DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cac and Catsper3

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001239416.1	Gene:	Catsper3 / 76856	MGIID:	1924106	Length:	395	Species:	Mus musculus

Alignment Length:	399	Identity:	81/399 - (20%)
Similarity:	174/399 - (43%)	Gaps:	71/399 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   425 RAEKRFRFWIRHTVKTQWFYWFVIVLVFLNT-VCVAVEHYG-QPSFLTEFLYYAEFIFLGLFMSE 487
            |.:|..:.:.|..:|:.:|...:|..|..|: :.|...:|. |..|...| ..:|..|:.:::.|
Mouse    34 RKDKECQAYFRKVIKSTFFQIVMITTVTTNSFLLVLGTNYDIQFEFFRTF-EVSELFFVSVYVCE 97

  Fly   488 MFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGG-SFGLSVLRALRLLRIFKVTKYWS 551
            ..:|:| :.|..|::..:|..|.:::.......:..::||. |..|.....::.|||.|:..|..
Mouse    98 FLMKVY-VDPITYWKDGYNILDVIILIILTIPYLLRKIKGNHSAYLHFADGIQSLRILKLISYSR 161

  Fly   552 SLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFG----GQFNLPGGTPETNFNTFPIALL 612
            .:|.|:|::..::.::.|:|.||||.:.:||:||..|||    |...        |:.....|..
Mouse   162 GIRTLIIAVGETVYTVASVLTLLFLLMFVFAILGFCLFGVTDRGDLE--------NWGNLASAFF 218

  Fly   613 TVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANA---- 673
            |:|.:.|.:.|.::.     .:...:|..:...:.|:.:|..::..||:|:.:.:.:..::
Mouse   219 TLFSLATVDGWTDLQ-----EELDKRKFTVSRAFTILFILLASFIFLNMFVGVMIMHTEDSMKKF 278

  Fly   674 -QELTAAEEEQVEEDKEKQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEVT 737
             ::||......:.|:|:..|:..::|:..|.                    ..::.......::.
Mouse   279 ERDLTLERNLAIMEEKQIILKRQQEEVNRLM--------------------NTQKSGSMNFIDMV 323

  Fly   738 EGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIM------VVIS---------MSSIALA 787
            ||.|..|.::...:|.         .:..:|.:.|.:::      |::|         ::.::|.
Mouse   324 EGFKKTLRHTDPMVLD---------DFSTSLSFIDIYLVTLDNQDVIVSKLQELYCEIVNVLSLM 379

  Fly   788 AEDPVRENS 796
            .||..:|:|
Mouse   380 LEDMPKESS 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124
		Ion_trans	441..677	CDD:334124	56/247 (23%)
		Ion_trans	769..1050	CDD:334124	8/43 (19%)
		Ion_trans	1094..1345	CDD:334124
		GPHH	1346..1416	CDD:339854
		Ca_chan_IQ	1418..1492	CDD:337190
Catsper3	NP_001239416.1	Ion_trans	49..269	CDD:366146	56/234 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900