DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and TPC1

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_567258.1	Gene:	TPC1 / 825655	AraportID:	AT4G03560	Length:	733	Species:	Arabidopsis thaliana

Alignment Length:	740	Identity:	154/740 - (20%)
Similarity:	263/740 - (35%)	Gaps:	237/740 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   755 TNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAE----DPVRENSRRNKI---------LNYF- 805
            |:.:||........|:.....:|.::...|.|..|    ....|::|...|         ||||
plant    16 TDRVRRSEAITHGTPFQKAAALVDLAEDGIGLPVEILDQSSFGESARYYFIFTRLDLIWSLNYFA 80

  Fly   806 ------------------------DYAFTGVFTI-----EMLLKIVDLGVIL----HPGSY--LR 835
                                    ||.:.|....     .::.:::.|.::|    .|.||  .|
plant    81 LLFLNFFEQPLWCEKNPKPSCKDRDYYYLGELPYLTNAESIIYEVITLAILLVHTFFPISYEGSR 145

  Fly   836 EFW-NIMDAVVVICAAVSF-------------GFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKR 886
            .|| :.::.|.|.|..:.|             .||            ....|:...:|.:..|..
plant   146 IFWTSRLNLVKVACVVILFVDVLVDFLYLSPLAFD------------FLPFRIAPYVRVIIFILS 198

  Fly   887 VPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKY 951
            :.:|:.....:...|...:|||.:::||....|.|...:|
plant   199 IRELRDTLVLLSGMLGTYLNILALWMLFLLFASWIAFVMF------------------------- 238

  Fly   952 EEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEM 1016
             ||   .:|.|.|       :.:..|.:..:|.:.|....|.|.   :.|....|.        .
plant   239 -ED---TQQGLTV-------FTSYGATLYQMFILFTTSNNPDVW---IPAYKSSRW--------S 281

  Fly  1017 SIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAEL---------------------QDGEIDKNQ 1060
            |:|:::|.::..:|..|:.:|::..:|:||...::                     ::|||||||
plant   282 SVFFVLYVLIGVYFVTNLILAVVYDSFKEQLAKQVSGMDQMKRRMLEKAFGLIDSDKNGEIDKNQ 346

  Fly  1061 KSCI-------------------------------DFTIG-------------------ARPLER 1075
              ||                               ||.|.                   ...|..
plant   347 --CIKLFEQLTNYRTLPKISKEEFGLIFDELDDTRDFKINKDEFADLCQAIALRFQKEEVPSLFE 409

  Fly  1076 YMPKNRNTFKYKVWRIVVSTP-FEYFIMMLIVFNTLLLMMKYHNQGDMYEKSL----KYINMGFT 1135
            :.|:..::...:..|..|.:| |.|.|..:::.|.:.::::  ...|:.|.|.    :.....|.
plant   410 HFPQIYHSALSQQLRAFVRSPNFGYAISFILIINFIAVVVE--TTLDIEESSAQKPWQVAEFVFG 472

  Fly  1136 GMFSVETVLKIIGFGVKNFFKDPWNIFD-LIT---VLGSIVDALWME---FGSNSINVGFLRLFR 1193
            .::.:|..|||..:|.:|::::..|.|| |:|   |:|.....:..:   |.||...:.:|.|.|
plant   473 WIYVLEMALKIYTYGFENYWREGANRFDFLVTWVIVIGETATFITPDENTFFSNGEWIRYLLLAR 537

  Fly  1194 AARLIKLLRQGYTIRILLWTFVQSFKAL-PYVCLLIAMLFFIYAIIGMQVF------GNIKLGTV 1251
            ..|||:||......|..:.||:....:| ||:..:..:| .||..||:|||      ||.||  .
plant   538 MLRLIRLLMNVQRYRAFIATFITLIPSLMPYLGTIFCVL-CIYCSIGVQVFGGLVNAGNKKL--F 599

  Fly  1252 ENSITRHN----NFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYA 1312
            |..:...:    ||..:..|::.||.......| .:.:...|             :..|:..:..
plant   600 ETELAEDDYLLFNFNDYPNGMVTLFNLLVMGNW-QVWMESYK-------------DLTGTWWSIT 650

  Fly  1313 YFVSFIFFCSFLMLNLFVAVIMDNF 1337
            |||||......|:|||.||.:::.|
plant   651 YFVSFYVITILLLLNLVVAFVLEAF 675

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124
		Ion_trans	769..1050	CDD:334124	63/343 (18%)
		Ion_trans	1094..1345	CDD:334124	72/267 (27%)
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
TPC1	NP_567258.1	Ion_trans	124..311	CDD:278921	46/245 (19%)
		EFh	326..391	CDD:238008	12/66 (18%)
		EF-hand_7	327..392	CDD:290234	12/66 (18%)
		Ion_trans	456..675	CDD:278921	65/235 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	73	1.000	Domainoid score	I3264
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810