DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and CCH1

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_011733.3 Gene:CCH1 / 853131 SGDID:S000003449 Length:2039 Species:Saccharomyces cerevisiae


Alignment Length:1985 Identity:402/1985 - (20%)
Similarity:726/1985 - (36%) Gaps:638/1985 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIR-KYTRFIIEWP-PFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            ||.:.:..||:| |..||::... ...|..|||..|  ::||:..:.|  ...|...:......|
Yeast   323 SLGVFSPTNPLRIKIARFLLHRRYSLLYNTLLTFYA--ILLAIRTYNP--HNVVFLYRFSNWTDY 383

  Fly    80 FLCIF--CVEAS--LKILALGL----------------------VLHKHSYLRNIWN------IM 112
            |:.|.  |...:  .||:|.|.                      ::..:.|||..:.      |:
Yeast   384 FIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFII 448

  Fly   113 DFFVVVTGFMTQY-----------PQIGPE------------------VDL-------------- 134
            .|.::..|..|:|           |....|                  :||              
Yeast   449 PFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSI 513

  Fly   135 ---------RTLRAIRVLRPLKLV---SGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIG 187
                     |..:.:.:||.|:||   :|:||   :|:.:...:..|:.:..::::..:.|.|:|
Yeast   514 KSYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRGLKYGIPQLVNVSSMLVYFWIFFGILG 575

  Fly   188 LEFYSGALHKTC--YSLEDP-----------------------NKLVKEGESETPCNTDNILEKA 227
            ::.:.|:..:.|  ::.|||                       |.:.::|...:          .
Yeast   576 VQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGS----------V 630

  Fly   228 TGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIY 292
            :..|:|.. .|.|:.. ..|.:|..|||||..:|..||..::...:|.::|:|.|:...| ..::
Yeast   631 SKGFLCPQ-YSKCVSN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMA-ACLF 692

  Fly   293 FVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWI-CKAEE-- 354
            |:..|.:.:.::|||::.||...|....|:.:.::.....|:...:.|.:.||.::. .||.:  
Yeast   693 FIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFKLKANQTK 757

  Fly   355 -------------------VILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEA 400
                               |||.           |.:...|.:.|        .|.|.:......
Yeast   758 FPNWSQKGLAIYSHVEFIFVILI-----------ICDIGMRASVK--------VSTSANCNNILL 803

  Fly   401 EEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWI----RHTVKTQWFYWFVIVLVFLNTVCVAVE 461
            :.|.|.            |...|..:..|...::    :...|..:.|.|:|.::.|...|:|||
Yeast   804 KTDRGI------------SIVLFIESLARLVLYLPNMWKFLTKPSYVYDFIISIITLVISCLAVE 856

  Fly   462 ----HYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIW 522
                |.              :.:|.:|                   ..:||..|:||.::.:.:|
Yeast   857 GVLGHM--------------YAWLSIF-------------------HISRFYRVIISFNLTKKLW 888

  Fly   523 SEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL---- 583
            .::....           :.|:.::.::                    .|..||..:|.|:    
Yeast   889 KQILSNG-----------VMIWNLSSFY--------------------FFFTFLVAIIMAVYFEG 922

  Fly   584 ------LGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMI 642
                  :..|.| |.::||        |:|    |::|.|.:.|:|.:::|..............
Yeast   923 VIPPEEMADQPF-GMYSLP--------NSF----LSLFIIGSTENWTDILYALQKHSPNISSTFF 974

  Fly   643 YSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQEL------EKEMEA 701
            .|::||:..|..|..:||:|:|:..:::          |.:.||.:.:|::..      :|..|.
Yeast   975 CSVFFIIWFLLSNSVILNIFIALISESM----------EVKEEEKRPQQIKHYLKFVYPQKIQEY 1029

  Fly   702 LQAD----------GVHVENGD---------------------GAVA------PSKS---KGKKK 726
            ..|.          |.| .|.|                     |.:|      ||::   ||..|
Yeast  1030 THASLVARIRKKFFGGH-RNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPPSENLFKKGLSK 1093

  Fly   727 ----------------------------------------EEEKKEEEEVTEGPK-PMLPYSSMF 750
                                                    |..:.|:|::....| |:..||..|
Yeast  1094 LTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRTYILELNEYEDEKLDYLKKYPLFNYSYYF 1158

  Fly   751 ILSPTNPIRRGAHWVV----------------------NLPYF-----DFFIMVVISMSSIALAA 788
             .||.:..||....:|                      ...||     |.|:. :.::::|.|..
Yeast  1159 -FSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVF-IFALATILLIV 1221

  Fly   789 ----EDPVRENSRRNKILNY---FDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVV 846
                ..|:.....:....|:   .|.||.|.|:||.::|.|..|.|..|.:|||..||.:|..|:
Yeast  1222 CSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVL 1286

  Fly   847 ICAAVSFGFDMSGSSAGQNLSTI-KSLRVLRVLRPLKTIKRVPKLKAVFDCVV-NSLKNVVNILI 909
            |...::....:..:.   |||.| |.|..||.||.| ||...  .:..|:.|: :.|..:....:
Yeast  1287 ISMWINLIAYLKNNG---NLSRIFKGLTALRALRCL-TISNT--ARQTFNLVMFDGLNKIFEAGL 1345

  Fly   910 VYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFK--YEEDELLPKQELRVWKPRAFHY 972
            :.:...|.|:|.|:.:|.|:...|.|.|. ..|:|...|..  ::.|.:.|    ||::....|.
Yeast  1346 ISLSLLFPFTVWGLSIFKGRLGTCNDGSL-GRADCYNEYSNSVFQWDIMSP----RVYQQPYLHL 1405

  Fly   973 DNVAAAMLTLFAVQTGEGWPQVLQHSM-------AATYEDRGPIQNFRIEMSIFYIVYFIVFPFF 1030
            |:.|:|..:|:.:.:.|||..:|::.|       .||.  .|...|     ::|.:::..:...|
Yeast  1406 DSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATV--MGSAGN-----ALFLVLFNFLSMVF 1463

  Fly  1031 FVNIFVALII-----------ITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPK----- 1079
            .:|:||:.|:           .|.:|:...|.|                  :.|.:..||     
Yeast  1464 ILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQ------------------KLLSQAKPKAIPNL 1510

  Fly  1080 ----NRNTFKYKVWRIVVSTPFEY--FIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMF 1138
                ....|.|::  .|....|.|  |:.:::..:.::|:.:.:|.|::......|. |..|.:|
Yeast  1511 IELSRVRQFFYQL--AVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYF-MFSTSVF 1572

  Fly  1139 SVETVLKIIGFGVKNFFKDPWNIFDL-ITVLGSIVDAL---------WMEFGSNSINV-GFLRLF 1192
            .::..|.:.|.|.:.:|:..||...| |.::..|::|:         |..      |: ||   |
Yeast  1573 LIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPASHYWFH------NIKGF---F 1628

  Fly  1193 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITR 1257
            .....:.::.|..|:..||.|.:.|...:..:.....:||.:|||...|:||..:||   ::.|.
Yeast  1629 LLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLG---SNTTD 1690

  Fly  1258 HNNFQSFIQGVMLLFRCATGEAWPNIML-ACLKGKACDDDAEKAPGEYCGS-TLAYAYFVSFIFF 1320
            :.||::.|:.:::||||:.||.|..||. ..:....|..| :.:....||| |.||...:|:...
Yeast  1691 NINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSD-DNSTYTDCGSETYAYLLLMSWNII 1754

  Fly  1321 CSFLMLNLFVAVIMDNFDYLTRDS---SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNM 1382
            ..::.:|:||::|:.||.|:.|..   |.:....:.:::..|:::|.:.||::..:.:..::.:.
Yeast  1755 SMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSF 1819

  Fly  1383 DPPLGFGNKCPNRLAYKKLIR--MNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMEL 1445
            |.||.| .....||..|.|:.  |.:..||...|:..     ||..|..:......::.|..::.
Yeast  1820 DGPLSF-KIWEGRLTIKSLVENYMEVNPDDPYDVKID-----LIGLNKELNTIDKAKIIQRKLQY 1878

  Fly  1446 RETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQD 1510
            |..:.:|....|                        |.|.:        ||..|     :|::..
Yeast  1879 RRFVQSIHYTNA------------------------YNGCI--------RFSDL-----LLQIPL 1906

  Fly  1511 ASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTV 1575
            .:.:.::|.| |.|. ::|  |.|:.|                      :..:|:.:...|    
Yeast  1907 YTAYSARECL-GIDQ-YVH--HLYILG----------------------KVDKYLENQRNF---- 1941

  Fly  1576 SNVVEMV----------KETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLP 1630
             :|:|||          |.|..|            .|.     .:.|:.|   .|:|.......|
Yeast  1942 -DVLEMVVTRWKFHCRMKRTIEP------------EWD-----VKDPTVS---SHISNINVNLEP 1985

  Fly  1631 YPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGID 1665
            .|     .:.:|....:|          |:.||::
Yeast  1986 AP-----GILEREPIATP----------RMDYGVN 2005

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 78/399 (20%)
Ion_trans 441..677 CDD:334124 45/249 (18%)
Ion_trans 769..1050 CDD:334124 82/314 (26%)
Ion_trans 1094..1345 CDD:334124 71/268 (26%)
GPHH 1346..1416 CDD:339854 16/71 (23%)
Ca_chan_IQ 1418..1492 CDD:337190 9/73 (12%)
CCH1NP_011733.3 Ion_trans <483..722 CDD:395416 50/254 (20%)
Ion_trans 769..1010 CDD:395416 62/358 (17%)
Ion_trans 1210..1480 CDD:395416 76/288 (26%)
Ion_trans 1529..1776 CDD:395416 70/260 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C157344072
Domainoid 1 1.000 91 1.000 Domainoid score I1740
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 311 1.000 Inparanoid score I473
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
87.920

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