DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1sa

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_005168332.1 Gene:cacna1sa / 570683 ZFINID:ZDB-GENE-090514-1 Length:1778 Species:Danio rerio


Alignment Length:1765 Identity:752/1765 - (42%)
Similarity:1009/1765 - (57%) Gaps:247/1765 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 KEENPPGGGP---TSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKT 67
            |:....||.|   .||..||..||.||....|:||.|||..:||||.||||.||:...:|..|..
Zfish    28 KKLQATGGNPRPARSLLFLTLKNPFRKACINIVEWKPFEIIILLTIFANCVALAVFMPMPEEDTN 92

  Fly    68 VLAQKLEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQI---- 128
            .....||..|..||.||.:|..|||:|.|.:.|..:||||.|||:||.:|..|..|.....    
Zfish    93 NTNSNLESLEYIFLIIFTMECFLKIVAYGFLFHADAYLRNCWNILDFVIVTMGLFTVVVDFINSI 157

  Fly   129 -GPEV--------DLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFA 184
             |.|.        |::.|||.||||||:||||:||||||:.||:|:|.||..|.|||.|.:.|:|
Zfish   158 SGVEAPVEQKGGFDMKALRAFRVLRPLRLVSGVPSLQVVMSSILKSMLPLFHISLLVFFMVTIYA 222

  Fly   185 IIGLEFYSGALHKTCYSLEDPNKLVKEGE--SETPCNTDNILEKATGSFVCNNTTSMCLEKWEGP 247
            |||||.:...:|||||  .....::..|:  ...||      .:|.....|....:.|...|.||
Zfish   223 IIGLELFKCKMHKTCY--HTGTDIIATGDDAQAAPC------AQAGNGRRCTLNGTECRGDWPGP 279

  Fly   248 NSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVL 312
            |:|||.|||:||:||||:||||.:|||.:|||.|||:|..:.|:|||.||::||||:||||||||
Zfish   280 NNGITHFDNLGFSMLTVYQCITTQGWTDVLYWVNDAIGMEWPWLYFVTLILLGSFFILNLVLGVL 344

  Fly   313 SGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAE--------EVILAEERTTEEEKM- 368
            .|||.|||||.....|:..||.:||.:.:|.||:|||.:||        :.:|..:..:|.|.: 
Zfish   345 CGEFTKEREKSSRSGEYQILRERQQFDEDLKGYMEWITQAEVMDNDQEGQGLLPLQDGSETETLY 409

  Fly   369 ----------HIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGDDGYLKTRSKPQGSCTGF 423
                      ::..|||.|...|:|                                    |   
Zfish   410 ELDILNKLMFYVRHARRWNRFFRRK------------------------------------C--- 435

  Fly   424 WRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEM 488
                   |.|    ||::.|||.||:|||.||:.:|.||:.||..||.|........|.||..||
Zfish   436 -------RVW----VKSKLFYWLVILLVFFNTLAIATEHHQQPDSLTNFQDNTNKALLSLFAVEM 489

  Fly   489 FIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVKGGS-FGLSVLRALRLLRIFKVTKYWSS 552
            |:||||:|...||.|.||||||.|:|..|.|:|...:...| .|:||||.:|||||.|:|::|::
Zfish   490 FLKMYAMGLPSYFMSLFNRFDCFVVSVGILELILVRMDVMSVMGISVLRCIRLLRIIKITRHWTT 554

  Fly   553 LRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGG-TPETNFNTFPIALLTVFQ 616
            |.|||.|||||:|||.|||.||||||:||||||||:|||:||.|.. ...:||:.||.||:||||
Zfish   555 LSNLVASLLNSVRSIASLLLLLFLFIVIFALLGMQVFGGKFNFPDDRVRRSNFDNFPQALITVFQ 619

  Fly   617 ILTGEDWNEVMYQGIISQGG-AQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAE 680
            |||||.||.|||.||::.|| |..|::.|||||:|.:.|||.||||||||||||||.|:.||:|:
Zfish   620 ILTGEGWNYVMYDGIMAHGGPAIPGILVSIYFIILFICGNYILLNVFLAIAVDNLAEAESLTSAQ 684

  Fly   681 EEQVEEDKEKQ-----LQELEKEMEALQADGVHVENG--DGAVAPSKSKGKKKE----------- 727
            :|:.||.|.|:     |.:..:|.:||.|..:..:..  ||....:|.|..:.|           
Zfish   685 KEKAEEKKRKRLLRENLPDKGEEEKALLAKKLAEQRAKIDGIPTTAKLKVDEFESNVNEIKDPFP 749

  Fly   728 ------EEKKEEEEVTEGPK--------------PMLPYSSMFILSPTNPIRRGAHWVVNLPYFD 772
                  ::::||.|:...|:              ||...|:.|:..|.|..|:..|.::|...|.
Zfish   750 PADFPGDDEEEEPEIPLSPRPRPMADLQLKETEVPMPEASAFFLFGPQNKFRKLCHRIINATTFT 814

  Fly   773 FFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREF 837
            ..|::.|.:|||:||||||:...|.||::|.|.||.||.|||.|::||:...|..||.||:.|..
Zfish   815 NIILLFILLSSISLAAEDPIDPMSFRNQVLAYADYVFTSVFTAEIVLKMTTYGAFLHKGSFCRNS 879

  Fly   838 WNIMDAVVVICAAVSFGFDMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLK 902
            :||:|.:||..:.:|.|.:.|.      :|.:|.||||||||||:.|.|...||.|..||..::|
Zfish   880 FNILDLIVVGVSLLSMGMESSA------ISVVKILRVLRVLRPLRAINRAKGLKHVVQCVFVAIK 938

  Fly   903 NVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEED---ELLPKQELRV 964
            .:.||::|.:|..|:|:.||||||.|||.||||..|.|:.||||::.:::|:   :::..|  |:
Zfish   939 TIGNIVLVTMLLDFMFACIGVQLFKGKFLYCTDPLKMTAEECQGTFIQHQENALHDMVVSQ--RL 1001

  Fly   965 WKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPF 1029
            |.....::|||...||.||.|.|.||||.:|..::.:..|:.||:.|..||:|||:|||.|:..|
Zfish  1002 WMNSDLNFDNVLNGMLALFTVSTFEGWPDLLYKAIDSNLENMGPVYNNHIEISIFFIVYLILIAF 1066

  Fly  1030 FFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVS 1094
            |.:||||..:|:|||||||.|.::.|:||||:.|:.:.:.||||..|:||  |.::|:||.||.|
Zfish  1067 FMMNIFVGFVIVTFQEQGEQEYKNCELDKNQRQCVQYALKARPLRCYIPK--NPYQYQVWYIVTS 1129

  Fly  1095 TPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPW 1159
            ..|||.:.:||:.||:.|.|::..|.|........:|:.||.:|:||.:||:..|..|.:|.|||
Zfish  1130 CYFEYLMFLLIMLNTMCLGMQHCKQSDHITDLADTLNVIFTVLFTVEMILKLGAFKAKGYFGDPW 1194

  Fly  1160 NIFDLITVLGSIVDALWMEFG----------------------------SNSINVGFLRLFRAAR 1196
            |:||.:.|:|||||.:..|..                            :.|:::...||||..|
Zfish  1195 NVFDFVIVVGSIVDVILSEIDAALAAQGGLYCLTGCSEVNPMQAIADSENMSVSITLFRLFRVMR 1259

  Fly  1197 LIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQVFGNIKL--GTVENSITRHN 1259
            |:|||.:...||.|||||::||:|||||.|||.|||||||:|||||||.|.|  ||:   |.|:|
Zfish  1260 LVKLLNRFEGIRNLLWTFIKSFQALPYVALLIVMLFFIYAVIGMQVFGKIALLDGTI---INRNN 1321

  Fly  1260 NFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAPGE--YCGSTLAYAYFVSFIFFCS 1322
            |||:|.|.|:|||||||||.|..|||.||.|:.||..:|..|||  .|||..|..||:||...|:
Zfish  1322 NFQTFPQAVLLLFRCATGEGWHEIMLGCLYGQRCDPKSEYLPGEEYTCGSGFAILYFMSFYMLCA 1386

  Fly  1323 FLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLG 1387
            ||::|||||||||||||||||.||||..|||||.:|||||||.|||:|.:.::..:|:.:.||||
Zfish  1387 FLIINLFVAVIMDNFDYLTRDWSILGPQHLDEFKKIWAEYDPEATGRIKHLDVVTLLRRIQPPLG 1451

  Fly  1388 FGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENLSIKMRAPEEMDQADMELRETITNI 1452
            ||..||:|:|.|:||.|||||:.:..|.|..|||||:|..|.||...  ..:||:.|||..|..|
Zfish  1452 FGKFCPHRVACKRLISMNMPLNSDGTVTFNATLFALVRTGLKIKTEG--NFEQANEELRAIIKKI 1514

  Fly  1453 WPLQAKKMLNLLVPPSDQLNKGKLSVGKIYAGFLILESWR------STRFG-----------QLD 1500
            |...:.|:|:.::|   .|...:::|||.||.|||.:.:|      ...:|           ::.
Zfish  1515 WKRTSMKLLDQVIP---ALGDDEVTVGKFYATFLIQDHFRKFMKRQEEYYGYRPSKKNKNTTEIQ 1576

  Fly  1501 SGMPMLE---------------LQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSP 1550
            :|:..:|               |.|.....:.|. :|.::.:...|..:  |:...|.....|:.
Zfish  1577 AGLRSIEEEAAPELQRAISGDLLNDEEMDRAMEE-SGEESIYRRAGGLF--GNHVDPFSMERGTG 1638

  Fly  1551 LARSPSPR----------RRGHQYIHHDIGFSDTVSNVVEMVKETRHPRHGNSHPRYPRGSWSAS 1605
            .|:..|.|          |....|..:....::|.:|        ...||....|.:|     |.
Zfish  1639 AAQVTSQRPLQLADSRADRTETTYASYHANNNNTNNN--------NRRRHSRCEPHFP-----AC 1690

  Fly  1606 TSPARSPSPS 1615
            .|.:|..||:
Zfish  1691 ISASRLHSPA 1700

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 149/301 (50%)
Ion_trans 441..677 CDD:334124 142/238 (60%)
Ion_trans 769..1050 CDD:334124 131/283 (46%)
Ion_trans 1094..1345 CDD:334124 140/282 (50%)
GPHH 1346..1416 CDD:339854 39/69 (57%)
Ca_chan_IQ 1418..1492 CDD:337190 29/73 (40%)
cacna1saXP_005168332.1 Ion_trans 80..356 CDD:278921 137/283 (48%)
Ion_trans 459..682 CDD:278921 133/222 (60%)
Ion_trans 828..1087 CDD:278921 125/266 (47%)
Ion_trans 1147..1409 CDD:278921 132/264 (50%)
GPHH 1417..1480 CDD:293510 34/62 (55%)
Ca_chan_IQ 1482..1553 CDD:285917 30/75 (40%)
CAC1F_C <1686..1754 CDD:293490 6/20 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R175
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.750

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