DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Selp

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_035477.1	Gene:	Selp / 20344	MGIID:	98280	Length:	768	Species:	Mus musculus

Alignment Length:	840	Identity:	198/840 - (23%)
Similarity:	306/840 - (36%)	Gaps:	239/840 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   287 TKGESFDKAQAICKQTGGDLV-----------HDFRGATSSYILSELERRKSELKPQLVWIGAQK 340
            ||..|::.::..|::...|||           :|.....:||                .|||.:|
Mouse    48 TKAYSWNNSRVFCRRHFTDLVAIQNKNEIAHLNDVIPFFNSY----------------YWIGIRK 96

  Fly   341 EPGITSRTWKWVNGD---VVQKPTWGKDQPNNYNGEQNCV---VLDGGRNWLWNDVGC--NLDYL 397
                .:..|.||..:   ..:...|..::|||....|:||   :........|||..|  ....|
Mouse    97 ----INNKWTWVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRAL 157

  Fly   398 HFICQHSPLSCGSPDAQQNTTVMGKKFTLGEKIQ----YTCPKGHSLLGQTERECRLDGTWSGSS 458
            .:......:||.:.               ||.|:    |||.......|
Mouse   158 CYTASCQDMSCSNQ---------------GECIETIGSYTCSCYPGFYG---------------- 191

  Fly   459 PTCKYV-DCGSLPELKFGSIHMSEERTSFGVVATYSCHENYTLIGNENRTCAMDGWSGKQPECLV 522
            |.|:|| :||.:                                              ..|:.::
Mouse   192 PECEYVKECGKV----------------------------------------------NIPQHVL 210

  Fly   523 DWCPDPQPIAGGDVRFNDKRAGSTATYVCEPGYVLVGEAIISCGLGGEWSSKTPSCRFVDCGAPA 587
            ..|..|.    |:..||     |..|:.|..||.|.|...:.|...|.|::..|.|..|.|.:..
Mouse   211 MNCSHPL----GEFSFN-----SQCTFSCAEGYELDGPGELQCLASGIWTNNPPKCDAVQCQSLE 266

  Fly   588 RPNRGIAILLN--GTTTVNSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETPSVP- 649
            .|..|....::  .....:|..|:||...:...|.:.|:||..|:||...|.||.:.||.|.:|
Mouse   267 APPHGTMACMHPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQWSEPLPTCEAIACEPPEIPI 331

  Fly   650 ---------SGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDCGTIL 705
                     :|:|  ||    :|...:.|..|.::.|...::|.|||:|:|.||:||.:.|.. .
Mouse   332 HGSMDCVPSTGTF--GY----NSSCTFLCAEGFVLKGNDAIQCADSGQWTAPAPFCEALQCPE-F 389

  Fly   706 PI----------PYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEEIR 760
            |:          |:|:..|       .|...|||.:...|.|.....||.:..|:.|.|:|:.:.
Mouse   390 PVPSKAQVNCSDPFGTLTY-------QSVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVS 447

  Fly   761 CP---EPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCERGYKMVGEALAT 822
            |.   .|:..:.:.:...||                   .|||  :..::.|:.|:.:.|.....
Mouse   448 CAPMLSPENGSMTCVQPLGN-------------------STYK--STCQFMCDEGFYLSGPERLD 491

  Fly   823 CTDSGQWSGTIPECVYVECG---APEGIN------NGKVVLATNATYYGAAVLYECNVNFKLNGV 878
            |:.||.|:||.|.|..::|.   |||..|      :|:..:       |:...:.||.:|:|.|.
Mouse   492 CSPSGHWTGTPPTCEAIKCPGIFAPEQGNLDCSHVHGEFGV-------GSICHFSCNEDFELLGS 549

  Fly   879 SRRLCTEHGNWSHEAPECVEVV--------C---DTPNIN----ENLIVEAGPRAVGSVATFKCA 928
            ....||..|.||...|.|..:.        |   .||...    ::.:...||   .:...|.|.
Mouse   550 ENVECTVSGRWSAPPPTCKGITSLPAPAVRCPALTTPGQGTMSCQHHLGSFGP---NTTCYFGCK 611

  Fly   929 KGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDST-----LYGGSAEYHCI 988
            .|..:.|.::..|:.:|:||..:|.||.|.|..   :.....:.:|.|.     .||.:..:.|.
Mouse   612 TGFTLRGANSLRCRASGQWTAVTPMCRAVKCSE---LHMDTAVAMNCSNPWGNFSYGSTCTFQCP 673

  Fly   989 PNYNRIGQYLRKCTEDGAWSGKQPRCELATAEGQET-SELG------TGVGIGATVIVAL 1041
            ...:..|.....|.|||.||...|.|:..|...||. :.||      ||:.:|.|::..|
Mouse   674 EGQSLNGSVRATCREDGHWSDAMPTCQAGTLTIQEALTYLGGAVASTTGLAVGGTLLALL 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057	29/134 (22%)
		CCP	408..462	CDD:153056	9/57 (16%)
		CCP	466..520	CDD:153056	3/53 (6%)
		CCP	525..579	CDD:153056	16/53 (30%)
		CCP	583..639	CDD:153056	15/57 (26%)
		PHA02927	637..897	CDD:222943	77/291 (26%)
		CCP	643..697	CDD:153056	20/63 (32%)
		CCP	701..757	CDD:153056	16/65 (25%)
		Sushi	<799..836	CDD:278512	12/36 (33%)
		Sushi	841..896	CDD:278512	18/63 (29%)
		CCP	901..955	CDD:153056	14/60 (23%)
		CCP	959..1015	CDD:153056	14/60 (23%)
Selp	NP_035477.1	CLECT_selectins_like	42..160	CDD:153062	29/131 (22%)
		EGF_CA	<168..195	CDD:238011	9/57 (16%)
		CCP	200..257	CDD:153056	19/111 (17%)
		CCP	262..320	CDD:153056	15/57 (26%)
		CCP	324..382	CDD:153056	20/63 (32%)
		CCP	386..444	CDD:153056	16/65 (25%)
		CCP	448..506	CDD:153056	17/78 (22%)
		CCP	510..568	CDD:153056	18/64 (28%)
		CCP	580..638	CDD:153056	14/60 (23%)
		CCP	642..700	CDD:153056	14/60 (23%)
		Endocytosis signal. /evidence=ECO:0000305	756..759
		Interaction with SNX17. /evidence=ECO:0000250	759..768
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002067
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000