DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1s

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_446325.1 Gene:Cacna1s / 682930 RGDID:70983 Length:1850 Species:Rattus norvegicus


Alignment Length:1834 Identity:779/1834 - (42%)
Similarity:1053/1834 - (57%) Gaps:272/1834 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 PTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAY 79
            |.:||.||..||:||....::||.|||..:||||.||||.||:...:|..|...|...|||.|.:
  Rat    28 PRALFCLTLQNPLRKACISVVEWKPFETIILLTIFANCVALAVYLPMPEDDNNTLNLGLEKLEYF 92

  Fly    80 FLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQ-YPQI-------------GP 130
            ||.:|.:||::||:|.|.:.|:.:|||:.||::||.:|..|..|. ..|:             |.
  Rat    93 FLIVFSIEAAMKIIAYGFLFHQDAYLRSGWNVLDFIIVFLGVFTAILEQVNIIQTNTAPMSSKGA 157

  Fly   131 EVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGAL 195
            .:|::.|||.||||||:||||:|||||||.||.|||.||..|.|||||.::|:||||||.:.|.:
  Rat   158 GLDVKALRAFRVLRPLRLVSGVPSLQVVLNSIFKAMLPLFHIALLVLFMVIIYAIIGLELFKGKM 222

  Fly   196 HKTCYSLEDPNKLVKEGESETPCNTDNILEKATGS-FVCNNTTSMCLEKWEGPNSGITSFDNIGF 259
            |||||.:........|.|..:||       ..||| ..|....|.|...|.|||.|||.|||.||
  Rat   223 HKTCYFIGTDIVATVENEKPSPC-------ARTGSGRPCTINGSECRGGWPGPNHGITHFDNFGF 280

  Fly   260 AMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVE 324
            :||||:|||:|||||.:|||.|||:|:.:.|||||.||::||||:||||||||||||.|||||.:
  Rat   281 SMLTVYQCISMEGWTDVLYWVNDAIGNEWPWIYFVTLILLGSFFILNLVLGVLSGEFTKEREKAK 345

  Fly   325 NRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGK 389
            :|..|.|||.:||||.:|.||:.||             |:.|.|.:.:.|.            ||
  Rat   346 SRGTFQKLREKQQLEEDLRGYMSWI-------------TQGEVMDVDDLRE------------GK 385

  Fly   390 SKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKR-FRFWIRHTVKTQWFYWFVIVLVFL 453
             .|.|....:.|..|..:|..|..     .....||...| ||:.....||::.|||.||::|.|
  Rat   386 -LSLDEGGSDTESLYEIEGLNKII-----QFIRHWRQWNRVFRWKCHDLVKSKVFYWLVILIVAL 444

  Fly   454 NTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF 518
            ||:.:|.||:.||.:||.....|..:.|.||..||.:|||.||.|.||.|.||||||.|:...|.
  Rat   445 NTLSIASEHHNQPLWLTHLQDVANRVLLALFTIEMLMKMYGLGLRQYFMSIFNRFDCFVVCSGIL 509

  Fly   519 EVIWSEVKGGS---FGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILI 580
            |::.  |:.|:   .|:||||.:||||:||:||||:||.|||.|||||:|||.|||.|||||::|
  Rat   510 EILL--VESGAMTPLGISVLRCIRLLRLFKITKYWTSLSNLVASLLNSIRSIASLLLLLFLFMII 572

  Fly   581 FALLGMQLFGGQFNLPG-GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG-AQKGMIY 643
            |||||||||||:::... ....:||:.||.||::|||:|||||||.|||.||::.|| :..|::.
  Rat   573 FALLGMQLFGGRYDFEDTEVRRSNFDNFPQALISVFQVLTGEDWNSVMYNGIMAYGGPSYPGVLV 637

  Fly   644 SIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQL-----QELEKEMEALQ 703
            .||||:|.:.|||.||||||||||||||.|:.||:|::.:.||.|.:::     .:.|:|...:.
  Rat   638 CIYFIILFVCGNYILLNVFLAIAVDNLAEAESLTSAQKAKAEERKRRKMSRGLPDKSEEERSTMT 702

  Fly   704 ADGVHVENGDGAVAPSKSKGKKKE-----------------EEKKEEEEVTEGPKPM-------- 743
            ........|:|....:|.|..:.|                 :::::|.|:...|:|.        
  Rat   703 KKLEQKPKGEGIPTTAKLKIDEFESNVNEVKDPYPSADFPGDDEEDEPEIPASPRPRPLAELQLK 767

  Fly   744 -----LP-YSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKIL 802
                 :| .||.||.||||.||...|.:||..:|..||::.|.:||.|||||||:|.:|.||:||
  Rat   768 EKAVPIPEASSFFIFSPTNKIRVLCHRIVNATWFTNFILLFILLSSAALAAEDPIRADSMRNQIL 832

  Fly   803 NYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLS 867
            .||||.||.|||:|::||:...|..||.||:.|.::||:|.:||..:.:|.|.:.|.      :|
  Rat   833 EYFDYVFTAVFTVEIVLKMTTYGAFLHKGSFCRNYFNILDLLVVAVSLISMGLESSA------IS 891

  Fly   868 TIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFY 932
            .:|.||||||||||:.|.|...||.|..||..:::.:.||::|..|.||:|:.||||||.|||:.
  Rat   892 VVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIRTIGNIVLVTTLLQFMFACIGVQLFKGKFYS 956

  Fly   933 CTDESKHTSAECQGSYFKYEED-----ELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWP 992
            |.|.||.|..||:|.|:.|::.     ||.|:|    |....||:|||.:||::||.|.|.||||
  Rat   957 CNDLSKMTEEECRGYYYIYKDGDPTQIELRPRQ----WIHNDFHFDNVLSAMMSLFTVSTFEGWP 1017

  Fly   993 QVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAELQDGEID 1057
            |:|..::.:..||.||:.|.|:||:||:|:|.|:..||.:||||..:|:|||||||.|.::.|:|
  Rat  1018 QLLYKAIDSNEEDTGPVYNNRVEMAIFFIIYIILIAFFMMNIFVGFVIVTFQEQGETEYKNCELD 1082

  Fly  1058 KNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDM 1122
            |||:.|:.:.:.||||..|:||  |.::|:||.:|.|:.|||.:..||:.||:.|.|:::||.:.
  Rat  1083 KNQRQCVQYALKARPLRCYIPK--NPYQYQVWYVVTSSYFEYLMFALIMLNTICLGMQHYNQSEQ 1145

  Fly  1123 YEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWMEFG------- 1180
            .......:|:.||.:|::|.:||:|.|..:.:|.||||:||.:.|:|||:|.:..|..       
  Rat  1146 MNHISDILNVAFTIIFTLEMILKLIAFKPRGYFGDPWNVFDFLIVIGSIIDVILSEIDTLLASSG 1210

  Fly  1181 ----------------SNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIA 1229
                            |..|:..|.||||..||||||.:...:|.|||||::||:|||||.|||.
  Rat  1211 GLYCLGGGCGNVDPDESARISSAFFRLFRVMRLIKLLSRAEGVRTLLWTFIKSFQALPYVALLIV 1275

  Fly  1230 MLFFIYAIIGMQVFGNIKL--GTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA 1292
            |||||||:||||:||.|.:  ||   .|.|:||||:|.|.|:|||||||||||..|:|||..||.
  Rat  1276 MLFFIYAVIGMQMFGKIAMVDGT---QINRNNNFQTFPQAVLLLFRCATGEAWQEILLACSYGKR 1337

  Fly  1293 CDDDAEKAPGE--YCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEF 1355
            ||.:::.||||  .||:..||.||:||...|:||::|||||||||||||||||.||||.||||||
  Rat  1338 CDPESDYAPGEEYACGTNFAYYYFISFYMLCAFLIINLFVAVIMDNFDYLTRDWSILGPHHLDEF 1402

  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTL 1420
            ..|||||||.|.|:|.:.::..:|:.:.||||||..||:|:|.|:|:.|||||:.:..|.|..||
  Rat  1403 KAIWAEYDPEAKGRIKHLDVVTLLRRIQPPLGFGKFCPHRVACKRLVGMNMPLNSDGTVTFNATL 1467

  Fly  1421 FALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGF 1485
            |||:|..|.||...  ..:||:.|||..|..||...:.|:|:.::||   :...:::|||.||.|
  Rat  1468 FALVRTALKIKTEG--NFEQANEELRAIIKKIWKRTSMKLLDQVIPP---IGDDEVTVGKFYATF 1527

  Fly  1486 LILESWRSTR------------------------------------------------------- 1495
            ||.|.:|...                                                       
  Rat  1528 LIQEHFRKFMKRQEEYYGYRPKKDTVQIQAGLRTIEEEAAPEIHRAISGDLTAEEELERAMVEAA 1592

  Fly  1496 ------------FGQLDS-----------------------GMPMLE----LQDASRHPSQESLT 1521
                        |||:|:                       .|..||    |:|..::|....|.
  Rat  1593 MEEGIFRRTGGLFGQVDNFLERTNSLPPVMANQRPLQFAEMEMEELESPVFLEDFPQNPGTHPLA 1657

  Fly  1522 GADAGHLHPGHSYMN-GHRRSP---SLRHNGSPLARSPSPRRRGHQYIH----HDIGFSDTVSNV 1578
            .|:..:.:...:|.| .||.||   |:|:....|..:..|..|...:..    ..:.....|..:
  Rat  1658 RANTNNANANVAYGNSSHRNSPVFSSIRYERELLEEAGRPVTREGPFSQPCSVSGVNSRSHVDKL 1722

  Fly  1579 VEMVKETRHPR----------HGNSHPRYPRG----SWSASTSPARSPSPSRYGGHLSRSKRTQL 1629
            ...:.:.|.|:          ....||.:..|    |||..||.:.|     :...:.|:...:.
  Rat  1723 ERQMSQRRMPKGQVPPSPCQLSQEKHPVHEEGKGPRSWSTETSDSES-----FEERVPRNSAHKC 1782

  Fly  1630 PYPTYGTTSLCQRS 1643
            ..|  .||.|.|.:
  Rat  1783 TAP--ATTMLIQEA 1794

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 159/301 (53%)
Ion_trans 441..677 CDD:334124 137/240 (57%)
Ion_trans 769..1050 CDD:334124 139/285 (49%)
Ion_trans 1094..1345 CDD:334124 139/277 (50%)
GPHH 1346..1416 CDD:339854 38/69 (55%)
Ca_chan_IQ 1418..1492 CDD:337190 30/73 (41%)
Cacna1sNP_446325.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..23
I. /evidence=ECO:0000305 38..337 157/305 (51%)
Ion_trans 50..345 CDD:306908 159/301 (53%)
Selectivity filter of repeat I. /evidence=ECO:0000250|UniProtKB:P07293 290..293 1/2 (50%)
Binding to the beta subunit. /evidence=ECO:0000250|UniProtKB:Q02789 357..374 10/29 (34%)
II. /evidence=ECO:0000305 418..664 138/247 (56%)
Ion_trans 431..672 CDD:306908 138/242 (57%)
Selectivity filter of repeat II. /evidence=ECO:0000250|UniProtKB:P07293 612..615 2/2 (100%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 673..717 8/43 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 731..758 3/26 (12%)
III. /evidence=ECO:0000305 786..1068 138/291 (47%)
Ion_trans 798..1075 CDD:306908 139/286 (49%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 988..1077 47/92 (51%)
Selectivity filter of repeat III. /evidence=ECO:0000250|UniProtKB:P07293 1012..1015 1/2 (50%)
IV. /evidence=ECO:0000305 1105..1384 136/281 (48%)
Ion_trans 1117..1392 CDD:306908 139/277 (50%)
Selectivity filter of repeat IV. /evidence=ECO:0000250|UniProtKB:P07293 1321..1324 2/2 (100%)
Dihydropyridine binding. /evidence=ECO:0000250|UniProtKB:P07293 1337..1403 43/65 (66%)
Phenylalkylamine binding. /evidence=ECO:0000250|UniProtKB:P07293 1349..1391 27/41 (66%)
GPHH 1393..1463 CDD:318993 38/69 (55%)
Ca_chan_IQ 1465..1536 CDD:312334 31/75 (41%)
Interaction with calmodulin. /evidence=ECO:0000250|UniProtKB:Q13698 1522..1542 8/19 (42%)
CAC1F_C 1558..1838 CDD:318975 41/244 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1697..1779 15/86 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
65.720

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