DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fw and CR2

DIOPT Version :9

Sequence 1:NP_001285146.1 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_001006659.1 Gene:CR2 / 1380 HGNCID:2336 Length:1092 Species:Homo sapiens


Alignment Length:1208 Identity:267/1208 - (22%)
Similarity:416/1208 - (34%) Gaps:349/1208 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 LLLALCAAG-NGQICGPPAVPLNAKV----RTITVDSQIAEAHYECDAGYELFGPSAVKC---DR 101
            :.|||.|.| .|..||.|...||.::    ..|.|.:.|   .|.|...:.|.|..::.|   |:
Human     9 VFLALVAPGVLGISCGSPPPILNGRISYYSTPIAVGTVI---RYSCSGTFRLIGEKSLLCITKDK 70

  Fly   102 RTG-WDRDLPFCGVNVAYR---KPVNQSSYTRSGPASY-----------ANDGKPGNKNPDGQEC 151
            ..| ||:..|.|.....|.   :|:....|...|...|           .|....|||       
Human    71 VDGTWDKPAPKCEYFNKYSSCPEPIVPGGYKIRGSTPYRHGDSVTFACKTNFSMNGNK------- 128

  Fly   152 SETQKEPSPWWRVDLL-----TPQAVHVVRITTRGCCGHQPLQDLEIRVGNSSADLQRNPLCAWY 211
                   |.|.:.:.:     .|..|.|..:.    |...|:    |..|:.:::         .
Human   129 -------SVWCQANNMWGPTRLPTCVSVFPLE----CPALPM----IHNGHHTSE---------N 169

  Fly   212 PGTLDEGVVKTFTCARP--LVGQYVAIQLVGVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVV 274
            .|::..|:..|::|...  |||:                          .:..|||.  |..:.|
Human   170 VGSIAPGLSVTYSCESGYLLVGE--------------------------KIINCLSS--GKWSAV 206

  Fly   275 TTFSKTCYDFHITKGESFDKAQAICKQTG----GDLVHD--FR-GATSSYILSELERRKSELKPQ 332
               ..||             .:|.||..|    |.:...  .| |.|:::...|..|.:.....:
Human   207 ---PPTC-------------EEARCKSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSSR 255

  Fly   333 LVWIGAQKEPGITSRTWKWVN---------------------GDVVQKPTWGK--------DQPN 368
            .|..|    .|:.     |..                     |:.:...::|.        |...
Human   256 CVIAG----QGVA-----WTKMPVCEEIFCPSPPPILNGRHIGNSLANVSYGSIVTYTCDPDPEE 311

  Fly   369 NYN----GEQ--NCVVLDGGRNWLWNDVG--CNLDYLHFICQHSPLSCGSPDAQQNTTVMGKK-- 423
            ..|    ||.  .|.| |..:...|:...  |.|       ..|.:.|..|...:...|.|:|  
Human   312 GVNFILIGESTLRCTV-DSQKTGTWSGPAPRCEL-------STSAVQCPHPQILRGRMVSGQKDR 368

  Fly   424 FTLGEKIQYTCPKGHSLLGQTERECRLDGTWSGSSPTCKYVDCGSLPELKFG---SIHMSEERTS 485
            :|..:.:.:.|..|.:|.|..:..|...|||..|:|.|: .:|.:.|.:..|   ..||  .|..
Human   369 YTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCE-KECQAPPNILNGQKEDRHM--VRFD 430

  Fly   486 FGVVATYSCHENYTLIGNENRTCAMDG-WSGKQPEC----------------------------- 520
            .|....|||:..|.|:|.|:..|..:| |:...|:|                             
Human   431 PGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEATGRQLLTKPQHQFVRPDVNSSC 495

  Fly   521 ----------------LVDW-----------CPDPQPIAGG---DVRFNDKRAGSTATYVCEPG- 554
                            .:.|           ||.|..|..|   .....|...|:|.||.|.|| 
Human   496 GEGYKLSGSVYQECQGTIPWFMEIRLCKEITCPPPPVIYNGAHTGSSLEDFPYGTTVTYTCNPGP 560

  Fly   555 -----YVLVGEAIISCGLG----GEWSSKTPSCRF----VDCGAPARPNRGIAILLNGTTT---V 603
                 :.|:||:.|.|...    |.||...|.|:.    |.|......|   ...::|...   .
Human   561 ERGVEFSLIGESTIRCTSNDQERGTWSGPAPLCKLSLLAVQCSHVHIAN---GYKISGKEAPYFY 622

  Fly   604 NSVVKYECDEDHWLDGQSELYCTREGKWSGEAPVCELVTCETPSVPSGSFVIGYDYNVHS----- 663
            |..|.::|.....|.|.|::.|..:..|..|.|||| ..|::|.        |..:..|:     
Human   623 NDTVTFKCYSGFTLKGSSQIRCKADNTWDPEIPVCE-KGCQSPP--------GLHHGRHTGGNTV 678

  Fly   664 ------KIQYNCDPGHIMHGTPVLECLDSGEWSADAPYCEYIDC----GTILPIPYGSHKYVTNT 718
                  .:.|.||||:::.|...:.|:.||.||..||.||. .|    .::..:|.||...:.||
Human   679 FFVSGMTVDYTCDPGYLLVGNKSIHCMPSGNWSPSAPRCEE-TCQHVRQSLQELPAGSRVELVNT 742

  Fly   719 TYVGSEVVFSCSQSHKLSGVLKRTC--LESAVWSDASPKCEEIRCPEPKLAAHSLLSVTGNDRMY 781
                     ||...::|:|...:.|  .|:.:|....|.|:.|.|..|                 
Human   743 ---------SCQDGYQLTGHAYQMCQDAENGIWFKKIPLCKVIHCHPP----------------- 781

  Fly   782 GRTLIRTSESSQNTAQTYKIGALAKYRCERGYKMVGEALATC-TDS---GQWSGTIPECV----Y 838
              .:|...:.:...|:.:..|....|.|::|:.::||....| :||   |.|||..|:|:    .
Human   782 --PVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGHGSWSGPSPQCLRSPPV 844

  Fly   839 VECGAPEGINNGKVVLATNATYYGAAVLY-ECNVNFKLNGVSRRLCTEHGNWSHEAPECVE---V 899
            ..|..|| :.:|..:..|::.|....::| :||..|.:||.....|.....|....|.|::   :
Human   845 TRCPNPE-VKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRCHTDNTWVPGVPTCIKKAFI 908

  Fly   900 VCDTPNINENLIVEAGPRAVGSVATF--------KCAKGRIMMGNDTRVCQKNGKWTGKSPTCRP 956
            .|..|....|     |....|::|.|        .|.:|.:::|....:|...|.|:..:|.|:.
Human   909 GCPPPPKTPN-----GNHTGGNIARFSPGMSILYSCDQGYLLVGEALLLCTHEGTWSQPAPHCKE 968

  Fly   957 VDCGRPL---AIENGRVIVVNDSTLYGGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELAT 1018
            |:|..|.   .|:.|  :.......||......|...|...|....:|..|..|:.     .||.
Human   969 VNCSSPADMDGIQKG--LEPRKMYQYGAVVTLECEDGYMLEGSPQSQCQSDHQWNP-----PLAV 1026

  Fly  1019 AEGQETSELGTGVGIGATVIVALLVIFGLIFLYRNKAR 1056
            ...:..:.:..|:..| .:::..|::..|..:.:::||
Human  1027 CRSRSLAPVLCGIAAG-LILLTFLIVITLYVISKHRAR 1063

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_001285146.1 CCP 58..112 CDD:153056 18/61 (30%)
FTP 113..261 CDD:128870 25/168 (15%)
CLECT 281..403 CDD:153057 27/165 (16%)
CCP 408..462 CDD:153056 16/55 (29%)
CCP 466..520 CDD:153056 18/57 (32%)
CCP 525..579 CDD:153056 22/66 (33%)
CCP 583..639 CDD:153056 14/58 (24%)
PHA02927 637..897 CDD:222943 72/285 (25%)
CCP 643..697 CDD:153056 17/64 (27%)
CCP 701..757 CDD:153056 14/61 (23%)
Sushi <799..836 CDD:278512 14/40 (35%)
Sushi 841..896 CDD:278512 15/55 (27%)
CCP 901..955 CDD:153056 14/61 (23%)
CCP 959..1015 CDD:153056 12/58 (21%)
CR2NP_001006659.1 CCP 23..83 CDD:153056 18/62 (29%)
CCP 91..147 CDD:153056 11/69 (16%)
CCP 154..211 CDD:153056 18/113 (16%)
CCP 215..272 CDD:153056 13/65 (20%)
CCP 276..343 CDD:153056 10/67 (15%)
CCP 351..407 CDD:153056 16/55 (29%)
CCP 410..467 CDD:153056 18/58 (31%)
CCP 527..594 CDD:153056 22/66 (33%)
CCP 602..658 CDD:153056 14/58 (24%)
CCP 661..718 CDD:153056 17/64 (27%)
CCP 778..838 CDD:153056 18/78 (23%)
CCP 847..903 CDD:153056 15/56 (27%)
CCP 910..967 CDD:153056 14/61 (23%)
CCP <990..1028 CDD:153056 10/42 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E33208_3BCEG
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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