| Sequence 1: | NP_001356945.1 | Gene: | cac / 32158 | FlyBaseID: | FBgn0263111 | Length: | 2110 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_001352465.1 | Gene: | SCN9A / 6335 | HGNCID: | 10597 | Length: | 1988 | Species: | Homo sapiens |
| Alignment Length: | 1895 | Identity: | 475/1895 - (25%) |
|---|---|---|---|
| Similarity: | 825/1895 - (43%) | Gaps: | 475/1895 - (25%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
Fly 82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
Fly 147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY--SLEDPNKLV 209
Fly 210 KEGESETPCNTDN----------ILEKATGSFVCNNTTS--------MCLEKWEGPNSGITSFDN 256
Fly 257 IGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSG------- 314
Fly 315 ---EFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA---------------EER 361
Fly 362 TTEEEKMHIMEAR-RRNAAKR---KKLKS---------LGKSKSTD------------------- 394
Fly 395 ---------------------------------------TEEEEAEED---YGDD----GYLKTR 413
Fly 414 SKPQ------------------------------------------------------------- 417
Fly 418 --GS---------CTGFWRAEK-------RFRFWIRHTVKTQ---------------WF------ 443
Fly 444 -------YW--------FVI----------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGL 483
Fly 484 FMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTK 548
Fly 549 YWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNT 606
Fly 607 FPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLA 671
Fly 672 NAQELTAAEEE-------------------------------------------QVEEDKEKQ-- 691
Fly 692 ------LQELE------KEMEALQADGVHV-----ENGDG-------------AVAPSKSKGKKK 726
Fly 727 EEEKKEEEEVTEGPKPMLPYSSMFILSPT-NP--------------------------------- 757
Fly 758 --------------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFDY 807
Fly 808 AFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSL 872
Fly 873 RVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC---T 934
Fly 935 DESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSM 999
Fly 1000 AATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQGEAEL--QDGEIDKNQKS 1062
Fly 1063 CIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEK 1125
Fly 1126 SLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIV-----DALWMEFGSNSIN 1185
Fly 1186 VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGT 1250
Fly 1251 VENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TL 1309
Fly 1310 AYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYT 1373
Fly 1374 EMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEM 1438
Fly 1439 DQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGM 1503
Fly 1504 PMLELQDASR 1513 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| cac | NP_001356945.1 | Ion_trans | 37..324 | CDD:334124 | 92/316 (29%) |
| Ion_trans | 441..677 | CDD:334124 | 82/288 (28%) | ||
| Ion_trans | 769..1050 | CDD:334124 | 92/284 (32%) | ||
| Ion_trans | 1094..1345 | CDD:334124 | 84/261 (32%) | ||
| GPHH | 1346..1416 | CDD:339854 | 20/69 (29%) | ||
| Ca_chan_IQ | 1418..1492 | CDD:337190 | 13/73 (18%) | ||
| SCN9A | NP_001352465.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 26..55 | ||
| I. /evidence=ECO:0000305 | 112..410 | 91/316 (29%) | |||
| Ion_trans | 125..410 | CDD:306908 | 88/303 (29%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..543 | 16/81 (20%) | |||
| Na_trans_cytopl | 488..681 | CDD:314757 | 19/192 (10%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 565..611 | 9/45 (20%) | |||
| II. /evidence=ECO:0000305 | 726..989 | 86/272 (32%) | |||
| Ion_trans | 743..956 | CDD:306908 | 71/221 (32%) | ||
| Na_trans_assoc | 982..1187 | CDD:310839 | 26/204 (13%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1102..1148 | 9/45 (20%) | |||
| III. /evidence=ECO:0000305 | 1180..1488 | 100/318 (31%) | |||
| Ion_trans | 1191..1466 | CDD:306908 | 92/285 (32%) | ||
| Na_channel_gate | 1458..1510 | CDD:240441 | 10/52 (19%) | ||
| IV. /evidence=ECO:0000305 | 1497..1795 | 94/302 (31%) | |||
| Ion_trans | 1514..1770 | CDD:306908 | 84/260 (32%) | ||
| GPHH | 1774..1837 | CDD:318993 | 20/67 (30%) | ||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1934..1988 | ||||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 2 | 1.810 | |||||