DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Scn9a

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_579823.1 Gene:Scn9a / 78956 RGDID:69368 Length:1984 Species:Rattus norvegicus


Alignment Length:1902 Identity:471/1902 - (24%)
Similarity:821/1902 - (43%) Gaps:478/1902 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:|:|:.:..|:....|...::.||:.||:.:.| .:.|...|.|        |..|.
  Rat   105 ALYMLSPFSPLRRISIKILVHSLFSMLIMCTILTNCIFMTL-SNPPEWTKNV--------EYTFT 160

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..:.:.::||:.||.:||.|:|..::|::..:|   ::..||..||||.|
  Rat   161 GIYTFESLIKILARGFCVGEFTFLRDPWNWLDFVVIVFAYLTEFVNLG---NVSALRTFRVLRAL 222

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|:     .|.::|
  Rat   223 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLKHKCF-----RKELEE 282

  Fly   212 GES-ETPCNTDN----------ILEKATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNI 257
            .|: |:..||..          .||.:..:.:|..:|.        :|::....|:.|.||||..
  Rat   283 NETLESIMNTAESEEELKKYFYYLEGSKDALLCGFSTDSGQCPEGYICVKAGRNPDYGYTSFDTF 347

  Fly   258 GFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG-------- 314
            .:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.|::.        
  Rat   348 SWAFLALFRLMTQDYWENLYQQTLRAAGKTY-MIFFVVVIFLGSFYLINLILAVVAMAYEEQNQA 411

  Fly   315 --EFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA---------------EERT 362
              |.||::| :|.:|...:|:::|:             :||.:..|               .|.:
  Rat   412 NIEEAKQKE-LEFQQMLDRLKKEQE-------------EAEAIAAAAAEFTSIGRSRIMGLSESS 462

  Fly   363 TEEEKMHIMEAR-RRNAAKRKKLK-SLGKSKSTD-------TEEEEAEEDY--GDDGYLKTRSK- 415
            :|..::....|: |||..|:||.| |.|:.|..|       :||...::.:  |.:|:.:||.| 
  Rat   463 SETSRLSSKSAKERRNRRKKKKQKMSSGEEKGDDEKLSKSGSEESIRKKSFHLGVEGHHRTREKR 527

  Fly   416 ----------------------------------------------------------------- 415
                                                                             
  Rat   528 LSTPNQSPLSIRGSLFSARRSSRTSLFSFKGRGRDLGSETEFADDEHSIFGDNESRRGSLFVPHR 592

  Fly   416 ----------------------------------------------PQG---------------- 418
                                                          |.|                
  Rat   593 PRERRSSNISQASRSPPVLPVNGKMHSAVDCNGVVSLVDGPSALMLPNGQLLPEVIIDKATSDDS 657

  Fly   419 --------------------------------------------------SCTGFW-RAEKRFRF 432
                                                              .|..:| |....|..
  Rat   658 GTTNQMRKKRLSSSYFLSEDMLNDPHLRQRAMSRASILTNTVEELEESRQKCPPWWYRFAHTFLI 722

  Fly   433 W--IRHTVKTQWFYWFVI----------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFM 485
            |  ..:.:|.:...:|::          :.:.|||:.:|:||:.........|.....||.|:|.
  Rat   723 WNCSPYWIKFKKLIYFIVMDPFVDLAITICIVLNTLFMAMEHHPMTEEFKNVLAVGNLIFTGIFA 787

  Fly   486 SEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYW 550
            :||.:|:.|:.|..||:..:|.||.::::.|:.|:..::|:    ||||||:.||||:||:.|.|
  Rat   788 AEMVLKLIAMDPYEYFQVGWNIFDSLIVTLSLIELFLADVE----GLSVLRSFRLLRVFKLAKSW 848

  Fly   551 SSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFP 608
            .:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:       |:....|..:.|.|.
  Rat   849 PTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINVDCKLPRWHMNDFF 913

  Fly   609 IALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAV-----D 668
            .:.|.||::|.|| |.|.|:..:...|   :.|...:|.:|:|: ||..:||:|||:.:     |
  Rat   914 HSFLIVFRVLCGE-WIETMWDCMEVAG---QTMCLIVYMMVMVI-GNLVVLNLFLALLLSSFSSD 973

  Fly   669 NLANAQELTAAEEEQV----------------------------------------EEDKE---- 689
            ||...:|.|.|...|:                                        ...||    
  Rat   974 NLTAIEEDTDANNLQIAVARIKRGINYVKQTLREFILKSFSKKPKGSKDTKRTADPNNKKENYIS 1038

  Fly   690 -KQLQELEKEMEAL-QADGVHVENGDGA--------------------------VAPSK------ 720
             :.|.|:.|:...| :.|.:   :|.|:                          :||.:      
  Rat  1039 NRTLAEMSKDHNFLKEKDRI---SGYGSSLDKSFMDENDYQSFIHNPSLTVTVPIAPGESDLEIM 1100

  Fly   721 -------------SKGKKKE---------------EEKKEEEEV---------TEGPKPMLPYSS 748
                         ||.|:..               ||:.|.|.|         |:|.....|...
  Rat  1101 NTEELSSDSDSDYSKEKRNRSSSSECSTVDNPLPGEEEAEAEPVNADEPEACFTDGCVRRFPCCQ 1165

  Fly   749 MFILSPTN----PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFDYA 808
            :.:.|...    .||:..:.:|...:|:.||:::|.:||.|||.||...|..:..| ||.|.|..
  Rat  1166 VNVDSGKGKVWWTIRKTCYRIVEHSWFESFIVLMILLSSGALAFEDIYIEKKKTIKIILEYADKI 1230

  Fly   809 FTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLR 873
            ||.:|.:|||||.|..|.    .:|....|..:|.::|..:.|:...:..|.|   :|..|||||
  Rat  1231 FTYIFILEMLLKWVAYGY----KTYFTNAWCWLDFLIVDVSLVTLVANTLGYS---DLGPIKSLR 1288

  Fly   874 VLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---TD 935
            .||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.|||:.|   ||
  Rat  1289 TLRALRPLRALSRFEGMRVVVNALIGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYECVNTTD 1353

  Fly   936 ESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMA 1000
            .|:..:::...   :.|...|:.......||....::|||....|:|..|.|.:||..::..::.
  Rat  1354 GSRFPTSQVAN---RSECFALMNVSGNVRWKNLKVNFDNVGLGYLSLLQVATFKGWMDIMYAAVD 1415

  Fly  1001 ATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKSC 1063
            :...:..|...:.:.|.|:::::.|...||.:|:|:.:||..|.:| :.:|  ||..:.:.||..
  Rat  1416 SVNVNEQPKYEYSLYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQ-KKKLGGQDIFMTEEQKKY 1479

  Fly  1064 IDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKS 1126
            .:.  .:|::..::.:|:..|.|:..::.:|.:..|:..||:||..|.:.:|::...|.:..:..
  Rat  1480 YNAMKKLGSKKPQKPIPRPGNKFQGCIFDLVTNQAFDITIMVLICLNMVTMMVEKEGQTEYMDYV 1544

  Fly  1127 LKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWME-----FGSNSINV 1186
            |.:|||.|..:|:.|.|||:|... ..:|...|||||.:.|:.|||.....|     |.|.:: .
  Rat  1545 LHWINMVFIILFTGECVLKLISLR-HYYFTVGWNIFDFVVVILSIVGMFLAEMIEKYFVSPTL-F 1607

  Fly  1187 GFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV 1251
            ..:||.|..|:::|::....||.||:..:.|..||..:.||:.::.|||||.||..|..:|   .
  Rat  1608 RVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAIFGMSNFAYVK---K 1669

  Fly  1252 ENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TLA 1310
            |..|....||::|...::.||:..|...|..::...|.....|.|.:|. ||..    ||: ::.
  Rat  1670 EAGINDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPKKVHPGSSVEGDCGNPSVG 1734

  Fly  1311 YAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTE 1374
            ..||||:|.....:::|:::|||::||...|.:|: .|.....:.|..:|.::||:||..|.:.:
  Rat  1735 IFYFVSYIIISFLVVVNMYIAVILENFSVATEESTEPLSEDDFEMFYEVWEKFDPDATQFIEFCK 1799

  Fly  1375 MYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMD 1439
            :.|....:||||....  ||::   :||.|::|:....|:.....|||..:..|.    ...|||
  Rat  1800 LSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTKRVLG----EGGEMD 1855

  Fly  1440 QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMP 1504
            ....::.|...:..|.:..     ..|.:..|.:.:..|    :..:|..::|..|..|....:.
  Rat  1856 SLRSQMEERFMSANPSKVS-----YEPITTTLKRKQEEV----SATIIQRAYRRYRLRQHVKNIS 1911

  Fly  1505 MLELQDASRH---PSQE 1518
            .:.::|..|.   |::|
  Rat  1912 SIYIKDGDRDDDLPNKE 1928

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 92/315 (29%)
Ion_trans 441..677 CDD:334124 83/257 (32%)
Ion_trans 769..1050 CDD:334124 91/284 (32%)
Ion_trans 1094..1345 CDD:334124 84/261 (32%)
GPHH 1346..1416 CDD:339854 20/69 (29%)
Ca_chan_IQ 1418..1492 CDD:337190 13/73 (18%)
Scn9aNP_579823.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..55
I. /evidence=ECO:0000305 112..410 91/315 (29%)
Ion_trans 147..410 CDD:278921 82/279 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..542 20/80 (25%)
Na_trans_cytopl 487..606 CDD:288761 11/118 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 576..609 0/32 (0%)
II. /evidence=ECO:0000305 725..988 86/271 (32%)
Ion_trans 760..955 CDD:278921 68/203 (33%)
Na_trans_assoc 981..1185 CDD:284034 28/206 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1015..1040 2/24 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1145 7/41 (17%)
III. /evidence=ECO:0000305 1178..1486 99/318 (31%)
Ion_trans 1224..1464 CDD:278921 77/250 (31%)
Na_channel_gate 1456..1508 CDD:240441 11/52 (21%)
IV. /evidence=ECO:0000305 1495..1793 95/302 (31%)
Ion_trans 1530..1768 CDD:278921 78/242 (32%)
GPHH 1780..1835 CDD:293510 19/59 (32%)
IQ 1886..1908 CDD:197470 5/25 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1984 4/13 (31%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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