DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and CACNA1A

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_075461.2 Gene:CACNA1A / 773 HGNCID:1388 Length:2512 Species:Homo sapiens


Alignment Length:2584 Identity:1086/2584 - (42%)
Similarity:1353/2584 - (52%) Gaps:749/2584 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            |||:.:|||.:|||.:.|.|||||||.:|.||||||:|||||:|||..|||.::::|:.||.||:
Human    77 SLFLFSEDNVVRKYAKKITEWPPFEYMILATIIANCIVLALEQHLPDDDKTPMSERLDDTEPYFI 141

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|||.||.:||:|||...||.|||||.||:|||.||:||.:.   .:|.|.|||||||:||||||
Human   142 GIFCFEAGIKIIALGFAFHKGSYLRNGWNVMDFVVVLTGILA---TVGTEFDLRTLRAVRVLRPL 203

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            ||||||||||||||||:|||.||||||||:.|||:||||||||||.|..|.||:. |..:.:  :
Human   204 KLVSGIPSLQVVLKSIMKAMIPLLQIGLLLFFAILIFAIIGLEFYMGKFHTTCFE-EGTDDI--Q 265

  Fly   212 GESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAI 276
            |||..||.|:   |.|.   .|.|.|. |...|||||:|||.||||.||:|||||||||||||.:
Human   266 GESPAPCGTE---EPAR---TCPNGTK-CQPYWEGPNNGITQFDNILFAVLTVFQCITMEGWTDL 323

  Fly   277 LYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERE 341
            ||.:|||.|:.:||:||:|||:|||||||||||||||||||||||:||||:.|||||||||:|||
Human   324 LYNSNDASGNTWNWLYFIPLIIIGSFFMLNLVLGVLSGEFAKERERVENRRAFLKLRRQQQIERE 388

  Fly   342 LNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD 406
            ||||:|||.|||||||||:.|..|::.....|.||...|        |||:.....||||:...|
Human   389 LNGYMEWISKAEEVILAEDETDGEQRHPFDGALRRTTIK--------KSKTDLLNPEEAEDQLAD 445

  Fly   407 DGYL-------KTRSKPQGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYG 464
            ...:       ..:|....:.|.|.:.|:|.||:||..||||.|||.|:.||.|||:|||:.||.
Human   446 IASVGSPFARASIKSAKLENSTFFHKKERRMRFYIRRMVKTQAFYWTVLSLVALNTLCVAIVHYN 510

  Fly   465 QPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GG 528
            ||.:|::||||||||||||||||||||||.||.|.||.||||.|||.||.||||||||:.:| |.
Human   511 QPEWLSDFLYYAEFIFLGLFMSEMFIKMYGLGTRPYFHSSFNCFDCGVIIGSIFEVIWAVIKPGT 575

  Fly   529 SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF 593
            |||:||||||||||||||||||:||||||:||||||:|||||||||||||::|||||||||||||
Human   576 SFGISVLRALRLLRIFKVTKYWASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQF 640

  Fly   594 NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
            |...|||.|||:|||.|::||||||||||||||||.||.||||.|.||::|||||||.|||||||
Human   641 NFDEGTPPTNFDTFPAAIMTVFQILTGEDWNEVMYDGIKSQGGVQGGMVFSIYFIVLTLFGNYTL 705

  Fly   659 LNVFLAIAVDNLANAQELTAAEEEQVEEDK----------------------------------- 688
            |||||||||||||||||||..|.::.||::                                   
Human   706 LNVFLAIAVDNLANAQELTKVEADEQEEEEAANQKLALQKAKEVAEVSPLSAANMSIAVKEQQKN 770

  Fly   689 --------EKQLQELEKE-----MEALQ------------------------------------- 703
                    |::..|:.|:     .|||.                                     
Human   771 QKPAKSVWEQRTSEMRKQNLLASREALYNEMDPDERWKAAYTRHLRPDMKTHLDRPLVVDPQENR 835

  Fly   704 ----------------------------------------------------------------- 703
                                                                             
Human   836 NNNTNKSRAAEPTVDQRLGQQRAEDFLRKQARYHDRARDPSGSAGLDARRPWAGSQEAELSREGP 900

  Fly   704 ------------------------------------------------------ADGVH------ 708
                                                                  |||.|      
Human   901 YGRESDHHAREGSLEQPGFWEGEAERGKAGDPHRRHVHRQGGSRESRSGSPRTGADGEHRRHRAH 965

  Fly   709 ------------------------VENGDG----------------------------------- 714
                                    ...|:|                                   
Human   966 RRPGEEGPEDKAERRARHREGSRPARGGEGEGEGPDGGERRRRHRHGAPATYEGDARREDKERRH 1030

  Fly   715 ---------------------------------------------------AVAPSKSKG----- 723
                                                               :.||..|.|     
Human  1031 RRRKENQGSGVPVSGPNLSTTRPIQQDLGRQDPPLAEDIDNMKNNKLATAESAAPHGSLGHAGLP 1095

  Fly   724 ----------------------------------------------------------------- 723
                                                                             
Human  1096 QSPAKMGNSTDPGPMLAIPAMATNPQNAASRRTPNNPGNPSNPGPPKTPENSLIVTNPSGTQTNS 1160

  Fly   724 --------------------------------------KKKEEEKKEEEE---VTEGPKPMLPYS 747
                                                  .|||||||||||   ..:|||||.|||
Human  1161 AKTARKPDHTTVDIPPACPPPLNHTVVQVNKNANPDPLPKKEEEKKEEEEDDRGEDGPKPMPPYS 1225

  Fly   748 SMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGV 812
            ||||||.|||:||..|:::||.||:..|::||:||||||||||||:.|:.||.:|.||||.||||
Human  1226 SMFILSTTNPLRRLCHYILNLRYFEMCILMVIAMSSIALAAEDPVQPNAPRNNVLRYFDYVFTGV 1290

  Fly   813 FTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRV 877
            ||.||::|::|||::||.|:|.|:.|||:|.:||..|.|:|.|  :|:|.|::::||||||||||
Human  1291 FTFEMVIKMIDLGLVLHQGAYFRDLWNILDFIVVSGALVAFAF--TGNSKGKDINTIKSLRVLRV 1353

  Fly   878 LRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSA 942
            |||||||||:|||||||||||||||||.||||||:||.|||:|:.||||.||||:||||||....
Human  1354 LRPLKTIKRLPKLKAVFDCVVNSLKNVFNILIVYMLFMFIFAVVAVQLFKGKFFHCTDESKEFEK 1418

  Fly   943 ECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRG 1007
            :|:|.|..||::|:  |...|.||...||||||..|:||||.|.|||||||||:||:.||:|::|
Human  1419 DCRGKYLLYEKNEV--KARDREWKKYEFHYDNVLWALLTLFTVSTGEGWPQVLKHSVDATFENQG 1481

  Fly  1008 PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARP 1072
            |...:|:||||||:|||:||||||||||||||||||||||:..:::..::||:::||||.|.|:|
Human  1482 PSPGYRMEMSIFYVVYFVVFPFFFVNIFVALIIITFQEQGDKMMEEYSLEKNERACIDFAISAKP 1546

  Fly  1073 LERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGM 1137
            |.|:||:|:.:|:|::|:.|||.||||.||.:|..||::||||::.....||.:|:..|:.||.:
Human  1547 LTRHMPQNKQSFQYRMWQFVVSPPFEYTIMAMIALNTIVLMMKFYGASVAYENALRVFNIVFTSL 1611

  Fly  1138 FSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG--SNSINVGFLRLFRAARLIKL 1200
            ||:|.|||::.||:.|:|:|.|||||.:||||||.|.|..|||  :|.||:.|||||||||||||
Human  1612 FSLECVLKVMAFGILNYFRDAWNIFDFVTVLGSITDILVTEFGNPNNFINLSFLRLFRAARLIKL 1676

  Fly  1201 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTV-------ENSITRH 1258
            ||||||||||||||||||||||||||||||||||||||||||||||.:...       |..||.|
Human  1677 LRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIGIDVEDEDSDEDEFQITEH 1741

  Fly  1259 NNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSF 1323
            |||::|.|.:|||||.||||||.||||:||.||.||.::.....| ||:..||.|||||||.|||
Human  1742 NNFRTFFQALMLLFRSATGEAWHNIMLSCLSGKPCDKNSGILTRE-CGNEFAYFYFVSFIFLCSF 1805

  Fly  1324 LMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGF 1388
            ||||||||||||||:||||||||||.|||||:||:||||||.|.|::.|.:||.||::|.||||.
Human  1806 LMLNLFVAVIMDNFEYLTRDSSILGPHHLDEYVRVWAEYDPAAWGRMPYLDMYQMLRHMSPPLGL 1870

  Fly  1389 GNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNI 1452
            |.|||.|:|||:|:||::|:.|:..|.|.:||.||||..|.||: :...:..|.|.|||:.:..|
Human  1871 GKKCPARVAYKRLLRMDLPVADDNTVHFNSTLMALIRTALDIKIAKGGADKQQMDAELRKEMMAI 1935

  Fly  1453 WPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDAS----- 1512
            ||..::|.|:|||.|....:   |:||||||..:|:|.:|.::..:|.:   |.|.||.:     
Human  1936 WPNLSQKTLDLLVTPHKSTD---LTVGKIYAAMMIMEYYRQSKAKKLQA---MREEQDRTPLMFQ 1994

  Fly  1513 ----RHPSQESLTGADA---GHLHPGHSYM---NGHRRSPSLRHNGSPLARSPSPRRRGHQYIHH 1567
                ..|:||...|.:|   ..|.||.:.|   :|.:.|||.                       
Human  1995 RMEPPSPTQEGGPGQNALPSTQLDPGGALMAHESGLKESPSW----------------------- 2036

  Fly  1568 DIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSASTSPARSPSPSRYGGHLSRSKRTQLPYP 1632
                  ......||.::|              |:||....|.                 |.:|  
Human  2037 ------VTQRAQEMFQKT--------------GTWSPEQGPP-----------------TDMP-- 2062

  Fly  1633 TYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQHSYPTLASRRAGIGRRLPPTPSKPS 1697
                       .|...::..||||..|.||      :..:|..|.....||.   .:|..|::..
Human  2063 -----------NSQPNSQSVEMREMGRDGY------SDSEHYLPMEGQGRAA---SMPRLPAENQ 2107

  Fly  1698 TLQLKPTNINFPKL-NASPTHTHHSTPHSVHSLPHHRDLLRDPRDMYYSSRERERDRERLRDRDR 1761
            ..:.:|...|...: :.||.....|...     |..|.|     |.|  |.||....|..|...|
Human  2108 RRRGRPRGNNLSTISDTSPMKRSASVLG-----PKARRL-----DDY--SLERVPPEENQRHHQR 2160

  Fly  1762 DRDRD-RLHEYDL-RYEYRD-----------RERELYERERDREREVERERLEYIAPLSFEQALA 1813
            .|||. |..|..| ||...|           :..:|..:|||:||                    
Human  2161 RRDRSHRASERSLGRYTDVDTGLGTDLSMTTQSGDLPSKERDQER-------------------- 2205

  Fly  1814 MGRTGRVLPSPVLNGFKPKSGLNPRH----------SDSDEEDWCXQRLXLRSRNRKDQIW---- 1864
                ||           ||...:.:|          ...|::.:. :|. ......:||.|    
Human  2206 ----GR-----------PKDRKHRQHHHHHHHHHHPPPPDKDRYAQERPDHGRARARDQRWSRSP 2255

  Fly  1865 ------VXHQAICSSLS---APNLDHNFDTIRHSYQIPE-------HLQNLPYL------CPPVH 1907
                  : |:...||:|   ||:........|...|:|:       |:...|.:      .||..
Human  2256 SEGREHMAHRQGSSSVSGSPAPSTSGTSTPRRGRRQLPQTPSTPRPHVSYSPVIRKAGGSGPPQQ 2320

  Fly  1908 QHQHQHQTQTQNQRQHQDQHLYQRYGTNVSTPKLGTTISDIKLAGVSLQEL----------SPNR 1962
            |.|.|.|.|.|                .|:.|....|....:..|.:.:.|          |..|
Human  2321 QQQQQQQQQQQ----------------AVARPGRAATSGPRRYPGPTAEPLAGDRPPTGGHSSGR 2369

  Fly  1963 QPQSQQK-------QEQQLHQDGWLRWYRQSGPY-----------------------------GS 1991
            .|:.:::       :..:..:.|..|| ..|||:                             |.
Human  2370 SPRMERRVPGPARSESPRACRHGGARW-PASGPHVSEGPPGPRHHGYYRGSDYDEADGPGSGGGE 2433

  Fly  1992 PVMASLPETRATSPHSDIEFIRTMKRSETGTTAITPRTTKTEAMILSVP 2040
            ..||...:  |..|         ::.:.:|.|..:|||.:......:.|
Human  2434 EAMAGAYD--APPP---------VRHASSGATGRSPRTPRASGPACASP 2471

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 190/286 (66%)
Ion_trans 441..677 CDD:334124 190/236 (81%)
Ion_trans 769..1050 CDD:334124 187/280 (67%)
Ion_trans 1094..1345 CDD:334124 173/259 (67%)
GPHH 1346..1416 CDD:339854 42/69 (61%)
Ca_chan_IQ 1418..1492 CDD:337190 32/74 (43%)
CACNA1ANP_075461.2 I 85..363 189/290 (65%)
Ion_trans 115..371 CDD:278921 176/268 (66%)
Binding to the beta subunit. /evidence=ECO:0000250 383..400 13/16 (81%)
II 473..717 192/243 (79%)
Ion_trans 504..725 CDD:278921 180/220 (82%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 822..1224 26/401 (6%)
III 1234..1517 188/286 (66%)
Ion_trans 1264..1523 CDD:278921 177/262 (68%)
Ion_trans 1586..1827 CDD:278921 163/241 (68%)
GPHH 1835..1898 CDD:293510 36/62 (58%)
Ca_chan_IQ 1900..1974 CDD:285917 33/76 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1994..2037 13/71 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2049..2512 105/537 (20%)
polyglutamine repeat 2319..2331 5/11 (45%)
Peptidase_C53 2352..>2424 CDD:283255 10/72 (14%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 386 1.000 Domainoid score I807
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1856 1.000 Inparanoid score I62
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 1 1.000 - - X841
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1312.860

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