Protein Alignment HOXB6 and HGTX

DIOPT Version :10

• Sequence 1: XP_011523029.1
• Gene: HOXB6 / 3216
• HGNCID: 5117
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_001368954.1
• Gene: HGTX / 53446
• FlyBaseID: FBgn0040318
• Length: 587
• Species: Drosophila melanogaster
• Alignment Length: 375
• Identity: 85/375 - (22%)
• Similarity: 130/375 - (34%)
• Gaps: 112/375 - (29%)

Human     7 SPGSLPENAQVSRHS-RRREPRSTGRQFCGFNAARRSDYKTQQIINPAE---QQRPRAPPLPMSS 67
            ||.:.|..|....|| ....||.......|.::|:  .|...|..:.||   |....|.|.|...
  Fly   178 SPSTTPPPASSRLHSDSSPSPRYEHNSSPGVDSAK--SYALSQRSSGAEDPCQTSESASPPPQGQ 240

Human    68 YFVNSTFPVTLASGQESF-----LGQLPLYSSGYAD---------------PLRHYPAPY----- 107
               |...|..|:|.:..|     :..|.|:::.:|.               ||.....|.
  Fly   241 ---NDYSPENLSSQRAKFQHHHGVNPLALHNANHAGNPGCHNNNNHMDHKLPLSFLGPPLAALHS 302

Human   108 ------GPGPGQDKGFATSSYYP-----------PAGGG-----------YGRAAPCDYG----- 139
                  |.|.|.....|....|.           .:||.           ..:.||..:|
  Fly   303 MTTEMKGQGVGGSSASANGLSYSHSPNSHLISDRGSGGSSSSSSTTTTNTNSQGAPNPHGIDTIL 367

Human   140 --PAPAFYREKESACALSGADEQPPFHPEPRKSDCAQD---------KSVFGETEEQKCSTPVY- 192
              |.|.   ......||:||. .|.|......:..||.         |:..|...::   |.:|
  Fly   368 SKPPPV---TSAGLSALTGAG-IPRFSIAAAAAGMAQYLSQSQGAPLKTHAGHIVDR---THLYW 425

Human   193 -----------PWMQRMNSCNSSSFG------PSG------RRGRQTYTRYQTLELEKEFHYNRY 234
                       .|.:|:::..|::..      ||.      :..|.|::..|...|||.|...:|
  Fly   426 PGLQGLVANPIAWRERLSNTMSANLSQSHQHHPSNDKDGKKKHTRPTFSGQQIFALEKTFEQTKY 490

Human   235 LTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKESKLLSASQLSAEEEEE 284
            |....|.::|:||.::|.|:|:||||||.||:|..   :|...:|:.:::
  Fly   491 LAGPERAKLAYALGMSESQVKVWFQNRRTKWRKRH---AAEMATAKRKQD 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB6	XP_011523029.1	Homeodomain	211..267	CDD:459649	24/55 (44%)
HGTX	NP_001368954.1	ROM1	179..>388	CDD:227709	44/217 (20%)
		Homeodomain	465..523	CDD:459649	24/57 (42%)