DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and CACNA1F

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_005174.2	Gene:	CACNA1F / 778	HGNCID:	1393	Length:	1977	Species:	Homo sapiens

Alignment Length:	1939	Identity:	832/1939 - (42%)
Similarity:	1111/1939 - (57%)	Gaps:	288/1939 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            |.:||.||..||:|:....|:||.||:..:||||.||||.|.:....|..|.......||:.|..
Human    69 PRALFCLTLANPLRRSCISIVEWKPFDILILLTIFANCVALGVYIPFPEDDSNTANHNLEQVEYV 133

  Fly    80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGP-------------- 130
            ||.||.||..|||:|.|||||..:|:||.||::||.:||.|..:...:.||
Human   134 FLVIFTVETVLKIVAYGLVLHPSAYIRNGWNLLDFIIVVVGLFSVLLEQGPGRPGDAPHTGGKPG 198

  Fly   131 EVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
            ..|::.|||.||||||:||||:|||.:||.||:||:.|||.|.|||||.|:|:||||||.:.|.:
Human   199 GFDVKALRAFRVLRPLRLVSGVPSLHIVLNSIMKALVPLLHIALLVLFVIIIYAIIGLELFLGRM 263

  Fly   196 HKTCYSL-------EDPNKLVKEGESETPCNTDNILEKATGS-FVCNNTTSMCLEKWEGPNSGIT 252
            |||||.|       |||          :||       .::|| ..|....:.|..:|.|||.|||
Human   264 HKTCYFLGSDMEAEEDP----------SPC-------ASSGSGRACTLNQTECRGRWPGPNGGIT 311

  Fly   253 SFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA 317
            :|||..|||||||||:||||||.:|||..||:|....|:|||.|::.||||:||||||||||||:
Human   312 NFDNFFFAMLTVFQCVTMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVLGVLSGEFS 376

  Fly   318 KEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEV------------ILAEE-RTTEEEKMH 369
            |||||.:.|.:|.|.|.:||:|.:|.||::||.:|||:            .:||| |.....::.
Human   377 KEREKAKARGDFQKQREKQQMEEDLRGYLDWITQAEELDMEDPSADDNLGSMAEEGRAGHRPQLA 441

  Fly   370 IMEARRR--------------NAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYL---------- 410
            .:..|||              :.:....|.:......|:|:.:|.||    :|.|
Human   442 ELTNRRRGRLRWFSHSTRSTHSTSSHASLPASDTGSMTETQGDEDEE----EGALASCTRCLNKI 502

  Fly   411 -KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLY 474
             |||     .|....||.:..|...|..||:...||.|::||||||:.:|.||:|||.:||:...
Human   503 MKTR-----VCRRLRRANRVLRARCRRAVKSNACYWAVLLLVFLNTLTIASEHHGQPVWLTQIQE 562

  Fly   475 YAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS---FGLSVLR 536
            ||..:.|.||..||.:|:|.|||..|..|.||||||.|:.|.|.|....||  |:   .|:||||
Human   563 YANKVLLCLFTVEMLLKLYGLGPSAYVSSFFNRFDCFVVCGGILETTLVEV--GAMQPLGISVLR 625

  Fly   537 ALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTP 600
            .:|||||||||::|:||.|||.||||||:||.|||.||||||:||:|||||||||:||. ...|.
Human   626 CVRLLRIFKVTRHWASLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDQTHTK 690

  Fly   601 ETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGA-QKGMIYSIYFIVLVLFGNYTLLNVFLA 664
            .:.|:|||.|||||||||||||||.|||.||::.||. ..||:..||||:|.:.|||.|||||||
Human   691 RSTFDTFPQALLTVFQILTGEDWNVVMYDGIMAYGGPFFPGMLVCIYFIILFICGNYILLNVFLA 755

  Fly   665 IAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKG-----K 724
            |||||||:....| |:::..|:..||   :|.:|.|.| ..||..|..:||    :.:|     :
Human   756 IAVDNLASGDAGT-AKDKGGEKSNEK---DLPQENEGL-VPGVEKEEEEGA----RREGADMEEE 811

  Fly   725 KKEEEKKEEEEVTEG-----------PK----PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFF 774
            ::|||::||||..||           ||    |:...|:.|.||.|||:|:|.|.:::...|...
Human   812 EEEEEEEEEEEEEEGAGGVELLQEVVPKEKVVPIPEGSAFFCLSQTNPLRKGCHTLIHHHVFTNL 876

  Fly   775 IMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWN 839
            |:|.|.:||::||||||:|.:|.||.||.|||||||.:||:|:|||:...|..||.||:.|.::|
Human   877 ILVFIILSSVSLAAEDPIRAHSFRNHILGYFDYAFTSIFTVEILLKMTVFGAFLHRGSFCRSWFN 941

  Fly   840 IMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNV 904
            ::|.:||..:.:|||...|.      :|.:|.||||||||||:.|.|...||.|..||..:::.:
Human   942 MLDLLVVSVSLISFGIHSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTI 1000

  Fly   905 VNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEE-DELLPKQELRVWKPR 968
            .||:||..|.||:|:.||||||.|||:.||||:|||..||:||:..|.: |...|....|:|...
Human  1001 GNIMIVTTLLQFMFACIGVQLFKGKFYTCTDEAKHTPQECKGSFLVYPDGDVSRPLVRERLWVNS 1065

  Fly   969 AFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVN 1033
            .|::|||.:||:.||.|.|.||||.:|..::.|..||.|||.|:|:|:|:|:|||.|:..||.:|
Human  1066 DFNFDNVLSAMMALFTVSTFEGWPALLYKAIDAYAEDHGPIYNYRVEISVFFIVYIIIIAFFMMN 1130

  Fly  1034 IFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFE 1098
            |||..:||||:.|||.|.|:.|:||||:.|:::.:.|:||.||:|||.:  :|:||..|.|..||
Human  1131 IFVGFVIITFRAQGEQEYQNCELDKNQRQCVEYALKAQPLRRYIPKNPH--QYRVWATVNSAAFE 1193

  Fly  1099 YFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFD 1163
            |.:.:||:.||:.|.|:::.|...:..::..:||.|||:|::|.|||||.|..|::|.|.||.||
Human  1194 YLMFLLILLNTVALAMQHYEQTAPFNYAMDILNMVFTGLFTIEMVLKIIAFKPKHYFTDAWNTFD 1258

  Fly  1164 LITVLGSIVDALWMEFG-----------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1217
            .:.|:|||||....|..           |:.|::.|.||||..||:|||.:|..||.|||||::|
Human  1259 ALIVVGSIVDIAVTEVNNGGHLGESSEDSSRISITFFRLFRVMRLVKLLSKGEGIRTLLWTFIKS 1323

  Fly  1218 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAW 1280
            |:|||||.|||||:|||||:||||:||.:.|  ||   .|.|:||||:|.|.|:|||||||||||
Human  1324 FQALPYVALLIAMIFFIYAVIGMQMFGKVALQDGT---QINRNNNFQTFPQAVLLLFRCATGEAW 1385

  Fly  1281 PNIMLACLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD 1343
            ..||||.|.|..||.:::..|||  .|||..|.|||:||...|:||::|||||||||||||||||
Human  1386 QEIMLASLPGNRCDPESDFGPGEEFTCGSNFAIAYFISFFMLCAFLIINLFVAVIMDNFDYLTRD 1450

  Fly  1344 SSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPL 1408
            .||||.||||||.|||:||||.|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||
Human  1451 WSILGPHHLDEFKRIWSEYDPGAKGRIKHLDVVALLRRIQPPLGFGKLCPHRVACKRLVAMNMPL 1515

  Fly  1409 DDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNK 1473
            :.:..|.|..|||||:|.:|.||...  .::||:.|||..|..||....:|:|:.::||.|:
Human  1516 NSDGTVTFNATLFALVRTSLKIKTEG--NLEQANQELRIVIKKIWKRMKQKLLDEVIPPPDE--- 1575

  Fly  1474 GKLSVGKIYAGFLILESWRSTR----------------FGQLDSGMPML-----ELQDA------ 1511
            .:::|||.||.|||.:.:|..|                ...|.:|:..|     |::.|
Human  1576 EEVTVGKFYATFLIQDYFRKFRRRKEKGLLGNDAAPSTSSALQAGLRSLQDLGPEMRQALTCDTE 1640

  Fly  1512 -SRHPSQESLTGADAGHLHPGHSYM----NGHRRS-------------------PSLRHNGSPLA 1552
             .....||.:...|...|....:.|    :..|.|                   ||....|:|.:
Human  1641 EEEEEGQEGVEEEDEKDLETNKATMVSQPSARRGSGISVSLPVGDRLPDSLSFGPSDDDRGTPTS 1705

  Fly  1553 RSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRG----------------- 1600
            ..||..:.|..  .|..|....:..:         |..|||.|:..:|
Human  1706 SQPSVPQAGSN--THRRGSGALIFTI---------PEEGNSQPKGTKGQNKQDEDEEVPDRLSYL 1759

  Fly  1601 SWSASTSPARSPSP----SRY-GGHLSRSKRTQLPYPTYGTTSL----------CQ--------- 1641
            ...|.|.|.....|    .|| .|||...:|...|.|.....|.          |:
Human  1760 DEQAGTPPCSVLLPPHRAQRYMDGHLVPRRRLLPPTPAGRKPSFTIQCLQRQGSCEDLPIPGTYH 1824

  Fly  1642 RSRSPSPARLQ----EMRERDRLGYG----IDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPST 1698
            |.|:..|.|.|    ...:|.||.|.    ::.|           |:....:||...|..:.
Human  1825 RGRNSGPNRAQGSWATPPQRGRLLYAPLLLVEEG-----------AAGEGYLGRSSGPLRTF--- 1875

  Fly  1699 LQLKPTNINFPKLNASPTHTHHSTPHS-VHSLPHHRDL---LRDPRDMYYSSRE 1748
                 |.::.|..::.|:|....:..| |.::.....|   .||||.:..:.:|
Human  1876 -----TCLHVPGTHSDPSHGKRGSADSLVEAVLISEGLGLFARDPRFVALAKQE 1924

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	157/308 (51%)
		Ion_trans	441..677	CDD:334124	145/240 (60%)
		Ion_trans	769..1050	CDD:334124	140/281 (50%)
		Ion_trans	1094..1345	CDD:334124	144/265 (54%)
		GPHH	1346..1416	CDD:339854	38/69 (55%)
		Ca_chan_IQ	1418..1492	CDD:337190	30/73 (41%)
CACNA1F	NP_005174.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..60
		I	79..375		155/312 (50%)
		Ion_trans	109..383	CDD:278921	146/290 (50%)
		Binding to the beta subunit. /evidence=ECO:0000250	395..412		8/16 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	418..441		4/22 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..488		4/32 (13%)
		II	515..761		146/247 (59%)
		Ion_trans	546..763	CDD:278921	135/218 (62%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	767..830		24/71 (34%)
		III	858..1140		140/287 (49%)
		Ion_trans	888..1107	CDD:278921	111/224 (50%)
		Dihydropyridine binding. /evidence=ECO:0000250	1060..1150		46/89 (52%)
		IV	1177..1444		141/271 (52%)
		Ion_trans	1207..1452	CDD:278921	136/247 (55%)
		Dihydropyridine binding. /evidence=ECO:0000250	1397..1463		43/65 (66%)
		Phenylalkylamine binding. /evidence=ECO:0000250	1409..1452		29/42 (69%)
		GPHH	1460..1523	CDD:293510	32/62 (52%)
		Ca_chan_IQ	1525..1596	CDD:285917	31/75 (41%)
		CAC1F_C	1620..1974	CDD:293490	66/335 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1637..1754		22/127 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1816..1841		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.720