DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn8aa

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_005162325.1 Gene:scn8aa / 58152 ZFINID:ZDB-GENE-000828-1 Length:1960 Species:Danio rerio


Alignment Length:1883 Identity:461/1883 - (24%)
Similarity:804/1883 - (42%) Gaps:423/1883 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            :|::::..|..|:....|:....|...::.||:.|||.:.. .:.|...|.|        |..|.
Zfish   111 ALYMISPFNLARRIAIKILIHSVFSMFIMCTILTNCVFMTF-SNPPEWSKQV--------EYTFT 166

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..|:::||:|.|..:...::||:.||.:||.|:...::|::..:|   ::..||..||||.|
Zfish   167 GIYTFESAVKIIARGFCIDGFTFLRDPWNWLDFMVISMAYVTEFVDLG---NVSALRTFRVLRAL 228

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY--------SLE 203
            |.:|.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|.:.|.        ...
Zfish   229 KTISVIPGLKTIVGALIQSVKKLSDVMILTVFCLSVFALIGLQLFMGNLRQKCVIWPINITEMFP 293

  Fly   204 DPNKLVKEGESETPCNTDN--ILEKATGSFVCNNTTS--------MCLEKWEGPNSGITSFDNIG 258
            |.|........|...|..|  .|.....:.:|.|::.        .|::....||.|.||||:.|
Zfish   294 DVNGSRAFNWDEYILNETNFYFLPDQLDALLCGNSSDSGRCPEGYTCMKAGRNPNYGYTSFDSFG 358

  Fly   259 FAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAK----- 318
            :|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:|.|::..:.:     
Zfish   359 WAFLALFRLMTQDFWENLYQLTLRAAGKTY-MIFFVLVIFVGSFYLVNLILAVVAMAYEEQNQAT 422

  Fly   319 ----EREKVENRQEFLKLRRQQQ------------------LERELNGYVEWICKAEEVI----- 356
                ||::.|.:....:|::||:                  :|.:.:|.....|.:.|:.     
Zfish   423 MEEAERKEAEFKAMLEQLKKQQEDAQANAMATSAGTVSEDVVEDDGDGEGNLSCSSSEMSKLSSK 487

  Fly   357 LAEERTTEEEKMHIMEARRRNAAKRKKLKS----------------LGK---------------- 389
            .|:||...::|....|..:......|.:||                ||:                
Zfish   488 SAKERRNRKKKWRQKEQDKEKGDSEKFVKSESDDGSRRRFRFPDNRLGRRSSIMNQSLLSIPGSP 552

  Fly   390 ------SKST--------DTEEEEAEED--------------------------YG--------- 405
                  |||:        .:|.|.|:::                          ||         
Zfish   553 FPSRRNSKSSIFSRCKDGGSENEFADDEHSTVEEYDERRDSFLSPQRRSSYTGFYGKRNSTVDCN 617

  Fly   406 -------------------------DDG---YLKTRSKPQGSC--------TGFWRAEK------ 428
                                     ||.   .|:.:.|..||.        |.|.|.|:      
Zfish   618 GVVSLIGPGPGGRLLPEVIIDKAATDDSPTTDLEIKKKLSGSLMVSVEQLNTSFGRKERANSVMS 682

  Fly   429 --------------------------RFRFW------------IRHTVKTQWFYWFVIVLVFLNT 455
                                      .|..|            :...|...:....:.:.:.|||
Zfish   683 ALTNTLVEELEESQRKCPPCWYKFANTFLIWECGPLWMSIKEIVNLIVMDPFVDLAITICIVLNT 747

  Fly   456 VCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEV 520
            :.:|:|||.........|.....:|.|:|.:|||.|:.|:.|..||:..:|.||..::|.|:.|:
Zfish   748 LFMAMEHYPMTPQFEHVLSVGNLVFTGIFTAEMFAKLVAMDPYYYFQEGWNIFDGFIVSLSLMEL 812

  Fly   521 IWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLG 585
            ..:.|:    ||||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||::|
Zfish   813 GLANVE----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAVVG 873

  Fly   586 MQLFGGQFN-------LPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIY 643
            |||||..:.       .....|..:.|.|..:.|.||::|.|| |.|.|:..:...|.|    :.
Zfish   874 MQLFGKSYKDCVCKIAQDCELPRWHMNDFFHSFLIVFRVLCGE-WIETMWDCMEVAGQA----MC 933

  Fly   644 SIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEE----------------------QVEE 686
            .|.|:::::.||..:||:|||:.:.:. :|..|.|::::                      :|.|
Zfish   934 LIVFMMVMVIGNLVVLNLFLALLLSSF-SADNLAASDDDGEMNNLQIAVIRIKKGIAWVKAKVRE 997

  Fly   687 -----------DKEKQLQEL-EKEMEAL-QADGVHV-------ENGDG----------------- 714
                       |:.|.|.:: ::::..: ...||.:       :||:|                 
Zfish   998 LVNIILGRKVTDEAKPLDDMYDRKLNCIANHTGVDISRDLDYQKNGNGTTSGIGSSVGKYMIDDD 1062

  Fly   715 ----------------AVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYS----SMFILSP----- 754
                            ||..|..:....|:...|.|  .||.|.:...|    |...:.|     
Zfish  1063 HMSFIHNPNLTVCVPIAVGESDFENLNTEDFSSESE--AEGSKELDDISSSEGSTIDIKPEVEEA 1125

  Fly   755 ---------TNP-----------------------------IRRGAHWVVNLPYFDFFIMVVISM 781
                     .:|                             :|:..:.:|...:|:..|:.:|.:
Zfish  1126 VVVETVEEYVDPEACWTEACIARYKCCDVPITEGWGKNWWFLRKTCYLIVEHNWFETLIIFMILL 1190

  Fly   782 SSIALAAEDPVRENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVV 845
            ||.|||.||...|..:..: ||.|.|..||.:|.:|||||.|..|.:    .|....|..:|..:
Zfish  1191 SSGALAFEDVYIEQRKTIRIILEYADMVFTYIFILEMLLKWVAYGFV----KYFTNAWCWLDFFI 1251

  Fly   846 VICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIV 910
            |..:.||...:..|.|   :|..|||||.||.||||:.:.|...::.|.:.:|.::.:::|:|:|
Zfish  1252 VDVSIVSLIANALGYS---DLGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLV 1313

  Fly   911 YILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRV-WKPRAFHYDN 974
            .::|..|||::||.:|.||::||.:|::....|......|.|...|:.:....| ||....::||
Zfish  1314 CLIFWLIFSIMGVNMFAGKYYYCYNETEKAYFELDVVNNKSECFALIEQNYTEVRWKNVKINFDN 1378

  Fly   975 VAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALI 1039
            |.|..|.|..|.|.:||..::..::.:...:..|.....|.|.|:::::.|...||.:|:|:.:|
Zfish  1379 VGAGYLALLQVATFKGWMDIMYAAVDSRRVEDQPKYEDNIYMYIYFVIFIIFGSFFTLNLFIGVI 1443

  Fly  1040 IITFQEQ-----GEAELQDGEIDKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPF 1097
            |..|.:|     |    ||..:.:.||...:.  .:|::..::.:|:.:|..:..|:..|....|
Zfish  1444 IDNFNQQKKKFGG----QDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPQNKLQGMVFDFVTQQVF 1504

  Fly  1098 EYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNI 1161
            :..||:||..|.:.:|::..:|....|..|.:||..|...|:.|.|||:  |.::: :|.:.|||
Zfish  1505 DISIMILICLNMVTMMVETDDQSQETENILYWINFIFIVAFTSEFVLKL--FALRHYYFTNGWNI 1567

  Fly  1162 FDLITVLGSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKAL 1221
            ||.:.|:.|||     |.:...|.|.:: ...:||.|..|:::|::....||.||:..:.|..||
Zfish  1568 FDCVVVILSIVGMFLADLIEKYFVSPTL-FRVIRLARIGRILRLIKGAKGIRTLLFALMMSLPAL 1631

  Fly  1222 PYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLA 1286
            ..:.||:.::.||::|.||..|..:|.   |:.|....||::|...::.||...|...|..::..
Zfish  1632 FNIGLLLFLVMFIFSIFGMSNFAYVKR---ESGIDDMYNFETFGNSMICLFMITTSAGWDGLLAP 1693

  Fly  1287 CLKGKACDDDAEKAPGE----YCGS-TLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSS- 1345
            .|......:..::.||.    .||: ::...:||.:|.....:::|:::|:|::||...|.:|: 
Zfish  1694 ILNYPPDCEPTKENPGTSVKGNCGNPSVGIFFFVMYIIVSFLIVVNMYIAIILENFSVATEESAD 1758

  Fly  1346 ILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDD 1410
            .|.....:.|..||.::||.|:..|.:.::.|....::.||....  ||.:   :||.|::|:..
Zfish  1759 PLCEDDFESFYEIWEKFDPTASQFITFAKLGDFADTLEHPLRVPK--PNTI---ELIAMDLPMVS 1818

  Fly  1411 ELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGK 1475
            ..|:.....|||..:..|...  ...:|.:..||.|....|...:..:.:...|....:.::.|.
Zfish  1819 GDRIHCLDILFAFTKRVLGDS--GDLDMMRQQMEERFIAANPSKVSFEPITTTLRRKQEHMSAGV 1881

  Fly  1476 LS----VGKIYAGFL---ILESWRSTRFG---QLDSGMP---MLELQDASRHPSQESLTGADA 1525
            :.    ...|..||:   :|.|.|....|   ....|.|   .|...|:...|.:|.|..:|:
Zfish  1882 IQRAFRAHLIRKGFICKRLLSSSRLENGGTNQDKKEGTPSTASLPSYDSVTKPEKEKLEESDS 1944

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 88/313 (28%)
Ion_trans 441..677 CDD:334124 79/242 (33%)
Ion_trans 769..1050 CDD:334124 94/287 (33%)
Ion_trans 1094..1345 CDD:334124 76/261 (29%)
GPHH 1346..1416 CDD:339854 18/69 (26%)
Ca_chan_IQ 1418..1492 CDD:337190 16/80 (20%)
scn8aaXP_005162325.1 Ion_trans 151..423 CDD:278921 80/284 (28%)
ATP-synt_B 363..>456 CDD:304375 23/93 (25%)
Na_trans_cytopl 498..604 CDD:288761 13/105 (12%)
Ion_trans 750..945 CDD:278921 68/203 (33%)
Na_trans_assoc 971..1172 CDD:284034 24/202 (12%)
Ion_trans 1195..1453 CDD:278921 87/264 (33%)
Na_channel_gate 1445..1497 CDD:240441 11/55 (20%)
Ion_trans 1519..1756 CDD:278921 70/242 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
32.820

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