DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn4aa

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:NP_001034914.1 Gene:scn4aa / 572442 ZFINID:ZDB-GENE-051201-2 Length:1829 Species:Danio rerio


Alignment Length:1842 Identity:478/1842 - (25%)
Similarity:824/1842 - (44%) Gaps:351/1842 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ::|.::..:.:|:....|:....|...:::||::|||.:.: .:.|...|||        |..|.
Zfish   103 AMFCISPFSIVRRGAIKILIHSLFSMFIMITILSNCVFMTM-SNPPAWSKTV--------EYVFT 158

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPL 146
            .|:..||::|:|:.|..:...::||:.||.:||.|:...::|::..:|   ::..||..||||.|
Zfish   159 GIYTFEATVKVLSRGFCIGPFTFLRDPWNWLDFMVISMAYVTEFVDLG---NVSALRTFRVLRAL 220

  Fly   147 KLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTC----------YS 201
            |.::.||.|:.::.::|:::..::.:.:|.:||:.:||:|||:.:.|.|.:.|          :.
Zfish   221 KTITVIPGLKTIVGALIQSVKKMIDVMILTIFALAVFALIGLQLFMGNLRQKCIRWPILNSTIFD 285

  Fly   202 LEDPNKLVKEGESETPCN-TDN--------------ILEKATGSFVCNNTTS--------MCLEK 243
            :.:.|.:     ::|..| ||.              .||.:..:.:|.|::.        .|::.
Zfish   286 VYNSNMV-----NDTTLNVTDTFDFKAYINNEENQYFLEGSLDALLCGNSSDAGRCPEGYTCMKA 345

  Fly   244 WEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLV 308
            ...||.|.||:||.|:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::||:
Zfish   346 GRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTY-MIFFVVVIFLGSFYLINLI 409

  Fly   309 LGVLS--------GEFAKEREKVENRQEFLKLRRQQQ---------------------------- 337
            |.|::        ...|:.|:|.|..|..|:..:.|:                            
Zfish   410 LAVVAMAYDEQNEATLAEARDKEEEFQRLLEQLKNQETGSKASLASQKTQSRGSNRTGSLHDLAD 474

  Fly   338 --LERELNGYVEWICKAEEVILAEERTTEEEKMHIMEARRRNAAKRKKL-KSLGKSKSTDTEEEE 399
              :.::.||.:........|...:|.:.||::..:..........:.|| |....:.|..|...|
Zfish   475 EDVIKDCNGRIVPRLIVNRVSSNKELSAEEDQKSLSSKHSMQYLDQPKLSKRTASALSVLTATME 539

  Fly   400 AEEDYGDDGYLKTRSKPQG-----------SCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFL 453
            ..||       ..|..|.|           .|...|..   |:.|:...|...:....:.:.:.|
Zfish   540 GLED-------AQRPCPPGWYKFADMFLKWDCCAPWIL---FKKWVHFVVMDPFVDLGITICIVL 594

  Fly   454 NTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIF 518
            ||:.:|:|||.........|.....:|.|:|.:||..|:.|:.|..||:..:|.||.::::.|:.
Zfish   595 NTLFMAMEHYPMSPHFEHVLSVGNLVFTGIFTAEMVFKLIAMDPYYYFQVGWNIFDSIIVTLSLV 659

  Fly   519 EVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFAL 583
            |:..:.|:    ||||||:.||||:||:.|.|.:|..|:..:.||:.::.:|..:|.:.:.|||:
Zfish   660 ELGLANVQ----GLSVLRSFRLLRVFKLAKSWPTLNMLIKIIGNSVGALGNLTLVLAIIVFIFAV 720

  Fly   584 LGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGM 641
            :||||||..:       :.....|..:.|.|..:.|.||:||.|| |.|.|:. .:...||...:
Zfish   721 VGMQLFGKSYKDCVCKISEDCELPRWHMNDFFHSFLIVFRILCGE-WIETMWD-CMEVAGASMCL 783

  Fly   642 IYSIYFIVLVLFGNYTLLNVFLAIAV-----DNLANAQE-----------------------LTA 678
               |.|:::::.||..:||:|||:.:     |||:...:                       |.|
Zfish   784 ---IVFMMVMVIGNLVVLNLFLALLLSSFSGDNLSGGDDDGEMNNLQIAIGRITRGIDWVKALVA 845

  Fly   679 AEEEQV---EEDKEKQLQELEKEMEAL-------QADGV-------------------------- 707
            :..:::   :.|..|:..|.:.|:.||       .|||:                          
Zfish   846 SMVQRILGKKPDNTKEEGEGDIELYALNHLDEGKMADGLTNCLSPTLTVPIARCESDVEEDEDSE 910

  Fly   708 ---------HVENGDGAVAPSKSKGKKKEEEKKEEEEVTEGPKPMLPYSSMFILSPTNPIRR--- 760
                     .:.:||.:|. |....:..|.|.:.||...|.|:|..|.:..    ....|||   
Zfish   911 SSDEEDAKATLNDGDSSVC-STVDYQPPEPEPEPEEVEEEEPEPEEPEACF----TEGCIRRCAC 970

  Fly   761 ---------GAHW---------VVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNK-ILNYFD 806
                     |..|         :|...||:.||:.:|.:||.|||.||...|..|..| ||.|.|
Zfish   971 LSVDITEGWGKKWWNLRRTCFTIVEHDYFETFIIFMILLSSGALAFEDINIERRRVIKTILEYAD 1035

  Fly   807 YAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKS 871
            ..||.:|.:|||||.|..|.    .:|....|..:|.::|..:.||...::.|.|   .|..|||
Zfish  1036 KVFTYIFIVEMLLKWVAYGF----KTYFTNAWCWLDFLIVDVSLVSLTANLMGYS---ELGAIKS 1093

  Fly   872 LRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYC--- 933
            ||.||.||||:.:.|...::.|.:.:|.::.::.|:|:|.::|..|||::||.||.|||::|   
Zfish  1094 LRTLRALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIMGVNLFAGKFYHCINT 1158

  Fly   934 TDESK------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWP 992
            |.|.:      :..::|..         |:...|:| |.....:||||....|:|..:.|.:||.
Zfish  1159 TTEERIPMDVVNNKSDCMA---------LMYTNEVR-WVNVKVNYDNVGLGYLSLLQIATFKGWM 1213

  Fly   993 QVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQ----GEAELQD 1053
            .::..::.:...|..|.....:.|.::::::.|...||.:|:|:.:||..|.:|    |..::..
Zfish  1214 DIMYAAVDSREVDEQPSYEINLYMYLYFVIFIIFGSFFTLNLFIGVIIDNFNQQKSKFGGKDIFM 1278

  Fly  1054 GEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLLMMKYHN 1118
            .|..|...:.:. .:||:...:.:|:..|..:..|:..:....|:.|||:||..|.:.:|::..:
Zfish  1279 TEEQKKYYNAMK-KLGAKKRPKPIPRPSNIIQGLVFDFISKQFFDIFIMVLICLNMVTMMIETDD 1342

  Fly  1119 QGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKN-FFKDPWNIFDLITVLGSIV-----DALWM 1177
            |....|..|..||:.|..:|:.|.|||:  |.::. ||...||:||.:.|:.||.     |.:..
Zfish  1343 QSAEKEYVLYQINLVFIVVFTSECVLKL--FALRQYFFTIGWNVFDFVVVILSIAGLMLSDIIEK 1405

  Fly  1178 EFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1242
            .|.|.:: ...:||.|..|:::|:|....||.||:..:.|..||..:.||:.::.||::|.||..
Zfish  1406 YFVSPTL-FRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLIMFIFSIFGMSN 1469

  Fly  1243 FGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKG--KACDDDAEKAPGE-- 1303
            |..:|   .:..|....||::|...::.||...|...|..::|..|..  ..||.|.|. ||.  
Zfish  1470 FAYVK---KQAGIDDIFNFETFGGSIICLFEITTSAGWDGLLLPILNSGPPDCDPDFEN-PGTDV 1530

  Fly  1304 --YCGST-LAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDS-SILGAHHLDEFVRIWAEYDP 1364
              .||:. :...:|.|:|.....:::|:::|:|::||:....:| ..|.....|.|...|.::|.
Zfish  1531 RGNCGNPGMGIMFFCSYIIMSFLVVVNMYIAIILENFNNAQEESGDPLCEDDFDMFDETWEKFDV 1595

  Fly  1365 NATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENL- 1428
            :||..|.|..::|.:..:..||....  ||||   |||.|::|:.:..::.....|.|:.||.| 
Zfish  1596 DATQFIEYDRLFDFVDALQEPLRIAK--PNRL---KLISMDIPIVNGDKIHSQDILLAVTREVLG 1655

  Fly  1429 -SIKMRAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWR 1492
             :|:|.|.:|    .:|.:..:.|......:.::..|....::  :..::|.:||...|:..:.|
Zfish  1656 DTIEMDAMKE----SIEAKFIMNNPTSASFEPIITTLRRKEEE--RAAIAVQRIYRRHLLKRAIR 1714

  Fly  1493 STRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPSP 1557
            ...|        |...:...|:|:.                             |..|.......
Zfish  1715 YACF--------MRRSKRKVRNPND-----------------------------NEPPETEGLIA 1742

  Fly  1558 RRRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAST-SPARSPSPSRYGGHL 1621
            |:....|     |.:..::..:|:  ||| |...||.|  |:.|....| :....|.|       
Zfish  1743 RKMNTLY-----GSNPELAMALEL--ETR-PMRPNSQP--PKPSQVTQTRASVTFPRP------- 1790

  Fly  1622 SRSKRTQLPYPTYGTTSLCQRS 1643
                :.||..|...|:.:..||
Zfish  1791 ----QGQLILPVELTSEVILRS 1808

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 90/327 (28%)
Ion_trans 441..677 CDD:334124 80/270 (30%)
Ion_trans 769..1050 CDD:334124 96/294 (33%)
Ion_trans 1094..1345 CDD:334124 81/264 (31%)
GPHH 1346..1416 CDD:339854 21/69 (30%)
Ca_chan_IQ 1418..1492 CDD:337190 16/75 (21%)
scn4aaNP_001034914.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 32..52
I. /evidence=ECO:0000305 106..421 89/332 (27%)
Ion_trans 149..424 CDD:278921 80/291 (27%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 446..468 0/21 (0%)
II. /evidence=ECO:0000305 564..836 85/283 (30%)
Ion_trans 599..794 CDD:278921 67/203 (33%)
Na_trans_assoc 820..992 CDD:284034 28/176 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..957 11/56 (20%)
III. /evidence=ECO:0000305 979..1292 101/330 (31%)
Ion_trans 1014..1270 CDD:278921 87/272 (32%)
Na_channel_gate 1262..1314 CDD:240441 10/52 (19%)
Important for rapid channel inactivation. /evidence=ECO:0000250|UniProtKB:P15390 1276..1278 0/1 (0%)
IV. /evidence=ECO:0000305 1301..1599 90/304 (30%)
Ion_trans 1336..1575 CDD:278921 73/245 (30%)
GPHH 1584..1641 CDD:293510 20/61 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1765..1786 7/22 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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