DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and Scn7a

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001375437.1	Gene:	Scn7a / 64155	RGDID:	61922	Length:	1680	Species:	Rattus norvegicus

Alignment Length:	1697	Identity:	409/1697 - (24%)
Similarity:	750/1697 - (44%)	Gaps:	311/1697 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ILTEDNPIRKYTRFIIE---WPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||...:|:....|.:|:   .|.|...:|::::.:.:::.: .:||   :.:||  :|.|   .|
  Rat    97 ILCTLSPLSSLRRAVIKVLVHPLFRLLILISVLTDSILMCM-SNLP---EWILA--VENT---LL 152

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|..:|::|.|:.....|:|.::||.:||.|.:...:|:...:......:|:|.:|:|:.:
  Rat   153 GIYTFEILVKVIARGIWAGSFSFLGDLWNWLDFSVTLFELITRSSPLSSLPMFKTIRTLRILKII 217

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC--YSLEDPNKLV 209
            .|..|:.|:.|.|   ::.:..||....|.||.:.:.::.|:..:.|.|...|  :..||.|.::
  Rat   218 PLNHGLQSIVVTL---VQCLKKLLGAIALALFFLTVSSLFGMGLFMGNLKHKCVRWPQEDGNDVM 279

  Fly   210 KEGESETPCNTDNILEK--------ATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNIG 258
            ..|..    :..:|||:        |..:.:|.|.|.        ||:::...|::|.|||||.|
  Rat   280 YNGTG----SQYHILERENFYYMEGARYALLCGNKTDAGLCPEGYMCVKEGSNPDNGFTSFDNFG 340

  Fly   259 FAMLTVFQCITMEG----WTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKE 319
            :|:|.:|:.:|.:.    :..|||    |.|..: .|:||.:....:|:|.:|.||:|:..:.:|
  Rat   341 WALLAMFRLMTQDYPELLYHQILY----ASGKIY-MIFFVLISFWFAFYMASLFLGILTMAYEQE 400

  Fly   320 REKVENRQEFLKLRRQQ---QLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKR 381
            :::.......:..:..|   :.|.|..|             ||..||:      :|.::|:....
  Rat   401 KQRASEESRDMDSKCHQTVKEFEEEHEG-------------AEMETTQ------IEMKKRSPTSI 446

  Fly   382 KKL------KSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGFWRAEKRF--RFWIRHTV 438
            ...      .:||..:..:|..:|....:    |..|::.....|:..|.....|  |. |.|.:
  Rat   447 NTTLDILEDTALGHKEEPETSRKECPLCW----YKFTKTCFIWKCSPCWIKLNEFADRI-ITHPL 506

  Fly   439 KTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFES 503
                |..|:::.:.||...:|:||:.....|...|.....:|:|::..||.:|:.|:.|..||:.
  Rat   507 ----FDLFLVICIILNICFLALEHFPMSEELMSLLAIGNLVFIGIYTIEMILKIIAMHPYGYFQI 567

  Fly   504 SFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSII 568
            |::.||.:::...:.|::.::::    .::|...:.|:.| |:.||....:||:..|..::.::.
  Rat   568 SWHIFDSILVVLGLTEMLLADIE----EITVFILVPLIFI-KLGKYAPPFKNLMRILGRALVALK 627

  Fly   569 SLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEV 626
            .|:.|:.:||...|:.||:|||..:       :........:.:.|..|.:|||:||.|| |.|.
  Rat   628 DLVLLVSIFIYFSAVFGMKLFGRSYKDCVCHVDQDCQRQRWHMSDFLHAYVTVFRILCGE-WIET 691

  Fly   627 MYQGIISQGGAQKGMIYSI-YFIVLVLFGNYTLLNVFLAIA-----------VDNLANAQELTAA 679
            :::.:...|.|     :.| ::::::|.||..:|.:|:|:.           |...|...:|..|
  Rat   692 LWECMEVAGEA-----WCIPFYMMVILIGNLLILYLFVALVSSFASYDATTEVSKEAKNLQLAVA 751

  Fly   680 ---------------EEEQVEEDKEKQ--------------LQEL-------------------- 695
                           :|:.|..:...|              |.||
  Rat   752 WIKMVINCVLLKILCKEKTVSTEATDQTCDPSVKENISGHTLSELSNTQTFLRYKDQSSGTEKTP 816

  Fly   696 --EKEMEAL---------------QADGVHVENGDGAVAPSKS-KGKKKEEEK------------ 730
              |.|.::|               ::|   :||.|.....||| .|..||:.|
  Rat   817 VTESESQSLIASPSVSETVPIASGESD---IENLDNKETRSKSANGSSKEKMKQSSSSECSTVDI 878

  Fly   731 ---KEEEEVTEGPKPMLPYSSMFILSPTNPI----RRGAHW---------VVNLPYFDFFIMVVI 779
               :|||.|.|..|..|..:.....|....:    |.|..|         :|...:|:.||.:|.
  Rat   879 AISEEEEMVYEHEKSKLHKNGYERKSSAGQVSRESRNGKIWRNIRKTCCKIVENSWFECFIGLVT 943

  Fly   780 SMSSIALAAEDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDA 843
            .:.:..||.||...:..:..|| |.|.|..|..:|.:|||||.|..|.    .:|....|..:|.
  Rat   944 LLCTGTLALEDIYIDQRKTIKIFLEYGDMIFAYIFILEMLLKWVAYGF----KAYFSNNWYKLDF 1004

  Fly   844 VVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNIL 908
            :|||...:|    :.|.:. ::|:.:.|::.||.||.|...:|   :|.|...::.:....|::.
  Rat  1005 MVVIVLCLS----LIGKTR-EDLNPLASIKFLRALRVLSQFER---MKVVLRALIKTTLPAVSVF 1061

  Fly   909 IVYILFQFIFSVIGVQLFNGKFFYCTDESK---------HTSAECQGSYFKYEEDELLPKQELRV 964
            :|.::...:|||:||.||.|||:.|.|.::         ...::|:...|    :|.:|
  Rat  1062 LVCLMIWLLFSVMGVFLFAGKFYECIDPTRGERFSVFEVMNKSQCENLVF----NESMP------ 1116

  Fly   965 WKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPF 1029
            |:....::|||....|:||.|.|..||..::..::.:......|.....:.|..::|: |:||..
  Rat  1117 WENAKLNFDNVGNGFLSLFQVATFNGWISIMNSAIDSVGVYMQPSFEHSLHMYTYFII-FVVFGL 1180

  Fly  1030 FF-VNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPK------------NR 1081
            |. :.:.:.:||..|.:|   :::.|      .|.|..|:..:...|.:.|            .|
  Rat  1181 FLPLCMLIGVIIRNFNKQ---KIKQG------GSNIFITVKQKKQYRALKKLLYADSQKPAARPR 1236

  Fly  1082 NTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKI 1146
            |.|:..:..:|....|...|::||.|....:|::...|....|.::.::|..||.:|::|.:||:
  Rat  1237 NKFQGFICDVVTHRVFNVIIILLICFQATTIMIQNDEQSPQIETAVFWMNSLFTMLFTLECILKL 1301

  Fly  1147 IGFGVKNFFKDPWNIFDLITVLGSIVDALW-MEFGSNSINVGFLRLFRAARLIKLLRQGYTIRI- 1209
            ..|.. ::|...||:.|.:.|:.||...|. :..|...:....::|...:|:|.:||.|...::
  Rat  1302 TAFRC-HYFTSAWNVHDFMVVVFSITGLLLPLSIGQYFVPPSLVQLLLLSRIIHVLRPGKGPKVF 1365

  Fly  1210 --LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLF 1272
              |:...:.|..||..:.|||.::.|||||.||..|..:|   .|..|...:||::|...::.||
  Rat  1366 HDLMLPLMLSLPALLNIALLIFLVMFIYAIFGMYNFAYVK---KEAGINDVSNFETFGSSMLCLF 1427

  Fly  1273 RCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVA 1331
            :..|...|..::.|....:..|.|.:|. ||..    ||| ::...||||:|.....:::|::|.
  Rat  1428 QVTTFSGWDGMLDAIFNSQWSDCDPDKINPGTQVRGDCGSPSVGIFYFVSYILISWLIIVNMYVV 1492

  Fly  1332 VIMDNFDYLT----RDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKC 1392
            :||   ::|:    |.:..|.......|.::|..:||:.|..|..|::.|....:||||....
  Rat  1493 LIM---EFLSIPSKRKNRTLSEDDFRRFFKVWNRFDPDRTQYIDSTKLSDFAAALDPPLFMAK-- 1552

  Fly  1393 PNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQA 1457
            ||:   .:|:.|::|:....|:.....|.|..:..:....|.  |...:::|....:.|.:.:..
  Rat  1553 PNK---GQLVAMDLPMAAGDRIHCLDILLAFTKRVMGKDERV--EKILSEIESGFMLANPFKITY 1612

  Fly  1458 KKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPML-ELQDASRHPSQESLT 1521
            :       |.:..|.:.:.:|    :..:|..:::|.|..|.|..:..: |:.|....|:.:
  Rat  1613 E-------PITTTLKRKQEAV----SATIIQRAYKSYRLRQSDKKIQDIPEIDDGREDPNSK--- 1663

  Fly  1522 GADAGHL 1528
            |..:|.:
  Rat  1664 GVHSGQI 1670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	81/308 (26%)
		Ion_trans	441..677	CDD:334124	63/254 (25%)
		Ion_trans	769..1050	CDD:334124	80/291 (27%)
		Ion_trans	1094..1345	CDD:334124	76/264 (29%)
		GPHH	1346..1416	CDD:339854	19/69 (28%)
		Ca_chan_IQ	1418..1492	CDD:337190	10/73 (14%)
Scn7a	NP_001375437.1	Ion_trans	117..405	CDD:395416	81/308 (26%)
		Ion_trans	504..738	CDD:395416	62/248 (25%)
		Na_trans_assoc	742..926	CDD:399489	34/186 (18%)
		Ion_trans	932..1203	CDD:395416	80/296 (27%)
		Na_channel_gate	1194..1245	CDD:240441	11/59 (19%)
		Ion_trans	1249..1496	CDD:395416	74/253 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910