DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and CACNA1C

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_016875415.1 Gene:CACNA1C / 775 HGNCID:1390 Length:2412 Species:Homo sapiens


Alignment Length:2294 Identity:911/2294 - (39%)
Similarity:1214/2294 - (52%) Gaps:427/2294 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GGPKKEENPPG-GGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGD 65
            |.|||:.:... ..|.:|..||..||||:....|:||.|||..:||||.||||.||:....|..|
Human   143 GKPKKQGSTTATRPPRALLCLTLKNPIRRACISIVEWKPFEIIILLTIFANCVALAIYIPFPEDD 207

  Fly    66 KTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQ--- 127
            .......||:.|..||.||.|||.||::|.||:.|.::||||.||::||.:||.|..:...:   
Human   208 SNATNSNLERVEYLFLIIFTVEAFLKVIAYGLLFHPNAYLRNGWNLLDFIIVVVGLFSAILEQAT 272

  Fly   128 ----------IGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVI 182
                      .|...|::.|||.||||||:||||:|||||||.||||||.|||.|.|||||.|:|
Human   273 KADGANALGGKGAGFDVKALRAFRVLRPLRLVSGVPSLQVVLNSIIKAMVPLLHIALLVLFVIII 337

  Fly   183 FAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDN---ILEKATGSFVCNNTTSMCLEKW 244
            :||||||.:.|.:|||||:        :||.::.|...|.   .||...|. .|.|.| :|...|
Human   338 YAIIGLELFMGKMHKTCYN--------QEGIADVPAEDDPSPCALETGHGR-QCQNGT-VCKPGW 392

  Fly   245 EGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVL 309
            :||..|||:|||..||||||||||||||||.:|||..||:|....|:|||.|::.||||:|||||
Human   393 DGPKHGITNFDNFAFAMLTVFQCITMEGWTDVLYWMQDAMGYELPWVYFVSLVIFGSFFVLNLVL 457

  Fly   310 GVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEAR 374
            |||||||:|||||.:.|.:|.|||.:||||.:|.||::||.:||::    :...|:|.|...:.|
Human   458 GVLSGEFSKEREKAKARGDFQKLREKQQLEEDLKGYLDWITQAEDI----DPENEDEGMDEEKPR 518

  Fly   375 RRNA----AKRKKLKSLGKSKST---------DTEEEEAEEDYGDD------------------- 407
            .|..    ..:||.|....|.||         :||....|...|.|                   
Human   519 NRGTPAGMLDQKKGKFAWFSHSTETHVSMPTSETESVNTENVAGGDIEGENCGARLAKGSRSAVE 583

  Fly   408 ------------------GYLKTRSKPQGS---------CTGFWRAEKRF-RFWIRHTVKTQWFY 444
                              ..|:|.:..|.|         .:.:||...|| |...|..||:..||
Human   584 PAVLLPWGVTTVNSPWPLEELQTEALSQTSPSHRISKSKFSRYWRRWNRFCRRKCRAAVKSNVFY 648

  Fly   445 WFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFD 509
            |.||.||||||:.:|.|||.||::|||....|....|.||.:||.:|||:||.:.||.|.|||||
Human   649 WLVIFLVFLNTLTIASEHYNQPNWLTEVQDTANKALLALFTAEMLLKMYSLGLQAYFVSLFNRFD 713

  Fly   510 CVVISGSIFEVIWSEVKGGS-FGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFL 573
            |.|:.|.|.|.|..|.|..| .|:||||.:|||||||:|:||:||.|||.|||||:|||.|||.|
Human   714 CFVVCGGILETILVETKIMSPLGISVLRCVRLLRIFKITRYWNSLSNLVASLLNSVRSIASLLLL 778

  Fly   574 LFLFILIFALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGA 637
            |||||:||:|||||||||:||... .|..:.|:.||.:||||||||||||||.|||.||::.||.
Human   779 LFLFIIIFSLLGMQLFGGKFNFDEMQTRRSTFDNFPQSLLTVFQILTGEDWNSVMYDGIMAYGGP 843

  Fly   638 Q-KGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQL--------- 692
            . .||:..||||:|.:.|||.||||||||||||||:|:.||:|::|:.||.:.|:|         
Human   844 SFPGMLVCIYFIILFICGNYILLNVFLAIAVDNLADAESLTSAQKEEEEEKERKKLARTASPEKK 908

  Fly   693 QEL-----------EK-EMEALQADG-------VHV------ENGDGAVAPS-KSKGKKKEEEKK 731
            |||           || |::::.|||       :::      ||.|.:..|: ::.|    ||.:
Human   909 QELVEKPAVGESKEEKIELKSITADGESPPATKINMDDLQPNENEDKSPYPNPETTG----EEDE 969

  Fly   732 EEEEVTEGPK--------------PMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMS 782
            ||.|:..||:              ||...|:.||.|..|..|...|.:||...|...|:..|.:|
Human   970 EEPEMPVGPRPRPLSELHLKEKAVPMPEASAFFIFSSNNRFRLQCHRIVNDTIFTNLILFFILLS 1034

  Fly   783 SIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVI 847
            ||:|||||||:..|.||.||.|||..||.:||||:.||:...|..||.||:.|.::||:|.:||.
Human  1035 SISLAAEDPVQHTSFRNHILFYFDIVFTTIFTIEIALKMTAYGAFLHKGSFCRNYFNILDLLVVS 1099

  Fly   848 CAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYI 912
            .:.:|||...|.      ::.:|.||||||||||:.|.|...||.|..||..:::.:.||:||..
Human  1100 VSLISFGIQSSA------INVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVIVTT 1158

  Fly   913 LFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL-LPKQELRVWKPRAFHYDNVA 976
            |.||:|:.||||||.||.:.|:|.||.|.|||:|:|..|::.|: .|..:.|.|:...|.:|||.
Human  1159 LLQFMFACIGVQLFKGKLYTCSDSSKQTEAECKGNYITYKDGEVDHPIIQPRSWENSKFDFDNVL 1223

  Fly   977 AAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIII 1041
            |||:.||.|.|.||||::|..|:.:..||:|||.|:|:|:|||:|:|.|:..||.:||||..:|:
Human  1224 AAMMALFTVSTFEGWPELLYRSIDSHTEDKGPIYNYRVEISIFFIIYIIIIAFFMMNIFVGFVIV 1288

  Fly  1042 TFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIV 1106
            |||||||.|.::.|:||||:.|:::.:.||||.||:|||::  :||||.:|.||.|||.:.:||:
Human  1289 TFQEQGEQEYKNCELDKNQRQCVEYALKARPLRRYIPKNQH--QYKVWYVVNSTYFEYLMFVLIL 1351

  Fly  1107 FNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSI 1171
            .||:.|.|:::.|..:::.::..:||.|||:|:||.:||:|.|..|.:|.||||:||.:.|:|||
Human  1352 LNTICLAMQHYGQSCLFKIAMNILNMLFTGLFTVEMILKLIAFKPKGYFSDPWNVFDFLIVIGSI 1416

  Fly  1172 VDAL-----------WMEF------GS-------------------------NS-INVGFLRLFR 1193
            :|.:           |..|      ||                         || |::.|.||||
Human  1417 IDVILSETNHYFCDAWNTFDALIVVGSIVDIAITEVNPAEHTQCSPSMNAEENSRISITFFRLFR 1481

  Fly  1194 AARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLG-TVENSITR 1257
            ..||:|||.:|..||.|||||::||:|||||.|||.|||||||:|||||||.|.|. |.|  |.|
Human  1482 VMRLVKLLSRGEGIRTLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALNDTTE--INR 1544

  Fly  1258 HNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAE---KAPGEY-CGSTLAYAYFVSFI 1318
            :||||:|.|.|:|||||||||||.:|||||:.||.|..::|   ...||. |||:.|..||:||.
Human  1545 NNNFQTFPQAVLLLFRCATGEAWQDIMLACMPGKKCAPESEPSNSTEGETPCGSSFAVFYFISFY 1609

  Fly  1319 FFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMD 1383
            ..|:||::|||||||||||||||||.||||.||||||.||||||||.|.|:|.:.::..:|:.:.
Human  1610 MLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEFKRIWAEYDPEAKGRIKHLDVVTLLRRIQ 1674

  Fly  1384 PPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMR---APEE-------- 1437
            ||||||..||:|:|.|:|:.|||||:.:..|.|..|||||:|..|.||..   :|.|        
Human  1675 PPLGFGKLCPHRVACKRLVSMNMPLNSDGTVMFNATLFALVRTALRIKTEEGPSPSEAHQGAEDP 1739

  Fly  1438 ------MDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRF 1496
                  ::||:.|||..|..||...:.|:|:.:|||:   ...:::|||.||.|||.|.:|..: 
Human  1740 FRPAGNLEQANEELRAIIKKIWKRTSMKLLDQVVPPA---GDDEVTVGKFYATFLIQEYFRKFK- 1800

  Fly  1497 GQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPS------------LRHNGS 1549
                    ..:.|.....|||.:.....|| |...|......||:.|            ::...|
Human  1801 --------KRKEQGLVGKPSQRNALSLQAG-LRTLHDIGPEIRRAISGDLTAEEELDKAMKEAVS 1856

  Fly  1550 PLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAST-SPARSP- 1612
            ..:.....||.|..:.:|...:.....:.......|:.|.|.|.     .||....| ||:... 
Human  1857 AASEDDIFRRAGGLFGNHVSYYQSDGRSAFPQTFTTQRPLHINK-----AGSSQGDTESPSHEKL 1916

  Fly  1613 -----SPSRY-----GGHLSRSKRT---QLPYPT-YGTTSLCQRSRSP--SPA-RLQEMR---ER 1657
                 :||.|     ..:::.:..|   :||.|. |.:|........|  ||| |:||:.   ..
Human  1917 VDSTFTPSSYSSTGSNANINNANNTALGRLPRPAGYPSTVSTVEGHGPPLSPAIRVQEVAWKLSS 1981

  Fly  1658 DRLGYGIDM--GVTHVQHSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTHTHH 1720
            :|: :..||  |.|..    |.|..|||      ||...:              :|..|......
Human  1982 NRM-HCCDMLDGGTFP----PALGPRRA------PPCLHQ--------------QLQGSLAGLRE 2021

  Fly  1721 STPHSVHSLPHHRDLLRDPR---------DMYYSSRERE----RDRERLRDRD-----------R 1761
            .||..|   |.|..|....|         .....:|||.    .|.|..||..           |
Human  2022 DTPCIV---PGHASLCCSSRVGEWLPAGCTAPQHARERHVPMCEDLELRRDSGSAGTQAHCLLLR 2083

  Fly  1762 DRDRDRLHEYDLRYEYRDRER----ELYERERDRERE-------VERERLEYIAPLSFEQALAMG 1815
            ..:..|.|..:.:.....:|.    |.||.:.:.:.|       :..|.|.|....:.:..|...
Human  2084 RANPSRCHSRESQAAMAGQEETSQDETYEVKMNHDTEACSEPSLLSTEMLSYQDDENRQLTLPEE 2148

  Fly  1816 RTGRVLPSPVLNGFKPKSGLNPRHSDSDEEDWCXQRLXLRSRNRKDQI---------WVXHQAIC 1871
            ....:..|| ..||...:.|..|.|...|   |.:    |.::|...|         .|.|||:.
Human  2149 DKRDIRQSP-KRGFLRSASLGRRASFHLE---CLK----RQKDRGGDISQKTVLPLHLVHHQALA 2205

  Fly  1872 SSLSAPNLDHNFDTIRHSYQIPEHLQNLPYLCPPVHQHQHQHQTQTQNQRQHQDQHLYQRYGTNV 1936
            .:..:|.|                                        ||.|......:.:.|..
Human  2206 VAGLSPLL----------------------------------------QRSHSPASFPRPFATPP 2230

  Fly  1937 STPKLGT------TISDIKLAGVSLQELSPNRQPQSQQKQEQQLHQDGWLRWYRQSGPYGS---- 1991
            :||  |:      .:..::|.||...|...:..|        .:|...|    .::.|.|.    
Human  2231 ATP--GSRGWPPQPVPTLRLEGVESSEKLNSSFP--------SIHCGSW----AETTPGGGGSSA 2281

  Fly  1992 -----PVMASLPETRATSP 2005
                 ||...:| ::|.:|
Human  2282 ARRVRPVSLMVP-SQAGAP 2299

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 162/302 (54%)
Ion_trans 441..677 CDD:334124 148/238 (62%)
Ion_trans 769..1050 CDD:334124 138/281 (49%)
Ion_trans 1094..1345 CDD:334124 149/298 (50%)
GPHH 1346..1416 CDD:339854 39/69 (57%)
Ca_chan_IQ 1418..1492 CDD:337190 33/90 (37%)
CACNA1CXP_016875415.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
54.850

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