DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and SCN4A

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_000325.4 Gene:SCN4A / 6329 HGNCID:10591 Length:1836 Species:Homo sapiens


Alignment Length:1811 Identity:456/1811 - (25%)
Similarity:801/1811 - (44%) Gaps:390/1811 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::|:..:.:|:....::....|...:::||:.|||.:.:.:..|..         :..|..|.
Human   110 ALYLLSPFSVVRRGAIKVLIHALFSMFIMITILTNCVFMTMSDPPPWS---------KNVEYTFT 165

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..:...::||:.||.:||.|::..::|::..:|   ::..||..||||.|
Human   166 GIYTFESLIKILARGFCVDDFTFLRDPWNWLDFSVIMMAYLTEFVDLG---NISALRTFRVLRAL 227

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDP------ 205
            |.::.||.|:.::.::|:::..|..:.:|.:|.:.:||::||:.:.|.|.:.|.....|      
Human   228 KTITVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALVGLQLFMGNLRQKCVRWPPPFNDTNT 292

  Fly   206 ----------------NKLVKEGESETPCNTDN------------------------ILEKATGS 230
                            |::....:|....:|.|                        .||.:..:
Human   293 TWYSNDTWYGNDTWYGNEMWYGNDSWYANDTWNSHASWATNDTFDWDAYISDEGNFYFLEGSNDA 357

  Fly   231 FVCNNTTSM--------CLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSA 287
            .:|.|::..        |::....||.|.||:|...:|.|.:|:.:|.:.|..:...|..|.|..
Human   358 LLCGNSSDAGHCPEGYECIKTGRNPNYGYTSYDTFSWAFLALFRLMTQDYWENLFQLTLRAAGKT 422

  Fly   288 FNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKA 352
            : .|:||.:|.:|||:::||:|.|::..:|::                                 
Human   423 Y-MIFFVVIIFLGSFYLINLILAVVAMAYAEQ--------------------------------- 453

  Fly   353 EEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSL--------------GK--SKSTDTEEEE-- 399
            .|..|||::..|||...::|..:::..:.:|.|:.              ||  :.|.||.:.|  
Human   454 NEATLAEDKEKEEEFQQMLEKFKKHQEELEKAKAAQALEGGEADGDPAHGKDCNGSLDTSQGEKG 518

  Fly   400 --AEEDYGDDGY---LKTRSKPQGSCTGFW-RAEKRFRFW-----------IRHTVKTQWFYWF- 446
              .:...||.|.   ::...:....|..:| :...:...|           |.|.:....|... 
Human   519 APRQSSSGDSGISDAMEELEEAHQKCPPWWYKCAHKVLIWNCCAPWLKFKNIIHLIVMDPFVDLG 583

  Fly   447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511
            :.:.:.|||:.:|:|||.........|.....:|.|:|.:||.:|:.|:.|..||:..:|.||.:
Human   584 ITICIVLNTLFMAMEHYPMTEHFDNVLTVGNLVFTGIFTAEMVLKLIAMDPYEYFQQGWNIFDSI 648

  Fly   512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576
            :::.|:.|:..:.|:    ||||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:
Human   649 IVTLSLVELGLANVQ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAI 709

  Fly   577 FILIFALLGMQLFGGQF-----------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQG 630
            .:.|||::||||||..:           |||.......|::|    |.||:||.|| |.|.|:..
Human   710 IVFIFAVVGMQLFGKSYKECVCKIALDCNLPRWHMHDFFHSF----LIVFRILCGE-WIETMWDC 769

  Fly   631 IISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKE------ 689
            :...|.|   |..:::.:|:|: ||..:||:|||:.:.:. :|..|.|::|:....:.:      
Human   770 MEVAGQA---MCLTVFLMVMVI-GNLVVLNLFLALLLSSF-SADSLAASDEDGEMNNLQIAIGRI 829

  Fly   690 -----------------KQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEV- 736
                             |.|...:..:...:|||.......|..||...|.:..||:.|::..: 
Human   830 KLGIGFAKAFLLGLLHGKILSPKDIMLSLGEADGAGEAGEAGETAPEDEKKEPPEEDLKKDNHIL 894

  Fly   737 -----TEGPKPML----------PYSSMFI--------------------------LSPTNPI-- 758
                 .:||...|          ||.::.:                          ..|..|:  
Human   895 NHMGLADGPPSSLELDHLNFINNPYLTIQVPIASEESDLEMPTEEETDTFSEPEDSKKPPQPLYD 959

  Fly   759 ----------------------------------------------------RRGAHW------- 764
                                                                .||..|       
Human   960 GNSSVCSTADYKPPEEDPEEQAEENPEGEQPEECFTEACVQRWPCLYVDISQGRGKKWWTLRRAC 1024

  Fly   765 --VVNLPYFDFFIMVVISMSSIALAAEDPVRENSR-RNKILNYFDYAFTGVFTIEMLLKIVDLGV 826
              :|...:|:.||:.:|.:||.|||.||...|..| ...||.|.|..||.:|.:|||||.|..|.
Human  1025 FKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRRVIRTILEYADKVFTYIFIMEMLLKWVAYGF 1089

  Fly   827 ILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLK 891
            .:    |....|..:|.::|..:.:|...:..|.|   .|..|||||.||.||||:.:.|...::
Human  1090 KV----YFTNAWCWLDFLIVDVSIISLVANWLGYS---ELGPIKSLRTLRALRPLRALSRFEGMR 1147

  Fly   892 AVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL 956
            .|.:.::.::.:::|:|:|.::|..|||::||.||.|||:||.:.:.....:......|.|.:.|
Human  1148 VVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYYCINTTTSERFDISEVNNKSECESL 1212

  Fly   957 LPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
            :...::| |.....:||||....|:|..|.|.:||..::..::.:..::..|.....:.|.::::
Human  1213 MHTGQVR-WLNVKVNYDNVGLGYLSLLQVATFKGWMDIMYAAVDSREKEEQPQYEVNLYMYLYFV 1276

  Fly  1022 VYFIVFPFFFVNIFVALIIITFQEQ----GEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRN 1082
            ::.|...||.:|:|:.:||..|.:|    |..::...|..|...:.:. .:|::..::.:|:.:|
Human  1277 IFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGKDIFMTEEQKKYYNAMK-KLGSKKPQKPIPRPQN 1340

  Fly  1083 TFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKII 1147
            ..:..|:.:|....|:..||:||..|.:.:|::..||..:....|..|||.|..:|:.|.|||::
Human  1341 KIQGMVYDLVTKQAFDITIMILICLNMVTMMVETDNQSQLKVDILYNINMIFIIIFTGECVLKML 1405

  Fly  1148 GFGVKNFFKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTI 1207
            ... :.:|...|||||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|:|....|
Human  1406 ALR-QYYFTVGWNIFDFVVVILSIVGLALSDLIQKYFVSPTL-FRVIRLARIGRVLRLIRGAKGI 1468

  Fly  1208 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLF 1272
            |.||:..:.|..||..:.||:.::.|||:|.||..|..:|   .|:.|....||::|...::.||
Human  1469 RTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMSNFAYVK---KESGIDDMFNFETFGNSIICLF 1530

  Fly  1273 RCATGEAWPNIMLACLKG--KACDDDAEKAPGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFV 1330
            ...|...|..::...|..  ..||.:.|. ||..    ||: ::...:|.|:|.....:::|:::
Human  1531 EITTSAGWDGLLNPILNSGPPDCDPNLEN-PGTSVKGDCGNPSIGICFFCSYIIISFLIVVNMYI 1594

  Fly  1331 AVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPN 1394
            |:|::||:..|.:|| .||....:.|...|.::||:||..|.|:.:.|.:..:..||....  ||
Human  1595 AIILENFNVATEESSEPLGEDDFEMFYETWEKFDPDATQFIAYSRLSDFVDTLQEPLRIAK--PN 1657

  Fly  1395 RLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADME-LRETITNIWPLQAK 1458
            ::   |||.:::|:....::.....||||.:|.|.         |..:|: |::|      ::.|
Human  1658 KI---KLITLDLPMVPGDKIHCLDILFALTKEVLG---------DSGEMDALKQT------MEEK 1704

  Fly  1459 KMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDA-SRHPSQESLTG 1522
            .|         ..|..|:|...|           :|...:....:..:::|.| .||..|.|:..
Human  1705 FM---------AANPSKVSYEPI-----------TTTLKRKHEEVCAIKIQRAYRRHLLQRSMKQ 1749

  Fly  1523 AD--AGHLHPGH---------------SYMNGHRRSPSLRHNGSPLARSPSPRRRG 1561
            |.  ..|.|.|.               |.|.||       .||:  :.||||..:|
Human  1750 ASYMYRHSHDGSGDDAPEKEGLLANTMSKMYGH-------ENGN--SSSPSPEEKG 1796

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 83/340 (24%)
Ion_trans 441..677 CDD:334124 82/247 (33%)
Ion_trans 769..1050 CDD:334124 91/285 (32%)
Ion_trans 1094..1345 CDD:334124 81/262 (31%)
GPHH 1346..1416 CDD:339854 19/69 (28%)
Ca_chan_IQ 1418..1492 CDD:337190 16/74 (22%)
SCN4ANP_000325.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 39..63
I. /evidence=ECO:0000305 113..454 85/386 (22%)
Ion_trans 152..457 CDD:278921 78/350 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 493..530 8/36 (22%)
II. /evidence=ECO:0000305 560..832 87/285 (31%)
Ion_trans 595..790 CDD:278921 70/207 (34%)
Na_trans_assoc 816..1026 CDD:284034 22/209 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 863..886 6/22 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 930..992 2/61 (3%)
III. /evidence=ECO:0000305 1013..1326 97/321 (30%)
Ion_trans 1048..1304 CDD:278921 83/263 (32%)
Na_channel_gate 1296..1348 CDD:240441 9/52 (17%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1310..1312 0/1 (0%)
IV. /evidence=ECO:0000305 1335..1633 94/303 (31%)
Ion_trans 1370..1609 CDD:278921 75/244 (31%)
GPHH 1620..1675 CDD:293510 17/59 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1778..1836 10/28 (36%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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