DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fw and Cfh

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_034018.2	Gene:	Cfh / 12628	MGIID:	88385	Length:	1252	Species:	Mus musculus

Alignment Length:	1158	Identity:	254/1158 - (21%)
Similarity:	392/1158 - (33%)	Gaps:	324/1158 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 CGPPAVPLNAKVRTITVDSQI---AEAHYECDAGYELFGPSAVKCDRRTGWDRDLPFCGVNVAYR 119
            ||.|........| :.|.||.   |:..|.||.||:|.|....:.....||..|:|.|  .|...
Mouse   103 CGHPGDTPFGSFR-LAVGSQFEFGAKVVYTCDDGYQLLGEIDYRECGADGWINDIPLC--EVVKC 164

  Fly   120 KPVNQSSYTR--SGPASYANDGKPGNKNPDGQECSETQKEPSPWWRVDLLTPQAVHVVRITTRGC 182
            .||.:....|  ||.|.                                 |.|..:..::....|
Mouse   165 LPVTELENGRIVSGAAE---------------------------------TDQEYYFGQVVRFEC 196

  Fly   183 C------GHQPLQDLEIRVGNSSADLQRNPLCAWYPGTLDEGVVKTFTCARPLV--GQYVAIQLV 239
            .      ||:     ||....:.......|.|.            ...|..|.|  |..:.::.|
Mouse   197 NSGFKIEGHK-----EIHCSENGLWSNEKPRCV------------EILCTPPRVENGDGINVKPV 244

  Fly   240 GVEGSL----------------SLCEVETFTNDEFSVD-RCLSPKI--GVDTVVTTFSKT----- 280
            ..|...                ::|....:::..|..: ||..|.|  |:.|......::
Mouse   245 YKENERYHYKCKHGYVPKERGDAVCTGSGWSSQPFCEEKRCSPPYILNGIYTPHRIIHRSDDEIR 309

  Fly   281 --C-YDFHITKGESFDKAQAICKQTGGDLV----------HDFRGATSSYILSELERRKSELKPQ 332
              | |.|:...|.:..|    |..||...|          ..|:.....|        :..|:|.
Mouse   310 YECNYGFYPVTGSTVSK----CTPTGWIPVPRCTLKPCEFPQFKYGRLYY--------EESLRPN 362

  Fly   333 L-VWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYNGEQNCVVLDGGRNWLWN-DVGC-NL 394
            . |.||       ...::|..|         |...|:.|:.:.......|     |. :|.| ..
Mouse   363 FPVSIG-------NKYSYKCDN---------GFSPPSGYSWDYLRCTAQG-----WEPEVPCVRK 406

  Fly   395 DYLHFICQHSPLSCGSPDAQQNTTVMGKKFTLGEKIQYTCPKGHSLL-GQTERECRLDGTWSGSS 458
            ...|::            ...::....|.:..|:.::..|..|:||. ||....|..:| || ..
Mouse   407 CVFHYV------------ENGDSAYWEKVYVQGQSLKVQCYNGYSLQNGQDTMTCTENG-WS-PP 457

  Fly   459 PTCKYVDCGSLPELKFGSIHMSEERTSFGV--VATYSCHENYTLIGNE---NRTCAMDGWSGKQP 518
            |.|..:...|..::...:..:||..:.:.:  ..:|.|.:.|.....|   :.||..:||| .||
Mouse   458 PKCIRIKTCSASDIHIDNGFLSESSSIYALNRETSYRCKQGYVTNTGEISGSITCLQNGWS-PQP 521

  Fly   519 ECLVDWCPDPQPIAGGDV--------RFNDKRAGSTATYVCEPGYVLVG--------EAIISCGL 567
            .|:.. |  ..|:....:        :.|||     ..|.|     |||        :..|:|..
Mouse   522 SCIKS-C--DMPVFENSITKNTRTWFKLNDK-----LDYEC-----LVGFENEYKHTKGSITCTY 573

  Fly   568 GGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKWS 632
            .| ||. ||||...:|..|....:.:.........|..::::.|...|.: |...:.|...| ||
Mouse   574 YG-WSD-TPSCYERECSVPTLDRKLVVSPRKEKYRVGDLLEFSCHSGHRV-GPDSVQCYHFG-WS 634

  Fly   633 GEAPVC--ELVTCETPSVPSGSFVIG---YDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSAD 692
            ...|.|  ::.:|..|.......:.|   .:|:....::|:|.|..::.|...::|:| |.|:.
Mouse   635 PGFPTCKGQVASCAPPLEILNGEINGAKKVEYSHGEVVKYDCKPRFLLKGPNKIQCVD-GNWTT- 697

  Fly   693 APYC--EYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSG------------------ 737
            .|.|  |...||.|..:.:||.|......:.|..|.|.|.::..:.|
Mouse   698 LPVCIEEERTCGDIPELEHGSAKCSVPPYHHGDSVEFICEENFTMIGHGSVSCISGKWTQLPKCV 762

  Fly   738 ---------VLKRTCLE-------------------------------SAVWSDASPKC-EEIRC 761
                     |||.|.:|                               :..| |..|.| .:..|
Mouse   763 ATDQLEKCRVLKSTGIEAIKPKLTEFTHNSTMDYKCRDKQEYERSICINGKW-DPEPNCTSKTSC 826

  Fly   762 PEP-------------KLAAHSLLSVTGNDRMY-----------GR------------------- 783
            |.|             |......|||...|...           ||
Mouse   827 PPPPQIPNTQVIETTVKYLDGEKLSVLCQDNYLTQDSEEMVCKDGRWQSLPRCIEKIPCSQPPTI 891

  Fly   784 -----TLIRTSESSQNT--AQTYKIGALAKYRCERGYKMVGEALATCTDSGQWSGTIPECVYVEC 841
                 .|.|:||..:::  :.:::.|....|.|:.|:::..|...||. .|:|| |.|.||.:.|
Mouse   892 EHGSINLPRSSEERRDSIESSSHEHGTTFSYVCDDGFRIPEENRITCY-MGKWS-TPPRCVGLPC 954

  Fly   842 GAPEGINNGKVVLATNATYYGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPECVEVVCDTPNI 906
            |.|..|..|.|.|...:..:|..|.|.|:..|.::|.:..:| |.|.|| :.|:|::..||....
Mouse   955 GPPPSIPLGTVSLELESYQHGEEVTYHCSTGFGIDGPAFIIC-EGGKWS-DPPKCIKTDCDVLPT 1017

  Fly   907 NENLIVEAGPR---AVGSVATFKCAKGRIMMGNDTRVCQKNGKWTGKSPTCRPVDCGRPLAIENG 968
            .:|.|:....:   ..|...||:|.....|.|:||..| .|.:|.|: |.|:...|..|..:.|.
Mouse  1018 VKNAIIRGKSKKSYRTGEQVTFRCQSPYQMNGSDTVTC-VNSRWIGQ-PVCKDNSCVDPPHVPNA 1080

  Fly   969 RVIV-VNDSTLYGGSAEYHCIPNYNRIGQYLRKCTEDGAWSGKQPRCELATAE 1020
            .::. ..:..|:|....|.|.......||....| |:|.|:.| |:|..:|.:
Mouse  1081 TIVTRTKNKYLHGDRVRYECNKPLELFGQVEVMC-ENGIWTEK-PKCRDSTGK 1131

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056	19/56 (34%)
		FTP	113..261	CDD:128870	24/173 (14%)
		CLECT	281..403	CDD:153057	26/135 (19%)
		CCP	408..462	CDD:153056	13/54 (24%)
		CCP	466..520	CDD:153056	14/58 (24%)
		CCP	525..579	CDD:153056	18/69 (26%)
		CCP	583..639	CDD:153056	12/57 (21%)
		PHA02927	637..897	CDD:222943	83/375 (22%)
		CCP	643..697	CDD:153056	14/58 (24%)
		CCP	701..757	CDD:153056	20/114 (18%)
		Sushi	<799..836	CDD:278512	12/36 (33%)
		Sushi	841..896	CDD:278512	19/54 (35%)
		CCP	901..955	CDD:153056	17/56 (30%)
		CCP	959..1015	CDD:153056	15/56 (27%)
Cfh	NP_034018.2	PHA02927	19..280	CDD:222943	43/229 (19%)
		CCP	39..99	CDD:153056
		CCP	103..160	CDD:153056	20/59 (34%)
		CCP	164..224	CDD:153056	14/97 (14%)
		CCP	229..281	CDD:153056	7/51 (14%)
		CCP	287..338	CDD:214478	13/54 (24%)
		CCP	412..461	CDD:153056	13/62 (21%)
		CCP	472..524	CDD:153056	13/52 (25%)
		PHA02927	523..762	CDD:222943	58/257 (23%)
		Sushi	587..640	CDD:278512	11/54 (20%)
		CCP	647..702	CDD:153056	13/56 (23%)
		CCP	708..762	CDD:153056	11/53 (21%)
		PHA02817	720..>821	CDD:165167	14/101 (14%)
		Sushi	826..879	CDD:278512	10/52 (19%)
		CCP	885..950	CDD:153056	16/66 (24%)
		PHA02927	949..1187	CDD:222943	57/189 (30%)
		CCP	954..1008	CDD:153056	19/55 (35%)
		CCP	1012..1067	CDD:153056	17/56 (30%)
		CCP	1071..1126	CDD:153056	15/56 (27%)
		CCP	1132..1186	CDD:153056	254/1158 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	2	1.960