Protein Alignment HOXB6 and E5

DIOPT Version :10

• Sequence 1: XP_011523029.1
• Gene: HOXB6 / 3216
• HGNCID: 5117
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Alignment Length: 305
• Identity: 73/305 - (23%)
• Similarity: 99/305 - (32%)
• Gaps: 108/305 - (35%)

Human    12 PENAQVSRHSRRREPRSTGRQFCGFNAARRSDYKTQQIINPAEQQRPRAPPLPMSSYFVNSTFPV 76
            |:.:.|||..  ..|.:.|......|.|:..| .:....||....||...|.|..:...|.|.|.
  Fly   115 PQRSPVSRSP--SPPNAGGNPAAAGNTAKSGD-PSSGTGNPPTLIRPLPLPAPNLALIGNRTSPN 176

Human    77 TLA----------SGQESFLG----------------------QLPLYSSGYA-DPLRHYPA--- 105
            .:|          |....||.                      |||...:|.. .|..|.|.
  Fly   177 AMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQI 241

Human   106 -----PYGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHP 165
                 |.||.||          :||..|.:      .:|.||...|:
  Fly   242 PLGIFPGGPHPG----------HPPPHGHH------PFGSAPHLIRD------------------ 272

Human   166 EPRKSDCAQDKSVFGETEEQKCSTPVYPWMQRMNS------CNSSSFGP--SGRRGRQTYTRYQT 222
                                  |.|:|||:...:.      ..:..|.|  ..:|.|..::..|.
  Fly   273 ----------------------SYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQL 315

Human   223 LELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKK 267
            |:||..|..|.|:....|.::|..|.|||.|:|:||||||.|.|:
  Fly   316 LKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKR 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB6	XP_011523029.1	Homeodomain	211..267	CDD:459649	24/55 (44%)
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	24/55 (44%)