Protein Alignment cac and CCH1

DIOPT Version :10

• Sequence 1: NP_001356945.1
• Gene: cac / 32158
• FlyBaseID: FBgn0263111
• Length: 2110
• Species: Drosophila melanogaster
• Sequence 2: NP_011733.3
• Gene: CCH1 / 853131
• SGDID: S000003449
• Length: 2039
• Species: Saccharomyces cerevisiae
• Alignment Length: 1985
• Identity: 402/1985 - (20%)
• Similarity: 726/1985 - (36%)
• Gaps: 638/1985 - (32%)

  Fly    17 SLFILTEDNPIR-KYTRFIIEWP-PFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            ||.:.:..||:| |..||::... ...|..|||..|  ::||:..:.|  ...|...:......|
Yeast   323 SLGVFSPTNPLRIKIARFLLHRRYSLLYNTLLTFYA--ILLAIRTYNP--HNVVFLYRFSNWTDY 383

  Fly    80 FLCIF--CVEAS--LKILALGL----------------------VLHKHSYLRNIWN------IM 112
            |:.|.  |...:  .||:|.|.                      ::..:.|||..:.      |:
Yeast   384 FIFILSACFTGNDIAKIIAFGFWDDSEMFKAYGREYKSILQRSGIMKLYIYLREKYGRKLIDFII 448

  Fly   113 DFFVVVTGFMTQY-----------PQIGPE------------------VDL-------------- 134
            .|.::..|..|:|           |....|                  :||
Yeast   449 PFRIISPGEETKYQRSSLSTSLTKPYGAKENQRPFGTPRAFARSSWNRIDLVSSVSFWLGMFLSI 513

  Fly   135 ---------RTLRAIRVLRPLKLV---SGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIG 187
                     |..:.:.:||.|:||   :|:||   :|:.:...:..|:.:..::::..:.|.|:|
Yeast   514 KSYDTKTGIRIFKPLAILRILRLVNVDTGMPS---ILRGLKYGIPQLVNVSSMLVYFWIFFGILG 575

  Fly   188 LEFYSGALHKTC--YSLEDP-----------------------NKLVKEGESETPCNTDNILEKA 227
            ::.:.|:..:.|  ::.|||                       |.:.::|...:          .
Yeast   576 VQIFQGSFRRQCVWFNPEDPTDTYQYDMQFCGGYLDPVTKRKQNYIYEDGSEGS----------V 630

  Fly   228 TGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIY 292
            :..|:|.. .|.|:.. ..|.:|..|||||..:|..||..::...:|.::|:|.|:...| ..::
Yeast   631 SKGFLCPQ-YSKCVSN-ANPYNGRISFDNIVNSMELVFVIMSANTFTDLMYYTMDSDEMA-ACLF 692

  Fly   293 FVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWI-CKAEE-- 354
            |:..|.:.:.::|||::.||...|....|:.:.::.....|:...:.|.:.||.::. .||.:
Yeast   693 FIVCIFVLTIWLLNLLIAVLVSSFEIANEEYKKKKFIYGSRKTGYVARIVTGYWKYFKLKANQTK 757

  Fly   355 -------------------VILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEA 400
                               |||.           |.:...|.:.|        .|.|.:......
Yeast   758 FPNWSQKGLAIYSHVEFIFVILI-----------ICDIGMRASVK--------VSTSANCNNILL 803

  Fly   401 EEDYGDDGYLKTRSKPQGSCTGFWRAEKRFRFWI----RHTVKTQWFYWFVIVLVFLNTVCVAVE 461
            :.|.|.            |...|..:..|...::    :...|..:.|.|:|.::.|...|:|||
Yeast   804 KTDRGI------------SIVLFIESLARLVLYLPNMWKFLTKPSYVYDFIISIITLVISCLAVE 856

  Fly   462 ----HYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIW 522
                |.              :.:|.:|                   ..:||..|:||.::.:.:|
Yeast   857 GVLGHM--------------YAWLSIF-------------------HISRFYRVIISFNLTKKLW 888

  Fly   523 SEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL---- 583
            .::....           :.|:.::.::                    .|..||..:|.|:
Yeast   889 KQILSNG-----------VMIWNLSSFY--------------------FFFTFLVAIIMAVYFEG 922

  Fly   584 ------LGMQLFGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMI 642
                  :..|.| |.::||        |:|    |::|.|.:.|:|.:::|..............
Yeast   923 VIPPEEMADQPF-GMYSLP--------NSF----LSLFIIGSTENWTDILYALQKHSPNISSTFF 974

  Fly   643 YSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQEL------EKEMEA 701
            .|::||:..|..|..:||:|:|:..:::          |.:.||.:.:|::..      :|..|.
Yeast   975 CSVFFIIWFLLSNSVILNIFIALISESM----------EVKEEEKRPQQIKHYLKFVYPQKIQEY 1029

  Fly   702 LQAD----------GVHVENGD---------------------GAVA------PSKS---KGKKK 726
            ..|.          |.| .|.|                     |.:|      ||::   ||..|
Yeast  1030 THASLVARIRKKFFGGH-RNEDTRDFKQFLMRGTAIMNIAQNMGELADEFKEPPSENLFKKGLSK 1093

  Fly   727 ----------------------------------------EEEKKEEEEVTEGPK-PMLPYSSMF 750
                                                    |..:.|:|::....| |:..||..|
Yeast  1094 LTIGVPSLKRLRMFANNPFYKNSDVVFTETNDINGRTYILELNEYEDEKLDYLKKYPLFNYSYYF 1158

  Fly   751 ILSPTNPIRRGAHWVV----------------------NLPYF-----DFFIMVVISMSSIALAA 788
             .||.:..||....:|                      ...||     |.|:. :.::::|.|..
Yeast  1159 -FSPQHRFRRFCQRLVPPSTGKRTDGSRFFEDSTDLYNKRSYFHHIERDVFVF-IFALATILLIV 1221

  Fly   789 ----EDPVRENSRRNKILNY---FDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVV 846
                ..|:.....:....|:   .|.||.|.|:||.::|.|..|.|..|.:|||..||.:|..|:
Yeast  1222 CSCYVTPLYRMHHKMGTWNWSSALDCAFIGAFSIEFIVKTVADGFIYSPNAYLRNPWNFIDFCVL 1286

  Fly   847 ICAAVSFGFDMSGSSAGQNLSTI-KSLRVLRVLRPLKTIKRVPKLKAVFDCVV-NSLKNVVNILI 909
            |...::....:..:.   |||.| |.|..||.||.| ||...  .:..|:.|: :.|..:....:
Yeast  1287 ISMWINLIAYLKNNG---NLSRIFKGLTALRALRCL-TISNT--ARQTFNLVMFDGLNKIFEAGL 1345

  Fly   910 VYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFK--YEEDELLPKQELRVWKPRAFHY 972
            :.:...|.|:|.|:.:|.|:...|.|.|. ..|:|...|..  ::.|.:.|    ||::....|.
Yeast  1346 ISLSLLFPFTVWGLSIFKGRLGTCNDGSL-GRADCYNEYSNSVFQWDIMSP----RVYQQPYLHL 1405

  Fly   973 DNVAAAMLTLFAVQTGEGWPQVLQHSM-------AATYEDRGPIQNFRIEMSIFYIVYFIVFPFF 1030
            |:.|:|..:|:.:.:.|||..:|::.|       .||.  .|...|     ::|.:::..:...|
Yeast  1406 DSFASAFSSLYQIISLEGWVDLLENMMNSSGIGTPATV--MGSAGN-----ALFLVLFNFLSMVF 1463

  Fly  1031 FVNIFVALII-----------ITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPK----- 1079
            .:|:||:.|:           .|.:|:...|.|                  :.|.:..||
Yeast  1464 ILNLFVSFIVNNQARTTGSAYFTIEEKAWLESQ------------------KLLSQAKPKAIPNL 1510

  Fly  1080 ----NRNTFKYKVWRIVVSTPFEY--FIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMF 1138
                ....|.|::  .|....|.|  |:.:::..:.::|:.:.:|.|::......|. |..|.:|
Yeast  1511 IELSRVRQFFYQL--AVEKKNFYYASFLQVVLYLHIIMLLSRSYNPGNLIGYQGVYF-MFSTSVF 1572

  Fly  1139 SVETVLKIIGFGVKNFFKDPWNIFDL-ITVLGSIVDAL---------WMEFGSNSINV-GFLRLF 1192
            .::..|.:.|.|.:.:|:..||...| |.::..|::|:         |..      |: ||   |
Yeast  1573 LIQEALHMCGEGPRLYFRQKWNSIRLSIIIIAFIMNAVAFHVPASHYWFH------NIKGF---F 1628

  Fly  1193 RAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITR 1257
            .....:.::.|..|:..||.|.:.|...:..:.....:||.:|||...|:||..:||   ::.|.
Yeast  1629 LLVIFLFIIPQNDTLTELLETAMASLPPILSLTYTWGVLFLVYAIALNQIFGLTRLG---SNTTD 1690

  Fly  1258 HNNFQSFIQGVMLLFRCATGEAWPNIML-ACLKGKACDDDAEKAPGEYCGS-TLAYAYFVSFIFF 1320
            :.||::.|:.:::||||:.||.|..||. ..:....|..| :.:....||| |.||...:|:...
Yeast  1691 NINFRTVIKSMIVLFRCSFGEGWNYIMADLTVSEPYCSSD-DNSTYTDCGSETYAYLLLMSWNII 1754

  Fly  1321 CSFLMLNLFVAVIMDNFDYLTRDS---SILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNM 1382
            ..::.:|:||::|:.||.|:.|..   |.:....:.:::..|:::|.:.||::..:.:..::.:.
Yeast  1755 SMYIFVNMFVSLIIGNFSYVYRSGGSRSGINRSEIKKYIEAWSKFDTDGTGELELSYLPRIMHSF 1819

  Fly  1383 DPPLGFGNKCPNRLAYKKLIR--MNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMEL 1445
            |.||.| .....||..|.|:.  |.:..||...|:..     ||..|..:......::.|..::.
Yeast  1820 DGPLSF-KIWEGRLTIKSLVENYMEVNPDDPYDVKID-----LIGLNKELNTIDKAKIIQRKLQY 1878

  Fly  1446 RETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQD 1510
            |..:.:|....|                        |.|.:        ||..|     :|::..
Yeast  1879 RRFVQSIHYTNA------------------------YNGCI--------RFSDL-----LLQIPL 1906

  Fly  1511 ASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTV 1575
            .:.:.::|.| |.|. ::|  |.|:.|                      :..:|:.:...|
Yeast  1907 YTAYSARECL-GIDQ-YVH--HLYILG----------------------KVDKYLENQRNF---- 1941

  Fly  1576 SNVVEMV----------KETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLP 1630
             :|:|||          |.|..|            .|.     .:.|:.|   .|:|.......|
Yeast  1942 -DVLEMVVTRWKFHCRMKRTIEP------------EWD-----VKDPTVS---SHISNINVNLEP 1985

  Fly  1631 YPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGID 1665
            .|     .:.:|....:|          |:.||::
Yeast  1986 AP-----GILEREPIATP----------RMDYGVN 2005

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:459842	78/399 (20%)
		Ion_trans	441..677	CDD:459842	45/249 (18%)
		Ion_trans	769..1050	CDD:459842	82/314 (26%)
		Ion_trans	1094..1345	CDD:459842	71/268 (26%)
		GPHH	1354..1407	CDD:465306	13/54 (24%)
		Ca_chan_IQ	1417..1496	CDD:462591	9/78 (12%)
		AF-4	<1512..>1704	CDD:461550	29/164 (18%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:459842	50/254 (20%)
		Ion_trans	769..1010	CDD:459842	62/358 (17%)
		Ion_trans	1210..1480	CDD:459842	76/288 (26%)
		Ion_trans	1529..1776	CDD:459842	70/260 (27%)