Protein Alignment fw and Cfhr4

DIOPT Version :10

• Sequence 1: NP_511136.2
• Gene: fw / 32162
• FlyBaseID: FBgn0001083
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_001025148.3
• Gene: Cfhr4 / 214403
• MGIID: 3646434
• Length: 879
• Species: Mus musculus
• Alignment Length: 741
• Identity: 183/741 - (24%)
• Similarity: 279/741 - (37%)
• Gaps: 182/741 - (24%)

  Fly   422 KKFTLGEKIQYTCPKGHSLL-GQTERECRLDGTWSGSSPTCKYVDCGSLPELKFGSIHMSEERTS 485
            |.:..|:.::..|..|:||. ||....|..:| || ..|.|..:...|:.:::..:...||...:
Mouse   107 KIYVQGQSLKVQCYNGYSLQNGQDTMTCTENG-WS-PPPKCIRIKTCSVSDIEIENGFFSESFRT 169

  Fly   486 FGV--VATYSCHENYTLIGNENR---TCAMDGWSGKQPECLVDWCPDPQPIAGGDV--------R 537
            :.:  ..:|.|.:.|.....|..   ||..:||| .||.|:.. |  .:|:....|        :
Mouse   170 YALNRETSYRCKQGYVTNTGETSGSITCLQNGWS-PQPSCIKS-C--ERPVFENSVTKNNSTWFK 230

  Fly   538 FNDKRAGSTATYVCEPGY---VLVGEAIISCGLGGEWSSKTPSCRFVDCGAPARPNRGIAILLNG 599
            .|||     ..|.|..||   ....:..|:|...| ||. ||||..::|..|....:.:......
Mouse   231 LNDK-----LDYECLIGYENEYKHTKGSITCTYYG-WSD-TPSCYEIECSVPILDRKLVVSPRKE 288

  Fly   600 TTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVC---ELVTC-ETPSVPSGSFVIG---Y 657
            ...|..::::.|...|.: |...:.|...| ||...|.|   ::.:| :.|.:|:|. :.|   .
Mouse   289 KYRVGDLLEFSCRSGHRV-GPDSVQCYHFG-WSPSFPTCKAGQVASCAQPPEIPNGE-INGAKRV 350

  Fly   658 DYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYC--EYIDCGTILPIPYGSHKYVTNTTY 720
            :|:....:.|:|.|..::.|...::|:| |.|:. .|.|  |...||.|..:.:||.|:.....:
Mouse   351 EYSHGEVVGYDCKPRFLLKGPNKIQCVD-GMWTT-LPVCVEEERTCGDIPELEHGSVKFSVPPYH 413

  Fly   721 VGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKC----------------------------- 756
            .|..|.|:|:::..:.|:....|| |..|:.. |||
Mouse   414 HGDSVEFTCAETFTMIGLGSVFCL-SGKWTQL-PKCVATDQLEKCRVLKSTDIEAIKPKRKEFQH 476

  Fly   757 -------------------------------EEIRCPEP-------------KLAAHSLLSVTGN 777
                                           .:|.||.|             |......|||...
Mouse   477 NSTMYYKCRDKQEYEHSICINGKWNPEPNCIRKISCPPPPQIPNTQVIETTVKYLDGEKLSVLCQ 541

  Fly   778 DRMY-----------GR------------------------TLIRTSESSQNTAQ--TYKIGALA 805
            |...           ||                        .|.||||..:.:.:  :::.|...
Mouse   542 DNYLTQDPEEMMCKDGRWQSLPHCIEKIPCSQPPTIEHGSIKLPRTSEKRRKSIEFSSHEHGTTF 606

  Fly   806 KYRCERGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVLYECN 870
            .|.|:.|:::..|....|. .|:|| |.|.||.:.||.|..|..|.|.|...:..:|..|.|.|:
Mouse   607 SYVCDDGFRIPEENGVACY-MGKWS-TPPRCVGLPCGPPPSIPLGTVSLELESYQHGEEVTYHCS 669

  Fly   871 VNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNINENLIVEAGPR---AVGSVATFKCAKGRI 932
            ..|.::|.:...| |.|.|| :.|:|::..||.....||.|:....:   ..|...|.:|.....
Mouse   670 TGFGIDGPALIKC-EGGKWS-DPPKCIKTDCDILPTIENAIIRGKNKKSYRTGEQVTVRCQSPYQ 732

  Fly   933 MMGNDTRVCQKNGKWTGKSPTCRPV--DCGRPLAIENGRVIVVNDSTLYG-------GSAEYHCI 988
            |.|:||..| .||:|.|| |.|:..  .||.|..|:||      |.|...       .|.:|.|.
Mouse   733 MNGSDTVTC-INGRWIGK-PVCKDSRGKCGPPPPIDNG------DITSLSLPEYEPFSSVDYQCQ 789

  Fly   989 PNYNRIGQYLRKCTEDGAWSGKQPRC 1014
            ..|...|:....| .:|.|| :.|.|
Mouse   790 KYYLLKGKKTITC-RNGKWS-EPPTC 813

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_511136.2	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057
		PHA02927	<408..578	CDD:222943	46/172 (27%)
		PHA02927	<508..696	CDD:222943	53/205 (26%)
		PHA02639	643..>837	CDD:165022	62/309 (20%)
		PHA02927	798..1014	CDD:222943	71/227 (31%)
Cfhr4	NP_001025148.3	PHA02927	<50..210	CDD:222943	29/105 (28%)
		PHA02927	208..448	CDD:222943	66/256 (26%)
		PHA02927	510..744	CDD:222943	62/238 (26%)
		PHA02927	635..861	CDD:222943	61/191 (32%)