DRSC/TRiP Functional Genomics Resources

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Protein Alignment cac and SCN7A

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_002967.2 Gene:SCN7A / 6332 HGNCID:10594 Length:1682 Species:Homo sapiens


Alignment Length:1698 Identity:420/1698 - (24%)
Similarity:754/1698 - (44%) Gaps:327/1698 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    18 LFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLC 82
            |..|:..|.||:.|..::..|.|:..:|::::.:||.::| .:||.....     ||.|   .|.
Human    98 LCTLSPFNCIRRTTIKVLVHPFFQLFILISVLIDCVFMSL-TNLPKWRPV-----LENT---LLG 153

  Fly    83 IFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLK 147
            |:..|..:|:.|.|:.....|:|.:.||.:||.|.|...:.:|..:.....|:|.|.:|:|:.:.
Human   154 IYTFEILVKLFARGVWAGSFSFLGDPWNWLDFSVTVFEVIIRYSPLDFIPTLQTARTLRILKIIP 218

  Fly   148 LVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEG 212
            |..|:.||..||   |..:..|:.:.:|.||.:.||::||:..:.|.|...|:      :..:|.
Human   219 LNQGLKSLVGVL---IHCLKQLIGVIILTLFFLSIFSLIGMGLFMGNLKHKCF------RWPQEN 274

  Fly   213 ESETPCN----------TDNI--LEKATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNI 257
            |:||..|          |:|.  ||....:.:|.|.|.        :|::....|:.|.|:||:.
Human   275 ENETLHNRTGNPYYIRETENFYYLEGERYALLCGNRTDAGQCPEGYVCVKAGINPDQGFTNFDSF 339

  Fly   258 GFAMLTVFQCITMEG----WTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAK 318
            |:|:..:|:.:..:.    :..|||    |.|..: .|:||.:..:.||:|.:|.||:|:..:.:
Human   340 GWALFALFRLMAQDYPEVLYHQILY----ASGKVY-MIFFVVVSFLFSFYMASLFLGILAMAYEE 399

  Fly   319 EREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKK 383
            |:::|....:.:: .:.||..:||.               |...|:|.|...:|.::|:..    
Human   400 EKQRVGEISKKIE-PKFQQTGKELQ---------------EGNETDEAKTIQIEMKKRSPI---- 444

  Fly   384 LKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGS---CTGFW-RAEKRFRFW----------- 433
                    ||||..:..|     |..|:.:.:.:.|   |..:| :..|.|..|           
Human   445 --------STDTSLDVLE-----DATLRHKEELEKSKKICPLYWYKFAKTFLIWNCSPCWLKLKE 496

  Fly   434 -IRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGP 497
             :...:...:...|:|:.:.||...:.:|||.........|.....:|:|:|.:||..|:.|:.|
Human   497 FVHRIIMAPFTDLFLIICIILNVCFLTLEHYPMSKQTNTLLNIGNLVFIGIFTAEMIFKIIAMHP 561

  Fly   498 RIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLN 562
            ..||:..:|.||.:::...:.|:..:.|.    |:::||..|:|||||:.|||.:.:.|:.||.|
Human   562 YGYFQVGWNIFDSMIVFHGLIELCLANVA----GMALLRLFRMLRIFKLGKYWPTFQILMWSLSN 622

  Fly   563 SMRSIISLLFLLFLFILIFALLGMQLFGGQF-----------NLPGGTPETNFNTFPIALLTVFQ 616
            |..::..|:.|||.||...|..||:|||..:           .||.......|::|    |.||:
Human   623 SWVALKDLVLLLFTFIFFSAAFGMKLFGKNYEEFVCHIDKDCQLPRWHMHDFFHSF----LNVFR 683

  Fly   617 ILTGEDWNEVMYQGIISQGGAQKGMIYSI-YFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE 680
            ||.|| |.|.::..:     ...|..:.| ::::::|.||..:|.:|||: |.:.::.:::||.|
Human   684 ILCGE-WVETLWDCM-----EVAGQSWCIPFYLMVILIGNLLVLYLFLAL-VSSFSSCKDVTAEE 741

  Fly   681 EEQVE-----------------------------------------------------------E 686
            ..:.:                                                           :
Human   742 NNEAKNLQLAVARIKKGINYVLLKILCKTQNVPKDTMDHVNEVYVKEDISDHTLSELSNTQDFLK 806

  Fly   687 DKEK-----------QLQEL---------------EKEMEALQADGVHVENGDGAVAPSKSKGKK 725
            ||||           :.|.|               |.::|.|....:..::|||.   ||.|.|:
Human   807 DKEKSSGTEKNATENESQSLIPSPSVSETVPIASGESDIENLDNKEIQSKSGDGG---SKEKIKQ 868

  Fly   726 KEEEK--------KEEEEVTEGPKPMLPY-------SSMFILSPTNPIRRGAHW---------VV 766
            ....:        .||||:..|.:.....       ||:..:|..:  ::|..|         :|
Human   869 SSSSECSTVDIAISEEEEMFYGGERSKHLKNGCRRGSSLGQISGAS--KKGKIWQNIRKTCCKIV 931

  Fly   767 NLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHP 830
            ...:|..||.:|..:|:..||.||...:..:..|| |.|.|..||.:|.:|||||.:..|.    
Human   932 ENNWFKCFIGLVTLLSTGTLAFEDIYMDQRKTIKILLEYADMIFTYIFILEMLLKWMAYGF---- 992

  Fly   831 GSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFD 895
            .:|....|..:|.||||...:|.        .|:....:|.|..::.||||:.:.:..::|.|..
Human   993 KAYFSNGWYRLDFVVVIVFCLSL--------IGKTREELKPLISMKFLRPLRVLSQFERMKVVVR 1049

  Fly   896 CVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPK- 959
            .::.:....:|:.:|.::...|||::||.||.|:|:.|.|.   ||.|      ::...|::.| 
Human  1050 ALIKTTLPTLNVFLVCLMIWLIFSIMGVDLFAGRFYECIDP---TSGE------RFPSSEVMNKS 1105

  Fly   960 -------QELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMS 1017
                   .|..:|:....::|||....|:|..|.|..||..::..::.:...:..|  :|.:.:.
Human  1106 RCESLLFNESMLWENAKMNFDNVGNGFLSLLQVATFNGWITIMNSAIDSVAVNIQP--HFEVNIY 1168

  Fly  1018 IF-YIVYFIVFPFFF-VNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGAR--------- 1071
            :: |.:.||:|..|. :::.:.:||..|.:.   :::.|      .|.|..|:..|         
Human  1169 MYCYFINFIIFGVFLPLSMLITVIIDNFNKH---KIKLG------GSNIFITVKQRKQYRRLKKL 1224

  Fly  1072 ---PLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMG 1133
               ..:|.:|:..|..:..::.:|.|..|...:|:||.|..:.:|:....|......:|.:||..
Human  1225 MYEDSQRPVPRPLNKLQGFIFDVVTSQAFNVIVMVLICFQAIAMMIDTDVQSLQMSIALYWINSI 1289

  Fly  1134 FTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVD-ALWMEFGSNSINVGFLRLFRAARL 1197
            |..::::|.:||:|.|.. .:|...|||||.:.|:.||.. .|.|..||..:....::|...:|:
Human  1290 FVMLYTMECILKLIAFRC-FYFTIAWNIFDFMVVIFSITGLCLPMTVGSYLVPPSLVQLILLSRI 1353

  Fly  1198 IKLLRQGYTIRI---LLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHN 1259
            |.:||.|...::   |:...:.|..||..:.|||.::.||||:.||..|..:|   .|..|...:
Human  1354 IHMLRLGKGPKVFHNLMLPLMLSLPALLNIILLIFLVMFIYAVFGMYNFAYVK---KEAGINDVS 1415

  Fly  1260 NFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKA-PGEY----CGS-TLAYAYFVSFI 1318
            ||::|...::.||:.|....|..::.|....|..|.|.:|. ||..    ||: ::...||||:|
Human  1416 NFETFGNSMLCLFQVAIFAGWDGMLDAIFNSKWSDCDPDKINPGTQVRGDCGNPSVGIFYFVSYI 1480

  Fly  1319 FFCSFLMLNLFVAVIMDNFDYLT-RDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNM 1382
            .....:::|:::.|:|:..:..: :.:..|......:|.::|..:||:.|..|..:::.|....:
Human  1481 LISWLIIVNMYIVVVMEFLNIASKKKNKTLSEDDFRKFFQVWKRFDPDRTQYIDSSKLSDFAAAL 1545

  Fly  1383 DPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRE 1447
            ||||....  ||:   .:||.:::|:....|:.....|.|..:..:...:|.  |...:::|...
Human  1546 DPPLFMAK--PNK---GQLIALDLPMAVGDRIHCLDILLAFTKRVMGQDVRM--EKVVSEIESGF 1603

  Fly  1448 TITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDAS 1512
            .:.|.:.:..:       |.:..|.:.:.:|    :..:|..::::.|..:.|.....:.:.|..
Human  1604 LLANPFKITCE-------PITTTLKRKQEAV----SATIIQRAYKNYRLRRNDKNTSDIHMIDGD 1657

  Fly  1513 R--HPSQE 1518
            |  |.::|
Human  1658 RDVHATKE 1665

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 86/310 (28%)
Ion_trans 441..677 CDD:334124 75/247 (30%)
Ion_trans 769..1050 CDD:334124 79/291 (27%)
Ion_trans 1094..1345 CDD:334124 77/261 (30%)
GPHH 1346..1416 CDD:339854 18/69 (26%)
Ca_chan_IQ 1418..1492 CDD:337190 10/73 (14%)
SCN7ANP_002967.2 I. /evidence=ECO:0000305 100..401 90/323 (28%)
Ion_trans 146..403 CDD:278921 78/278 (28%)
II. /evidence=ECO:0000305 487..758 78/285 (27%)
Ion_trans 522..717 CDD:278921 64/208 (31%)
Na_trans_assoc 743..927 CDD:284034 26/188 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 801..871 16/72 (22%)
III. /evidence=ECO:0000305 916..1224 87/339 (26%)
Ion_trans 951..1198 CDD:278921 74/269 (28%)
Na_channel_gate 1194..1246 CDD:240441 9/60 (15%)
IV. /evidence=ECO:0000305 1233..1531 85/301 (28%)
Ion_trans 1268..1497 CDD:278921 70/232 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.910

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