Protein Alignment HOXB6 and en

DIOPT Version :10

• Sequence 1: XP_011523029.1
• Gene: HOXB6 / 3216
• HGNCID: 5117
• Length: 288
• Species: Homo sapiens
• Sequence 2: NP_523700.2
• Gene: en / 36240
• FlyBaseID: FBgn0000577
• Length: 552
• Species: Drosophila melanogaster
• Alignment Length: 280
• Identity: 81/280 - (28%)
• Similarity: 112/280 - (40%)
• Gaps: 73/280 - (26%)

Human    62 PLPMSSYFVNSTFPVTLASGQESFLGQL------------------PLYS--SGYADPLRHYPAP 106
            |.||||       .::.|:.::|.||.|                  ||.|  |..|.|   .||.
  Fly   279 PPPMSS-------KMSDANPEKSALGSLCKAVSQIGQPAAPTMTQPPLSSSASSLASP---PPAS 333

Human   107 YGPGPGQDKGFATSSYYPPAGGGYGRAAPCDYGPAPAFYREKESACALSGADEQPPFHPEPRKSD 171
            ...........||||....:|..   :|......:|: .|...|...::.:..||  .|.|..|.
  Fly   334 NASTISSTSSVATSSSSSSSGCS---SAASSLNSSPS-SRLGASGSGVNASSPQP--QPIPPPSA 392

Human   172 CAQD---------KSVFGETEEQKCSTPVYP-WMQRMNSCNSSSFGPSGRRGRQ----------- 215
            .::|         :|..|.|..:.....::| |:......:..|.||..||.:|
  Fly   393 VSRDSGMESSDDTRSETGSTTTEGGKNEMWPAWVYCTRYSDRPSSGPRYRRPKQPKDKTNDEKRP 457

Human   216 --TYTRYQTLELEKEFHYNRYLTRRRRIEIAHALCLTERQIKIWFQNRRMKWKKE--SKLLSASQ 276
              .::..|...|::||:.|||||.|||.:::..|.|.|.||||||||:|.|.||.  ||...|.|
  Fly   458 RTAFSSEQLARLKREFNENRYLTERRRQQLSSELGLNEAQIKIWFQNKRAKIKKSTGSKNPLALQ 522

Human   277 LSAE------------EEEE 284
            |.|:            ||||
  Fly   523 LMAQGLYNHTTVPLTKEEEE 542

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
HOXB6	XP_011523029.1	Homeodomain	211..267	CDD:459649	28/68 (41%)
en	NP_523700.2	Homeodomain	455..511	CDD:459649	25/55 (45%)
		Engrail_1_C_sig	512..542	CDD:431338	8/29 (28%)