DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and CACNA1B

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_000709.1 Gene:CACNA1B / 774 HGNCID:1389 Length:2339 Species:Homo sapiens


Alignment Length:2352 Identity:1056/2352 - (44%)
Similarity:1292/2352 - (54%) Gaps:606/2352 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            |||:.:|||.:|||.:.|.|||||||.:|.||||||:|||||:|||.||||.::::|:.||.||:
Human    74 SLFVFSEDNVVRKYAKRITEWPPFEYMILATIIANCIVLALEQHLPDGDKTPMSERLDDTEPYFI 138

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|||.||.:||:|||.|.||.|||||.||:|||.||:||.:.   ..|.:.|||||||:||||||
Human   139 GIFCFEAGIKIIALGFVFHKGSYLRNGWNVMDFVVVLTGILA---TAGTDFDLRTLRAVRVLRPL 200

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            ||||||||||||||||:|||.||||||||:.|||::|||||||||.|..||.|:    ||....|
Human   201 KLVSGIPSLQVVLKSIMKAMVPLLQIGLLLFFAILMFAIIGLEFYMGKFHKACF----PNSTDAE 261

  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276
            ...:.||.      |...:.:|...|. |.|.|.|||.|||:||||.||:|||||||||||||.|
Human   262 PVGDFPCG------KEAPARLCEGDTE-CREYWPGPNFGITNFDNILFAILTVFQCITMEGWTDI 319

  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341
            ||.||||.|:.:||:||:|||:|||||||||||||||||||||||:||||:.|||||||||:|||
Human   320 LYNTNDAAGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 384

  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD 406
            ||||:|||.|||||:||||....|||.. ::..:|.|.|        ||::.....||.|:.:.|
Human   385 LNGYLEWIFKAEEVMLAEEDRNAEEKSP-LDVLKRAATK--------KSRNDLIHAEEGEDRFAD 440

  Fly   407 -------DGYLKTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
                   ......:|....|.:.|.|.||.|||:||..||.|.|||.|:.:|.|||:|||:.||.
Human   441 LCAVGSPFARASLKSGKTESSSYFRRKEKMFRFFIRRMVKAQSFYWVVLCVVALNTLCVAMVHYN 505

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||..||..||:|||:|||||::||.:|||.||||.||.||||.||..||.||:|||:|:.:| |.
Human   506 QPRRLTTTLYFAEFVFLGLFLTEMSLKMYGLGPRSYFRSSFNCFDFGVIVGSVFEVVWAAIKPGS 570

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:|||||||||||||||||||||||||:||||||:|||||||||||||::|||||||||||||
Human   571 SFGISVLRALRLLRIFKVTKYWSSLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 635

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |....||.|||:|||.|:|||||||||||||.|||.||.||||..|||..|.|||||.|||||||
Human   636 NFQDETPTTNFDTFPAAILTVFQILTGEDWNAVMYHGIESQGGVSKGMFSSFYFIVLTLFGNYTL 700

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQ---------------------------------------- 683
            |||||||||||||||||||..|||.                                        
Human   701 LNVFLAIAVDNLANAQELTKDEEEMEEAANQKLALQKAKEVAEVSPMSAANISIAARQQNSAKAR 765

  Fly   684 ----------------------------------------------------------------- 683
                                                                             
Human   766 SVWEQRASQLRLQNLRASCEALYSEMDPEERLRFATTRHLRPDMKTHLDRPLVVELGRDGARGPV 830

  Fly   684 ----------------------------------------------------------------- 683
                                                                             
Human   831 GGKARPEAAEAPEGVDPPRRHHRHRDKDKTPAAGDQDRAEAPKAESGEPGAREERPRPHRSHSKE 895

  Fly   684 ----------------------------------------------------------------- 683
                                                                             
Human   896 AAGPPEARSERGRGPGPEGGRRHHRRGSPEEAAEREPRRHRAHRHQDPSKECAGAKGERRARHRG 960

  Fly   684 ------------------------------------------------VEEDKEKQ--------- 691
                                                            ||.||||:         
Human   961 GPRAGPREAESGEEPARRHRARHKAQPAHEAVEKETTEKEATEKEAEIVEADKEKELRNHQPREP 1025

  Fly   692 ----------------------LQELEKEMEALQADG-----------------VHV------EN 711
                                  ||::|::.|  .||.                 ||:      ..
Human  1026 HCDLETSGTVTVGPMHTLPSTCLQKVEEQPE--DADNQRNVTRMGSQPPDPNTIVHIPVMLTGPL 1088

  Fly   712 GDGAVAPSKSKGKKKEEEKKEEEEVTE----GPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFD 772
            |:..|.||.:...:.:.|.|:|.|..:    ||:|::||||||.|||||.:||..|::|.:.||:
Human  1089 GEATVVPSGNVDLESQAEGKKEVEADDVMRSGPRPIVPYSSMFCLSPTNLLRRFCHYIVTMRYFE 1153

  Fly   773 FFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREF 837
            ..|:|||::||||||||||||.:|.||..|.|.||.||||||.||::|::|||::||||:|.|:.
Human  1154 VVILVVIALSSIALAAEDPVRTDSPRNNALKYLDYIFTGVFTFEMVIKMIDLGLLLHPGAYFRDL 1218

  Fly   838 WNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
            |||:|.:||..|.|:|.|  |||. |::::|||||||||||||||||||:|||||||||||||||
Human  1219 WNILDFIVVSGALVAFAF--SGSK-GKDINTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVNSLK 1280

  Fly   903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKP 967
            ||:||||||:||.|||:||.||||.|||||||||||....:|:|.|..||::|:  :.:.|.||.
Human  1281 NVLNILIVYMLFMFIFAVIAVQLFKGKFFYCTDESKELERDCRGQYLDYEKEEV--EAQPRQWKK 1343

  Fly   968 RAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFV 1032
            ..||||||..|:||||.|.||||||.||:||:.||||::||...:|:|:||||:|||:|||||||
Human  1344 YDFHYDNVLWALLTLFTVSTGEGWPMVLKHSVDATYEEQGPSPGYRMELSIFYVVYFVVFPFFFV 1408

  Fly  1033 NIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPF 1097
            |||||||||||||||:..:.:..::||:::||||.|.|:||.||||:||.:|:||.|..|||.||
Human  1409 NIFVALIIITFQEQGDKVMSECSLEKNERACIDFAISAKPLTRYMPQNRQSFQYKTWTFVVSPPF 1473

  Fly  1098 EYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIF 1162
            |||||.:|..||::||||:::....||..||.:|:.||.|||:|.|||||.|||.|:|:|.||:|
Human  1474 EYFIMAMIALNTVVLMMKFYDAPYEYELMLKCLNIVFTSMFSMECVLKIIAFGVLNYFRDAWNVF 1538

  Fly  1163 DLITVLGSIVDALWMEFG--SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1225
            |.:||||||.|.|..|..  :|.||:.||||||||||||||||||||||||||||||||||||||
Human  1539 DFVTVLGSITDILVTEIAETNNFINLSFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVC 1603

  Fly  1226 LLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKG 1290
            |||||||||||||||||||||.|.. :.||.|||||::|:|.:|||||.||||||..|||:||..
Human  1604 LLIAMLFFIYAIIGMQVFGNIALDD-DTSINRHNNFRTFLQALMLLFRSATGEAWHEIMLSCLSN 1667

  Fly  1291 KACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEF 1355
            :|||   |:|....|||..||.|||||||.|||||||||||||||||:||||||||||.||||||
Human  1668 QACD---EQANATECGSDFAYFYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEF 1729

  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDE-LRVQFTTT 1419
            :|:||||||.|.|:|.|.:|::|||:|.||||.|.|||.|:|||:|:|||||:.:| :.|.||:|
Human  1730 IRVWAEYDPAACGRISYNDMFEMLKHMSPPLGLGKKCPARVAYKRLVRMNMPISNEDMTVHFTST 1794

  Fly  1420 LFALIRENLSIKMR-APEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYA 1483
            |.||||..|.||:. |..:..|.|.|||:.|:.:|....:|.|:|||||.   ...:::|||:||
Human  1795 LMALIRTALEIKLAPAGTKQHQCDAELRKEISVVWANLPQKTLDLLVPPH---KPDEMTVGKVYA 1856

  Fly  1484 GFLILESWRSTR-----FGQLDSGMPML--------------ELQDASRHPSQESLTGADAGHLH 1529
            ..:|.:.::..:     ..|...|:..:              :.|.|....::..|....:..|.
Human  1857 ALMIFDFYKQNKTTRDQMQQAPGGLSQMGPVSLFHPLKATLEQTQPAVLRGARVFLRQKSSTSLS 1921

  Fly  1530 PGHSYMN-----------GHRRSPSLRHNGSPLARSPSPRRRGHQYIHHDIGFSDTVSNVVEMVK 1583
            .|.:..|           |.:|:....|...|      |..|||. ....:|.|..::..|:|..
Human  1922 NGGAIQNQESGIKESVSWGTQRTQDAPHEARP------PLERGHS-TEIPVGRSGALAVDVQMQS 1979

  Fly  1584 ETRHPRHGNSHP-----------------------------------RYPRGSWSASTSPARSPS 1613
            .||....|...|                                   :.|||:...||:|.| |.
Human  1980 ITRRGPDGEPQPGLESQGRAASMPRLAAETQPVTDASPMKRSISTLAQRPRGTHLCSTTPDR-PP 2043

  Fly  1614 PSRYGGH---------LSRSKRT---------------------QLPYPTYGTTSLCQRSR---- 1644
            ||:...|         ..|.:|:                     .|| |..|.|. |:|.|    
Human  2044 PSQASSHHHHHRCHRRRDRKQRSLEKGPSLSADMDGAPSSAVGPGLP-PGEGPTG-CRRERERRQ 2106

  Fly  1645 -----------SPSPARLQEMRERDRLG-------------------YGIDMGVTHVQHS----- 1674
                       |.|.:..|.....||.|                   .|.:.| .|.|.|     
Human  2107 ERGRSQERRQPSSSSSEKQRFYSCDRFGGREPPKPKPSLSSHPTSPTAGQEPG-PHPQGSGSVNG 2170

  Fly  1675 YPTLASRRA-----GIGRRLPPTPSKPSTLQLKPTNINFPKLNASPTH---THHSTP-----HSV 1726
            .|.|::..|     |..|:||.||..|     :| :|.:...|:||.|   ...|.|     ...
Human  2171 SPLLSTSGASTPGRGGRRQLPQTPLTP-----RP-SITYKTANSSPIHFAGAQTSLPAFSPGRLS 2229

  Fly  1727 HSLPHHRDLL-RDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERD 1790
            ..|..|..|| |||.....:...|......|..|                  .|.|..::....|
Human  2230 RGLSEHNALLQRDPLSQPLAPGSRIGSDPYLGQR------------------LDSEASVHALPED 2276

  Fly  1791 REREVERERLEYIAPLSFEQALA--MGRTGRV-----LPSP------VLNGFKPKSGLN----PR 1838
                          .|:||:|:|  .||:.|.     |.|.      |.||:....||:    .|
Human  2277 --------------TLTFEEAVATNSGRSSRTSYVSSLTSQSHPLRRVPNGYHCTLGLSSGGRAR 2327

  Fly  1839 HS--DSDEEDWC 1848
            ||  ..|::.||
Human  2328 HSYHHPDQDHWC 2339

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 188/286 (66%)
Ion_trans 441..677 CDD:334124 180/236 (76%)
Ion_trans 769..1050 CDD:334124 189/280 (68%)
Ion_trans 1094..1345 CDD:334124 177/252 (70%)
GPHH 1346..1416 CDD:339854 45/70 (64%)
Ca_chan_IQ 1418..1492 CDD:337190 30/74 (41%)
CACNA1BNP_000709.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..37
I 82..359 187/290 (64%)
Ion_trans 112..367 CDD:278921 174/268 (65%)
Binding to the beta subunit. /evidence=ECO:0000250 379..396 13/16 (81%)
II 468..712 182/243 (75%)
Ion_trans 499..720 CDD:278921 171/220 (78%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 816..1038 6/221 (3%)
DUF3628 <822..929 CDD:289100 0/106 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1054..1076 3/23 (13%)
III 1137..1419 188/286 (66%)
Ion_trans 1167..1425 CDD:278921 179/262 (68%)
IV 1456..1711 178/258 (69%)
Ion_trans 1488..1719 CDD:278921 166/234 (71%)
GPHH 1727..1791 CDD:293510 39/63 (62%)
Ca_chan_IQ 1793..1867 CDD:285917 30/76 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1916..1968 12/58 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1981..2206 48/234 (21%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 386 1.000 Domainoid score I807
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H20184
Inparanoid 1 1.050 1856 1.000 Inparanoid score I62
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - LDO PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
1110.870

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