DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Cr2

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	XP_008768069.1	Gene:	Cr2 / 289395	RGDID:	1310065	Length:	1406	Species:	Rattus norvegicus

Alignment Length:	1183	Identity:	277/1183 - (23%)
Similarity:	411/1183 - (34%)	Gaps:	339/1183 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CGPPAVPLNAKVRT---ITVDSQIAEAHYECDAGYELFGPSAVKC---DRRTGWDRDLPFCGVNV 116
            |..|..||:..|..   ||..|.|.   |.|:.||.|.|.|:..|   |....||..:|.|.:..
  Rat    83 CMNPQEPLHGSVHINTGITFGSTIT---YSCNKGYRLIGDSSATCIISDNTVMWDNSVPICELIP 144

  Fly   117 AYRKPVNQSSYTRSGP---------ASY-----------------------ANDGKPGNKNPDGQ 149
            ....|...:.|.:|..         |:|                       :.|.:.|..|....
  Rat   145 CESPPAISNGYFQSSSRDSFFYGMVATYYCHVGKNREKLFDLVGEKSIYCTSKDNQVGIWNSPPP 209

  Fly   150 ECSETQKEPSP-------------------------------------W------WRVDLLTPQA 171
            :|....|.|.|                                     |      |...|.|
  Rat   210 QCIARVKCPMPEIENGDVESGFKPSFFLNDTVMFKCKSGFIMKGSSIVWCQPDSKWSPPLPT--- 271

  Fly   172 VHVVRITTRGCCGHQPL-------QDLE-IRVGNS---SAD----------LQRNPLCAWYPG-- 213
                  ..|||...|.:       :|.| ..||..   |.:          ::..||.||.|.
  Rat   272 ------CFRGCLPPQNILHGDYNEKDKEFFSVGQKVSYSCEPGYTLIGTNLVECTPLGAWSPSVP 330

  Fly   214 -----------------------TLDEGVVKTFTCARPLVGQYVAIQLVGVEGSLSLCEVET-FT 254
                                   .|..|...:|.|.       :..||.|...|..:.|.|| ..
  Rat   331 TCEVKSCDAIPNQLLNGRVLLPHNLQLGAEVSFVCD-------LGFQLKGKSSSQCVPEGETVIW 388

  Fly   255 NDEFSVDRCLS----PKIG------------VDTVVTTFSKTCYD----------FHITKGE--- 290
            |::|.|...||    |::.            ..|||   ..||..          |.|:|.:
  Rat   389 NNKFPVCEQLSCDPPPEVNNTRRLYYSLPVLPGTVV---RYTCLPGYRLIGEKAIFCISKDQVTA 450

  Fly   291 SFDKAQAICKQTGGDLVHDFRGATSSYILSELERRKSELKPQLVWIGAQKEPGITSRTWKWVNGD 355
            ::|||..||:.                 .:::......:.|     |....||  ||. .:.:||
  Rat   451 TWDKATPICEP-----------------WNKMSACSKPIVP-----GGIINPG--SRP-PFKHGD 490

  Fly   356 VV------------QKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVG---CNLDYLHFICQHSP 405
            .|            .|..|.:                  .|.:|....   |..|:        |
  Rat   491 SVTVTCKANFTMKGSKTVWCR------------------ANKMWGPTPLPVCESDF--------P 529

  Fly   406 LSCGSPDAQQNTTVMG---KKFTLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTCKYVDCG 467
            |.|.|.....|....|   :||..|..:.|:|..|:.|:|:...:|...|.|....||||...|.
  Rat   530 LECPSLPTIHNGHHTGQHVEKFVAGLSVTYSCEPGYLLVGKKTIKCLSSGAWDDVIPTCKEAKCE 594

  Fly   468 SLPELKFGSIHMSEERTSF--GVVATYSCHENYTLIGNENRTCAM----DGWSGKQPECLVDWCP 526
            ...:|..|.:   :|..|.  |....:||:|.|.|.|..:..|.:    ..|: |:|.|....||
  Rat   595 RPEKLPNGQV---KEPPSLRVGTTVYFSCNEGYELQGQPSSKCVIVEQKAVWT-KKPVCKEILCP 655

  Fly   527 DPQPIAGG--DVRFN-DKRAGSTATYVCEP------GYVLVGEAIISCGLGGE----WSSKTPSC 578
            .|.|:..|  ..||: :...|:..||:|:|      .:.|:||..|.|....|    ||...|.|
  Rat   656 PPPPVLNGRHSGRFSGNVPYGNNVTYMCDPSPEKGVNFTLIGEKTIYCTNSSEKTGIWSGPAPYC 720

  Fly   579 RF----VDCGAPARPNRG-IAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVC 638
            :.    ..|..| :.||| |..:|..:.:.|..|.:.|:....|.|...:.|:.:|.|....|||
  Rat   721 KLSISEAQCLRP-QINRGQILSILKESYSYNDTVAFSCEPGFTLKGSGRIRCSAQGTWKPPVPVC 784

  Fly   639 ELVTCETPSVPSGS----FVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYI 699
            |......|.:.:|.    :.:.:|..  :.|:|:||||:.:.|...:.|...|:|:...|.|:..
  Rat   785 EKGCQAPPKIINGQKEDRYFLNFDPG--TSIRYSCDPGYFLVGEDTIHCTSEGKWTPIPPQCKVA 847

  Fly   700 DCGTILPIPYGSHKYV-TNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIRCPE 763
            :|.     |.|.|.:. ....::...:..||.:..::|....:.|..:..|......|:||.||.
  Rat   848 ECK-----PVGPHVFERPQNHFIRPAINSSCDEGFQISESAYQLCQGTIPWFIEIRLCKEITCPP 907

  Fly   764 PKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCERG------YKMVGEALAT 822
            |.:    :|:.|           .|..||::.    ..|.:..|.|..|      :|::||....
  Rat   908 PPI----ILNGT-----------HTWRSSEDV----PYGTVITYMCYPGSEEGVKFKLIGEQTIH 953

  Fly   823 CT-DS---GQWSGTIPECVY----VECGAPEGINNGKVVLATNATY-YGAAVLYECNVNFKLNGV 878
            || ||   |.||...|.|..    |:| ....:.||..:....|.| |..:|.::|...:.|.|.
  Rat   954 CTSDSRGRGSWSSPAPLCKLSLPAVQC-TEVHVENGVKLTDNKAPYFYNNSVTFKCRDGYILIGS 1017

  Fly   879 SRRLCTEHGNWSHEAPECVEVVCD----TPNINENLIVEAGPRAVGSVATFKCAKGRIMMGNDTR 939
            |:..|..:..|..|||.|.:..|:    .|.|:::.:::...|.        |..|..:.|....
  Rat  1018 SQIRCKANNTWDPEAPHCKKEGCEPMRKLPGISDHSLIKLVNRT--------CQNGYQLTGYTYE 1074

  Fly   940 VCQ--KNGKWTGKSPTCRPVDCGRPLAIENG-RVIVVNDSTLYGGSAEYHCIPNYNRIGQYLRKC 1001
            .||  :||.|..|...|..:.|..|..|.|| ...::.:..|||....|.|...:..:|:...:|
  Rat  1075 KCQNAENGTWFQKIAVCTVILCPPPPTIANGSHTGMMAEHFLYGNEVSYECDKGFYLLGEKSLQC 1139

  Fly  1002 TEDGAWSGKQPRC 1014
            ...|:|||..|:|
  Rat  1140 KGHGSWSGPPPQC 1152

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	21/59 (36%)
		FTP	113..261	CDD:128870	43/269 (16%)
		CLECT	281..403	CDD:153057	24/149 (16%)
		CCP	408..462	CDD:153056	17/56 (30%)
		CCP	466..520	CDD:153056	16/59 (27%)
		CCP	525..579	CDD:153056	21/66 (32%)
		CCP	583..639	CDD:153056	17/56 (30%)
		PHA02927	637..897	CDD:222943	71/279 (25%)
		CCP	643..697	CDD:153056	14/57 (25%)
		CCP	701..757	CDD:153056	9/56 (16%)
		Sushi	<799..836	CDD:278512	15/46 (33%)
		Sushi	841..896	CDD:278512	16/55 (29%)
		CCP	901..955	CDD:153056	13/59 (22%)
		CCP	959..1015	CDD:153056	18/57 (32%)
Cr2	XP_008768069.1	PHA02927	10..274	CDD:222943	38/202 (19%)
		CCP	34..78	CDD:214478
		CCP	83..140	CDD:214478	21/59 (36%)
		CCP	145..212	CDD:153056	8/66 (12%)
		CCP	217..272	CDD:153056	6/63 (10%)
		CCP	276..333	CDD:153056	12/56 (21%)
		Sushi	337..395	CDD:278512	13/64 (20%)
		CCP	400..460	CDD:153056	13/62 (21%)
		CCP	468..525	CDD:153056	13/82 (16%)
		CCP	532..589	CDD:153056	17/56 (30%)
		CCP	593..650	CDD:153056	16/60 (27%)
		CCP	654..721	CDD:153056	21/66 (32%)
		CCP	729..785	CDD:153056	17/56 (30%)
		CCP	788..845	CDD:153056	14/58 (24%)
		CCP	905..972	CDD:153056	23/85 (27%)
		CCP	980..1036	CDD:153056	16/56 (29%)
		PHA02927	1088..1341	CDD:222943	19/65 (29%)
		CCP	1096..1152	CDD:153056	17/55 (31%)
		CCP	1161..1217	CDD:153056
		CCP	1224..1281	CDD:153056
		CCP	1285..1342	CDD:153056
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BCEG
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	269	1.000	Inparanoid score	I2941
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm45787
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.860