Sequence 1: | NP_001356945.1 | Gene: | cac / 32158 | FlyBaseID: | FBgn0263111 | Length: | 2110 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001092874.1 | Gene: | SCN5A / 6331 | HGNCID: | 10593 | Length: | 2016 | Species: | Homo sapiens |
Alignment Length: | 1984 | Identity: | 469/1984 - (23%) |
---|---|---|---|
Similarity: | 812/1984 - (40%) | Gaps: | 526/1984 - (26%) |
- Green bases have known domain annotations that are detailed below.
Fly 17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
Fly 82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
Fly 147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS---------- 201
Fly 202 ---------------LEDP-NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLE 242
Fly 243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
Fly 308 VLGVLS--------GEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTE 364
Fly 365 EEKMHIMEARRRNAAKRKKLKS---------LGKSKSTD-------------------------- 394
Fly 395 ------TEEEEAEEDYGDD-----GYLKT------------RSKPQG------------------ 418
Fly 419 ---SCTGF--------------------------------------------------------- 423
Fly 424 -----------------------------W-RAEKRFRFW--------IRHTVKTQWFYWF---- 446
Fly 447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511
Fly 512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576
Fly 577 FILIFALLGMQLFGGQFNL-----PGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG 636
Fly 637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEME- 700
Fly 701 ---------------------ALQADG--------------------------VHVENGDG---- 714
Fly 715 ------------AVAPSKSKGKKKEEE-----------KKEEEEVTEGP---------------- 740
Fly 741 -------------------KPMLP---------YSSMFILSPTNP-------------------- 757
Fly 758 --------------------------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENS 796
Fly 797 RRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGS 860
Fly 861 SAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQL 925
Fly 926 FNGKFFYCTDESK----------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAML 980
Fly 981 TLFAVQTGEGWPQVLQHSMAATYEDRG----PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIII 1041
Fly 1042 TFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIM 1102
Fly 1103 MLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITV 1167
Fly 1168 LGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1227
Fly 1228 IAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK--G 1290
Fly 1291 KACDDDAEKAPGEY--CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHH 1351
Fly 1352 LDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQF 1416
Fly 1417 TTTLFALIRENLSIKMRAPEEMDQADMELRETI--TNIWPLQAKKMLNLLVPPSDQLNKGKLSVG 1479
Fly 1480 KIYAGFLILESWRSTRF---GQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRS 1541
Fly 1542 PSLRHNGSP-------LARSPSPRRRGHQYIHHD 1568 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
cac | NP_001356945.1 | Ion_trans | 37..324 | CDD:334124 | 91/328 (28%) |
Ion_trans | 441..677 | CDD:334124 | 79/244 (32%) | ||
Ion_trans | 769..1050 | CDD:334124 | 92/295 (31%) | ||
Ion_trans | 1094..1345 | CDD:334124 | 76/260 (29%) | ||
GPHH | 1346..1416 | CDD:339854 | 21/69 (30%) | ||
Ca_chan_IQ | 1418..1492 | CDD:337190 | 12/75 (16%) | ||
SCN5A | NP_001092874.1 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 28..56 | ||
I. /evidence=ECO:0000305 | 113..420 | 93/333 (28%) | |||
Ion_trans | 151..423 | CDD:278921 | 81/298 (27%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 461..591 | 18/129 (14%) | |||
Na_trans_cytopl | 485..578 | CDD:288761 | 13/92 (14%) | ||
II. /evidence=ECO:0000305 | 699..969 | 87/279 (31%) | |||
Ion_trans | 734..927 | CDD:278921 | 67/201 (33%) | ||
Na_trans_assoc | 953..1200 | CDD:284034 | 23/246 (9%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1005..1141 | 15/135 (11%) | |||
III. /evidence=ECO:0000305 | 1187..1501 | 99/335 (30%) | |||
Ion_trans | 1222..1479 | CDD:278921 | 85/278 (31%) | ||
Na_channel_gate | 1471..1523 | CDD:240441 | 10/52 (19%) | ||
IV. /evidence=ECO:0000305 | 1510..1807 | 89/301 (30%) | |||
Ion_trans | 1545..1782 | CDD:278921 | 70/241 (29%) | ||
GPHH | 1792..1849 | CDD:293510 | 20/61 (33%) | ||
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 | 1839..1901 | 12/65 (18%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1959..2016 | 10/41 (24%) | |||
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 | 1974..1977 | 1/2 (50%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 1 | 1.010 | - | - | D172471at2759 | |
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
3 | 2.820 |