DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and SCN3A

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_008853.3	Gene:	SCN3A / 6328	HGNCID:	10590	Length:	2000	Species:	Homo sapiens

Alignment Length:	1846	Identity:	468/1846 - (25%)
Similarity:	784/1846 - (42%)	Gaps:	489/1846 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:||....|:....|...::.||:.|||.:.| .:.|...|.|        |..|
Human   106 SALYILTPLNPVRKIAIKILVHSLFSMLIMCTILTNCVFMTL-SNPPDWTKNV--------EYTF 161

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||||.|..|...::||:.||.:||.|:|..::|::..:|   ::..||..||||.
Human   162 TGIYTFESLIKILARGFCLEDFTFLRDPWNWLDFSVIVMAYVTEFVDLG---NVSALRTFRVLRA 223

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|  |:.|
Human   224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKC--LQWP----- 281

  Fly   211 EGESETPCNTDNILE---KATGSFV------------------------------CNNTTS---- 238
            ..:|....||.:...   .:.|:||                              |.|.:.
Human   282 PSDSAFETNTTSYFNGTMDSNGTFVNVTMSTFNWKDYIGDDSHFYVLDGQKDPLLCGNGSDAGQC 346

  Fly   239 ----MCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVI 299
                :|::....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:
Human   347 PEGYICVKAGRNPNYGYTSFDTFSWAFLSLFRLMTQDYWENLYQLTLRAAGKTY-MIFFVLVIFL 410

  Fly   300 GSFFMLNLVLGVLSGEFAK---------EREKVENRQEFLKLRRQQQ----------LERELNGY 345
            |||:::||:|.|::..:.:         |:::.|.:|...:|::||:          ..|:.:|
Human   411 GSFYLVNLILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAVAAASAASRDFSG- 474

  Fly   346 VEWICKAEEVILAEERTTEEEKMHIMEARR-RNAAKRKKLK------------SLGKSKSTDT-- 395
               |....|::   |.::|..|:....|:. ||..|:::.:            |..||:|.|:
Human   475 ---IGGLGELL---ESSSEASKLSSKSAKEWRNRRKKRRQREHLEGNNKGERDSFPKSESEDSVK 533

  Fly   396 ---------------------------------------------------EEEEAEEDYGDDGY 409
                                                               ::..:|.|:.||.:
Human   534 RSSFLFSMDGNRLTSDKKFCSPHQSLLSIRGSLFSPRRNSKTSIFSFRGRAKDVGSENDFADDEH 598

  Fly   410 ---------------------------------------LKTRSK-------------------- 415
                                                   |....|
Human   599 STFEDSESRRDSLFVPHRHGERRNSNVSQASMSSRMVPGLPANGKMHSTVDCNGVVSLVGGPSAL 663

  Fly   416 --------PQGSCT-----------------------GFWRA---------------EKR----- 429
                    |:|:.|                       |..||               |.|
Human   664 TSPTGQLPPEGTTTETEVRKRRLSSYQISMEMLEDSSGRQRAVSIASILTNTMEELEESRQKCPP 728

  Fly   430 --FRF------------W--IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTEFLY 474
              :||            |  ::|.|.......||    .:.:.|||:.:|:|||......:..|.
Human   729 CWYRFANVFLIWDCCDAWLKVKHLVNLIVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLT 793

  Fly   475 YAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALR 539
            ....:|.|:|.:||.:|:.|:.|..||:..:|.||.:::|.|:.|:..|.|:    ||||||:.|
Human   794 VGNLVFTGIFTAEMVLKIIAMDPYYYFQEGWNIFDGIIVSLSLMELGLSNVE----GLSVLRSFR 854

  Fly   540 LLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-------NLPG 597
            |||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:       |...
Human   855 LLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKINDDC 919

  Fly   598 GTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVF 662
            ..|..:.|.|..:.|.||::|.|| |.|.|:..:...|   :.|...::.:|:|: ||..:||:|
Human   920 TLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAG---QTMCLIVFMLVMVI-GNLVVLNLF 979

  Fly   663 LAIAV-----DNLA---------NAQELTAAEEEQVEEDKEKQLQ-------------------- 693
            ||:.:     ||||         |.|......::.::..|.|..:
Human   980 LALLLSSFSSDNLAATDDDNEMNNLQIAVGRMQKGIDYVKNKMRECFQKAFFRKPKVIEIHEGNK 1044

  Fly   694 -----------ELEKEMEALQADGVHVENGDG------------------------------AV- 716
                       |:.||:..|: ||....:|.|                              ||
Human  1045 IDSCMSNNTGIEISKELNYLR-DGNGTTSGVGTGSSVEKYVIDENDYMSFINNPSLTVTVPIAVG 1108

  Fly   717 --------------------------APSKSKGK---------------KKEEEKKEEEEVTEGP 740
                                      |.|.|:|.               :.||:.|.|...|||.
Human  1109 ESDFENLNTEEFSSESELEESKEKLNATSSSEGSTVDVVLPREGEQAETEPEEDLKPEACFTEGC 1173

  Fly   741 KPMLPYSSMFILSPTNPI----RRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK- 800
            ....|:..:........|    |:..:.:|...:|:.||:.:|.:||.|||.||...|..:..|
Human  1174 IKKFPFCQVSTEEGKGKIWWNLRKTCYSIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKT 1238

  Fly   801 ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQN 865
            :|.|.|..||.:|.:|||||.|..|.    .:|....|..:|.::|..:.||...:..|.|   .
Human  1239 MLEYADKVFTYIFILEMLLKWVAYGF----QTYFTNAWCWLDFLIVDVSLVSLVANALGYS---E 1296

  Fly   866 LSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKF 930
            |..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|.::|..|||::||.||.|||
Human  1297 LGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKF 1361

  Fly   931 FYCTD---------ESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQ 986
            ::|.:         ...:..::||.          |.||..  ||....::|||.|..|.|..|.
Human  1362 YHCVNMTTGNMFDISDVNNLSDCQA----------LGKQAR--WKNVKVNFDNVGAGYLALLQVA 1414

  Fly   987 TGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ----- 1046
            |.:||..::..::.:......|:....:.|.::::::.|...||.:|:|:.:||..|.:|
Human  1415 TFKGWMDIMYAAVDSRDVKLQPVYEENLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFG 1479

  Fly  1047 GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNT 1109
            |    ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....|:..||:||..|.
Human  1480 G----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTRQVFDISIMILICLNM 1540

  Fly  1110 LLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDA 1174
            :.:|::..:||......|..||:.|..:|:.|.|||::... ..:|...|||||.:.|:.|||..
Human  1541 VTMMVETDDQGKYMTLVLSRINLVFIVLFTGEFVLKLVSLR-HYYFTIGWNIFDFVVVILSIVGM 1604

  Fly  1175 LWME-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFI 1234
            ...|     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.||
Human  1605 FLAEMIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFI 1668

  Fly  1235 YAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA--CDDDA 1297
            |||.||..|..:|   .|..|....||::|...::.||:..|...|..::...|....  ||.|.
Human  1669 YAIFGMSNFAYVK---KEAGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSAPPDCDPDT 1730

  Fly  1298 EKAPGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFV 1356
            .. ||..    ||: ::...:|||:|.....:::|:::|||::||...|.:|: .|.....:.|.
Human  1731 IH-PGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFY 1794

  Fly  1357 RIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLF 1421
            .:|.::||:||..|.::::.|....:||||....  ||::   :||.|::|:....|:.....||
Human  1795 EVWEKFDPDATQFIEFSKLSDFAAALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILF 1854

  Fly  1422 ALIRENLSIKMRAPEEMDQADMELRE 1447
            |..:..|.    ...|||...:::.:
Human  1855 AFTKRVLG----ESGEMDALRIQMED 1876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	92/336 (27%)
		Ion_trans	441..677	CDD:334124	87/260 (33%)
		Ion_trans	769..1050	CDD:334124	93/295 (32%)
		Ion_trans	1094..1345	CDD:334124	82/262 (31%)
		GPHH	1346..1416	CDD:339854	20/69 (29%)
		Ca_chan_IQ	1418..1492	CDD:337190	7/30 (23%)
SCN3A	NP_008853.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60
		I. /evidence=ECO:0000305	110..455		103/364 (28%)
		Ion_trans	149..434	CDD:278921	84/303 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	493..528		7/34 (21%)
		Na_trans_cytopl	510..629	CDD:288761	9/118 (8%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	587..631		4/43 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..681		3/18 (17%)
		II. /evidence=ECO:0000305	742..1014		90/280 (32%)
		Ion_trans	777..972	CDD:278921	69/203 (34%)
		Na_trans_assoc	998..1200	CDD:284034	28/202 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1118..1162		5/43 (12%)
		III. /evidence=ECO:0000305	1188..1499		100/333 (30%)
		Ion_trans	1223..1477	CDD:278921	85/272 (31%)
		Na_channel_gate	1469..1521	CDD:240441	12/55 (22%)
		IV. /evidence=ECO:0000305	1508..1806		94/303 (31%)
		Ion_trans	1543..1781	CDD:278921	76/243 (31%)
		ChtBD1	1708..>1743	CDD:302575	8/35 (23%)
		GPHH	1793..1848	CDD:293510	19/59 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1949..2000
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810