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Protein Alignment cac and SCN2A

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001035232.1	Gene:	SCN2A / 6326	HGNCID:	10588	Length:	2005	Species:	Homo sapiens

Alignment Length:	1842	Identity:	463/1842 - (25%)
Similarity:	785/1842 - (42%)	Gaps:	479/1842 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|:|||..|||||....|:....|...::.||:.|||.:.: .:.|...|.|        |..|.
Human   108 ALYILTPFNPIRKLAIKILVHSLFNMLIMCTILTNCVFMTM-SNPPDWTKNV--------EYTFT 163

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:.:||||.|..|...::||:.||.:||.|:...::|::..:|   ::..||..||||.|
Human   164 GIYTFESLIKILARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG---NVSALRTFRVLRAL 225

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK- 210
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|......|...:
Human   226 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCLQWPPDNSSFEI 290

  Fly   211 ----------EGESETPCNTDNI---------------LEKATGSFVCNNTTS--------MCLE 242
                      :|...|...|.:|               ||....:.:|.|::.        :|::
Human   291 NITSFFNNSLDGNGTTFNRTVSIFNWDEYIEDKSHFYFLEGQNDALLCGNSSDAGQCPEGYICVK 355

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||
Human   356 AGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINL 419

  Fly   308 VLGVLS------------------GEFAKEREKVENRQE-------------------------- 328
            :|.|::                  .||.:..|:::.:||
Human   420 ILAVVAMAYEEQNQATLEEAEQKEAEFQQMLEQLKKQQEEAQAAAAAASAESRDFSGAGGIGVFS 484

  Fly   329 ---------------FLKLRRQQQLERELNGYVEWICKAEEVILAE----------------ERT 362
                           .||.||:::.::|.:|..|   |.:.|..:|                .|.
Human   485 ESSSVASKLSSKSEKELKNRRKKKKQKEQSGEEE---KNDRVRKSESEDSIRRKGFRFSLEGSRL 546

  Fly   363 TEEEK-----MHIMEAR------RRNAAKRKKLKSL-GKSKSTDTEEEEAEEDY----------- 404
            |.|::     ..::..|      |||:  |..|.|. |::|...:|.:.|::::
Human   547 TYEKRFSSPHQSLLSIRGSLFSPRRNS--RASLFSFRGRAKDIGSENDFADDEHSTFEDNDSRRD 609

  Fly   405 ------------------------------------------------GDDGYLKTRSK--PQGS 419
                                                            |....|.:..:  |:|:
Human   610 SLFVPHRHGERRHSNVSQASRASRVLPILPMNGKMHSAVDCNGVVSLVGGPSTLTSAGQLLPEGT 674

  Fly   420 CTGFWRAEKR---------------------------------------------FRF------- 432
            .|.....::|                                             ::|
Human   675 TTETEIRKRRSSSYHVSMDLLEDPTSRQRAMSIASILTNTMEELEESRQKCPPCWYKFANMCLIW 739

  Fly   433 -----W--IRHTVKTQWFYWFV----IVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMS 486
                 |  ::|.|.......||    .:.:.|||:.:|:|||......:..|.....:|.|:|.:
Human   740 DCCKPWLKVKHLVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTEQFSSVLSVGNLVFTGIFTA 804

  Fly   487 EMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWS 551
            |||:|:.|:.|..||:..:|.||..::|.|:.|:..:.|:    ||||||:.||||:||:.|.|.
Human   805 EMFLKIIAMDPYYYFQEGWNIFDGFIVSLSLMELGLANVE----GLSVLRSFRLLRVFKLAKSWP 865

  Fly   552 SLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQF-----------NLPGGTPETNFN 605
            :|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:           .||.......|:
Human   866 TLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKECVCKISNDCELPRWHMHDFFH 930

  Fly   606 TFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAV--- 667
            :|    |.||::|.|| |.|.|:..:...|   :.|..:::.:|:|: ||..:||:|||:.:
Human   931 SF----LIVFRVLCGE-WIETMWDCMEVAG---QTMCLTVFMMVMVI-GNLVVLNLFLALLLSSF 986

  Fly   668 --DNLANAQE-----------------------------LTAAEEEQVEEDKEKQLQELEKEMEA 701
              ||||...:                             ..|...:|...|:.|.|::|..:.::
Human   987 SSDNLAATDDDNEMNNLQIAVGRMQKGIDFVKRKIREFIQKAFVRKQKALDEIKPLEDLNNKKDS 1051

  Fly   702 LQADGVHVENG-------DG------------------------------------AVAPSKSKG 723
            ..::...:|.|       ||                                    ||..|..:.
Human  1052 CISNHTTIEIGKDLNYLKDGNGTTSGIGSSVEKYVVDESDYMSFINNPSLTVTVPIAVGESDFEN 1116

  Fly   724 KKKE--------EEKKEEEEVT--------------EGPKPML-PYSSMFILSPTN--------- 756
            ...|        ||.||:...|              ||.:|.: |..|   |.|..
Human  1117 LNTEEFSSESDMEESKEKLNATSSSEGSTVDIGAPAEGEQPEVEPEES---LEPEACFTEDCVRK 1178

  Fly   757 -----------------PIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILN 803
                             .:|:..:.:|...:|:.||:.:|.:||.|||.||...|..:..| :|.
Human  1179 FKCCQISIEEGKGKLWWNLRKTCYKIVEHNWFETFIVFMILLSSGALAFEDIYIEQRKTIKTMLE 1243

  Fly   804 YFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLST 868
            |.|..||.:|.:|||||.|..|..:    |....|..:|.::|..:.||...:..|.|   .|..
Human  1244 YADKVFTYIFILEMLLKWVAYGFQV----YFTNAWCWLDFLIVDVSLVSLTANALGYS---ELGA 1301

  Fly   869 IKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC 933
            |||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||.||.|||::|
Human  1302 IKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGVNLFAGKFYHC 1366

  Fly   934 ----TDESKHTS-----AECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGE 989
                |.|....|     :||:.         |:...:...||....::|||....|:|..|.|.:
Human  1367 INYTTGEMFDVSVVNNYSECKA---------LIESNQTARWKNVKVNFDNVGLGYLSLLQVATFK 1422

  Fly   990 GWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ-----GEA 1049
            ||..::..::.:...:..|.....:.|.::::::.|...||.:|:|:.:||..|.:|     |
Human  1423 GWMDIMYAAVDSRNVELQPKYEDNLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKKKFGG-- 1485

  Fly  1050 ELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLL 1112
              ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....|:..||:||..|.:.:
Human  1486 --QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPANKFQGMVFDFVTKQVFDISIMILICLNMVTM 1548

  Fly  1113 MMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWM 1177
            |::..:|.......|.:||:.|..:|:.|.|||:|.... .:|...|||||.:.|:.|||.....
Human  1549 MVETDDQSQEMTNILYWINLVFIVLFTGECVLKLISLRY-YYFTIGWNIFDFVVVILSIVGMFLA 1612

  Fly  1178 E-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1237
            |     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||..:.||:.::.|||||
Human  1613 ELIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYAI 1676

  Fly  1238 IGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEK-AP 1301
            .||..|..:|.   |..|....||::|...::.||:..|...|..::...|.....|.|.:| .|
Human  1677 FGMSNFAYVKR---EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAPILNSGPPDCDPDKDHP 1738

  Fly  1302 GEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS-ILGAHHLDEFVRIWA 1360
            |..    ||: ::...:|||:|.....:::|:::|||::||...|.:|: .|.....:.|..:|.
Human  1739 GSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESAEPLSEDDFEMFYEVWE 1803

  Fly  1361 EYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIR 1425
            ::||:||..|.:.::.|....:||||....  ||::   :||.|::|:....|:.....|||..:
Human  1804 KFDPDATQFIEFAKLSDFADALDPPLLIAK--PNKV---QLIAMDLPMVSGDRIHCLDILFAFTK 1863

  Fly  1426 ENLSIKMRAPEEMDQADMELRE 1447
            ..|.    ...|||...:::.|
Human  1864 RVLG----ESGEMDALRIQMEE 1881

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.