DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fw and CFHR3

DIOPT Version :9

Sequence 1:	NP_001285146.1	Gene:	fw / 32162	FlyBaseID:	FBgn0001083	Length:	1174	Species:	Drosophila melanogaster
Sequence 2:	NP_066303.2	Gene:	CFHR3 / 10878	HGNCID:	16980	Length:	330	Species:	Homo sapiens

Alignment Length:	334	Identity:	85/334 - (25%)
Similarity:	136/334 - (40%)	Gaps:	54/334 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   463 YVDCGS-------LPELKFGSI-HMSEERTSFGVVA----TYSCHENY-TLIGN--ENRTCAMDG 512
            :|.|.:       .|::|.|.: |.:..|..|.|..    :|.|.|:: |..|:  :...|..:|
Human    12 WVSCANGQVKPCDFPDIKHGGLFHENMRRPYFPVAVGKYYSYYCDEHFETPSGSYWDYIHCTQNG 76

  Fly   513 WSGKQPECLVDWCPDPQPIAGGDVRFNDKRA-GSTATYVCEPGYVL-VGEAIISCGLGGEWSSKT 575
            ||...| ||.. |..|....|.:..:..|.. |::....|.|||.| ..:..::|...| | |.|
Human    77 WSPAVP-CLRK-CYFPYLENGYNQNYGRKFVQGNSTEVACHPGYGLPKAQTTVTCTEKG-W-SPT 137

  Fly   576 PSC-RFVDCG-APARPNRGIAILLNGTTTVNSVVKYECDEDH-WLDGQS--ELYCTREGKWSGEA 635
            |.| |...|. :......|.....:....:|..::|:|...: ..||.|  .:.|.:.| ||.:
Human   138 PRCIRVRTCSKSDIEIENGFISESSSIYILNKEIQYKCKPGYATADGNSSGSITCLQNG-WSAQ- 200

  Fly   636 PVC--ELVTC-ETPSVPSG---SFVIGYDYNVHSKIQYNCDPGHIMHGTPVLECLDSGEWSADAP 694
            |:|  ....| ..|.:.:|   ||::.. |...|:::|.|.|.:.:.|:..:.| .:|||| :.|
Human   201 PICINSSEKCGPPPPISNGDTTSFLLKV-YVPQSRVEYQCQPYYELQGSNYVTC-SNGEWS-EPP 262

  Fly   695 YC--------EYIDCGTILPIPYGSHKYVTNTTYVGSEVVFSCSQSHKLSGVL---KRTCLESAV 748
            .|        |.::...|........||...|   |..:.|.|...:..:..:   :..|.|..|
Human   263 RCIHPCIITEENMNKNNIKLKGRSDRKYYAKT---GDTIEFMCKLGYNANTSILSFQAVCREGIV 324

  Fly   749 WSDASPKCE 757
               ..|:||
Human   325 ---EYPRCE 330

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fw	NP_001285146.1	CCP	58..112	CDD:153056
		FTP	113..261	CDD:128870
		CLECT	281..403	CDD:153057
		CCP	408..462	CDD:153056
		CCP	466..520	CDD:153056	18/68 (26%)
		CCP	525..579	CDD:153056	17/56 (30%)
		CCP	583..639	CDD:153056	14/61 (23%)
		PHA02927	637..897	CDD:222943	33/138 (24%)
		CCP	643..697	CDD:153056	18/65 (28%)
		CCP	701..757	CDD:153056	11/58 (19%)
		Sushi	<799..836	CDD:278512
		Sushi	841..896	CDD:278512
		CCP	901..955	CDD:153056
		CCP	959..1015	CDD:153056
CFHR3	NP_066303.2	CCP	<13..>142	CDD:332582	38/132 (29%)
CFHR3	NP_066303.2	CCP	107..329	CDD:332582	58/234 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	1	0.960