DRSC/TRiP Functional Genomics Resources

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Protein Alignment fw and CSMD3

DIOPT Version :9

Sequence 1:NP_001285146.1 Gene:fw / 32162 FlyBaseID:FBgn0001083 Length:1174 Species:Drosophila melanogaster
Sequence 2:NP_937756.1 Gene:CSMD3 / 114788 HGNCID:19291 Length:3707 Species:Homo sapiens


Alignment Length:1413 Identity:330/1413 - (23%)
Similarity:473/1413 - (33%) Gaps:404/1413 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    56 QICGPPAVPLNAKVRTITVDSQIAE-AHYECDAGYELFGPSAVKC--DRRTGWDRDLPFCGVNVA 117
            ::|.||....||::.|...:.:|.: ..|:|..|:.|.|.:.:.|  ..|...|...|.|.|.. 
Human  2393 RVCQPPPPVPNAEILTEDDEFEIGDIIRYQCLPGFTLVGNAILTCRLGERLQMDGAPPVCQVLC- 2456

  Fly   118 YRKPVNQSSYTRSG-------PASYANDGKPGNKNPDGQECS------------------ETQKE 157
               |.|:.....:|       |.||          |:.|.|:                  :|:||
Human  2457 ---PANELRLDSTGVILSPGYPDSY----------PNLQMCAWSISVEKGYNITMFVEFFQTEKE 2508

  Fly   158 PSPWWRVDLLT----PQAVHVVRITTRG---------CCGHQPLQDLEIRVGNSSADLQRNPLCA 209
                  .|:|.    |.....|.|:..|         ..||:.........||:.... |....|
Human  2509 ------FDVLQVYDGPNIQSPVLISLSGDYSSAFNITSNGHEVFLQWSADHGNNKKGF-RIRYIA 2566

  Fly   210 WYPGTLDEGVVKTFTCARPLVGQYVAIQLVGVEGSLSLCEVETFTNDEFSVDRCLSPKIGVDTVV 274
            :|..|.:.          |..| |:..|..|...|:.          .::.||... .:|..:.|
Human  2567 FYCSTPES----------PPHG-YIISQTGGQLNSVV----------RWACDRGFR-LVGKSSAV 2609

  Fly   275 TTFSKTCYDFHITKGESFDKAQAICK----------QTGGDLVHDFRGAT-------SSYILSEL 322
            .  .|:.|.:|     ::|.....|:          ..||.|..|:...|       ..|.||..
Human  2610 C--RKSSYGYH-----AWDAPVPACQAISCGIPKAPTNGGILTTDYLVGTRVTYFCNDGYRLSSK 2667

  Fly   323 ERRKSELKPQLVWIGAQKEPGITSRTWKWVNGDVVQKPTWGKDQPNNYN---------------- 371
            |...:..:....|....|.|.....|...:|..:::...|.....::|.                
Human  2668 ELTTAVCQSDGTWSNHNKTPRCVVVTCPSINSFILEHGRWRIVNGSHYEYKTKVVFSCDPGYHGL 2732

  Fly   372 GEQNCVVLDGGRNWLW---------------------NDVGCNLDY---------LHFI------ 400
            |..:...|..| .|.|                     |.:|....|         |.|:      
Human  2733 GPASIECLPNG-TWSWRNERPYCQIISCGELPTPPNGNKIGTQTSYGSTAIFTCDLGFMLVGSAV 2796

  Fly   401 --CQHSPL-----------SCGSPDAQQNTTVMGKKFTLGEKIQYTCPKGHSLLGQTERECRLDG 452
              |..|.|           .||.|:...|..|:|:.:...:.:.|.|..|..|:|.:.|.|:.|.
Human  2797 RECLSSGLWSESETRCLAGHCGIPELIVNGQVIGENYGYRDTVVYQCNPGFRLIGSSVRICQQDH 2861

  Fly   453 TWSGSSPTCKYVDCGSLPELKFGSIHMSEERTS-----FGVVATYSCHENYTLIGNENRTC-AMD 511
            .|||..|:|..|.||......:|       |||     |..|.|:||:..|.:.|.....| |..
Human  2862 NWSGQLPSCVPVSCGHPGSPIYG-------RTSGNGFNFNDVVTFSCNIGYLMQGPTKAQCQANR 2919

  Fly   512 GWSGKQPECLVDWCPDPQPIAGGDVRFNDKRA----------GSTATYVCEPGYVLVGEAIISCG 566
            .||...|.|.|..|.||      .:..|.||.          |:...|.|.|||.|.|.:::.|.
Human  2920 QWSHPPPMCKVVNCSDP------GIPANSKRESKIEHGNFTYGTVVFYDCNPGYFLFGSSVLICQ 2978

  Fly   567 LGGEWSSKTPSCRFVDCGAPARPNRGIAILLNGTTTVNSVVKYECDEDHWLDGQSELYCTREGKW 631
            ..|:|....|.|..:|||.|..|..  |:|.....|..|.|.|.|.....|.|||...|...|.|
Human  2979 PNGQWDKPLPECIMIDCGHPGVPPN--AVLSGEKYTFGSTVHYSCTGKRSLLGQSSRTCQLNGHW 3041

  Fly   632 SGEAPVCE---LVTCETPSVPSGSFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADA 693
            ||..|.|.   ..||..|..|........::...|.::|.||.|:|:||:....||.:|.|:...
Human  3042 SGSQPHCSGDATGTCGDPGTPGHGSRQESNFRTKSTVRYACDTGYILHGSEERTCLANGSWTGRQ 3106

  Fly   694 PYCEYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVLKRTCLESAVWSDASPKCEE 758
            |.|:.:.||.......|....:..||: .|.|::||.:.:.|||...|.|..:..||...|.|..
Human  3107 PECKAVQCGNPGTTANGKVFRIDGTTF-SSSVIYSCMEGYILSGPSVRQCTANGTWSGTLPNCTI 3170

  Fly   759 IRCPEPKLAAHSLLSVTGNDRMYGRTLIRTSESSQNTAQTYKIGALAKYRCERGYKMV--GEALA 821
            |.|.:|.:.|:.|        .||              ..|.:|....|.|:.||.|.  |..:.
Human  3171 ISCGDPGIPANGL--------RYG--------------DDYVVGQNVSYMCQPGYTMELNGSRIR 3213

  Fly   822 TCTDSGQWSGTIPECVYVECGAPEGINNGKV-------------------------VLAT--NAT 859
            |||.:|.|||.:|.|..|.|..|..|:||::                         ||..  |.|
Human  3214 TCTINGTWSGVMPTCRAVTCPTPPQISNGRLEGTNFDWGFSISYICSPGYELSFPAVLTCVGNGT 3278

  Fly   860 Y-----------------------------YGAAVLYECNVNFKLNGVSRRLCTEHGNWSHEAPE 895
            :                             |.:.|.:.||..|.|.|.|.|:|...|.||..:|.
Human  3279 WSGEVPQCLPKFCGDPGIPAQGKREGKSFIYQSEVSFSCNFPFILVGSSTRICQADGTWSGSSPH 3343

  Fly   896 CVE---VVCDTPNINENLIVEAGPR----------AVGSVATFKCAKGRIMMGNDTRVCQKNGKW 947
            |:|   ..|:.|.:         ||          .||||..|.|.||.::.|:.||.|..:..|
Human  3344 CIEPTQTSCENPGV---------PRHGSQNNTFGFQVGSVVQFHCKKGHLLQGSTTRTCLPDLTW 3399

  Fly   948 TGKSPTCRPVDCGRPLAIENGRVIVVNDSTLYGGSAEYHCIPNYNRI-GQYLRKCTEDGAWSGKQ 1011
            :|..|.|.|..|.:|....:..|:.: |...:|.:..|.|.|.:... |...|.|..|..|:||.
Human  3400 SGIQPECIPHSCKQPETPAHANVVGM-DLPSHGYTLIYTCQPGFFLAGGTEHRVCRSDNTWTGKV 3463

  Fly  1012 PRCELAT---------AEGQETSELGTGVGIGATVIVALLVIFGLIFL----YRNKARPVKNTEN 1063
            |.||..:         |.|..:.:|.....           :|...::    |..|.|....|..
Human  3464 PICEAGSKILVKDPRPALGTPSPKLSVPDD-----------VFAQNYIWKGSYNFKGRKQPMTLT 3517

  Fly  1064 VQAAETKDERNAAVMSYSTLE---------------------------ANNRMHMDN-------- 1093
            |.:......|..|.:|.|.:|                           :..:|..:|        
Human  3518 VTSFNASTGRVNATLSNSNMELLLSGVYKSQEARLMLRIYLIKVPAHASVKKMKEENWAMDGFVS 3582

  Fly  1094 -NPSATFNTFHGGAGGRSNG-------GGNPDANSNGERLNNNRSEN------------------ 1132
             .|......|.|...|:..|       |.|....||.....:..:.:                  
Human  3583 AEPDGATYVFQGFIQGKDYGQFGLQRLGLNMSEGSNSSNQPHGTNSSSVAIAILVPFFALIFAGF 3647

  Fly  1133 ---IYDQ--IPNEQFYD-APYEMRTNDEVYEPEPVASNVITINGISVR 1174
               :|.|  .|..|:.. :.:|.......:|.....:|..::.|.:||
Human  3648 GFYLYKQRTAPKTQYTGCSVHENNNGQAAFENPMYDTNAKSVEGKAVR 3695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwNP_001285146.1 CCP 58..112 CDD:153056 16/56 (29%)
FTP 113..261 CDD:128870 33/185 (18%)
CLECT 281..403 CDD:153057 31/192 (16%)
CCP 408..462 CDD:153056 18/53 (34%)
CCP 466..520 CDD:153056 18/59 (31%)
CCP 525..579 CDD:153056 18/63 (29%)
CCP 583..639 CDD:153056 21/55 (38%)
PHA02927 637..897 CDD:222943 85/320 (27%)
CCP 643..697 CDD:153056 16/53 (30%)
CCP 701..757 CDD:153056 17/55 (31%)
Sushi <799..836 CDD:278512 16/38 (42%)
Sushi 841..896 CDD:278512 23/110 (21%)
CCP 901..955 CDD:153056 19/63 (30%)
CCP 959..1015 CDD:153056 16/56 (29%)
CSMD3NP_937756.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
CUB 65..171 CDD:238001
CCP 178..236 CDD:153056
CUB 257..343 CDD:238001
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..435
CCP 486..544 CDD:153056
CUB 548..656 CDD:238001
CCP 664..718 CDD:153056
CUB 721..828 CDD:238001
CCP 834..891 CDD:153056
CUB 895..1002 CDD:238001
CCP 1010..1063 CDD:214478
CUB 1067..1175 CDD:238001
CCP 1182..1238 CDD:153056
CUB 1241..1348 CDD:238001
CCP 1354..1411 CDD:153056
CUB 1414..1522 CDD:238001
CCP 1528..1585 CDD:153056
CUB 1588..1695 CDD:238001
Sushi 1701..1758 CDD:278512
CUB 1762..1869 CDD:238001
CCP 1878..1936 CDD:153056
CUB 1939..2046 CDD:238001
CCP 2052..2107 CDD:153056
CUB 2111..2218 CDD:238001
CCP 2224..2280 CDD:153056
CUB 2283..2389 CDD:238001
CCP 2395..2453 CDD:153056 16/57 (28%)
CUB 2460..2566 CDD:238001 21/122 (17%)
CCP 2569..2628 CDD:153056 15/87 (17%)
PHA02927 2627..2871 CDD:222943 48/244 (20%)
Sushi 2632..2689 CDD:278512 12/56 (21%)
CCP 2694..2755 CDD:153056 8/61 (13%)
PHA02927 2756..2991 CDD:222943 66/247 (27%)
CCP 2759..2812 CDD:153056 8/52 (15%)
CCP 2817..2871 CDD:153056 18/53 (34%)
CCP 2875..2929 CDD:153056 18/60 (30%)
PHA02927 2928..3168 CDD:222943 79/248 (32%)
CCP 2933..2991 CDD:153056 18/63 (29%)
CCP 2995..3048 CDD:153056 21/54 (39%)
CCP 3056..3110 CDD:153056 16/53 (30%)
CCP 3114..3168 CDD:153056 17/54 (31%)
PHA02927 3168..3407 CDD:222943 70/269 (26%)
CCP 3173..3229 CDD:153056 22/77 (29%)
Sushi 3233..3286 CDD:278512 9/52 (17%)
CCP 3291..3345 CDD:153056 14/53 (26%)
CCP 3352..3407 CDD:153056 19/63 (30%)
CCP 3411..3467 CDD:153056 16/56 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 62 1.000 Domainoid score I10337
eggNOG 1 0.900 - - E33208_3BCEG
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm41663
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3908
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.840

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