DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and CACNA1E

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_016857732.1	Gene:	CACNA1E / 777	HGNCID:	1392	Length:	2458	Species:	Homo sapiens

Alignment Length:	2341	Identity:	1027/2341 - (43%)
Similarity:	1287/2341 - (54%)	Gaps:	604/2341 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||..|||.:|||.:.:|:||||||.:|.||||||:|||||:|||..|||.::::|||||.||:
Human   213 SLFIFGEDNIVRKYAKKLIDWPPFEYMILATIIANCIVLALEQHLPEDDKTPMSRRLEKTEPYFI 277

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPEVDLRTLRAIRVLRP 145
            .|||.||.:||:|||.:.||.|||||.||:|||.||::|.: |........||||||||:|||||
Human   278 GIFCFEAGIKIVALGFIFHKGSYLRNGWNVMDFIVVLSGILATAGTHFNTHVDLRTLRAVRVLRP 342

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            |||||||||||:|||||:|||.||||||||:.|||::|||||||||||.||:.|:.   .|..:.
Human   343 LKLVSGIPSLQIVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHRACFM---NNSGIL 404

  Fly   211 EG-ESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWT 274
            || :...||.    ::.....:.|.:        |.|||.|||.||||.||:|||||||||||||
Human   405 EGFDPPHPCG----VQGCPAGYECKD--------WIGPNDGITQFDNILFAVLTVFQCITMEGWT 457

  Fly   275 AILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLE 339
            .:||.||||||:.:||:||:|||:|||||:|||||||||||||||||:||||:.|:|||||||:|
Human   458 TVLYNTNDALGATWNWLYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQIE 522

  Fly   340 RELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDY 404
            ||||||..||.|||||:||||  .:......:|..||...||.:.:::.:..|     :|...|.
Human   523 RELNGYRAWIDKAEEVMLAEE--NKNAGTSALEVLRRATIKRSRTEAMTRDSS-----DEHCVDI 580

  Fly   405 GDDGYLKTRSKPQGS----CTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQ 465
            ...|....|:..:.:    .:.|...|:..|..|||.||:|.|||.|:.||.|||.|||:.|:.|
Human   581 SSVGTPLARASIKSAKVDGVSYFRHKERLLRISIRHMVKSQVFYWIVLSLVALNTACVAIVHHNQ 645

  Fly   466 PSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGS 529
            |.:||..||||||:|||||:.||.:|||.:|||:||.||||.||..|..||||||:|:..: |.|
Human   646 PQWLTHLLYYAEFLFLGLFLLEMSLKMYGMGPRLYFHSSFNCFDFGVTVGSIFEVVWAIFRPGTS 710

  Fly   530 FGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFN 594
            ||:|||||||||||||:||||:||||||:||::||:|||||||||||||::|||||||||||:||
Human   711 FGISVLRALRLLRIFKITKYWASLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQLFGGRFN 775

  Fly   595 LPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLL 659
            ...|||..||:|||.|::||||||||||||||||.||.||||...||..:||||||.||||||||
Human   776 FNDGTPSANFDTFPAAIMTVFQILTGEDWNEVMYNGIRSQGGVSSGMWSAIYFIVLTLFGNYTLL 840

  Fly   660 NVFLAIAVDNLANAQELTAAEEEQ--------------------------VEEDK---------- 688
            ||||||||||||||||||..|:|:                          :|.|:
Human   841 NVFLAIAVDNLANAQELTKDEQEEEEAFNQKHALQKAKEVSPMSAPNMPSIERDRRRRHHMSMWE 905

  Fly   689 ------------------EKQLQELEKEME----------------------------------- 700
                              |::..:|.|.|:
Human   906 PRSSHLRERRRRHHMSVWEQRTSQLRKHMQMSSQEALNREEAPTMNPLNPLNPLSSLNPLNAHPS 970

  Fly   701 -----------------------------ALQADG------------------------------ 706
                                         :|:.||
Human   971 LYRRPRAIEGLALGLALEKFEEERISRGGSLKGDGGDRSSALDNQRTPLSLGQREPPWLARPCHG 1035

  Fly   707 ----------------------------------------------------------------- 706

Human  1036 NCDPTQQEAGGGEAVVTFEDRARHRQSQRRSRHRRVRTEGKESSSASRSRSASQERSLDEAMPTE 1100

  Fly   707 ----------------------------------------------------------------- 706

Human  1101 GEKDHELRGNHGAKEPTIQEERAQDLRRTNSLMVSRGSGLAGGLDEADTPLVLPHPELEVGKHVV 1165

  Fly   707 ----------------------------------------------------------------- 706

Human  1166 LTEQEPEGSSEQALLGNVQLDMGRVISQSEPDLSCITANTDKATTESTSVTVAIPDVDPLVDSTV 1230

  Fly   707 VHVEN-GDGAVAPSKSKGKKKEEE----KKEEEEVTEGPKPMLPYSSMFILSPTNPIRRGAHWVV 766
            ||:.| .||..:|.|....:::||    ||:::|..|..|.|:|:|||||.|.||||||..|::|
Human  1231 VHISNKTDGEASPLKEAEIREDEEEVEKKKQKKEKRETGKAMVPHSSMFIFSTTNPIRRACHYIV 1295

  Fly   767 NLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPG 831
            ||.||:..|::||:.|||||||||||..||.|||:|.||||.||||||.||::|::|.|:||..|
Human  1296 NLRYFEMCILLVIAASSIALAAEDPVLTNSERNKVLRYFDYVFTGVFTFEMVIKMIDQGLILQDG 1360

  Fly   832 SYLREFWNIMDAVVVICAAVSFGF-DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFD 895
            ||.|:.|||:|.|||:.|.|:|.. :..|::.|:::.|||||||||||||||||||:||||||||
Human  1361 SYFRDLWNILDFVVVVGALVAFALANALGTNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFD 1425

  Fly   896 CVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQ 960
            |||.|||||.||||||.||.|||:||.||||.||||||||.||.|..||.|:|..:|::::..|.
Human  1426 CVVTSLKNVFNILIVYKLFMFIFAVIAVQLFKGKFFYCTDSSKDTEKECIGNYVDHEKNKMEVKG 1490

  Fly   961 ELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFI 1025
              |.||...|||||:..|:||||.|.||||||||||||:..|.|||||.::.|:||||||:|||:
Human  1491 --REWKRHEFHYDNIIWALLTLFTVSTGEGWPQVLQHSVDVTEEDRGPSRSNRMEMSIFYVVYFV 1553

  Fly  1026 VFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWR 1090
            ||||||||||||||||||||||:..:::..::||:::||||.|.|:||.||||:||:||:|:||.
Human  1554 VFPFFFVNIFVALIIITFQEQGDKMMEECSLEKNERACIDFAISAKPLTRYMPQNRHTFQYRVWH 1618

  Fly  1091 IVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFF 1155
            .|||..|||.||.:|..||::|||||::....||.:|||:|:.||.:||:|.|||:|.||..|:|
Human  1619 FVVSPSFEYTIMAMIALNTVVLMMKYYSAPCTYELALKYLNIAFTMVFSLECVLKVIAFGFLNYF 1683

  Fly  1156 KDPWNIFDLITVLGSIVDALWME---FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1217
            :|.|||||.|||:|||.:.:..:   ..::..|:.||:|||||||||||||||||||||||||||
Human  1684 RDTWNIFDFITVIGSITEIILTDSKLVNTSGFNMSFLKLFRAARLIKLLRQGYTIRILLWTFVQS 1748

  Fly  1218 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPN 1282
            |||||||||||||||||||||||||||||||.. |:.|.|||||:||...:|||||.||||||..
Human  1749 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLDE-ESHINRHNNFRSFFGSLMLLFRSATGEAWQE 1812

  Fly  1283 IMLACLKGKACDDDAEKAPG----EYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRD 1343
            |||:||..|.|:.|.....|    |.||:.|||.|||||||||||||||||||||||||:|||||
Human  1813 IMLSCLGEKGCEPDTTAPSGQNENERCGTDLAYVYFVSFIFFCSFLMLNLFVAVIMDNFEYLTRD 1877

  Fly  1344 SSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPL 1408
            |||||.||||||||:|||||..|.|:|||||||:||..|.||||.|.:||:::|||:|:.||||:
Human  1878 SSILGPHHLDEFVRVWAEYDRAACGRIHYTEMYEMLTLMSPPLGLGKRCPSKVAYKRLVLMNMPV 1942

  Fly  1409 DDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNIWPLQAKKMLNLLVP---PSD 1469
            .:::.|.||:||.||||..|.||: :...:..|.|.||::....|||..::|||:||||   .||
Human  1943 AEDMTVHFTSTLMALIRTALDIKIAKGGADRQQLDSELQKETLAIWPHLSQKMLDLLVPMPKASD 2007

  Fly  1470 QLNKGKLSVGKIYAGFLILESWRSTR----------------FGQLD------------SGMPML 1506
                  |:||||||..:|::.::.::                |.:::            ..:|.|
Human  2008 ------LTVGKIYAAMMIMDYYKQSKVKKQRQQLEEQKNAPMFQRMEPSSLPQEIIANAKALPYL 2066

  Fly  1507 E------LQDASRHPSQESLT-----------GADAGH------LHPGHSYMNG--------HRR 1540
            :      |...|.:||...|:           .||.|.      |.|..|.:..        :..
Human  2067 QQDPVSGLSGRSGYPSMSPLSPQDIFQLACMDPADDGQFQERQSLEPEVSELKSVQPSNHGIYLP 2131

  Fly  1541 SPSLRHNGSPLARS-------------PSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGN 1592
            |.:..|.||..|.|             ||..||....|.      |..|| ...::|....|...
Human  2132 SDTQEHAGSGRASSMPRLTVDPQVVTDPSSMRRSFSTIR------DKRSN-SSWLEEFSMERSSE 2189

  Fly  1593 SHPRYPRGSWSAS--TSPARSPSPS-------RYGG-HLSRSK-RTQLPYPTYGTTSLC------ 1640
            :..:..|.|:.:|  .|..|..|.|       |.|| ...||| |..|..|   ..|.|
Human  2190 NTYKSRRRSYHSSLRLSAHRLNSDSGHKSDTHRSGGRERGRSKERKHLLSP---DVSRCNSEERG 2251

  Fly  1641 ----------QRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSK 1695
                      ::|||||..|.|   ..:|.|.| .:..:.:.....|...||:  .|:|||.|.|
Human  2252 TQADWESPERRQSRSPSEGRSQ---TPNRQGTG-SLSESSIPSVSDTSTPRRS--RRQLPPVPPK 2310

  Fly  1696 PSTL-----------QLKP-----------TNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRD 1738
            |..|           .:.|           |:......||..|.:.:|        ||
Human  2311 PRPLLSYSSLIRHAGSISPPADGSEEGSPLTSQALESNNACLTESSNS--------PH------- 2360

  Fly  1739 PRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERERLEYI 1803
            |:...::|.:|......|          .|||.....:..:.|
Human  2361 PQQSQHASPQRYISEPYL----------ALHEDSHASDCGEEE---------------------- 2393

  Fly  1804 APLSFEQALA--MGRTGRVLPSPVL-------NGF-------KPKSGL-----NPRHSDSDEEDW 1847
             .|:||.|:|  :||:..:..:|.|       ||.       .|..|:     |...||::|:|.
Human  2394 -TLTFEAAVATSLGRSNTIGSAPPLRHSWQMPNGHYRRRRRGGPGPGMMCGAVNNLLSDTEEDDK 2457

  Fly  1848 C 1848
            |
Human  2458 C 2458

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	183/288 (64%)
		Ion_trans	441..677	CDD:334124	173/236 (73%)
		Ion_trans	769..1050	CDD:334124	188/281 (67%)
		Ion_trans	1094..1345	CDD:334124	171/257 (67%)
		GPHH	1346..1416	CDD:339854	44/69 (64%)
		Ca_chan_IQ	1418..1492	CDD:337190	33/77 (43%)
CACNA1E	XP_016857732.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	386	1.000	Domainoid score	I807
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1856	1.000	Inparanoid score	I62
Isobase	1	0.950	-	0	Normalized mean entropy	S4478
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.780