DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and CACNA1H

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_006721026.1	Gene:	CACNA1H / 8912	HGNCID:	1395	Length:	2358	Species:	Homo sapiens

Alignment Length:	2202	Identity:	520/2202 - (23%)
Similarity:	885/2202 - (40%)	Gaps:	679/2202 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGPKKEENP-PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLAL----EEH 60
            :|..:::..| |....|..|.|.:....|.:...::..|.||:..:|.|:.|||.|.:    |:.
Human    62 LGADEEQRVPYPALAATVFFCLGQTTRPRSWCLRLVCNPWFEHVSMLVIMLNCVTLGMFRPCEDV 126

  Fly    61 LPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQY 125
            ..|.::..:   ||..:|:....|.||..:|::||||...| .||.:.||.:|||:||.|.| :|
Human   127 ECGSERCNI---LEAFDAFIFAFFAVEMVIKMVALGLFGQK-CYLGDTWNRLDFFIVVAGMM-EY 186

  Fly   126 PQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEF 190
            ...|..|.|..:|.:||||||:.::.:||:::::..::..:..|..:.||..|...||.|:|::.
Human   187 SLDGHNVSLSAIRTVRVLRPLRAINRVPSMRILVTLLLDTLPMLGNVLLLCFFVFFIFGIVGVQL 251

  Fly   191 YSGALHKTCY-----------SLEDPNKLVKEGESETP--CNT--DNILEK-------------- 226
            ::|.|...|:           :...|....:||| |.|  |::  ||.::|
Human   252 WAGLLRNRCFLDSAFVRNNNLTFLRPYYQTEEGE-ENPFICSSRRDNGMQKCSHIPGRRELRMPC 315

  Fly   227 -----------ATGSFVCNNTT-------SMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGW 273
                       |.|.....|..       ::|......|::|..:|||||:|.:.:||.||:|||
Human   316 TLGWEAYTQPQAEGVGAARNACINWNQYYNVCRSGDSNPHNGAINFDNIGYAWIAIFQVITLEGW 380

  Fly   274 TAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KEREKVENRQE-------- 328
            ..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||....|::
Human   381 VDIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQRESQLMREQRARHLSND 444

  Fly   329 -----------------------FLKLRRQQQLERELNGYVEWICK------------------- 351
                                   |.|::|     |.|..|..|..:
Human   445 STLASFSEPGSCYEELLKYVGHIFRKVKR-----RSLRLYARWQSRWRKKVDPSAVQGQGPGHRQ 504

  Fly   352 ----------------------------------------------------------------A 352
                                                                            |
Human   505 RRAGRHTASVHHLVYHHHHHHHHHYHFSHGSPRRPGPEPGACDTRLVRAGAPPSPPSPGRGPPDA 569

  Fly   353 EEV--ILAEERTTE--EEKMHIMEARRRNAAKRKKLKSLG-----------------------KS 390
            |.|  |...:...|  :|:..:..|....||..:....||                       |.
Human   570 ESVHSIYHADCHIEGPQERARVAHAAATAAASLRLATGLGTMNYPTILPSGVGSGKGSTSPGPKG 634

  Fly   391 K-----------------STDTEEE----EAEEDYGD-DGYLK---------------------- 411
            |                 |.|..|:    ..|...|. .|:|.
Human   635 KWAGGPPGTGGHGPLSLNSPDPYEKIPHVVGEHGLGQAPGHLSGLSVPCPLPSPPAGTLTCELKS 699

  Fly   412 ----TRS--KPQGSCTGF----------------------W---------------------RAE 427
                ||:  .|:|..:|.                      |                     ||:
Human   700 CPYCTRALEDPEGELSGSESGDSDGRGVYEFTQDVRHGDRWDPTRPPRATDTPGPGPGSPQRRAQ 764

  Fly   428 KRF---------RFWI------RHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAE 477
            :|.         |.|:      |..|.:::|...:::.:.:||:.:.||::.||..||..|..:.
Human   765 QRAAPGEPGWMGRLWVTFSGKLRRIVDSKYFSRGIMMAILVNTLSMGVEYHEQPEELTNALEISN 829

  Fly   478 FIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLR 542
            .:|..:|..||.:|:.|.||..|..:.:|.||.:::..|::|:: .:..|   ||||||..||||
Human   830 IVFTSMFALEMLLKLLACGPLGYIRNPYNIFDGIIVVISVWEIV-GQADG---GLSVLRTFRLLR 890

  Fly   543 IFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPET----- 602
            :.|:.::..:||..::.|:.:|.::.:...||.|||.||::|||.|||.:|:|...|.:|
Human   891 VLKLVRFLPALRRQLVVLVKTMDNVATFCTLLMLFIFIFSILGMHLFGCKFSLKTDTGDTVPDRK 955

  Fly   603 NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAV 667
            ||::...|::|||||||.||||.|:|.|:.|.....     ::||:.|:.||||.|.|:.:||.|
Human   956 NFDSLLWAIVTVFQILTQEDWNVVLYNGMASTSSWA-----ALYFVALMTFGNYVLFNLLVAILV 1015

  Fly   668 DNLANAQELTAAEEEQ------VEED--KEKQLQELEKEM--EALQADGVHVENGDGAVAPS--- 719
            :......:...::.::      .|||  |.::||..|.:|  .|:..:| |:| |.|:::|.
Human  1016 EGFQAEGDANRSDTDEDKTSVHFEEDFHKLRELQTTELKMCSLAVTPNG-HLE-GRGSLSPPLIM 1078

  Fly   720 ----------------------------------------------------------------- 719

Human  1079 CTAATPMPTPKSSPFLDAAPSLPDSRRGSSSSGDPPLGDQKPPASLRSSPCAPWGPSGAWSSRRS 1143

  Fly   720 ------------------------KSKGKKKEEEKKEEEEVTEGP-------------------- 740
                                    ..:||...:::.|:.....||
Human  1144 SWSSLGRAPSLKRRGQCGERESLLSGEGKGSTDDEAEDGRAAPGPRATPLRRAESLDPRPLRPAA 1208

  Fly   741 -----------------------------------------------KPMLPYS----------S 748
                                                           |.:.||.          :
Human  1209 LPPTKCRDRDGQVVALPSDFFLRIDSHREDAAELDDDSEDSCCLRLHKVLEPYKPQWCRSREAWA 1273

  Fly   749 MFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGV 812
            :::.||.|..|.....|:....||..::|.|.::.:.:|.|.| :...|.....|:..:|.||.:
Human  1274 LYLFSPQNRFRVSCQKVITHKMFDHVVLVFIFLNCVTIALERPDIDPGSTERVFLSVSNYIFTAI 1338

  Fly   813 FTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRV 877
            |..||::|:|.||::....:||:..||::|.::|:.:.|.....|:.:...:.|..::.||:||.
Human  1339 FVAEMMVKVVALGLLSGEHAYLQSSWNLLDGLLVLVSLVDIVVAMASAGGAKILGVLRVLRLLRT 1403

  Fly   878 LRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKH--- 939
            ||||:.|.|.|.||.|.:.:::||:.:.||:::...|..||.::|||||.|||:||......
Human  1404 LRPLRVISRAPGLKLVVETLISSLRPIGNIVLICCAFFIIFGILGVQLFKGKFYYCEGPDTRNIS 1468

  Fly   940 TSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYE 1004
            |.|:|:.::::              |..|.:::||:..|:::||.:.:.:||..::...:.|...
Human  1469 TKAQCRAAHYR--------------WVRRKYNFDNLGQALMSLFVLSSKDGWVNIMYDGLDAVGV 1519

  Fly  1005 DRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF------QEQGEAELQDGE----IDKN 1059
            |:.|:||....|.:::|.:.::..||.:|:||.:::..|      ||..||..::.:    :::.
Human  1520 DQQPVQNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAEEARRREEKRLRRLERR 1584

  Fly  1060 QKS-CIDFTIGARPLER------YMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYH 1117
            ::| .:...:.....:|      |.|..|:     :..:..|...:.||..:|..|.:.:.|:::
Human  1585 RRSKALPVAVAVAEAQRRPYYADYSPTRRS-----IHSLCTSHYLDLFITFIICVNVITMSMEHY 1644

  Fly  1118 NQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSN 1182
            ||....:::|||.|..||.:|..|..||::.||.:.||||.||..||..||.|::.....|...:
Human  1645 NQPKSLDEALKYCNYVFTIVFVFEAALKLVAFGFRRFFKDRWNQLDLAIVLLSLMGITLEEIEMS 1709

  Fly  1183 S---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQ 1241
            :   ||   :..:|:.|.||::|||:....:|.||.|.||:...:..:.||..:||||||.:|::
Human  1710 AALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVE 1774

  Fly  1242 VFGNIKLGTVEN---SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGE 1303
            :||.::. :.:|   .::||..|.:|....:.|||.:||:.|..||...|:..:.:|       :
Human  1775 LFGRLEC-SEDNPCEGLSRHATFSNFGMAFLTLFRVSTGDNWNGIMKDTLRECSRED-------K 1831

  Fly  1304 YCGS---TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPN 1365
            :|.|   .|:..|||:|:....|:::|:.|||:|.:.:...:::.  ....||..:.:.....|.
Human  1832 HCLSYLPALSPVYFVTFVLVAQFVLVNVVVAVLMKHLEESNKEAR--EDAELDAEIELEMAQGPG 1894

  Fly  1366 ATGKIHYTEMYDMLKNMDPPL-----GFGNKCPNRLAYKKLI--RMNMPLDDELRVQFTTTLFAL 1423
            :..::....         |||     | ....||.:|.|..:  .:::|.|.           .:
Human  1895 SARRVDADR---------PPLPQESPG-ARDAPNLVARKVSVSRMLSLPNDS-----------YM 1938

  Fly  1424 IRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLIL 1488
            .|..:......|..:.:.:||.....|   ||.:  :.::..||:
Human  1939 FRPVVPASAPHPRPLQEVEMETYGAGT---PLGS--VASVHSPPA-------------------- 1978

  Fly  1489 ESWRSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLAR 1553
            ||..|            |::..|...|::   :|.....|.|     .|..|||||   ...|.|
Human  1979 ESCAS------------LQIPLAVSSPAR---SGEPLHALSP-----RGTARSPSL---SRLLCR 2020

  Fly  1554 SPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRH-GNSHPRYPRGSWSASTSPARSPSPSRY 1617
                    .:.:|     :|::...::..::|..|.. |...|..|.....:..||.|||.|:
Human  2021 --------QEAVH-----TDSLEGKIDSPRDTLDPAEPGEKTPVRPVTQGGSLQSPPRSPRPA-- 2070

  Fly  1618 GGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHS 1674
                  |.||:  ..|:|  ..|..||..:|.. :|....|    ..|..|:|:..|
Human  2071 ------SVRTR--KHTFG--QRCVSSRPAAPGG-EEAEASD----PADEEVSHITSS 2112

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	111/339 (33%)
		Ion_trans	441..677	CDD:334124	87/240 (36%)
		Ion_trans	769..1050	CDD:334124	87/290 (30%)
		Ion_trans	1094..1345	CDD:334124	86/262 (33%)
		GPHH	1346..1416	CDD:339854	13/76 (17%)
		Ca_chan_IQ	1418..1492	CDD:337190	11/73 (15%)
CACNA1H	XP_006721026.1	Ion_trans	149..430	CDD:278921	95/284 (33%)
		Ion_trans	810..1019	CDD:278921	84/217 (39%)
		Ion_trans	1317..1565	CDD:278921	77/261 (30%)
		Ion_trans	1639..1852	CDD:278921	75/220 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820