Protein Alignment fw and Cfh

DIOPT Version :10

• Sequence 1: NP_511136.2
• Gene: fw / 32162
• FlyBaseID: FBgn0001083
• Length: 1174
• Species: Drosophila melanogaster
• Sequence 2: NP_569093.2
• Gene: Cfh / 155012
• RGDID: 620428
• Length: 1235
• Species: Rattus norvegicus
• Alignment Length: 1125
• Identity: 260/1125 - (23%)
• Similarity: 410/1125 - (36%)
• Gaps: 257/1125 - (22%)

  Fly    58 CGPPAVPLNAKVRTITVDSQI---AEAHYECDAGYELFGPSAVK-CDRRTGWDRDLPFCGVNVAY 118
            ||.|........| :.|.|:.   |:..|.||.||:|.|....: || ..||..|:|.|.|
  Rat    85 CGHPGDTPFGSFR-LAVGSEFEFGAKVVYTCDEGYQLLGEIDYRECD-ADGWTNDIPICEV---- 143

  Fly   119 RKPVNQSSYTRSGPASYANDGK--PGNKNPD-----GQ----ECS-----ETQKE----PSPWWR 163
                     .:..|.:...:|:  .|...||     ||    ||:     |.|||    .:..|.
  Rat   144 ---------VKCLPVTELENGRIVSGAAEPDQEYYFGQVVRFECNSGFKIEGQKEMHCSENGLWS 199

  Fly   164 VDLLTPQAVHVVRITTRGCCG--------HQPLQDLEIRVGNSSADLQR-NPLC---AWYPGTLD 216
            .:  .||.|.:..:..|...|        ::..:..:.:........:| :.:|   .|.|
  Rat   200 NE--KPQCVEISCLPPRVENGDGIYLKPVYKENERFQYKCKQGFVYKERGDAVCTGSGWNP---- 258

  Fly   217 EGVVKTFTCARPLV------------------------GQYVA----IQLVGVEG-------SLS 246
            :...:..||..|.:                        |.|.|    :....:.|       ||.
  Rat   259 QPSCEEMTCLTPYIPNGIYTPHRIKHRIDDEIRYECKNGFYPATRSPVSKCTITGWIPAPRCSLK 323

  Fly   247 LCEVETFTNDEFSVDRCLSPKIGV----------DTVVTTFSKTCYDF----------------- 284
            .|:...|.:.....:....|...|          |...||.|::.:|:
  Rat   324 PCDFPQFKHGRLYYEESRRPYFPVPIGKEYSYYCDNGFTTPSQSYWDYLRCTVNGWEPEVPCLRQ 388

  Fly   285 ----HITKGESF---------DKAQAICKQ-----TGGDLVHDFRGATSSYILSELERRKSELKP 331
                ::..|||.         ..|:..|..     .|.|.:.......|.             .|
  Rat   389 CIFHYVEYGESLYWQRRYIEGQSAKVQCHSGYSLPNGQDTILCTENGWSP-------------PP 440

  Fly   332 QLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWNDVGCNLDY 396
            :.|.|.......|......:...|.    |:..::...|..:|..|...|..:.:   :.|..|
  Rat   441 KCVRIKTCSVSDIEIENGFFSESDY----TYALNRKTRYRCKQGYVTNTGEISGI---ITCLQD- 497

  Fly   397 LHFICQHSP-----LSCGSPDAQQNTTVMGKK-FTLGEKIQYTCPKGHSLLGQTERE-------- 447
                 ..||     .||..|..:...|..... |.|.:|:.|.|..|:      |.|
  Rat   498 -----GWSPRPSCIKSCDMPVFENAMTKNNNTWFKLNDKLDYECHIGY------ENEYKHTKGSI 551

  Fly   448 -CRLDGTWSGSSPTCKYVDCGSLPELKFGSIHMSEE-RTSFGVVATYSCHENYTLIGNENRTCAM 510
             |..|| || |:|:|...:| |:|.|....:....| :...|...::||...:. :|.:...|..
  Rat   552 TCTYDG-WS-STPSCYEREC-SIPLLHQDLVVFPREVKYKVGDSLSFSCRSGHR-VGADLVQCYH 612

  Fly   511 DGWSGKQPEC--LVDWCPDPQPIAGGDVRFNDK---RAGSTATYVCEPGYVLVGEAIISCGLGGE 570
            .|||...|.|  .|..|..|..|..|:::...|   ..|....|.|:|.::|.|...|.| :.|:
  Rat   613 FGWSPNFPTCEGQVKSCDQPLEIPNGEIKGTKKVEYSHGDVVEYDCKPRFLLKGPNKIQC-VDGK 676

  Fly   571 WSSKTPSCRFVD--CG-APARPNRGIAILL----NGTTTVNSVVKYECDEDHWLDGQSELYCTRE 628
            |:: .|.|...:  || .||..:..:.:.:    :|.:     |::.|.|...:.|.:.::|. .
  Rat   677 WTT-LPICVEYERTCGDLPALEHGSVQLSVPPYHHGDS-----VEFTCAETFTMIGHAVVFCI-S 734

  Fly   629 GKWSGEAPVC----ELVTCETPSVPSGSFVI---GYDYNVHSKIQYNC-DPGHIMHGTPVLECLD 685
            |:|: |.|.|    :|..|:.|. .:|...|   ..::|.:..:.|.| ......|..    |:
  Rat   735 GRWT-ELPQCVATDQLEKCKAPK-STGIDAIHPNKNEFNHNFSVSYRCRQKQEYEHSI----CI- 792

  Fly   686 SGEWSADAPYCEYIDCGTILPIPYGSHKYVTNTT--YV-GSEVVFSCSQSHKLSGVLKRTCLESA 747
            :|.|..: |.|...:.....|.|...:..|..||  |: |.:|...|...:...|..:..| :..
  Rat   793 NGRWDPE-PNCTRNEKRFCPPPPQIPNAQVIETTVKYLDGEKVSVLCQDGYLTQGPEEMVC-KHG 855

  Fly   748 VWSDASPKC-EEIRCPEPKLAAH-SLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCE 810
            .| .:.|:| |:|.|.:|....| |:.|...::.   |.||.:|        :|:.|....|.|:
  Rat   856 RW-QSLPRCTEKIPCSQPPKIEHGSIKSPRSSEE---RDLIESS--------SYEHGTTFSYVCD 908

  Fly   811 RGYKMVGEALATCTDSGQWSGTIPECVYVECGAPEGINNGKVVLATNATYYGAAVLYECNVNFKL 875
            .|:::..|...|| :.|:|| ::|.||.:.||.|..|..|.|.....:..||..|.|.|:..|.:
  Rat   909 DGFRISEENRVTC-NMGKWS-SLPRCVGIPCGPPPSIPLGIVSHELESYQYGEEVTYNCSEGFGI 971

  Fly   876 NGVSRRLCTEHGNWSHEAPECVEVVCDT-PNINENLIVEAGPRAV--GSVATFKCAKGRIMMGND 937
            :|.:...|. .|.|| |.|:|::..||. |........|...::.  |...||:|.....|.|:|
  Rat   972 DGPAFIKCV-GGQWS-EPPKCIKTDCDNLPTFEIAKPTEKKKKSYRSGEQVTFRCPPPYRMDGSD 1034

  Fly   938 TRVCQKNGKWTGKSPTCRPVDCGRPLAIENGRVIVVNDSTLY--GGSAEYHCIPNYNRIGQYLRK 1000
            ...| .|.||.|: |.|:...|..|..:.|. .|:....|.|  |....|.|...:...|:....
  Rat  1035 IVTC-VNTKWIGQ-PVCKDNSCVNPPHVPNA-TILTRHKTKYPSGDKVRYDCNKPFELFGEVEVM 1096

  Fly  1001 CTEDGAWSGKQPRCELATAE 1020
            | ::|.|: :.|:|:.:|.:
  Rat  1097 C-QNGIWT-EPPKCKDSTGK 1114

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_511136.2	CCP	58..112	CDD:153056	20/57 (35%)
		FTP	113..261	CDD:128870	35/214 (16%)
		CLECT	281..403	CDD:153057	21/156 (13%)
		PHA02927	<408..578	CDD:222943	51/185 (28%)
		PHA02927	<508..696	CDD:222943	52/207 (25%)
		PHA02639	643..>837	CDD:165022	50/202 (25%)
		PHA02927	798..1014	CDD:222943	66/220 (30%)
Cfh	NP_569093.2	PHA02927	1..262	CDD:222943	45/197 (23%)
		PHA02927	262..507	CDD:222943	40/270 (15%)
		PHA02927	505..744	CDD:222943	67/257 (26%)
		PHA02954	<696..>811	CDD:165263	25/128 (20%)
		PHA02927	818..1038	CDD:222943	68/236 (29%)
		PHA02927	1013..1217	CDD:222943	30/107 (28%)