DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and SCN10A

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_005265428.1	Gene:	SCN10A / 6336	HGNCID:	10582	Length:	1959	Species:	Homo sapiens

Alignment Length:	1854	Identity:	446/1854 - (24%)
Similarity:	765/1854 - (41%)	Gaps:	493/1854 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGGPKKEENPPGGGPTSLFILTEDNPIRKY--TRFIIEWPPFEYA-------------------V 44
            :|.|.::.:|......:..:|.:...|.::  ||.:..:.||...                   :
Human    75 IGEPLEDLDPFYSTHRTFMVLNKGRTISRFSATRALWLFSPFNLIRRTAIKVSVHSYPLWFSLFI 139

  Fly    45 LLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIW 109
            .:||:.|||.:...: ||           ||.|..|..|:..||.:||||.|..|::.:|||:.|
Human   140 TVTILVNCVCMTRTD-LP-----------EKIEYVFTVIYTFEALIKILARGFCLNEFTYLRDPW 192

  Fly   110 NIMDFFVVVTGFMTQYPQIGPEVDLR---TLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQ 171
            |.:||.|:...:      :|..:|||   .||..||||.||.||.||.|:|::.::|.::..|..
Human   193 NWLDFSVITLAY------VGTAIDLRGISGLRTFRVLRALKTVSVIPGLKVIVGALIHSVKKLAD 251

  Fly   172 IGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKATGS---FVC 233
            :.:|.:|.:.:||::||:.:.|.|...|..   .:..|.|..:.:.....:|.....|:   .:|
Human   252 VTILTIFCLSVFALVGLQLFKGNLKNKCVK---NDMAVNETTNYSSHRKPDIYINKRGTSDPLLC 313

  Fly   234 NNTTS--------MCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNW 290
            .|.:.        :||:..:.|:...||||:..:|.|::|:.:|.:.|..:...|....|..: .
Human   314 GNGSDSGHCPDGYICLKTSDNPDFNYTSFDSFAWAFLSLFRLMTQDSWERLYQQTLRTSGKIY-M 377

  Fly   291 IYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEV 355
            |:||.:|.:|||:::||:|.|::..:.::.:...:..|..:.:.|:.|        |.:.|.:||
Human   378 IFFVLVIFLGSFYLVNLILAVVTMAYEEQNQATTDEIEAKEKKFQEAL--------EMLRKEQEV 434

  Fly   356 ILA--------------------------------EERTTEEEKMHIMEARRRNAAKRKKLKSLG 388
            :.|                                .|.:||:.|     :.|.:...::::..||
Human   435 LAALGIDTTSLHSHNGSPLTSKNASERRHRIKPRVSEGSTEDNK-----SPRSDPYNQRRMSFLG 494

  Fly   389 ----------------KSKSTDTEEEEAEED--------------------YGDDGYLKTRSKPQ 417
                            :|...|....|...|                    .|..|.|.....||
Human   495 LASGKRRASHGSVFHFRSPGRDISLPEGVTDDGVFPGDHESHRGSLLLGGGAGQQGPLPRSPLPQ 559

  Fly   418 GS-------------------------CTGFWRAEKR-----------FR--------------- 431
            .|                         .:.|...:|:           ||
Human   560 PSNPDSRHGEDEHQPPPTSELAPGAVDVSAFDAGQKKTFLSAEYLDEPFRAQRAMSVVSIITSVL 624

  Fly   432 ----------------------------FWIRHTVKTQWF--------YWFVIVLVFLNTVCVAV 460
                                        .|::  :||..|        ...:.:.:.:||:.:|:
Human   625 EELEESEQKCPPCLTSLSQKYLIWDCCPMWVK--LKTILFGLVTDPFAELTITLCIVVNTIFMAM 687

  Fly   461 EHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEV 525
            ||:|........|.....:|...|.:||..|:.|..|..||:..:|.|||::::.|:.|:  ...
Human   688 EHHGMSPTFEAMLQIGNIVFTIFFTAEMVFKIIAFDPYYYFQKKWNIFDCIIVTVSLLEL--GVA 750

  Fly   526 KGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFG 590
            |.||  |||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.:|||:|.||.|
Human   751 KKGS--LSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTIILAIIVFVFALVGKQLLG 813

  Fly   591 GQF-----NLPG---GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYF 647
            ..:     |:..   ..|..:.:.|..:.|.||:||.|| |.|.|: ..:..|  ||.:...::.
Human   814 ENYRNNRKNISAPHEDWPRWHMHDFFHSFLIVFRILCGE-WIENMW-ACMEVG--QKSICLILFL 874

  Fly   648 IVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE-------------QVEEDKEKQ-------- 691
            .|:|| ||..:||:|:|:.: |..:|..|||.|::             ||...:.||
Human   875 TVMVL-GNLVVLNLFIALLL-NSFSADNLTAPEDDGEVNNLQVALARIQVFGHRTKQALCSFFSR 937

  Fly   692 ----------------------------------------------------------------L 692
                                                                            :
Human   938 SCPFPQPKAEPELVVKLPLSSSKAENHIAANTARGSSGGLQAPRGPRDEHSDFIANPTVWVSVPI 1002

  Fly   693 QELEKEMEALQADG--------------------VHVEN-GDGAVAPSKSKGKKKEE------EK 730
            .|.|.:::.|:.||                    ..||. ||.....|...|...|:      |.
Human  1003 AEGESDLDDLEDDGGEDAQSFQQEVIPKGQQEQLQQVERCGDHLTPRSPGTGTSSEDLAPSLGET 1067

  Fly   731 KEEEEVTEGPKPMLPY-----------SSMFILSPTN---------------------------- 756
            .::|.|     |.:|.           |::..|.|..
Human  1068 WKDESV-----PQVPAEGVDDTSSSEGSTVDCLDPEEILRKIPELADDLEEPDDCFTEGCIRHCP 1127

  Fly   757 ---------------PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYF 805
                           .:|:..:.:|...:|:.||:.:|.:||.:||.||...:.....| :|.|.
Human  1128 CCKLDTTKSPWDVGWQVRKTCYRIVEHSWFESFIIFMILLSSGSLAFEDYYLDQKPTVKALLEYT 1192

  Fly   806 DYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIK 870
            |..||.:|..|||||.|..|.    ..|....|..:|.::|..:.:|....:...|   .::.||
Human  1193 DRVFTFIFVFEMLLKWVAYGF----KKYFTNAWCWLDFLIVNISLISLTAKILEYS---EVAPIK 1250

  Fly   871 SLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTD 935
            :||.||.||||:.:.|...::.|.|.:|.::.:::|:|:|.::|..|||::||.||.|||:.|.:
Human  1251 ALRTLRALRPLRALSRFEGMRVVVDALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFWRCIN 1315

  Fly   936 ESK-----------HTSAECQ-----GSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFA 984
            .:.           :..::|:     ||:|               |.....::||||...|.|..
Human  1316 YTDGEFSLVPLSIVNNKSDCKIQNSTGSFF---------------WVNVKVNFDNVAMGYLALLQ 1365

  Fly   985 VQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEA 1049
            |.|.:||..::..::.:...:..|.....:.|.::::::.|...||.:|:||.:||..|.:| :.
Human  1366 VATFKGWMDIMYAAVDSREVNMQPKWEDNVYMYLYFVIFIIFGGFFTLNLFVGVIIDNFNQQ-KK 1429

  Fly  1050 EL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTL 1110
            :|  ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:.||....|:..||:||..|.:
Human  1430 KLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKFQGFVFDIVTRQAFDITIMVLICLNMI 1494

  Fly  1111 LLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITVL------ 1168
            .:|::..:|.:...|.|..||..|..:|:.|.|:|:  |.::. :|.:.||:||.|.|:
Human  1495 TMMVETDDQSEEKTKILGKINQFFVAVFTGECVMKM--FALRQYYFTNGWNVFDFIVVVLSIASL 1557

  Fly  1169 --GSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAML 1231
              .:|:.:|...|......|  :||.|..|:::|:|....||.||:..:.|..||..:.||:.::
Human  1558 IFSAILKSLQSYFSPTLFRV--IRLARIGRILRLIRAAKGIRTLLFALMMSLPALFNIGLLLFLV 1620

  Fly  1232 FFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK--GKACD 1294
            .|||:|.||..|.:::.   |..|....|||:|...::.||:..|...|..::...|.  ...||
Human  1621 MFIYSIFGMSSFPHVRW---EAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCD 1682

  Fly  1295 DDAEKAPGEY--CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEF 1355
            .:...:.|..  ||| .:...:|.::|.....:|:|:::|||::||:..|.:|: .|.....|.|
Human  1683 PNLPNSNGTRGDCGSPAVGIIFFTTYIIISFLIMVNMYIAVILENFNVATEESTEPLSEDDFDMF 1747

  Fly  1356 VRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTL 1420
            ...|.::||.||..|.::.:.|....:..||....  |||   ..||:|::||....::.....|
Human  1748 YETWEKFDPEATQFITFSALSDFADTLSGPLRIPK--PNR---NILIQMDLPLVPGDKIHCLDIL 1807

  Fly  1421 FALIRENLSIKMRAPEEMD--QADMELRETITNI 1452
            ||..:..|.    ...|:|  :|:||.:...||:
Human  1808 FAFTKNVLG----ESGELDSLKANMEEKFMATNL 1837

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	90/319 (28%)
		Ion_trans	441..677	CDD:334124	79/251 (31%)
		Ion_trans	769..1050	CDD:334124	86/297 (29%)
		Ion_trans	1094..1345	CDD:334124	78/264 (30%)
		GPHH	1346..1416	CDD:339854	20/69 (29%)
		Ca_chan_IQ	1418..1492	CDD:337190	11/37 (30%)
SCN10A	XP_005265428.1	Ion_trans	150..410	CDD:278921	83/281 (30%)
		Na_trans_cytopl	466..>537	CDD:288761	11/75 (15%)
		Ion_trans	685..897	CDD:278921	75/221 (34%)
		Na_trans_assoc	907..1150	CDD:284034	25/247 (10%)
		Ion_trans	1172..1430	CDD:278921	80/280 (29%)
		Na_channel_gate	1422..1474	CDD:240441	12/52 (23%)
		Ion_trans	1496..1735	CDD:278921	72/245 (29%)
		GPHH	1745..1802	CDD:293510	19/61 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820