DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and CACNA1D

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_011532396.1 Gene:CACNA1D / 776 HGNCID:1391 Length:2246 Species:Homo sapiens


Alignment Length:2285 Identity:889/2285 - (38%)
Similarity:1216/2285 - (53%) Gaps:381/2285 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 KKEENPPGGGPT-SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTV 68
            ||:.|.....|. :||.|:.:||||:....|:||.||:..:||.|.||||.||:....|..|...
Human   129 KKQGNSSNSRPARALFCLSLNNPIRRACISIVEWKPFDIFILLAIFANCVALAIYIPFPEDDSNS 193

  Fly    69 LAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTG-FMTQYPQIGPEV 132
            ....|||.|..||.||.||..|||:|.||:||.::|:||.||::||.:|:.| |.....|:..|.
Human   194 TNHNLEKVEYAFLIIFTVETFLKIIAYGLLLHPNAYVRNGWNLLDFVIVIVGLFSVILEQLTKET 258

  Fly   133 -------------DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFA 184
                         |::.|||.||||||:||||:|||||||.||||||.|||.|.|||||.|:|:|
Human   259 EGGNHSSGKSGGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIIIYA 323

  Fly   185 IIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNS 249
            |||||.:.|.:||||:..:  :.:|.| |...||.......:.|    .|.|.  |...|.|||.
Human   324 IIGLELFIGKMHKTCFFAD--SDIVAE-EDPAPCAFSGNGRQCT----ANGTE--CRSGWVGPNG 379

  Fly   250 GITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG 314
            |||:|||..||||||||||||||||.:|||.|||:|....|:|||.|::.||||:||||||||||
Human   380 GITNFDNFAFAMLTVFQCITMEGWTDVLYWMNDAMGFELPWVYFVSLVIFGSFFVLNLVLGVLSG 444

  Fly   315 EFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAA 379
            ||:|||||.:.|.:|.|||.:||||.:|.||::||.:||::....|....||            .
Human   445 EFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDIDPENEEEGGEE------------G 497

  Fly   380 KRKKLKSLGKSKSTDTEEEEAE-EDYGDDGYL--------KTRSKPQGSCTGFWRA------EKR 429
            ||.......:::|.:||....| |:.|..|.|        ..::.|.| |..:.:|      .:|
Human   498 KRNTSMPTSETESVNTENVSGEGENRGCCGSLWCWWRRRGAAKAGPSG-CRRWGQAISKSKLSRR 561

  Fly   430 FRFW-------IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSE 487
            :|.|       .|..||:..|||.|||||||||:.::.|||.||.:||:....|..:.|.||..|
Human   562 WRRWNRFNRRRCRAAVKSVTFYWLVIVLVFLNTLTISSEHYNQPDWLTQIQDIANKVLLALFTCE 626

  Fly   488 MFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVLRALRLLRIFKVTKYWS 551
            |.:|||:||.:.||.|.||||||.|:.|.|.|.|..|::..| .|:||.|.:|||||||||::|:
Human   627 MLVKMYSLGLQAYFVSLFNRFDCFVVCGGITETILVELEIMSPLGISVFRCVRLLRIFKVTRHWT 691

  Fly   552 SLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNL-PGGTPETNFNTFPIALLTVF 615
            ||.|||.||||||:||.|||.||||||:||:|||||||||:||. ...|..:.|:.||.||||||
Human   692 SLSNLVASLLNSMKSIASLLLLLFLFIIIFSLLGMQLFGGKFNFDETQTKRSTFDNFPQALLTVF 756

  Fly   616 QILTGEDWNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAA 679
            |||||||||.|||.||::.|| :..|||..||||:|.:.|||.||||||||||||||:|:.|..|
Human   757 QILTGEDWNAVMYDGIMAYGGPSSSGMIVCIYFIILFICGNYILLNVFLAIAVDNLADAESLNTA 821

  Fly   680 EEEQVEEDKEKQL---QELEKEMEALQADGVHVENGDGAVAPSKSK----------------GKK 725
            ::|:.||.:.|::   :.||.:... :.:...:.|.|..|.....:                |::
Human   822 QKEEAEEKERKKIARKESLENKKNN-KPEVNQIANSDNKVTIDDYREEDEDKDPYPPCDVPVGEE 885

  Fly   726 KEEEKKEEEEVTEGPKPM-------------LPY-SSMFILSPTNPIRRGAHWVVNLPYFDFFIM 776
            :|||:::|.||..||:|.             :|. |:.||||.|||||.|.|.::|...|...|:
Human   886 EEEEEEDEPEVPAGPRPRRISELNMKEKIAPIPEGSAFFILSKTNPIRVGCHKLINHHIFTNLIL 950

  Fly   777 VVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIM 841
            |.|.:||.|||||||:|.:|.||.||.|||||||.:||:|:|||:...|..||.|::.|.::|::
Human   951 VFIMLSSAALAAEDPIRSHSFRNTILGYFDYAFTAIFTVEILLKMTTFGAFLHKGAFCRNYFNLL 1015

  Fly   842 DAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVN 906
            |.:||..:.||||...|.      :|.:|.||||||||||:.|.|...||.|..||..:::.:.|
Human  1016 DMLVVGVSLVSFGIQSSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGN 1074

  Fly   907 ILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL-LPKQELRVWKPRAF 970
            |:||..|.||:|:.||||||.|||:.||||:|....||:|.:..|::.:: .|....|:|:...|
Human  1075 IMIVTTLLQFMFACIGVQLFKGKFYRCTDEAKSNPEECRGLFILYKDGDVDSPVVRERIWQNSDF 1139

  Fly   971 HYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIF 1035
            ::|||.:||:.||.|.|.||||.:|..::.:..|:.|||.|.|:|:|||:|:|.|:..||.:|||
Human  1140 NFDNVLSAMMALFTVSTFEGWPALLYKAIDSNGENIGPIYNHRVEISIFFIIYIIIVAFFMMNIF 1204

  Fly  1036 VALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYF 1100
            |..:|:|||||||.|.::.|:||||:.|:::.:.||||.||:||  |.::||.|.:|.|:||||.
Human  1205 VGFVIVTFQEQGEKEYKNCELDKNQRQCVEYALKARPLRRYIPK--NPYQYKFWYVVNSSPFEYM 1267

  Fly  1101 IMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLI 1165
            :.:||:.|||.|.|:::.|..|:..::..:||.|||:|:||.|||:|.|..|.:|.|.||.||.:
Human  1268 MFVLIMLNTLCLAMQHYEQSKMFNDAMDILNMVFTGVFTVEMVLKVIAFKPKGYFSDAWNTFDSL 1332

  Fly  1166 TVLGSIVDA-----------LWMEFG------------------------------------SNS 1183
            .|:|||:|.           .|..|.                                    ||.
Human  1333 IVIGSIIDVALSEADHYFTDAWNTFDALIVVGSVVDIAITEVNPTESENVPVPTATPGNSEESNR 1397

  Fly  1184 INVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL 1248
            |::.|.||||..||:|||.:|..||.|||||::||:|||||.|||||||||||:||||:||.:.:
Human  1398 ISITFFRLFRVMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIAMLFFIYAVIGMQMFGKVAM 1462

  Fly  1249 GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGE--YCGSTLAY 1311
            .. .|.|.|:||||:|.|.|:|||||||||||..||||||.||.||.:::..|||  .|||..|.
Human  1463 RD-NNQINRNNNFQTFPQAVLLLFRCATGEAWQEIMLACLPGKLCDPESDYNPGEEYTCGSNFAI 1526

  Fly  1312 AYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMY 1376
            .||:||...|:||::|||||||||||||||||.||||.||||||.|||:||||.|.|:|.:.::.
Human  1527 VYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWSEYDPEAKGRIKHLDVV 1591

  Fly  1377 DMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQA 1441
            .:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..|||||:|..|.||...  .::||
Human  1592 TLLRRIQPPLGFGKLCPHRVACKRLVAMNMPLNSDGTVMFNATLFALVRTALKIKTEG--NLEQA 1654

  Fly  1442 DMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPML 1506
            :.|||..|..||...:.|:|:.:|||:   ...:::|||.||.|||.:.:|..: .:.:.|:   
Human  1655 NEELRAVIKKIWKKTSMKLLDQVVPPA---GDDEVTVGKFYATFLIQDYFRKFK-KRKEQGL--- 1712

  Fly  1507 ELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGF 1571
                ..::|::.:.....||       ....|...|.:|...|...:...|.....:  ..|   
Human  1713 ----VGKYPAKNTTIALQAG-------LRTLHDIGPEIRRAISCDLQDDEPEETKRE--EED--- 1761

  Fly  1572 SDTVSNVVEMVKET-----RHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLP- 1630
                    ::.|..     .|..|.||..|......:.:..|.....||     :..:..|:.| 
Human  1762 --------DVFKRNGALLGNHVNHVNSDRRDSLQQTNTTHRPLHVQRPS-----IPPASDTEKPL 1813

  Fly  1631 YPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSK 1695
            :|..| .|:|                             |..|::.:       ||:::|.:   
Human  1814 FPPAG-NSVC-----------------------------HNHHNHNS-------IGKQVPTS--- 1838

  Fly  1696 PSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRER----- 1755
                    ||.|..  ||:.:...|....|:.:|.|..:      :.::||.:.:|:.:|     
Human  1839 --------TNANLN--NANMSKAAHGKRPSIGNLEHVSE------NGHHSSHKHDREPQRRSSVK 1887

  Fly  1756 --------LRDRDRD-------RDRDRLHEYDLRYEYRD----RERELYERER----DREREVER 1797
                    :|....|       |:...:|.|     :||    .|:|.:..|.    |......|
Human  1888 RTRYYETYIRSDSGDEQLPTICREDPEIHGY-----FRDPHCLGEQEYFSSEECYEDDSSPTWSR 1947

  Fly  1798 ERLEYIAPLSFEQALAMGRTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQ 1862
            :...|.:..          .||.:.|....|:....|.    .:.|:...|..  ..||..|:  
Human  1948 QNYGYYSRY----------PGRNIDSERPRGYHHPQGF----LEDDDSPVCYD--SRRSPRRR-- 1994

  Fly  1863 IWVXHQAICSSLSAPN-LDH-----NFDTIRHSYQIPEHLQNLPYLCP-----PVHQHQHQHQT- 1915
                       |..|. ..|     ||:.:|.. ...|.:.:.| :.|     |:|..|.|... 
Human  1995 -----------LLPPTPASHRRSSFNFECLRRQ-SSQEEVPSSP-IFPHRTALPLHLMQQQIMAV 2046

  Fly  1916 ---QTQNQRQHQDQHLYQRYGTNVSTPKLGTTISDIKLAGVSLQELSPNRQPQSQQKQEQ----- 1972
               .:...:::...|..:.:.|..:||              ..::.:|...|..|.:|.:     
Human  2047 AGLDSSKAQKYSPSHSTRSWATPPATP--------------PYRDWTPCYTPLIQVEQSEALDQV 2097

  Fly  1973 -----QLHQDGWLR-----WYRQSGPYGSPVMASLPETRATSPHSDIEFIRTMKRSE-TGTTAIT 2026
                 .||:..|..     .||...|....|.:|.....:....|....:..:..|| .|..|..
Human  2098 NGSLPSLHRSSWYTDEPDISYRTFTPASLTVPSSFRNKNSDKQRSADSLVEAVLISEGLGRYARD 2162

  Fly  2027 PR---TTKTEAMILSVPITITSPLAIKKIYS--DNDINYNTERGTDNDRVDDAPAHHYHQPELTT 2086
            |:   .||.|       |.....|.|.::.|  ...:|.|.....:.   |..|..|....||..
Human  2163 PKFVSATKHE-------IADACDLTIDEMESAASTLLNGNVRPRANG---DVGPLSHRQDYELQD 2217

  Fly  2087 --PDLQDEPP 2094
              |...||.|
Human  2218 FGPGYSDEEP 2227

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 161/300 (54%)
Ion_trans 441..677 CDD:334124 147/238 (62%)
Ion_trans 769..1050 CDD:334124 136/281 (48%)
Ion_trans 1094..1345 CDD:334124 148/299 (49%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
CACNA1DXP_011532396.1 Ion_trans 180..454 CDD:278921 151/282 (54%)
Ion_trans 600..817 CDD:278921 135/216 (63%)
Ion_trans 960..1219 CDD:278921 129/264 (49%)
Ion_trans 1279..1560 CDD:278921 138/281 (49%)
GPHH 1568..1631 CDD:293510 32/62 (52%)
Ca_chan_IQ 1633..1704 CDD:285917 31/75 (41%)
CAC1F_C 1728..2243 CDD:293490 116/641 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
65.750

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