DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and CACNA1S

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_000060.2 Gene:CACNA1S / 779 HGNCID:1397 Length:1873 Species:Homo sapiens


Alignment Length:1852 Identity:793/1852 - (42%)
Similarity:1073/1852 - (57%) Gaps:242/1852 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            |.:||.||.:||:||....|:||.|||..:||||.||||.||:...:|..|...|...|||.|.:
Human    28 PRALFCLTLENPLRKACISIVEWKPFETIILLTIFANCVALAVYLPMPEDDNNSLNLGLEKLEYF 92

  Fly    80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMT----QYPQI----------GP 130
            ||.:|.:||::||:|.|.:.|:.:|||:.||::||.:|..|..|    |...|          |.
Human    93 FLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFTIVFLGVFTVILEQVNVIQSHTAPMSSKGA 157

  Fly   131 EVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
            .:|::.|||.||||||:||||:|||||||.||.|||.||..|.|||||.::|:||||||.:.|.:
Human   158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKM 222

  Fly   196 HKTCYSLEDPNKLVKEGESETPCNTDNILEKATGS-FVCNNTTSMCLEKWEGPNSGITSFDNIGF 259
            |||||.:........|.|..:||       ..||| ..|....|.|...|.|||.|||.|||.||
Human   223 HKTCYFIGTDIVATVENEEPSPC-------ARTGSGRRCTINGSECRGGWPGPNHGITHFDNFGF 280

  Fly   260 AMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVE 324
            :||||:|||||||||.:|||.|||:|:.:.|||||.||::||||:||||||||||||.|||||.:
Human   281 SMLTVYQCITMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAK 345

  Fly   325 NRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGK 389
            :|..|.|||.:|||:.:|.||:.||             |:.|.|.:.:.|.            ||
Human   346 SRGTFQKLREKQQLDEDLRGYMSWI-------------TQGEVMDVEDFRE------------GK 385

  Fly   390 SKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKR-FRFWIRHTVKTQWFYWFVIVLVFL 453
             .|.|....:.|..|...|..|..     .....||...| ||:.....||::.|||.||::|.|
Human   386 -LSLDEGGSDTESLYEIAGLNKII-----QFIRHWRQWNRIFRWKCHDIVKSKVFYWLVILIVAL 444

  Fly   454 NTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF 518
            ||:.:|.||:.||.:||.....|..:.|.||.:||.:|||.||.|.||.|.||||||.|:...|.
Human   445 NTLSIASEHHNQPLWLTRLQDIANRVLLSLFTTEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGIL 509

  Fly   519 EVIWSEVKGGS---FGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILI 580
            |::.  |:.|:   .|:||||.:|||||||:||||:||.|||.|||||:|||.|||.||||||:|
Human   510 EILL--VESGAMTPLGISVLRCIRLLRIFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFIVI 572

  Fly   581 FALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG-AQKGMIY 643
            |||||||||||:::... ....:||:.||.||::|||:||||||..:||.||::.|| :..||:.
Human   573 FALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWTSMMYNGIMAYGGPSYPGMLV 637

  Fly   644 SIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQL-----QELEKEMEALQ 703
            .||||:|.:.|||.||||||||||||||.|:.||:|::.:.||.|.:::     .:.|:|...:.
Human   638 CIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEEKKRRKMSKGLPDKSEEEKSTMA 702

  Fly   704 ADGVHVENGDGAVAPSKSKGKKKE-----------------EEKKEEEEVTEGPKPM-------- 743
            ........|:|....:|.|..:.|                 :::::|.|:...|:|.        
Human   703 KKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPLSPRPRPLAELQLK 767

  Fly   744 -----LP-YSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKIL 802
                 :| .||.||.||||.||...|.:||..:|..||::.|.:||.|||||||:|.:|.||:||
Human   768 EKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQIL 832

  Fly   803 NYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLS 867
            .:||..||.|||:|::||:...|..||.||:.|.::|::|.:||..:.:|.|.:.|.      :|
Human   833 KHFDIGFTSVFTVEIVLKMTTYGAFLHKGSFCRNYFNMLDLLVVAVSLISMGLESSA------IS 891

  Fly   868 TIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFY 932
            .:|.||||||||||:.|.|...||.|..|:..::..:.||::|..|.||:|:.||||||.||||.
Human   892 VVKILRVLRVLRPLRAINRAKGLKHVVQCMFVAISTIGNIVLVTTLLQFMFACIGVQLFKGKFFR 956

  Fly   933 CTDESKHTSAECQGSYFKYEEDELLPKQ-EL--RVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQV 994
            |||.||.|..||:|.|:.|::.:  |.| ||  |.|....||:|||.:||::||.|.|.|||||:
Human   957 CTDLSKMTEEECRGYYYVYKDGD--PMQIELRHREWVHSDFHFDNVLSAMMSLFTVSTFEGWPQL 1019

  Fly   995 LQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKN 1059
            |..::.:..||.|||.|.|:||:||:|:|.|:..||.:||||..:|:|||||||.|.::.|:|||
Human  1020 LYKAIDSNAEDVGPIYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELDKN 1084

  Fly  1060 QKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYE 1124
            |:.|:.:.:.||||..|:||  |.::|:||.||.|:.|||.:..||:.||:.|.|:::||.:...
Human  1085 QRQCVQYALKARPLRCYIPK--NPYQYQVWYIVTSSYFEYLMFALIMLNTICLGMQHYNQSEQMN 1147

  Fly  1125 KSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG--------- 1180
            .....:|:.||.:|::|.:||::.|..:.:|.||||:||.:.|:|||:|.:..|..         
Human  1148 HISDILNVAFTIIFTLEMILKLMAFKARGYFGDPWNVFDFLIVIGSIIDVILSEIDTFLASSGGL 1212

  Fly  1181 --------------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1231
                          |..|:..|.||||..||||||.:...:|.|||||::||:|||||.|||.||
Human  1213 YCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIVML 1277

  Fly  1232 FFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACD 1294
            |||||:||||:||.|.|  ||   .|.|:||||:|.|.|:|||||||||||..|:|||..||.||
Human  1278 FFIYAVIGMQMFGKIALVDGT---QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKLCD 1339

  Fly  1295 DDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVR 1357
            .:::.||||  .||:..||.||:||...|:||::|||||||||||||||||.||||.||||||..
Human  1340 PESDYAPGEEYTCGTNFAYYYFISFYMLCAFLVINLFVAVIMDNFDYLTRDWSILGPHHLDEFKA 1404

  Fly  1358 IWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFA 1422
            |||||||.|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..||||
Human  1405 IWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATLFA 1469

  Fly  1423 LIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLI 1487
            |:|..|.||...  ..:||:.|||..|..||...:.|:|:.::||   :...:::|||.||.|||
Human  1470 LVRTALKIKTEG--NFEQANEELRAIIKKIWKRTSMKLLDQVIPP---IGDDEVTVGKFYATFLI 1529

  Fly  1488 LESWR------STRFG--------QLDSGMPMLELQDASR--------HPSQESL---------- 1520
            .|.:|      ...:|        |:.:|:..:|.:.|..        ..::|.|          
Human  1530 QEHFRKFMKRQEEYYGYRPKKDIVQIQAGLRTIEEEAAPEICRTVSGDLAAEEELERAMVEAAME 1594

  Fly  1521 ------TGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVV 1579
                  ||...|.:   .:::......|.:..|..||.                  |::     :
Human  1595 EGIFRRTGGLFGQV---DNFLERTNSLPPVMANQRPLQ------------------FAE-----I 1633

  Fly  1580 EMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYG------GHLSRSKRTQLPYPTYGTTS 1638
            || :|...|......|:.||.:..|..:...:.:...||      .|:..|...:..:|....|.
Human  1634 EM-EEMESPVFLEDFPQDPRTNPLARANTNNANANVAYGNSNHSNSHVFSSVHYEREFPEETETP 1697

  Fly  1639 LCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKP 1703
            ..:......|.|:        ||          .||.|.:...:..:.:|..|....|      |
Human  1698 ATRGRALGQPCRV--------LG----------PHSKPCVEMLKGLLTQRAMPRGQAP------P 1738

  Fly  1704 TNINFPKLNAS-PTHTHHSTPHSVH-SLPHHR 1733
            .....|::.:| |.....|||.|:| ..||.|
Human  1739 APCQCPRVESSMPEDRKSSTPGSLHEETPHSR 1770

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 161/301 (53%)
Ion_trans 441..677 CDD:334124 138/240 (58%)
Ion_trans 769..1050 CDD:334124 139/283 (49%)
Ion_trans 1094..1345 CDD:334124 139/277 (50%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
CACNA1SNP_000060.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 160/305 (52%)
Ion_trans 68..345 CDD:278921 149/283 (53%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 2/2 (100%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 9/29 (31%)
II. /evidence=ECO:0000305 418..664 139/247 (56%)
Ion_trans 449..672 CDD:278921 130/224 (58%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 2/2 (100%)
Rib_recp_KP_reg 671..>777 CDD:282899 17/105 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 675..717 7/41 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..757 2/25 (8%)
Interaction with STAC, STAC2 and STAC3 (via SH3 domains). /evidence=ECO:0000269|PubMed:29078335 747..760 4/12 (33%)
III. /evidence=ECO:0000305 786..1068 138/289 (48%)
Ion_trans 816..1075 CDD:278921 132/266 (50%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 48/88 (55%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 1/2 (50%)
IV. /evidence=ECO:0000305 1105..1384 137/281 (49%)
Ion_trans 1135..1392 CDD:278921 131/259 (51%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 43/65 (66%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 27/41 (66%)
GPHH 1400..1463 CDD:293510 32/62 (52%)
Ca_chan_IQ 1465..1536 CDD:285917 31/75 (41%)
Interaction with calmodulin. /evidence=ECO:0000269|PubMed:19473981 1522..1542 8/19 (42%)
CAC1F_C <1692..1833 CDD:293490 23/103 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1731..1780 14/46 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.750

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