DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fw and CFHR1

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_002104.2	Gene:	CFHR1 / 3078	HGNCID:	4888	Length:	330	Species:	Homo sapiens

Alignment Length:	416	Identity:	98/416 - (23%)
Similarity:	144/416 - (34%)	Gaps:	141/416 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   456 GSSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVAT-----YSCHENY--------TLIGNENRT 507
            |.:..|.:      |::..|.::..|:...|..|.|     |||..|:        |.|     |
Human    18 GEATFCDF------PKINHGILYDEEKYKPFSQVPTGEVFYYSCEYNFVSPSKSFWTRI-----T 71

  Fly   508 CAMDGWSGKQPECL----VDWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLV-GEAIISCGL 567
            |..:||| ..|:||    ..:..:....:.|.....    |.|...:|..||.|. .|..|||..
Human    72 CTEEGWS-PTPKCLRLCFFPFVENGHSESSGQTHLE----GDTVQIICNTGYRLQNNENNISCVE 131

  Fly   568 GGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKWS 632
            .| ||: .|.||..|...           :|..|..|:         |.|..|...|
Human   132 RG-WST-PPKCRSTDTSC-----------VNPPTVQNA---------HILSRQMSKY-------- 166

  Fly   633 GEAPVCELVTCETPSVPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCE 697
                            |||           .:::|.|...:.|.|...:.|| :|.|: :.|.|:
Human   167 ----------------PSG-----------ERVRYECRSPYEMFGDEEVMCL-NGNWT-EPPQCK 202

  Fly   698 YID----CGTILPIPYGSHKYVTNTTYV-GSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCE 757
              |    ||...||..|.......:.|. .|.|.:.|...::|.|..:.|| .:..||: .||
Human   203 --DSTGKCGPPPPIDNGDITSFPLSVYAPASSVEYQCQNLYQLEGNKRITC-RNGQWSE-PPK-- 261

  Fly   758 EIRCPEPKLAAHSL-------LSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCERGYKM 815
               |..|.:.:..:       |..|...::|    :||.||             |::.|:|||::
Human   262 ---CLHPCVISREIMENYNIALRWTAKQKLY----LRTGES-------------AEFVCKRGYRL 306

  Fly   816 VGEA---LATCTDSGQWSGTI--PEC 836
            ...:   ..||     |.|.:  |.|
Human   307 SSRSHTLRTTC-----WDGKLEYPTC 327

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057
		CCP	408..462	CDD:153056	1/5 (20%)
		CCP	466..520	CDD:153056	18/66 (27%)
		CCP	525..579	CDD:153056	15/54 (28%)
		CCP	583..639	CDD:153056	7/55 (13%)
		PHA02927	637..897	CDD:222943	51/217 (24%)
		CCP	643..697	CDD:153056	12/53 (23%)
		CCP	701..757	CDD:153056	17/56 (30%)
		Sushi	<799..836	CDD:278512	10/41 (24%)
		Sushi	841..896	CDD:278512
		CCP	901..955	CDD:153056
		CCP	959..1015	CDD:153056
CFHR1	NP_002104.2	CCP	90..141	CDD:153056	15/56 (27%)
		CCP	147..202	CDD:153056	19/111 (17%)
		CCP	208..262	CDD:153056	17/60 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960