DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and PKD2L1

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_057196.2 Gene:PKD2L1 / 9033 HGNCID:9011 Length:805 Species:Homo sapiens


Alignment Length:660 Identity:129/660 - (19%)
Similarity:230/660 - (34%) Gaps:232/660 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   901 LKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESK----HTSAEC----------------- 944
            :|..:..|:|||:|.....::...:.:...:|.|....    ||.::.                 
Human    97 IKTTLRELLVYIVFLVDICLLTYGMTSSSAYYYTKVMSELFLHTPSDTGVSFQAISSMADFWDFA 161

  Fly   945 --------------------QGSY-FKYEEDELLPKQELRVWKPR---AFHYDNVAAAMLTLFAV 985
                                .||: |.|.|:.||....||..|.|   ...:::....:|:.:.|
Human   162 QGPLLDSLYWTKWYNNQSLGHGSHSFIYYENMLLGVPRLRQLKVRNDSCVVHEDFREDILSCYDV 226

  Fly   986 QT-------------GEGWPQVLQHSMA--------ATYEDRGPIQNFRIEMSIFYIVYFIVFPF 1029
            .:             |..|....|..:.        .:|...|               |::..| 
Human   227 YSPDKEEQLPFGPFNGTAWTYHSQDELGGFSHWGRLTSYSGGG---------------YYLDLP- 275

  Fly  1030 FFVNIFVALIIITFQEQGEAE----LQDG-EIDKNQKSC-IDFTIGARPLERYMPKNRNTFKYKV 1088
                         ...||.||    ||:| .:|:..:.. |||::          .|.|...:.|
Human   276 -------------GSRQGSAEALRALQEGLWLDRGTRVVFIDFSV----------YNANINLFCV 317

  Fly  1089 WRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN 1153
            .|:||..|.....:......|:.| ::|.:..|.:....:.|...|...:.||.:|::....:: 
Human   318 LRLVVEFPATGGAIPSWQIRTVKL-IRYVSNWDFFIVGCEVIFCVFIFYYVVEEILELHIHRLR- 380

  Fly  1154 FFKDPWNIFDLITVLGSIVD-------------------------------ALWM-EFGS-NSIN 1185
            :....|||.||:.:|.|||.                               |.|. ::.: |::|
Human   381 YLSSIWNILDLVVILLSIVAVGFHIFRTLEVNRLMGKLLQQPNTYADFEFLAFWQTQYNNMNAVN 445

  Fly  1186 VGF--LRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1248
            :.|  :::|:.....|.:.|      |..|..:..|.:....::..::||.||.:|..:||    
Human   446 LFFAWIKIFKYISFNKTMTQ------LSSTLARCAKDILGFAVMFFIVFFAYAQLGYLLFG---- 500

  Fly  1249 GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAY 1313
                   |:..||.:||:.:...||...|:...|.:          |:|.:..|.        ||
Human   501 -------TQVENFSTFIKCIFTQFRIILGDFDYNAI----------DNANRILGP--------AY 540

  Fly  1314 FVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDM 1378
            ||:::||..|::||:|:|:|.|.:                      :|......|:....::.|:
Human   541 FVTYVFFVFFVLLNMFLAIINDTY----------------------SEVKEELAGQKDELQLSDL 583

  Fly  1379 LKNMDPPLGFGNKCPNRLAYKK-----LIRMNMPLDDELRVQ-FTTTLFALIRENLSIKMRAPEE 1437
            ||.     |: ||...||..:|     :.::....:.|::.: ||.||               .|
Human   584 LKQ-----GY-NKTLLRLRLRKERVSDVQKVLQGGEQEIQFEDFTNTL---------------RE 627

  Fly  1438 MDQADMELRE 1447
            :..|:.|:.|
Human   628 LGHAEHEITE 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124
Ion_trans 441..677 CDD:334124
Ion_trans 769..1050 CDD:334124 32/214 (15%)
Ion_trans 1094..1345 CDD:334124 62/285 (22%)
GPHH 1346..1416 CDD:339854 12/75 (16%)
Ca_chan_IQ 1418..1492 CDD:337190 6/30 (20%)
PKD2L1NP_057196.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..59
PKD_channel 147..567 CDD:400395 99/517 (19%)
Fer4_24 702..735 CDD:407943
Required for homooligomerization 704..763
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 759..805
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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