DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and SCN8A

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001317189.1 Gene:SCN8A / 6334 HGNCID:10596 Length:1980 Species:Homo sapiens


Alignment Length:1922 Identity:477/1922 - (24%)
Similarity:810/1922 - (42%) Gaps:496/1922 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|:||:..|.||:....|:....|...::.||:.|||.:.. .:.|...|.|        |..|.
Human   111 ALYILSPFNLIRRIAIKILIHSVFSMIIMCTILTNCVFMTF-SNPPDWSKNV--------EYTFT 166

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||:|.|..:...::||:.||.:||.|::..::|::..:|   ::..||..||||.|
Human   167 GIYTFESLVKIIARGFCIDGFTFLRDPWNWLDFSVIMMAYVTEFVDLG---NVSALRTFRVLRAL 228

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKE 211
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|.           
Human   229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCV----------- 282

  Fly   212 GESETPCN-TDNILEKATGSF----------------------VCNNTTS--------MCLEKWE 245
               ..|.| .::.||..|..|                      :|.|::.        .|::...
Human   283 ---VWPINFNESYLENGTKGFDWEEYINNKTNFYTVPGMLEPLLCGNSSDAGQCPEGYQCMKAGR 344

  Fly   246 GPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLG 310
            .||.|.||||...:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.
Human   345 NPNYGYTSFDTFSWAFLALFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFVGSFYLVNLILA 408

  Fly   311 VLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA----------EERTTEE 365
            |::..:.::.:..        |...:|.|.|....:|.:.|.:|...|          .|...||
Human   409 VVAMAYEEQNQAT--------LEEAEQKEAEFKAMLEQLKKQQEEAQAAAMATSAGTVSEDAIEE 465

  Fly   366 E---------------KMHIMEAR-RRNAAKRKKLKSLG------------KSKSTD-------- 394
            |               |:....|: |||..|::|.|.|.            ||:|.|        
Human   466 EGEEGGGSPRSSSEISKLSSKSAKERRNRRKKRKQKELSEGEEKGDPEKVFKSESEDGMRRKAFR 530

  Fly   395 ------------------------------------------------TEEEEAEEDYG------ 405
                                                            :|.|.|::::.      
Human   531 LPDNRIGRKFSIMNQSLLSIPGSPFLSRHNSKSSIFSFRGPGRFRDPGSENEFADDEHSTVEESE 595

  Fly   406 ---DDGYLKTRSKPQGSC----TGFWRAEKRFRFW--IRHTVKTQ-------------------- 441
               |..::..|::.:.|.    :|:.:..:..|.:  :|.:||..                    
Human   596 GRRDSLFIPIRARERRSSYSGYSGYSQGSRSSRIFPSLRRSVKRNSTVDCNGVVSLIGGPGSHIG 660

  Fly   442 --------------------------------------------------------------WF- 443
                                                                          |: 
Human   661 GRLLPEATTEVEIKKKGPGSLLVSMDQLASYGRKDRINSIMSVVTNTLVEELEESQRKCPPCWYK 725

  Fly   444 ------------YWF------------------VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEF 478
                        ||.                  :.:.:.|||:.:|:||:.........|.....
Human   726 FANTFLIWECHPYWIKLKEIVNLIVMDPFVDLAITICIVLNTLFMAMEHHPMTPQFEHVLAVGNL 790

  Fly   479 IFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRI 543
            :|.|:|.:|||:|:.|:.|..||:..:|.||..::|.|:.|:..::|:    ||||||:.||||:
Human   791 VFTGIFTAEMFLKLIAMDPYYYFQEGWNIFDGFIVSLSLMELSLADVE----GLSVLRSFRLLRV 851

  Fly   544 FKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPE 601
            ||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:       |.....|.
Human   852 FKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINQDCELPR 916

  Fly   602 TNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAI- 665
            .:.:.|..:.|.||::|.|| |.|.|:..:...|.|    :..|.|:::::.||..:||:|||: 
Human   917 WHMHDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA----MCLIVFMMVMVIGNLVVLNLFLALL 976

  Fly   666 ----AVDNLANAQE---------------------------LTAAEEEQVEEDKEKQLQEL-EKE 698
                :.||||...:                           ...|..:|.|.|:.|.|.|| ||:
Human   977 LSSFSADNLAATDDDGEMNNLQISVIRIKKGVAWTKLKVHAFMQAHFKQREADEVKPLDELYEKK 1041

  Fly   699 MEA--------LQADGVHVENGDGAVA-------------------------------------- 717
            ...        :..:|...:||:|..:                                      
Human  1042 ANCIANHTGADIHRNGDFQKNGNGTTSGIGSSVEKYIIDEDHMSFINNPNLTVRVPIAVGESDFE 1106

  Fly   718 ------------PSKSKGKKKE---------EEKKEEEEV-TEGPKPMLPYSSMFILSPTNPIRR 760
                        |..||.|..:         :.|.|.||| .|.|:..|...:.|   ....::|
Human  1107 NLNTEDVSSESDPEGSKDKLDDTSSSEGSTIDIKPEVEEVPVEQPEEYLDPDACF---TEGCVQR 1168

  Fly   761 ------------GAHW---------VVNLPYFDFFIMVVISMSSIALAAED-PVRENSRRNKILN 803
                        |..|         :|...:|:.||:.:|.:||.|||.|| .:.:......||.
Human  1169 FKCCQVNIEEGLGKSWWILRKTCFLIVEHNWFETFIIFMILLSSGALAFEDIYIEQRKTIRTILE 1233

  Fly   804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLST 868
            |.|..||.:|.:|||||....|.:    .:....|..:|.::|..:.||...:..|.|   .|..
Human  1234 YADKVFTYIFILEMLLKWTAYGFV----KFFTNAWCWLDFLIVAVSLVSLIANALGYS---ELGA 1291

  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933
            |||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.||.||:.||
Human  1292 IKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKYHYC 1356

  Fly   934 TDESKHTSAECQGSYFKYEEDELLP--KQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQ 996
            .:|:.....|.:....|.|.::|:.  ..|:| ||....::|||.|..|.|..|.|.:||..:  
Human  1357 FNETSEIRFEIEDVNNKTECEKLMEGNNTEIR-WKNVKINFDNVGAGYLALLQVATFKGWMDI-- 1418

  Fly   997 HSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFFVNIFVALIIITFQEQ-----GEAELQ 1052
              |.|..:.|.|.:..:.|.:|:..:||::|    .||.:|:|:.:||..|.:|     |    |
Human  1419 --MYAAVDSRKPDEQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG----Q 1477

  Fly  1053 DGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMK 1115
            |..:.:.||...:.  .:|::..::.:|:..|..:..|:..|....|:..|||||..|.:.:|::
Human  1478 DIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKIQGIVFDFVTQQAFDIVIMMLICLNMVTMMVE 1542

  Fly  1116 YHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITVLGSIV-----DA 1174
            ...|....|..|.:||:.|...|:.|.|||:  |.::: :|...|||||.:.|:.|||     |.
Human  1543 TDTQSKQMENILYWINLVFVIFFTCECVLKM--FALRHYYFTIGWNIFDFVVVILSIVGMFLADI 1605

  Fly  1175 LWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIG 1239
            :...|.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.||::|.|
Human  1606 IEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIFSIFG 1669

  Fly  1240 MQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACL-KGKACDDDAEKAPGE 1303
            |..|..:|   .|..|....||::|...::.||:..|...|..::|..| :...|..|.|. ||.
Human  1670 MSNFAYVK---HEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLLPILNRPPDCSLDKEH-PGS 1730

  Fly  1304 ----YCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEY 1362
                .||: ::...:|||:|.....:::|:::|:|::||...|.:|: .|.....:.|..||.::
Human  1731 GFKGDCGNPSVGIFFFVSYIIISFLIVVNMYIAIILENFSVATEESADPLSEDDFETFYEIWEKF 1795

  Fly  1363 DPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIREN 1427
            ||:||..|.|.::.|....::.||....  ||.:   :||.|::|:....|:.....|||..:..
Human  1796 DPDATQFIEYCKLADFADALEHPLRVPK--PNTI---ELIAMDLPMVSGDRIHCLDILFAFTKRV 1855

  Fly  1428 LSIKMRAPEEMD--QADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILES 1490
            |.    ...|:|  :..||.|...:|...:..:.:...|....::::...|.  :.|.|.|....
Human  1856 LG----DSGELDILRQQMEERFVASNPSKVSYEPITTTLRRKQEEVSAVVLQ--RAYRGHLARRG 1914

  Fly  1491 W--RSTRFGQLDSGMPMLELQDASRHPSQESLTGADA 1525
            :  :.|...:|::|....|.::::  ||..||...|:
Human  1915 FICKKTTSNKLENGGTHREKKEST--PSTASLPSYDS 1949

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 85/317 (27%)
Ion_trans 441..677 CDD:334124 84/387 (22%)
Ion_trans 769..1050 CDD:334124 98/292 (34%)
Ion_trans 1094..1345 CDD:334124 82/262 (31%)
GPHH 1346..1416 CDD:339854 20/69 (29%)
Ca_chan_IQ 1418..1492 CDD:337190 15/77 (19%)
SCN8ANP_001317189.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..62
I. /evidence=ECO:0000305 114..442 96/362 (27%)
Ion_trans 131..421 CDD:395416 85/316 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..530 18/83 (22%)
Na_trans_cytopl 504..702 CDD:403218 15/197 (8%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 568..602 4/33 (12%)
II. /evidence=ECO:0000305 735..1007 83/280 (30%)
Ion_trans 752..965 CDD:395416 70/221 (32%)
Na_trans_assoc 991..1192 CDD:399489 30/203 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1107..1148 9/40 (23%)
III. /evidence=ECO:0000305 1180..1495 105/330 (32%)
Ion_trans 1197..1473 CDD:395416 97/287 (34%)
Na_channel_gate 1465..1517 CDD:240441 11/55 (20%)
IV. /evidence=ECO:0000305 1504..1801 94/303 (31%)
Ion_trans 1522..1776 CDD:395416 82/260 (32%)
GPHH 1788..1835 CDD:407139 17/51 (33%)
IQ 1894..1915 CDD:197470 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1922..1980 8/30 (27%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
43.850

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