DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and CACNA1G

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_061496.2 Gene:CACNA1G / 8913 HGNCID:1394 Length:2377 Species:Homo sapiens


Alignment Length:2192 Identity:509/2192 - (23%)
Similarity:855/2192 - (39%) Gaps:674/2192 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPKKEENPPGG-------------GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVV 54
            ||...|..||.             .|...|.|::|:..|.:....:..|.||...:|.|:.|||.
Human    33 GPGSAEKDPGSADSEAEGLPYPALAPVVFFYLSQDSRPRSWCLRTVCNPWFERISMLVILLNCVT 97

  Fly    55 LALEEHLPGGDKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFV 116
            |.:  ..|..|....:|:   |:..:.:....|.||..:|::||| :..|..||.:.||.:|||:
Human    98 LGM--FRPCEDIACDSQRCRILQAFDDFIFAFFAVEMVVKMVALG-IFGKKCYLGDTWNRLDFFI 159

  Fly   117 VVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIV 181
            |:.| |.:|......|....:|.:||||||:.::.:||:::::..::..:..|..:.||..|...
Human   160 VIAG-MLEYSLDLQNVSFSAVRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFF 223

  Fly   182 IFAIIGLEFYSGALHKTC-----YSL--------------EDPNKLV------------------ 209
            ||.|:|::.::|.|...|     :||              ||.:..:                  
Human   224 IFGIVGVQLWAGLLRNRCFLPENFSLPLSVDLERYYQTENEDESPFICSQPRENGMRSCRSVPTL 288

  Fly   210 -KEGESETPCNTDNILEKATGSFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITM 270
             .:|....||..|.....::.:..|   |...:.|......|..|..:|||||:|.:.:||.||:
Human   289 RGDGGGGPPCGLDYEAYNSSSNTTCVNWNQYYTNCSAGEHNPFKGAINFDNIGYAWIAIFQVITL 353

  Fly   271 EGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREKV---ENRQEFL 330
            |||..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||..   |.|..||
Human   354 EGWVDIMYFVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRVRFL 417

  Fly   331 K-----------------------------LRRQQQL---------------------------- 338
            .                             .||..|:                            
Human   418 SNASTLASFSEPGSCYEELLKYLVYILRKAARRLAQVSRAAGVRVGLLSSPAPLGGQETQPSSSC 482

  Fly   339 ----------------------------------------ERELNG------------------- 344
                                                    :|:.||                   
Human   483 SRSHRRLSVHHLVHHHHHHHHHYHLGNGTLRAPRASPEIQDRDANGSRRLMLPPPSTPALSGAPP 547

  Fly   345 --------YVEWICKAEEVIL----------AEERT-----------------TEEEK------- 367
                    :....|..|.|..          |..||                 |.:||       
Human   548 GGAESVHSFYHADCHLEPVRCQAPPPRSPSEASGRTVGSGKVYPTVHTSPPPETLKEKALVEVAA 612

  Fly   368 -------------------MH-IMEARRRNAAKRK-KLKS----------------------LGK 389
                               || ::|.:...|.:.. |:.|                      .|:
Human   613 SSGPPTLTSLNIPPGPYSSMHKLLETQSTGACQSSCKISSPCLKADSGACGPDSCPYCARAGAGE 677

  Fly   390 SKSTDTE----EEEAEEDYGDDGYLKTRSKPQ-------------GSCTGFWRAEKRFRFWIRHT 437
            .:..|.|    :.||..::..|........|.             .|...|||.   .....|..
Human   678 VELADREMPDSDSEAVYEFTQDAQHSDLRDPHSRRQRSLGPDAEPSSVLAFWRL---ICDTFRKI 739

  Fly   438 VKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFE 502
            |.:::|...:::.:.:||:.:.:|::.||..||..|..:..:|..||..||.:|:...||..|.:
Human   740 VDSKYFGRGIMIAILVNTLSMGIEYHEQPEELTNALEISNIVFTSLFALEMLLKLLVYGPFGYIK 804

  Fly   503 SSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSI 567
            :.:|.||.|::..|::|::..:  ||  ||||||..||:|:.|:.::..:|:..::.|:.:|.::
Human   805 NPYNIFDGVIVVISVWEIVGQQ--GG--GLSVLRTFRLMRVLKLVRFLPALQRQLVVLMKTMDNV 865

  Fly   568 ISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNE 625
            .:...||.|||.||::|||.|||.:|       .||   ...||::...|::|||||||.||||:
Human   866 ATFCMLLMLFIFIFSILGMHLFGCKFASERDGDTLP---DRKNFDSLLWAIVTVFQILTQEDWNK 927

  Fly   626 VMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE---------- 680
            |:|.|:.|.....     ::|||.|:.||||.|.|:.:||.|:.. .|:|::..|          
Human   928 VLYNGMASTSSWA-----ALYFIALMTFGNYVLFNLLVAILVEGF-QAEEISKREDASGQLSCIQ 986

  Fly   681 ----------------------------------------------------------------- 680
                                                                             
Human   987 LPVDSQGGDANKSESEPDFFSPSLDGDGDRKKCLALVSLGEHPELRKSLLPPLIIHTAATPMSLP 1051

  Fly   681 ----------------------------------------------------------------- 680
                                                                             
Human  1052 KSTSTGLGEALGPASRRTSSSGSAEPGAAHEMKSPPSARSSPHSPWSAASSWTSRRSSRNSLGRA 1116

  Fly   681 ------------------EEQVEEDKEKQLQE---------------LEKEM-------EALQAD 705
                              |.|..:|:|:..:|               ||:|.       :.||..
Human  1117 PSLKRRSPSGERRSLLSGEGQESQDEEESSEEERASPAGSDHRHRGSLEREAKSSFDLPDTLQVP 1181

  Fly   706 GVH-VENGDGAVAPSKS-KGKKKE----------------EEKKEEEEVTEGP------KPMLPY 746
            |:| ..:|.|:.:..:. .||...                ::..:|..:::|.      :..||.
Human  1182 GLHRTASGRGSASEHQDCNGKSASGRLARALRPDDPPLDGDDADDEGNLSKGERVRAWIRARLPA 1246

  Fly   747 S-------SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILN 803
            .       |.:|..|.:..|...|.::....||..::|:|.::.|.:|.|.| :..:|.....|.
Human  1247 CCLERDSWSAYIFPPQSRFRLLCHRIITHKMFDHVVLVIIFLNCITIAMERPKIDPHSAERIFLT 1311

  Fly   804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLST 868
            ..:|.||.||..||.:|:|.||......:|||..||::|.::|:.:.:.....|...|..:.|..
Human  1312 LSNYIFTAVFLAEMTVKVVALGWCFGEQAYLRSSWNVLDGLLVLISVIDILVSMVSDSGTKILGM 1376

  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933
            ::.||:||.||||:.|.|...||.|.:.:::|||.:.||:::...|..||.::|||||.||||.|
Human  1377 LRVLRLLRTLRPLRVISRAQGLKLVVETLMSSLKPIGNIVVICCAFFIIFGILGVQLFKGKFFVC 1441

  Fly   934 TDESKH---TSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVL 995
            ..|...   ..::|..:.::              |....:::||:..|:::||.:.:.:||..::
Human  1442 QGEDTRNITNKSDCAEASYR--------------WVRHKYNFDNLGQALMSLFVLASKDGWVDIM 1492

  Fly   996 QHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF------QEQGEAELQDG 1054
            ...:.|...|:.||.|....|.:::|.:.::..||.:|:||.:::..|      ||:.||..::.
Human  1493 YDGLDAVGVDQQPIMNHNPWMLLYFISFLLIVAFFVLNMFVGVVVENFHKCRQHQEEEEARRREE 1557

  Fly  1055 E----IDKNQKS-CIDFTIGA------------RPLERYMPKNRNTFKYKVWRIVVSTPFEYFIM 1102
            :    ::|.::: .:|..|.:            :|.  |...:|  |:..|..:..|...:.||.
Human  1558 KRLRRLEKKRRNLMLDDVIASGSSASAASEAQCKPY--YSDYSR--FRLLVHHLCTSHYLDLFIT 1618

  Fly  1103 MLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITV 1167
            .:|..|.:.:.|:::.|..:.:::||..|..||.:|.:|:|.|::.||.:.||:|.||..||..|
Human  1619 GVIGLNVVTMAMEHYQQPQILDEALKICNYIFTVIFVLESVFKLVAFGFRRFFQDRWNQLDLAIV 1683

  Fly  1168 LGSIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCL 1226
            |.||:.....|...|:   ||   :..:|:.|.||::|||:....:|.||.|.:|:...:..:.|
Human  1684 LLSIMGITLEEIEVNASLPINPTIIRIMRVLRIARVLKLLKMAVGMRALLDTVMQALPQVGNLGL 1748

  Fly  1227 LIAMLFFIYAIIGMQVFGNIKLGTVE--NSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK 1289
            |..:||||:|.:|:::||:::.....  ..:.||..|::|....:.|||.:||:.|..||...|:
Human  1749 LFMLLFFIFAALGVELFGDLECDETHPCEGLGRHATFRNFGMAFLTLFRVSTGDNWNGIMKDTLR 1813

  Fly  1290 GKACDDDAEKAPGEYCGST-LAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLD 1353
            .  ||.::.      |.:| ::..|||||:....|:::|:.:||:|.:.:...:::.        
Human  1814 D--CDQEST------CYNTVISPIYFVSFVLTAQFVLVNVVIAVLMKHLEESNKEAK-------- 1862

  Fly  1354 EFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGF-----GNKCPNRLAYKKLIRMNMPLDDELR 1413
            |...:.||.:         .||..:......|||.     |.:.|:        ..:.|....|.
Human  1863 EEAELEAELE---------LEMKTLSPQPHSPLGSPFLWPGVEGPD--------SPDSPKPGALH 1910

  Fly  1414 VQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNI------WPLQAKKMLNLLVPPSDQL- 1471
            ..      |..|......:..|     .|.:|.:||:.:      |.|   |:::.|..|..|. 
Human  1911 PA------AHARSASHFSLEHP-----TDRQLFDTISLLIQGSLEWEL---KLMDELAGPGGQPS 1961

  Fly  1472 ----------NKGKLSVGKIYAGFLILE--SWRSTRFGQLDSGMP------MLELQDASRHPSQE 1518
                      :..::.:.::.|..|..|  |..|......|..:|      :|...:::..|...
Human  1962 AFPSAPSLGGSDPQIPLAEMEALSLTSEIVSEPSCSLALTDDSLPDDMHTLLLSALESNMQPHPT 2026

  Fly  1519 SLTGAD------AG----HLHPGHSYM--NGHRRSPSLRHN--GSPLARSPSPRRRGHQYIHHDI 1569
            .|.|.|      :|    |..|..|||  :|......|.|.  |.|.|:|.|...     :|...
Human  2027 ELPGPDLLTVRKSGVSRTHSLPNDSYMCRHGSTAEGPLGHRGWGLPKAQSGSVLS-----VHSQP 2086

  Fly  1570 GFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSR 1616
              :|| |.::::.|:..|....:|.|.:  |:......|.|||...|
Human  2087 --ADT-SYILQLPKDAPHLLQPHSAPTW--GTIPKLPPPGRSPLAQR 2128

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 103/335 (31%)
Ion_trans 441..677 CDD:334124 88/242 (36%)
Ion_trans 769..1050 CDD:334124 88/290 (30%)
Ion_trans 1094..1345 CDD:334124 82/259 (32%)
GPHH 1346..1416 CDD:339854 12/74 (16%)
Ca_chan_IQ 1418..1492 CDD:337190 17/92 (18%)
CACNA1GNP_061496.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 5/14 (36%)
I 68..398 100/334 (30%)
Ion_trans 130..406 CDD:278921 88/278 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 521..551 3/29 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 569..600 3/30 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 699..720 2/20 (10%)
II 729..967 90/252 (36%)
Ion_trans 760..968 CDD:278921 83/220 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 991..1012 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1047..1230 17/182 (9%)
III 1263..1540 86/290 (30%)
Ion_trans 1293..1547 CDD:278921 80/267 (30%)
IV 1596..1854 85/267 (32%)
Ion_trans 1628..1851 CDD:278921 76/230 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1878..1917 8/52 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2107..2129 8/24 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2171..2244
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2272..2377
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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