DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and SCN1A

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	NP_001159435.1	Gene:	SCN1A / 6323	HGNCID:	10585	Length:	2009	Species:	Homo sapiens

Alignment Length:	1858	Identity:	461/1858 - (24%)
Similarity:	765/1858 - (41%)	Gaps:	498/1858 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYF 80
            ::|:|||..||:||....|:....|...::.||:.|||.:.: .:.|...|.|        |..|
Human   106 SALYILTPFNPLRKIAIKILVHSLFSMLIMCTILTNCVFMTM-SNPPDWTKNV--------EYTF 161

  Fly    81 LCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRP 145
            ..|:..|:.:||:|.|..|...::||:.||.:||.|:...::|::..:|   ::..||..||||.
Human   162 TGIYTFESLIKIIARGFCLEDFTFLRDPWNWLDFTVITFAYVTEFVDLG---NVSALRTFRVLRA 223

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVK 210
            ||.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|...|......|..::
Human   224 LKTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRNKCIQWPPTNASLE 288

  Fly   211 EGE--------------SETPCNTD-----------NILEKATGSFVCNNTTS--------MCLE 242
            |..              :||....|           ..||....:.:|.|::.        ||::
Human   289 EHSIEKNITVNYNGTLINETVFEFDWKSYIQDSRYHYFLEGFLDALLCGNSSDAGQCPEGYMCVK 353

  Fly   243 KWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNL 307
            ....||.|.||||...:|.|::|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||
Human   354 AGRNPNYGYTSFDTFSWAFLSLFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFLGSFYLINL 417

  Fly   308 VLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHIME 372
            :|.|::..:.::.:..        |...:|.|.|....:|.:.|.:|.  |::..|.....|..|
Human   418 ILAVVAMAYEEQNQAT--------LEEAEQKEAEFQQMIEQLKKQQEA--AQQAATATASEHSRE 472

  Fly   373 ----------------------ARRRNAAKRKKLK--SLGKSKSTD----TEEEE---------- 399
                                  ..|||..|::|.|  |.|:.|..|    :|.|:
Human   473 PSAAGRLSDSSSEASKLSSKSAKERRNRRKKRKQKEQSGGEEKDEDEFQKSESEDSIRRKGFRFS 537

  Fly   400 ------------------------------------------------AEEDYGDD--------- 407
                                                            :|.|:.||
Human   538 IEGNRLTYEKRYSSPHQSLLSIRGSLFSPRRNSRTSLFSFRGRAKDVGSENDFADDEHSTFEDNE 602

  Fly   408 ------------GYLKTRSKPQGS--------------------CTGF----------------- 423
                        |..:..:..|.|                    |.|.
Human   603 SRRDSLFVPRRHGERRNSNLSQTSRSSRMLAVFPANGKMHSTVDCNGVVSLVGGPSVPTSPVGQL 667

  Fly   424 ---------------------WRAEKRFRFWI-------------------------------RH 436
                                 .|..:...|.:                               |.
Human   668 LPEVIIDKPATDDNGTTTETEMRKRRSSSFHVSMDFLEDPSQRQRAMSIASILTNTVEELEESRQ 732

  Fly   437 TVKTQWF-------------YWF------------------VIVLVFLNTVCVAVEHYGQPSFLT 470
            .....|:             ||.                  :.:.:.|||:.:|:|||.......
Human   733 KCPPCWYKFSNIFLIWDCSPYWLKVKHVVNLVVMDPFVDLAITICIVLNTLFMAMEHYPMTDHFN 797

  Fly   471 EFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVL 535
            ..|.....:|.|:|.:|||:|:.|:.|..||:..:|.||..:::.|:.|:..:.|:    |||||
Human   798 NVLTVGNLVFTGIFTAEMFLKIIAMDPYYYFQEGWNIFDGFIVTLSLVELGLANVE----GLSVL 858

  Fly   536 RALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFN------ 594
            |:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::||||||..:.
Human   859 RSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKSYKDCVCKI 923

  Fly   595 -LPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTL 658
             .....|..:.|.|..:.|.||::|.|| |.|.|:..:...|.|   |..:::.:|:|: ||..:
Human   924 ASDCQLPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA---MCLTVFMMVMVI-GNLVV 983

  Fly   659 LNVFLAI-----AVDNLANAQELTAAEEEQVEED-----------------------KEKQLQEL 695
            ||:|||:     :.||||...:.......|:..|                       |:|.|.|:
Human   984 LNLFLALLLSSFSADNLAATDDDNEMNNLQIAVDRMHKGVAYVKRKIYEFIQQSFIRKQKILDEI 1048

  Fly   696 E---------------------KEMEALQ-ADGVHVENGDG------------------------ 714
            :                     |:::.|: .:|.....|.|
Human  1049 KPLDDLNNKKDSCMSNHTAEIGKDLDYLKDVNGTTSGIGTGSSVEKYIIDESDYMSFINNPSLTV 1113

  Fly   715 ----AVAPSKSKGKKKE--------EEKKE--------------------EEEVTEGPKPMLPYS 747
                ||..|..:....|        ||.||                    ||:....|:..|...
Human  1114 TVPIAVGESDFENLNTEDFSSESDLEESKEKLNESSSSSEGSTVDIGAPVEEQPVVEPEETLEPE 1178

  Fly   748 SMFILSPTNPIR---------RGAHW---------VVNLPYFDFFIMVVISMSSIALAAEDPVRE 794
            :.|........:         ||..|         :|...:|:.||:.:|.:||.|||.||...:
Human  1179 ACFTEGCVQRFKCCQINVEEGRGKQWWNLRRTCFRIVEHNWFETFIVFMILLSSGALAFEDIYID 1243

  Fly   795 NSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMS 858
            ..:..| :|.|.|..||.:|.:|||||.|..|.    .:|....|..:|.::|..:.||...:..
Human  1244 QRKTIKTMLEYADKVFTYIFILEMLLKWVAYGY----QTYFTNAWCWLDFLIVDVSLVSLTANAL 1304

  Fly   859 GSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGV 923
            |.|   .|..|||||.||.||||:.:.|...::.|.:.::.::.:::|:|:|.::|..|||::||
Human  1305 GYS---ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALLGAIPSIMNVLLVCLIFWLIFSIMGV 1366

  Fly   924 QLFNGKFFYC-----------TDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAA 977
            .||.|||::|           .|.:.||  :|.         :|:.:.|...||....::|||..
Human  1367 NLFAGKFYHCINTTTGDRFDIEDVNNHT--DCL---------KLIERNETARWKNVKVNFDNVGF 1420

  Fly   978 AMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVF----PFFFVNIFVAL 1038
            ..|:|..|.|.:||..:    |.|..:.|......:.|.|::..:||::|    .||.:|:|:.:
Human  1421 GYLSLLQVATFKGWMDI----MYAAVDSRNVELQPKYEESLYMYLYFVIFIIFGSFFTLNLFIGV 1481

  Fly  1039 IIITFQEQ-----GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTP 1096
            ||..|.:|     |    ||..:.:.||...:.  .:|::..::.:|:..|.|:..|:..|....
Human  1482 IIDNFNQQKKKFGG----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPGNKFQGMVFDFVTRQV 1542

  Fly  1097 FEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNI 1161
            |:..||:||..|.:.:|::..:|.:.....|..||:.|..:|:.|.|||:|... ..:|...|||
Human  1543 FDISIMILICLNMVTMMVETDDQSEYVTTILSRINLVFIVLFTGECVLKLISLR-HYYFTIGWNI 1606

  Fly  1162 FDLITVLGSIVDALWME-----FGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKAL 1221
            ||.:.|:.|||.....|     |.|.:: ...:||.|..|:::|::....||.||:..:.|..||
Human  1607 FDFVVVILSIVGMFLAELIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1670

  Fly  1222 PYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLA 1286
            ..:.||:.::.|||||.||..|..:|.   |..|....||::|...::.||:..|...|..::..
Human  1671 FNIGLLLFLVMFIYAIFGMSNFAYVKR---EVGIDDMFNFETFGNSMICLFQITTSAGWDGLLAP 1732

  Fly  1287 CLKGKACDDDAEKA-PGEY----CGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS 1345
            .|..|..|.|..|. ||..    ||: ::...:|||:|.....:::|:::|||::||...|.:|:
Human  1733 ILNSKPPDCDPNKVNPGSSVKGDCGNPSVGIFFFVSYIIISFLVVVNMYIAVILENFSVATEESA 1797

  Fly  1346 -ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLD 1409
             .|.....:.|..:|.::||:||..:.:.::......::|||....  ||:|   :||.|::|:.
Human  1798 EPLSEDDFEMFYEVWEKFDPDATQFMEFEKLSQFAAALEPPLNLPQ--PNKL---QLIAMDLPMV 1857

  Fly  1410 DELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRE 1447
            ...|:.....|||..:..|.    ...|||...:::.|
Human  1858 SGDRIHCLDILFAFTKRVLG----ESGEMDALRIQMEE 1891

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	88/319 (28%)
		Ion_trans	441..677	CDD:334124	85/278 (31%)
		Ion_trans	769..1050	CDD:334124	96/301 (32%)
		Ion_trans	1094..1345	CDD:334124	83/261 (32%)
		GPHH	1346..1416	CDD:339854	18/69 (26%)
		Ca_chan_IQ	1418..1492	CDD:337190	8/30 (27%)
SCN1A	NP_001159435.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..60
		I. /evidence=ECO:0000305	110..454		101/364 (28%)
		Ion_trans	127..433	CDD:306908	88/318 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	455..529		17/75 (23%)
		Na_trans_cytopl	510..705	CDD:314757	17/194 (9%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..627		6/42 (14%)
		II. /evidence=ECO:0000305	750..1022		86/280 (31%)
		Ion_trans	767..980	CDD:306908	71/221 (32%)
		Na_trans_assoc	1006..1213	CDD:310839	27/206 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1129..1163		5/33 (15%)
		III. /evidence=ECO:0000305	1200..1514		104/339 (31%)
		Ion_trans	1217..1492	CDD:306908	95/296 (32%)
		Na_channel_gate	1484..1536	CDD:240441	12/55 (22%)
		IV. /evidence=ECO:0000305	1523..1821		95/302 (31%)
		Ion_trans	1540..1796	CDD:306908	83/260 (32%)
		S1-S2 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1561..1571		1/9 (11%)
		S3b-S4 loop of repeat IV. /evidence=ECO:0000250\|UniProtKB:A2APX8	1619..1636		3/17 (18%)
		GPHH	1800..1863	CDD:318993	18/67 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1986..2009
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910