DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and SCN5A

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001092874.1 Gene:SCN5A / 6331 HGNCID:10593 Length:2016 Species:Homo sapiens


Alignment Length:1984 Identity:469/1984 - (23%)
Similarity:812/1984 - (40%) Gaps:526/1984 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:|||:....|:....|...::.||:.|||.:|..:..|.         .:..|..|.
Human   110 ALYVLSPFHPIRRAAVKILVHSLFNMLIMCTILTNCVFMAQHDPPPW---------TKYVEYTFT 165

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..||..::||:.||.:||.|::..::::..::|   :|..||..||||.|
Human   166 AIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIIMAYVSENIKLG---NLSALRTFRVLRAL 227

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYS---------- 201
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|..          
Human   228 KTISVIPGLKTIVGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTALNGTNG 292

  Fly   202 ---------------LEDP-NKLVKEGESETPCNTDNILEKATGSFVCNNTTS--------MCLE 242
                           |.|| |.|:|.|.|:.              .:|.|::.        .||:
Human   293 SVEADGLVWESLDLYLSDPENYLLKNGTSDV--------------LLCGNSSDAGTCPEGYRCLK 343

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ..|.|:.|.||||:..:|.|.:|:.:|.:.|..:...|..:.|..: .|:|:.:|.:|||:::||
Human   344 AGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIY-MIFFMLVIFLGSFYLVNL 407

  Fly   308 VLGVLS--------GEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTE 364
            :|.|::        ...|:..||.:..||.:::.:::.....:.| |:.:.::         :.|
Human   408 ILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRG-VDTVSRS---------SLE 462

  Fly   365 EEKMHIMEARRRNAAKRKKLKS---------LGKSKSTD-------------------------- 394
            ...:..:.:..|.:.:||::.|         |.||.|.|                          
Human   463 MSPLAPVNSHERRSKRRKRMSSGTEECGEDRLPKSDSEDGPRAMNHLSLTRGLSRTSMKPRSSRG 527

  Fly   395 ------TEEEEAEEDYGDD-----GYLKT------------RSKPQG------------------ 418
                  ..:..:|.|:.||     |..::            |:..||                  
Human   528 SIFTFRRRDLGSEADFADDENSTAGESESHHTSLLVPWPLRRTSAQGQPSPGTSAPGHALHGKKN 592

  Fly   419 ---SCTGF--------------------------------------------------------- 423
               .|.|.                                                         
Human   593 STVDCNGVVSLLGAGDPEATSPGSHLLRPVMLEHPPDTTTPSEEPGGPQMLTSQAPCVDGFEEPG 657

  Fly   424 -----------------------------W-RAEKRFRFW--------IRHTVKTQWFYWF---- 446
                                         | |..:|:..|        |:..||......|    
Human   658 ARQRALSAVSVLTSALEELEESRHKCPPCWNRLAQRYLIWECCPLWMSIKQGVKLVVMDPFTDLT 722

  Fly   447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511
            :.:.:.|||:.:|:|||...|...|.|.....:|.|:|.:||..|:.||.|..||:..:|.||.:
Human   723 ITMCIVLNTLFMALEHYNMTSEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSI 787

  Fly   512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576
            ::..|:.|:..|.:.    .|||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:
Human   788 IVILSLMELGLSRMS----NLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAI 848

  Fly   577 FILIFALLGMQLFGGQFNL-----PGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGG 636
            .:.|||::||||||..::.     .|..|..:...|..|.|.:|:||.|| |.|.|:..:...|.
Human   849 IVFIFAVVGMQLFGKNYSELRDSDSGLLPRWHMMDFFHAFLIIFRILCGE-WIETMWDCMEVSGQ 912

  Fly   637 AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQELEKEME- 700
            :    :..:.|:::::.||..:||:|||:.:.:. :|..|||.:|::...:.:..|..:::.:. 
Human   913 S----LCLLVFLLVMVIGNLVVLNLFLALLLSSF-SADNLTAPDEDREMNNLQLALARIQRGLRF 972

  Fly   701 ---------------------ALQADG--------------------------VHVENGDG---- 714
                                 ||.|.|                          ...|.|:.    
Human   973 VKRTTWDFCCGLLRQRPQKPAALAAQGQLPSCIATPYSPPPPETEKVPPTRKETRFEEGEQPGQG 1037

  Fly   715 ------------AVAPSKSKGKKKEEE-----------KKEEEEVTEGP---------------- 740
                        |||.|.:..::::||           ::|.:.|:.||                
Human  1038 TPGDPEPVCVPIAVAESDTDDQEEDEENSLGTEEESSKQQESQPVSGGPEAPPDSRTWSQVSATA 1102

  Fly   741 -------------------KPMLP---------YSSMFILSPTNP-------------------- 757
                               :|..|         .|.......||.                    
Human  1103 SSEAEASASQADWRQQWKAEPQAPGCGETPEDSCSEGSTADMTNTAELLEQIPDLGQDVKDPEDC 1167

  Fly   758 --------------------------IRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENS 796
                                      :|:..:.:|...:|:.||:.:|.:||.|||.||...|..
Human  1168 FTEGCVRRCPCCAVDTTQAPGKVWWRLRKTCYHIVEHSWFETFIIFMILLSSGALAFEDIYLEER 1232

  Fly   797 RRNKI-LNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGS 860
            :..|: |.|.|..||.||.:|||||.|..|.    ..|....|..:|.::|..:.||...:..|.
Human  1233 KTIKVLLEYADKMFTYVFVLEMLLKWVAYGF----KKYFTNAWCWLDFLIVDVSLVSLVANTLGF 1293

  Fly   861 SAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQL 925
            :   .:..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.|
Human  1294 A---EMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNL 1355

  Fly   926 FNGKFFYCTDESK----------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAML 980
            |.|||..|.::::          :..::|:......|          ..|.....::|||.|..|
Human  1356 FAGKFGRCINQTEGDLPLNYTIVNNKSQCESLNLTGE----------LYWTKVKVNFDNVGAGYL 1410

  Fly   981 TLFAVQTGEGWPQVLQHSMAATYEDRG----PIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIII 1041
            .|..|.|.:||..:    |.|..:.||    |...:.:.|.|:::::.|...||.:|:|:.:||.
Human  1411 ALLQVATFKGWMDI----MYAAVDSRGYEEQPQWEYNLYMYIYFVIFIIFGSFFTLNLFIGVIID 1471

  Fly  1042 TFQEQGEAEL--QDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIM 1102
            .|.:| :.:|  ||..:.:.||...:.  .:|::..::.:|:..|.::..::.||....|:..||
Human  1472 NFNQQ-KKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQGFIFDIVTKQAFDVTIM 1535

  Fly  1103 MLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITV 1167
            .||..|.:.:|::..:|.......|..||:.|..:|:.|.::|:.... ..:|.:.|||||.:.|
Human  1536 FLICLNMVTMMVETDDQSPEKINILAKINLLFVAIFTGECIVKLAALR-HYYFTNSWNIFDFVVV 1599

  Fly  1168 LGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLL 1227
            :.|||     |.:...|.|.:: ...:||.|..|:::|:|....||.||:..:.|..||..:.||
Human  1600 ILSIVGTVLSDIIQKYFFSPTL-FRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLL 1663

  Fly  1228 IAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLK--G 1290
            :.::.|||:|.||..|..:|.   |..|....|||:|...::.||:..|...|..::...|.  .
Human  1664 LFLVMFIYSIFGMANFAYVKW---EAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGP 1725

  Fly  1291 KACDDDAEKAPGEY--CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHH 1351
            ..||.....:.|..  ||| .:...:|.::|.....:::|:::|:|::||...|.:|: .|....
Human  1726 PYCDPTLPNSNGSRGDCGSPAVGILFFTTYIIISFLIVVNMYIAIILENFSVATEESTEPLSEDD 1790

  Fly  1352 LDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQF 1416
            .|.|..||.::||.||..|.|:.:.|....:..||....  ||:::   ||.|::|:....|:..
Human  1791 FDMFYEIWEKFDPEATQFIEYSVLSDFADALSEPLRIAK--PNQIS---LINMDLPMVSGDRIHC 1850

  Fly  1417 TTTLFALIRENLSIKMRAPEEMDQADMELRETI--TNIWPLQAKKMLNLLVPPSDQLNKGKLSVG 1479
            ...|||..:..|.    ...|||...:::.|..  .|...:..:.:...|....::::  .:.:.
Human  1851 MDILFAFTKRVLG----ESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVS--AMVIQ 1909

  Fly  1480 KIYAGFLILESWRSTRF---GQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRS 1541
            :.:...|:..|.:...|   .|..||   |..:||   |.:|.|.   |..:....|...|...|
Human  1910 RAFRRHLLQRSLKHASFLFRQQAGSG---LSEEDA---PEREGLI---AYVMSENFSRPLGPPSS 1965

  Fly  1542 PSLRHNGSP-------LARSPSPRRRGHQYIHHD 1568
            .|:.....|       .|.|.:.:.||..|.|.:
Human  1966 SSISSTSFPPSYDSVTRATSDNLQVRGSDYSHSE 1999

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 91/328 (28%)
Ion_trans 441..677 CDD:334124 79/244 (32%)
Ion_trans 769..1050 CDD:334124 92/295 (31%)
Ion_trans 1094..1345 CDD:334124 76/260 (29%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 12/75 (16%)
SCN5ANP_001092874.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 28..56
I. /evidence=ECO:0000305 113..420 93/333 (28%)
Ion_trans 151..423 CDD:278921 81/298 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 461..591 18/129 (14%)
Na_trans_cytopl 485..578 CDD:288761 13/92 (14%)
II. /evidence=ECO:0000305 699..969 87/279 (31%)
Ion_trans 734..927 CDD:278921 67/201 (33%)
Na_trans_assoc 953..1200 CDD:284034 23/246 (9%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1005..1141 15/135 (11%)
III. /evidence=ECO:0000305 1187..1501 99/335 (30%)
Ion_trans 1222..1479 CDD:278921 85/278 (31%)
Na_channel_gate 1471..1523 CDD:240441 10/52 (19%)
IV. /evidence=ECO:0000305 1510..1807 89/301 (30%)
Ion_trans 1545..1782 CDD:278921 70/241 (29%)
GPHH 1792..1849 CDD:293510 20/61 (33%)
Interaction with FGF13. /evidence=ECO:0000269|PubMed:22705208 1839..1901 12/65 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1959..2016 10/41 (24%)
Interaction with NEDD4, NEDD4L and WWP2. /evidence=ECO:0000269|PubMed:15548568 1974..1977 1/2 (50%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.820

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