Sequence 1: | NP_001356945.1 | Gene: | cac / 32158 | FlyBaseID: | FBgn0263111 | Length: | 2110 | Species: | Drosophila melanogaster |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_000325.4 | Gene: | SCN4A / 6329 | HGNCID: | 10591 | Length: | 1836 | Species: | Homo sapiens |
Alignment Length: | 1811 | Identity: | 456/1811 - (25%) |
---|---|---|---|
Similarity: | 801/1811 - (44%) | Gaps: | 390/1811 - (21%) |
- Green bases have known domain annotations that are detailed below.
Fly 17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
Fly 82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
Fly 147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDP------ 205
Fly 206 ----------------NKLVKEGESETPCNTDN------------------------ILEKATGS 230
Fly 231 FVCNNTTSM--------CLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSA 287
Fly 288 FNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKA 352
Fly 353 EEVILAEERTTEEEKMHIMEARRRNAAKRKKLKSL--------------GK--SKSTDTEEEE-- 399
Fly 400 --AEEDYGDDGY---LKTRSKPQGSCTGFW-RAEKRFRFW-----------IRHTVKTQWFYWF- 446
Fly 447 VIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCV 511
Fly 512 VISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFL 576
Fly 577 FILIFALLGMQLFGGQF-----------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQG 630
Fly 631 IISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKE------ 689
Fly 690 -----------------KQLQELEKEMEALQADGVHVENGDGAVAPSKSKGKKKEEEKKEEEEV- 736
Fly 737 -----TEGPKPML----------PYSSMFI--------------------------LSPTNPI-- 758
Fly 759 ----------------------------------------------------RRGAHW------- 764
Fly 765 --VVNLPYFDFFIMVVISMSSIALAAEDPVRENSR-RNKILNYFDYAFTGVFTIEMLLKIVDLGV 826
Fly 827 ILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLK 891
Fly 892 AVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDEL 956
Fly 957 LPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYI 1021
Fly 1022 VYFIVFPFFFVNIFVALIIITFQEQ----GEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRN 1082
Fly 1083 TFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKII 1147
Fly 1148 GFGVKNFFKDPWNIFDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTI 1207
Fly 1208 RILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLF 1272
Fly 1273 RCATGEAWPNIMLACLKG--KACDDDAEKAPGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFV 1330
Fly 1331 AVIMDNFDYLTRDSS-ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPN 1394
Fly 1395 RLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADME-LRETITNIWPLQAK 1458
Fly 1459 KMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWRSTRFGQLDSGMPMLELQDA-SRHPSQESLTG 1522
Fly 1523 AD--AGHLHPGH---------------SYMNGHRRSPSLRHNGSPLARSPSPRRRG 1561 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
cac | NP_001356945.1 | Ion_trans | 37..324 | CDD:334124 | 83/340 (24%) |
Ion_trans | 441..677 | CDD:334124 | 82/247 (33%) | ||
Ion_trans | 769..1050 | CDD:334124 | 91/285 (32%) | ||
Ion_trans | 1094..1345 | CDD:334124 | 81/262 (31%) | ||
GPHH | 1346..1416 | CDD:339854 | 19/69 (28%) | ||
Ca_chan_IQ | 1418..1492 | CDD:337190 | 16/74 (22%) | ||
SCN4A | NP_000325.4 | Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 39..63 | ||
I. /evidence=ECO:0000305 | 113..454 | 85/386 (22%) | |||
Ion_trans | 152..457 | CDD:278921 | 78/350 (22%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 493..530 | 8/36 (22%) | |||
II. /evidence=ECO:0000305 | 560..832 | 87/285 (31%) | |||
Ion_trans | 595..790 | CDD:278921 | 70/207 (34%) | ||
Na_trans_assoc | 816..1026 | CDD:284034 | 22/209 (11%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 863..886 | 6/22 (27%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 930..992 | 2/61 (3%) | |||
III. /evidence=ECO:0000305 | 1013..1326 | 97/321 (30%) | |||
Ion_trans | 1048..1304 | CDD:278921 | 83/263 (32%) | ||
Na_channel_gate | 1296..1348 | CDD:240441 | 9/52 (17%) | ||
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 | 1310..1312 | 0/1 (0%) | |||
IV. /evidence=ECO:0000305 | 1335..1633 | 94/303 (31%) | |||
Ion_trans | 1370..1609 | CDD:278921 | 75/244 (31%) | ||
GPHH | 1620..1675 | CDD:293510 | 17/59 (29%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1778..1836 | 10/28 (36%) | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_KOG2301 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
2 | 1.810 |