPLPRCEVPC 2185

  Fly   113 GVNVAYRKPVNQSSYTRSGPASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVH---- 173
            |.|:.   ..|.:.|:...|:.|::          .|:|.         |::.:.....||
Mouse  2186 GGNIT---SFNGTVYSPGYPSPYSS----------SQDCV---------WQITVPIGHGVHLNLS 2228

  Fly   174 VVRITTRGCCGHQPLQD---------------------LEIRVGNSSADLQRNPLCAWYPGTLDE 217
            :::|        :|..|                     |..::.:||::   ..|..::..|...
Mouse  2229 LLQI--------EPFGDYITVWDGPQQTSLQLGVFTRSLSKKIAHSSSN---QVLLKFHRDTATG 2282

  Fly   218 GVVKTFTCARPLVGQYVAIQLVGVEGSLSLC---------EVETFTNDEFSVD-----RCLSPKI 268
            |:......|.|                |:.|         ||.| .|:||::.     |||....
Mouse  2283 GIFAIAFSAYP----------------LTKCPPPTILPNAEVVT-ENEEFNIGDIVRYRCLPGFT 2330

  Fly   269 GVDTVVTTFSKTCYDFHITKGESFDKAQAICK-----------QTGGDLVHDFRGA--------- 313
            .|.:.:.|.....|       ..|:....||:           .||..|...:.|:
Mouse  2331 LVGSEILTCKLGTY-------LQFEGPPPICEVHCPTNELLTDSTGVILSQSYPGSYPQFQTCSW 2388

  Fly   314 ------------TSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQ 366
                        |..|.|||.:..:.|:                      .:|...|.|.. |..
Mouse  2389 LVRVEPEYNISITVEYFLSEKQYDEFEI----------------------FDGPSGQSPLL-KAL 2430

  Fly   367 PNNYN------GEQNCVVLDGGRNWLWNDVGCNLDY---------------------------LH 398
            ..||:      ...|.|.|....:..:|..|..:.|                           :|
Mouse  2431 SGNYSAPLIVTSSSNSVYLRWSSDHAYNRKGFKIRYSAPYCSLPKAPLHGFILGQTTTQPGGSIH 2495

  Fly   399 F--------------ICQHSP---------------LSCGSPDAQQNTTVMGKKFTLGEKIQYTC 434
            |              ||...|               ||||.|||.:|..|.||::|:|.|..|:|
Mouse  2496 FGCNTGYRLVGHSMAICTRHPQGYHLWSEAIPLCQALSCGLPDAPKNGIVFGKEYTVGTKAVYSC 2560

  Fly   435 PKGHSL----------------------------------------------------------- 440
            .:|:.|
Mouse  2561 NEGYHLQAGAEATAECLDTGLWSNSNVPPQCVPVTCPDISSISVEHGRWRLIFETQYQFQAQLML 2625

  Fly   441 --------LGQTERECRLDGTWS--GSSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVATYSCH 495
                    .||....|:.:|.||  .|.|||:.:.||.||....|  |.....:.:|..|.:||:
Mouse  2626 ICDPGYYYTGQRVIRCQANGRWSLGESMPTCQIISCGELPTPPSG--HRIGTMSVYGATAIFSCN 2688

  Fly   496 ENYTLIGNENRTCAMDG-WSGKQPECLVDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVG 559
            ..|||:|:..|.|..:| |||.:..||...|..|:||..|.:...:.....:..|.|..|:.|:|
Mouse  2689 SGYTLVGSRVRECMANGLWSGSEVRCLAGHCGTPEPIVNGHINGENFNYRGSVVYQCRAGFRLIG 2753

  Fly   560 EAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTT-----TVNSVVKYECDEDHWLDG 619
            .::..|.....||.|||.|..:.||.|..|       :||.|     .:|.|||:.|:..:..:|
Mouse  2754 MSVRICQQDHHWSGKTPFCVPITCGHPGNP-------VNGLTQGSQFNLNDVVKFICNPGYIAEG 2811

  Fly   620 QSELYCTREGKWSGEAPVCELVTCETPSVPSGSFVIGYDYN----VHSK----------IQYNCD 670
            .:...|...|:||...|.|.::.|..|         |:..|    ||:.          :.|.|:
Mouse  2812 AARSQCLASGQWSDTLPTCRIINCTDP---------GHQENSVRQVHTSGPHRFSFGTTVSYQCN 2867

  Fly   671 PGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTILPIPYGS--HKYVTNTTY-VGSEVVFSCSQS 732
            .|..:.|||.|.|...|.|....|.|..:.||.    | ||  |..::..:| ||:.|.:||:..
Mouse  2868 HGFYLLGTPALSCQGDGTWDRPRPQCLLVSCGH----P-GSPPHAQMSGDSYIVGAVVRYSCTGK 2927

  Fly   733 HKLSGVLKRTCLESAVWSDASPKCEEIR---CPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQN 794
            ..|.|...|.|.....|:.:.|.|....   |.:|.:.||.               ||..:|
Mouse  2928 RTLVGNSTRMCGLDGHWTGSLPHCSGTSTGVCGDPGIPAHG---------------IRLGDS--- 2974

  Fly   795 TAQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNAT 859
                :..|::.::.|:.|:.:.|.:...|..:|.|||:.|||..:.||.|...:|.:||. ::..
Mouse  2975 ----FAPGSVMRFSCDAGHVLRGSSERMCQANGSWSGSQPECGVISCGNPGTPSNARVVF-SDGL 3034

  Fly   860 YYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPRAVGSVAT 924
            .:.::|:|||...:...|:..|.|:.:|.|:...|||..:.|..|.|..|.|............|
Mouse  3035 VFSSSVVYECREGYYATGLLSRHCSVNGTWTGSDPECTVINCGDPGIPANGIRLGNDFRYNKTVT 3099

  Fly   925 FKCAKGRIMMGNDTRV--CQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHC 987
            ::|..|.:|..:...|  |.|:..|.|..|.|:.:.|..|..|.||:| |.:|.| :|.|..|.|
Mouse  3100 YQCVPGYVMESHRVSVLSCTKDRTWNGTKPVCKAIMCKPPQLIPNGKV-VGSDFT-WGSSVSYAC 3162

  Fly   988 IPNYNRIGQYLRKCTEDGAWSGKQPRC 1014
            :..|......:..|..:|:|:|:.|:|
Mouse  3163 LEGYQLSLPAVLTCEGNGSWTGELPQC 3189

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	18/61 (30%)
		FTP	113..261	CDD:128870	30/181 (17%)
		CLECT	281..403	CDD:153057	30/200 (15%)
		CCP	408..462	CDD:153056	25/122 (20%)
		CCP	466..520	CDD:153056	20/54 (37%)
		CCP	525..579	CDD:153056	16/53 (30%)
		CCP	583..639	CDD:153056	18/60 (30%)
		PHA02927	637..897	CDD:222943	74/279 (27%)
		CCP	643..697	CDD:153056	17/67 (25%)
		CCP	701..757	CDD:153056	18/58 (31%)
		Sushi	<799..836	CDD:278512	10/36 (28%)
		Sushi	841..896	CDD:278512	16/54 (30%)
		CCP	901..955	CDD:153056	15/55 (27%)
		CCP	959..1015	CDD:153056	20/56 (36%)
Csmd2	XP_011238862.1	CUB	71..178	CDD:238001
		CCP	184..241	CDD:214478
		CUB	247..350	CDD:238001
		CCP	388..446	CDD:153056
		CUB	450..558	CDD:366096
		CCP	566..620	CDD:153056
		CUB	623..730	CDD:238001
		CCP	736..794	CDD:153056
		CUB	797..904	CDD:238001
		CCP	912..966	CDD:153056
		CUB	969..1077	CDD:238001
		CCP	1084..1140	CDD:153056
		CUB	1143..1250	CDD:238001
		CCP	1256..1313	CDD:153056
		CUB	1316..1424	CDD:238001
		CCP	1430..1487	CDD:153056
		CUB	1490..1595	CDD:366096
		CCP	1603..1660	CDD:153056
		CUB	1664..1771	CDD:238001
		CCP	1780..1838	CDD:153056
		CUB	1841..1946	CDD:238001
		CCP	1954..2010	CDD:153056
		CUB	2013..2120	CDD:238001
		CCP	2126..2182	CDD:153056	18/58 (31%)
		CUB	2185..2291	CDD:238001	21/138 (15%)
		Sushi	2297..2354	CDD:365861	14/64 (22%)
		CUB	2362..2468	CDD:238001	22/128 (17%)
		CCP	2471..2530	CDD:153056	5/58 (9%)
		PHA02927	2529..2773	CDD:222943	66/245 (27%)
		PHA02927	2658..2894	CDD:222943	75/253 (30%)
		CCP	2898..2951	CDD:153056	18/57 (32%)
		CCP	2959..3012	CDD:153056	17/74 (23%)
		CCP	3017..3071	CDD:153056	16/54 (30%)
		PHA02927	3071..3310	CDD:222943	37/121 (31%)
		CCP	3314..3369	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	62	1.000	Domainoid score	I10279
eggNOG	1	0.900	-	-		E33208_3BCEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43710
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.810