DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and CACNA1I

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_066919.2 Gene:CACNA1I / 8911 HGNCID:1396 Length:2223 Species:Homo sapiens


Alignment Length:2282 Identity:549/2282 - (24%)
Similarity:900/2282 - (39%) Gaps:675/2282 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 GPKKEENPPGG-----------------GPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIA 50
            ||:...:.|.|                 .|.:.|.|.:....|.:...::..|.||...:|.|:.
Human    27 GPRSPPSSPPGLEEPLDGADPHVPHPDLAPIAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILL 91

  Fly    51 NCVVLALEEHLPGGDKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIM 112
            |||.|.:  :.|..|...|:.:   |:..:.:....|.:|..||::||| :..|..||.:.||.:
Human    92 NCVTLGM--YQPCDDMDCLSDRCKILQVFDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRL 153

  Fly   113 DFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVL 177
            |||:|:.| |.:|......::|..:|.:|||||||.::.:||:::::..::..:..|..:.||..
Human   154 DFFIVMAG-MVEYSLDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCF 217

  Fly   178 FAIVIFAIIGLEFYSGALHKTCY-----------------------------SLEDPNKL----- 208
            |...||.|||::.::|.|...|:                             ||...|.:     
Human   218 FVFFIFGIIGVQLWAGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLSGDNGIMGCHE 282

  Fly   209 ---VKEGESETPCNTDNILEKATG------SFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAM 261
               :||...|...:.|::.:...|      |.:|   |...::|......|:.|..:|||||:|.
Human   283 IPPLKEQGRECCLSKDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGSANPHKGAINFDNIGYAW 347

  Fly   262 LTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KERE--- 321
            :.:||.||:|||..|:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||   
Human   348 IVIFQVITLEGWVEIMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRL 411

  Fly   322 KVENRQEFLKLRRQQQLERELNGYVE---WIC----KAEEVILAEERTTEEEKM----------- 368
            .:|.||.:|............:.|.|   ::|    ||:...|...:..:..:.           
Human   412 MLEQRQRYLSSSTVASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQSRRQALGPEAPAPAK 476

  Fly   369 ---HIMEARR------------RNAAKR------------------------------------- 381
               |..|.|.            |:...|                                     
Human   477 PGPHAKEPRHYHGKTKGQGDEGRHLGSRHCQTLHGPASPGNDHSGRELCPQHSPLDATPHTLVQP 541

  Fly   382 --------------------KKLKSLGKSKSTDTEEEEA--------EEDYGDDGYLKTRSKPQG 418
                                ::...||   |||:.:|.:        |::...||   .||...|
Human   542 IPATLASDPASCPCCQHEDGRRPSGLG---STDSGQEGSGSGSSAGGEDEADGDG---ARSSEDG 600

  Fly   419 S--------------------CTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHY 463
            :                    |...|| |.|.:  :|..|.:::|...:::.:.:|||.:.:||:
Human   601 ASSELGKEEEEEEQADGAVWLCGDVWR-ETRAK--LRGIVDSKYFNRGIMMAILVNTVSMGIEHH 662

  Fly   464 GQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGG 528
            .||..||..|.....:|..:|..||.:|:.|.|...|..:.:|.||.:::..||:|:: .:..| 
Human   663 EQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNPYNIFDSIIVIISIWEIV-GQADG- 725

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
              ||||||..||||:.|:.::..:||..::.|:.:|.::.:...||.|||.||::|||.:||.:|
Human   726 --GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVATFCMLLMLFIFIFSILGMHIFGCKF 788

  Fly   594 NLPGGTPET-----NFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLF 653
            :|...|.:|     ||::...|::|||||||.||||.|:|.|:     |......|:||:.|:.|
Human   789 SLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYNGM-----ASTSPWASLYFVALMTF 848

  Fly   654 GNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADG-------VHVEN 711
            |||.|.|:.:||.|:..  ..|..|......|:.....::|.:|..|.|.:.|       ....|
Human   849 GNYVLFNLLVAILVEGF--QAEGDANRSYSDEDQSSSNIEEFDKLQEGLDSSGDPKLCPIPMTPN 911

  Fly   712 GD--------------GAVAPS------------------------------------------- 719
            |.              ||..|:                                           
Human   912 GHLDPSLPLGGHLGPAGAAGPAPRLSLQPDPMLVALGSRKSSVMSLGRMSYDQRSLSSSRSSYYG 976

  Fly   720 ------------------KSKGKKKEEE------------------------------------- 729
                              |.|....|.|                                     
Human   977 PWGRSAAWASRRSSWNSLKHKPPSAEHESLLSAERGGGARVCEVAADEGPPRAAPLHTPHAHHIH 1041

  Fly   730 -------------------KKEEEEVTE----------------GPKP----------------- 742
                               .::..::.|                ||.|                 
Human  1042 HGPHLAHRHRHHRRTLSLDNRDSVDLAELVPAVGAHPRAAWRAAGPAPGHEDCNGRMPSIAKDVF 1106

  Fly   743 --------------MLPYS-----------------------SMFILSPTNPIRRGAHWVVNLPY 770
                          .:.|:                       |:::.||.|..|.....::....
Human  1107 TKMGDRGDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVREDWSVYLFSPENRFRVLCQTIIAHKL 1171

  Fly   771 FDFFIMVVISMSSIALAAEDP-VRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYL 834
            ||:.::..|.::.|.:|.|.| :...|.....|...:|.||.:|..||.||:|.||:.....:||
Human  1172 FDYVVLAFIFLNCITIALERPQIEAGSTERIFLTVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYL 1236

  Fly   835 REFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVN 899
            |..||::|..:|..:.:.....::.:...:.|..::.||:||.||||:.|.|.|.||.|.:.:::
Human  1237 RSSWNVLDGFLVFVSIIDIVVSLASAGGAKILGVLRVLRLLRTLRPLRVISRAPGLKLVVETLIS 1301

  Fly   900 SLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC--TDESKHTS-AECQGSYFKYEEDELLPKQE 961
            |||.:.||:::...|..||.::|||||.|||::|  .|....|: ::|..:.::           
Human  1302 SLKPIGNIVLICCAFFIIFGILGVQLFKGKFYHCLGVDTRNITNRSDCMAANYR----------- 1355

  Fly   962 LRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIV 1026
               |....:::||:..|:::||.:.:.:||..::.:.:.|...|:.|:.|....|.:::|.:.::
Human  1356 ---WVHHKYNFDNLGQALMSLFVLASKDGWVNIMYNGLDAVAVDQQPVTNHNPWMLLYFISFLLI 1417

  Fly  1027 FPFFFVNIFVALIIITF---QEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKV 1088
            ..||.:|:||.:::..|   ::..|||    |..:.::..:      |.||:...|.:....|..
Human  1418 VSFFVLNMFVGVVVENFHKCRQHQEAE----EARRREEKRL------RRLEKKRRKAQRLPYYAT 1472

  Fly  1089 W---RIVV-----STPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLK 1145
            :   |:::     |...:.||..:|..|.:.:.::::||....|.:|||.|..||.:|.:|.|||
Human  1473 YCHTRLLIHSMCTSHYLDIFITFIICLNVVTMSLEHYNQPTSLETALKYCNYMFTTVFVLEAVLK 1537

  Fly  1146 IIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFGSNS---IN---VGFLRLFRAARLIKLLRQG 1204
            ::.||::.||||.||..||..||.|::.....|...|:   ||   :..:|:.|.||::|||:..
Human  1538 LVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEEIEINAALPINPTIIRIMRVLRIARVLKLLKMA 1602

  Fly  1205 YTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVEN---SITRHNNFQSFIQ 1266
            ..:|.||.|.||:...:..:.||..:||||||.:|:::||.:.... ||   .::||..|::|..
Human  1603 TGMRALLDTVVQALPQVGNLGLLFMLLFFIYAALGVELFGKLVCND-ENPCEGMSRHATFENFGM 1666

  Fly  1267 GVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYA---YFVSFIFFCSFLMLNL 1328
            ..:.||:.:||:.|..||...|:.  |..|...     |.|:|.:.   |||||:....|:::|:
Human  1667 AFLTLFQVSTGDNWNGIMKDTLRD--CTHDERS-----CLSSLQFVSPLYFVSFVLTAQFVLINV 1724

  Fly  1329 FVAVIMDNFDYLTRDS----------SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMD 1383
            .|||:|.:.|...:::          .:..||.|....|: ....|.|.|:              
Human  1725 VVAVLMKHLDDSNKEAQEDAEMDAELELEMAHGLGPGPRL-PTGSPGAPGR-------------- 1774

  Fly  1384 PPLGF-------GNKCPNRLAYKK------LIRMNMPLDDELRVQFTTTLFALIRENLSIKM--- 1432
            .|.|.       |..|  |..|..      |..:::.:.|.|..:.|      |.:|||..:   
Human  1775 GPGGAGGGGDTEGGLC--RRCYSPAQENLWLDSVSLIIKDSLEGELT------IIDNLSGSIFHH 1831

  Fly  1433 -RAPE-----EMDQADMELRETITNIWPLQAKKMLNLLV------------PPSDQLNKGKLSVG 1479
             .:|.     ..|:.:::|.|  |..:.|.:.:..::|:            ||..:.:||:    
Human  1832 YSSPAGCKKCHHDKQEVQLAE--TEAFSLNSDRSSSILLGDDLSLEDPTACPPGRKDSKGE---- 1890

  Fly  1480 KIYAGFLILESWRSTRFGQLDSGMPMLELQDASRHPSQES-LTGADAGHLHPGHSYMNGHRRSPS 1543
                    |:.....|.|  |.|.....|...:..|..|: |...:....:|..|:         
Human  1891 --------LDPPEPMRVG--DLGECFFPLSSTAVSPDPENFLCEMEEIPFNPVRSW--------- 1936

  Fly  1544 LRHNGSPLARSP-SPRRRGHQYIHHDIGFSDTVSNVVEMVKETRH---------PRHGNSHPRYP 1598
            |:|:.|....|| ||               |..|.::.|..|..|         |..|......|
Human  1937 LKHDSSQAPPSPFSP---------------DASSPLLPMPAEFFHPAVSASQKGPEKGTGTGTLP 1986

  Fly  1599 R----GSWSASTSP---------------ARSPSPSRYGGH----------LSRSKRTQL----- 1629
            :    |||::..||               :...|||...|.          ||.|.|..|     
Human  1987 KIALQGSWASLRSPRVNCTLLRQATGSDTSLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPAP 2051

  Fly  1630 -PYPTYGTTSLCQRS---RSPSPARLQEMRERDR---LGYGIDMGVTHVQHSYPTLASRRAGIG- 1686
             |.|..|.:...:|.   |......|:.:|...|   .|.....|.||.....|:....|.|.| 
Human  2052 APGPRAGLSPAARRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGG 2116

  Fly  1687 --------RRL-----------PPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHH 1732
                    ..|           ||.|..|.   |.|..    |.:::.:......||:. :|.| 
Human  2117 GGAGSEHSETLSSLSLTSLFCPPPPPPAPG---LTPAR----KFSSTSSLAAPGRPHAA-ALAH- 2172

  Fly  1733 RDLLRDP 1739
             .|.|.|
Human  2173 -GLARSP 2178

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 106/340 (31%)
Ion_trans 441..677 CDD:334124 89/240 (37%)
Ion_trans 769..1050 CDD:334124 83/287 (29%)
Ion_trans 1094..1345 CDD:334124 91/272 (33%)
GPHH 1346..1416 CDD:339854 16/82 (20%)
Ca_chan_IQ 1418..1492 CDD:337190 16/94 (17%)
CACNA1INP_066919.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..46 4/18 (22%)
I 66..401 103/339 (30%)
Ion_trans 127..409 CDD:278921 91/284 (32%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 467..536 5/68 (7%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..616 12/66 (18%)
II 626..865 94/250 (38%)
Ion_trans 657..866 CDD:278921 84/219 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 899..936 6/36 (17%)
III 1157..1434 83/290 (29%)
Ion_trans 1202..1441 CDD:278921 74/252 (29%)
IV 1472..1733 91/268 (34%)
Ion_trans 1504..1741 CDD:278921 86/244 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1758..1784 7/40 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1868..1897 5/40 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1937..1960 9/37 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2013..2062 12/48 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2076..2223 26/113 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.820

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