DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and CFH

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_000177.2	Gene:	CFH / 3075	HGNCID:	4883	Length:	1231	Species:	Homo sapiens

Alignment Length:	1278	Identity:	274/1278 - (21%)
Similarity:	424/1278 - (33%)	Gaps:	474/1278 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 LIMLLLLALCAAGNGQICG--PPAVPLNAKVRTITVDSQI----AEAHYECDAGYELFGPSAVKC 99
            :|.|:|.|:|.|   :.|.  ||.  .|.::.|.:...|.    .:|.|:|..||...|...:.|
Human     7 IICLMLWAICVA---EDCNELPPR--RNTEILTGSWSDQTYPEGTQAIYKCRPGYRSLGNVIMVC 66

  Fly   100 DRRTGWDRDLPFCGVNVAYRKPVNQSSYTRSGPASYANDGKPGNKNPDGQECSETQKEPSPWWRV 164
             |:..|          ||.                          ||    ..:.||.|
Human    67 -RKGEW----------VAL--------------------------NP----LRKCQKRP------ 84

  Fly   165 DLLTPQAVHVVRITTRGCCGH---QPLQDLEIRVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCA 226
                              |||   .|.....:..||                ..:.||...:||.
Human    85 ------------------CGHPGDTPFGTFTLTGGN----------------VFEYGVKAVYTCN 115

  Fly   227 RPLVGQYVAIQLVGVEGSLSLCEVETFTND--EFSVDRCL---SPKIGVDTVVTTFSKTCYDFHI 286
            .       ..||:| |.:...|:.:.:|||  ...|.:||   :|:.|  .:|::..:...::|.
Human   116 E-------GYQLLG-EINYRECDTDGWTNDIPICEVVKCLPVTAPENG--KIVSSAMEPDREYHF 170

  Fly   287 TKGESFDKAQAICKQTGGDLVHDFRGATSSYILSELERRK-------SELKPQLVWIGAQKEPGI 344
            .:...|     :|              .|.|.:...|...       |:.||:.|.|.. |.|.:
Human   171 GQAVRF-----VC--------------NSGYKIEGDEEMHCSDDGFWSKEKPKCVEISC-KSPDV 215

  Fly   345 TSRTWKWVNGD-VVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVGCNLDYLH-----FICQH 403
                   :||. :.||..:.:::...|.                    ||:.|.:     .:|..
Human   216 -------INGSPISQKIIYKENERFQYK--------------------CNMGYEYSERGDAVCTE 253

  Fly   404 S---PL------SCGSPDAQQ-NTTVMGKKFTLGEKIQYTCPKGH--SLLGQTERECRLDGTWSG 456
            |   ||      ||.:|.... :.:.:..|...|::|.|.|..|.  :..|.|.: |...| |.
Human   254 SGWRPLPSCEEKSCDNPYIPNGDYSPLRIKHRTGDEITYQCRNGFYPATRGNTAK-CTSTG-WI- 315

  Fly   457 SSPTCKYVDCGSLPELKFGSIHMSEERTSFGVVA-----TYSCHENY-TLIGN--ENRTCAMDGW 513
            .:|.|....| ..|::|.|.::....|..:..||     :|.|.|:: |..|:  ::..|..|||
Human   316 PAPRCTLKPC-DYPDIKHGGLYHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDHIHCTQDGW 379

  Fly   514 SGKQPECL-------------------------VD----------------------WCPDPQPI 531
            |...| ||                         :|                      |.|.|:.|
Human   380 SPAVP-CLRKCYFPYLENGYNQNHGRKFVQGKSIDVACHPGYALPKAQTTVTCMENGWSPTPRCI 443

  Fly   532 AGGDVRFNDKRA-----------------GSTATYVCEPGYVLV-GE--AIISCGLGGEWSSKTP 576
            .   |:...|.:                 ...|.|.|:.|||.. ||  ..|:||..| ||:: |
Human   444 R---VKTCSKSSIDIENGFISESQYTYALKEKAKYQCKLGYVTADGETSGSITCGKDG-WSAQ-P 503

  Fly   577 SCRFVDCGAPARPNRGIAILLNGTT-------TVNSVVKYECDEDHWLDGQS---ELYCTREGKW 631
            :| ...|..|        :.:|..|       .:|..:.|||.:.:..:..|   .:.|...| |
Human   504 TC-IKSCDIP--------VFMNARTKNDFTWFKLNDTLDYECHDGYESNTGSTTGSIVCGYNG-W 558

  Fly   632 SGEAPVCELVTCETPS-----VPS------------------GSFVIG------YDYNV------ 661
            | :.|:|....||.|.     ||.                  |..::|      |.:.:
Human   559 S-DLPICYERECELPKIDVHLVPDRKKDQYKVGEVLKFSCKPGFTIVGPNSVQCYHFGLSPDLPI 622

  Fly   662 ----------------------------HSK-IQYNCDPGHIMHGTPVLECLDSGEWSADAPYC- 696
                                        ||: ::|.|:|..:|.|...::|:| |||:. .|.|
Human   623 CKEQVQSCGPPPELLNGNVKEKTKEEYGHSEVVEYYCNPRFLMKGPNKIQCVD-GEWTT-LPVCI 685

  Fly   697 -EYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWS--------DA 752
             |...||.|..:.:|..:..:...|.|..|.|:||:|..:.|....||:. .||:        |.
Human   686 VEESTCGDIPELEHGWAQLSSPPYYYGDSVEFNCSESFTMIGHRSITCIH-GVWTQLPQCVAIDK 749

  Fly   753 SPKCE---------------------------------------------EIRC---------PE 763
            ..||:                                             |:.|         |.
Human   750 LKKCKSSNLIILEEHLKNKKEFDHNSNIRYRCRGKEGWIHTVCINGRWDPEVNCSMAQIQLCPPP 814

  Fly   764 PKLAAHSLLSVTGNDR--------MYGRTLIRTSE------------------------------ 790
            |::.....::.|.|.|        .....||:..|
Human   815 PQIPNSHNMTTTLNYRDGEKVSVLCQENYLIQEGEEITCKDGRWQSIPLCVEKIPCSQPPQIEHG 879

  Fly   791 ---SSQNTAQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKV 852
               ||:::.::|..|....|.||.|:::..|...||. .|:||.. |:|..:.|.:|..|::|.|
Human   880 TINSSRSSQESYAHGTKLSYTCEGGFRISEENETTCY-MGKWSSP-PQCEGLPCKSPPEISHGVV 942

  Fly   853 VLATNATYYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPR 917
            ...:::..||..|.|:|...|.::|.:...|... .||| .|.|::..|.:....||.|.....:
Human   943 AHMSDSYQYGEEVTYKCFEGFGIDGPAIAKCLGE-KWSH-PPSCIKTDCLSLPSFENAIPMGEKK 1005

  Fly   918 AV---GSVATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLY 979
            .|   |...|:.||....|.|.....| .|.:|||: ||||...|..|..::|. .||....:.|
Human  1006 DVYKAGEQVTYTCATYYKMDGASNVTC-INSRWTGR-PTCRDTSCVNPPTVQNA-YIVSRQMSKY 1067

  Fly   980 --GGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELATAE 1020
              |....|.|...|...|.....|. :|.|: :.|:|:.:|.:
Human  1068 PSGERVRYQCRSPYEMFGDEEVMCL-NGNWT-EPPQCKDSTGK 1108

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	15/59 (25%)
		FTP	113..261	CDD:128870	25/152 (16%)
		CLECT	281..403	CDD:153057	22/134 (16%)
		CCP	408..462	CDD:153056	14/56 (25%)
		CCP	466..520	CDD:153056	18/61 (30%)
		CCP	525..579	CDD:153056	20/73 (27%)
		CCP	583..639	CDD:153056	14/65 (22%)
		PHA02927	637..897	CDD:222943	86/428 (20%)
		CCP	643..697	CDD:153056	22/119 (18%)
		CCP	701..757	CDD:153056	18/63 (29%)
		Sushi	<799..836	CDD:278512	13/36 (36%)
		Sushi	841..896	CDD:278512	17/54 (31%)
		CCP	901..955	CDD:153056	18/56 (32%)
		CCP	959..1015	CDD:153056	15/57 (26%)
CFH	NP_000177.2	PHA02927	10..262	CDD:222943	76/394 (19%)
		CCP	85..142	CDD:153056	18/80 (23%)
		CCP	146..205	CDD:214478	14/79 (18%)
		CCP	210..263	CDD:153056	14/80 (18%)
		CCP	267..320	CDD:214478	14/55 (25%)
		Sushi	325..384	CDD:278512	17/59 (29%)
		CCP	389..443	CDD:153056	4/53 (8%)
		CCP	454..506	CDD:153056	16/54 (30%)
		PHA02927	505..745	CDD:222943	55/253 (22%)
		CCP	569..624	CDD:153056	8/54 (15%)
		CCP	630..685	CDD:153056	13/56 (23%)
		CCP	691..745	CDD:153056	16/54 (30%)
		Sushi	811..864	CDD:278512	8/52 (15%)
		CCP	870..927	CDD:153056	15/58 (26%)
		CCP	931..985	CDD:153056	17/55 (31%)
		PHA02927	989..1230	CDD:222943	37/125 (30%)
		CCP	989..1044	CDD:153056	18/56 (32%)
		CCP	1048..1103	CDD:153056	15/57 (26%)
		CCP	1109..1163	CDD:153056	274/1278 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960