DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and cacna1ab

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_021335317.1 Gene:cacna1ab / 569528 ZFINID:ZDB-GENE-090514-3 Length:2336 Species:Danio rerio


Alignment Length:2430 Identity:1059/2430 - (43%)
Similarity:1302/2430 - (53%) Gaps:699/2430 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     2 GGPKKEENPPGGGP---------------------------------TSLFILTEDNPIRKYTRF 33
            |||.:..:..||.|                                 .|||:.:|||.:|||.:.
Zfish    23 GGPGRGGSRQGGPPGAQRMYKQSMAQRARTMAIYNPIPVRQNCLTVNRSLFLFSEDNIVRKYAKK 87

  Fly    34 IIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCIFCVEASLKILALGLV 98
            |.||||||:.:|.||||||:|||||:|||.||||.|:::||:||.||:.|||.|:.:||||||..
Zfish    88 ITEWPPFEWMILTTIIANCIVLALEQHLPVGDKTPLSERLEETEPYFIAIFCFESGIKILALGFA 152

  Fly    99 LHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSII 163
            .||.|||||.||:|||.||:||.::   .:|.|:|||||||:||||||||||||||||||||||:
Zfish   153 FHKGSYLRNGWNVMDFVVVLTGILS---SVGSELDLRTLRAVRVLRPLKLVSGIPSLQVVLKSIM 214

  Fly   164 KAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLEDPNKLVKEGESETPCNTDNILEKAT 228
            |||.||||||:|:..||::|||||||||.|..|.||:     |.:..|...|.||          
Zfish   215 KAMIPLLQIGVLLFVAILMFAIIGLEFYMGKFHTTCF-----NTITGEMYDERPC---------- 264

  Fly   229 GSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYF 293
            |:..|:...:.|...|.|||.|||.|||:.||:|||||||||||||.:||::|||||||:||:|:
Zfish   265 GARTCDANNTQCQGYWLGPNYGITQFDNVLFAVLTVFQCITMEGWTDMLYYSNDALGSAWNWMYY 329

  Fly   294 VPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILA 358
            ||||:|||||||||||||||||||||||:||||.|||||:||||:|||||||:||||||||||||
Zfish   330 VPLIIIGSFFMLNLVLGVLSGEFAKERERVENRSEFLKLKRQQQIERELNGYLEWICKAEEVILA 394

  Fly   359 EERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEEDYGD---DGYLKTRSKPQGSC 420
            |:...       ..:|||...|:.|...|        ..:|..:..||   ..:.:.....:|..
Zfish   395 EDDND-------TGSRRRPTLKKNKADLL--------NPQEGVDHMGDSVGSPFARGSMSGKGDE 444

  Fly   421 TGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFM 485
            |.|.:.|:|.||.||..||||.|||.||.||.|||:||||.||.||..|::||||||||||||||
Zfish   445 TPFSKKERRLRFLIRKMVKTQAFYWTVISLVALNTLCVAVVHYDQPELLSDFLYYAEFIFLGLFM 509

  Fly   486 SEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSEVK-GGSFGLSVLRALRLLRIFKVTKY 549
            |||.||||.||.|.||.||||.|||.||.||||||:|:.|| |.|||:|||||||||||||||||
Zfish   510 SEMLIKMYGLGTRPYFHSSFNCFDCAVIVGSIFEVVWAMVKPGTSFGISVLRALRLLRIFKVTKY 574

  Fly   550 WSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQLFGGQFNLPGGTPETNFNTFPIALLTV 614
            |:||||||:||||||:|||||||||||||::||||||||||||||...|||.|||:|||.|::||
Zfish   575 WASLRNLVVSLLNSMKSIISLLFLLFLFIVVFALLGMQLFGGQFNFELGTPPTNFDTFPAAIMTV 639

  Fly   615 FQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAA 679
            ||||||||||.|||.||.||||..||||:|::||||.||||||||||||||||||||||||||..
Zfish   640 FQILTGEDWNVVMYDGIKSQGGVDKGMIFSVFFIVLTLFGNYTLLNVFLAIAVDNLANAQELTKD 704

  Fly   680 EEEQVEEDKEKQLQELEKEM--------------------------------------------- 699
            |:|:.|...:|...:..||:                                             
Zfish   705 EQEEEEATTQKMALQKAKEVAEVSPLSAANLSIAAKEQQKNSKGSKSVWEQRTSEIRRQNLMTSR 769

  Fly   700 EAL-------------------------------------------------------------- 702
            |||                                                              
Zfish   770 EALYNELDAEDHWKMNYRNRPDVKTHLDRPLVVNPQENRNNNTNKPRPDDPNPQERSEEHPSRSH 834

  Fly   703 -----------------------------------------------------QADG-------- 706
                                                                 ..||        
Zfish   835 HHHSHHHHHHHHHTHHSSRQSLHLPELAETGFECDVEGAGEHRRPRHHQHRRRDEDGGERGRKHR 899

  Fly   707 ------------------------VHVENGDGAVAPSKS---KGKK------------------- 725
                                    .|..:|||.....:|   :.||                   
Zfish   900 DHHSRGETAGGDAEDGQEKRQRRHRHANHGDGDGRRERSRLHRNKKEGSLSTARPIQPGLPHTES 964

  Fly   726 ----------------------------------------------------------------- 725
                                                                             
Zfish   965 QYSEDLDNLRNSSKMAIHDPDPDLYDPYYDPEQANNLLNLRGPDLHDSSLILTDSSKLEHTAIDM 1029

  Fly   726 ----------------------KEEEKKEEEE----VTEGPKPMLPYSSMFILSPTNPIRRGAHW 764
                                  ||.|||||||    ..||.|.:.|:||.||||.|||.||..|:
Zfish  1030 PPIYPSLNAKLQVNKNANTEPAKEGEKKEEEEDDGGDEEGHKRIPPFSSCFILSTTNPFRRCCHY 1094

  Fly   765 VVNLPYFDFFIMVVISMSSIALAAEDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILH 829
            ::.|.||:..|:.||:||||||||||||.::|.|||:|.||||.||||||.|||:|:|.||:|||
Zfish  1095 ILTLRYFEMCILSVIAMSSIALAAEDPVSQDSERNKVLRYFDYVFTGVFTFEMLIKMVVLGLILH 1159

  Fly   830 PGSYLREFWNIMDAVVVICAAVSFGFD--MSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKA 892
            .|||.|:.||.:|.|||..|.|:|.|.  ..||..|:::|.||||||||||||||||||:|||||
Zfish  1160 EGSYFRDLWNFLDFVVVSGALVAFAFTSFSGGSGKGKDISIIKSLRVLRVLRPLKTIKRLPKLKA 1224

  Fly   893 VFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELL 957
            ||||||||||||:||||||:||.|||:|:.||||.|:|||||||||..:.:|:|.|..||.|..:
Zfish  1225 VFDCVVNSLKNVLNILIVYMLFMFIFAVVAVQLFKGRFFYCTDESKEFARDCRGEYLVYERDNEV 1289

  Fly   958 PKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIV 1022
             |.:.|.||...||||||..|:||||.|.||||||.||:||:.:|||:|||...:|:||||||:|
Zfish  1290 -KSQKREWKKYDFHYDNVLWALLTLFTVSTGEGWPDVLKHSVDSTYENRGPSPGYRMEMSIFYVV 1353

  Fly  1023 YFIVFPFFFVNIFVALIIITFQEQGEAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYK 1087
            ||:||||||||||||||||||||||:..::|..::||:::||||.|.|:||.|:||:|:.:|:|:
Zfish  1354 YFVVFPFFFVNIFVALIIITFQEQGDKMMEDYSLEKNERACIDFAINAKPLTRHMPQNKQSFQYR 1418

  Fly  1088 VWRIVVSTPFEYFIMMLIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVK 1152
            :|:.|||.||||.||.||..||::|||||:...|.|:|.||.:|:.||..|.:|::||||.|||:
Zfish  1419 MWQFVVSPPFEYSIMSLIALNTIILMMKYNGASDAYDKVLKNLNIVFTTFFFMESILKIIAFGVR 1483

  Fly  1153 NFFKDPWNIFDLITVLGSIVDALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQS 1217
            |||:|.|||||.::|:|||.|.|..|..:|.||:.|||||||||||||||||.||||||||||||
Zfish  1484 NFFRDAWNIFDFVSVIGSITDILVTELVNNFINLSFLRLFRAARLIKLLRQGETIRILLWTFVQS 1548

  Fly  1218 FKALPYVCLLIAMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPN 1282
            ||||||||||||:|||||||||||:|||:.|.. |.:|..||||::|...:|||||.||||||.:
Zfish  1549 FKALPYVCLLIAILFFIYAIIGMQLFGNLALDD-EGAINEHNNFRTFFMALMLLFRSATGEAWHD 1612

  Fly  1283 IMLACLKGKACDDDAEKAPGEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSIL 1347
            |||:||.|..|:.:   ..|..|||.:||||||||||.|||||||||||||||||:|||||||||
Zfish  1613 IMLSCLGGMPCEPE---EVGSECGSNVAYAYFVSFIFLCSFLMLNLFVAVIMDNFEYLTRDSSIL 1674

  Fly  1348 GAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDEL 1412
            |.|||||:|||||||||.|.|:|||.:||.:|:.:|||||.|.|||:|:|.|:|:||::|:.|:.
Zfish  1675 GPHHLDEYVRIWAEYDPAACGRIHYKDMYSLLRVIDPPLGLGKKCPHRVACKRLLRMDLPVADDN 1739

  Fly  1413 RVQFTTTLFALIRENLSIKM-RAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKGKL 1476
            .|.|.:||.||||..|.||: :...:..|.|.|||:.:..|||..::|.|:|||.|.....  .|
Zfish  1740 TVHFNSTLMALIRTALDIKIAKGGADKHQMDAELRKEMMAIWPNLSQKNLDLLVTPHKSAT--DL 1802

  Fly  1477 SVGKIYAGFLILESWRSTRFGQLD----------------------------SGMPMLELQDASR 1513
            :||||||..:|:|.:|.::..:|.                            :|:|.|..:..:.
Zfish  1803 TVGKIYAAMMIMEYYRQSKAKKLQALREEQNRTPLMFQRMEPSPNQEGGPGLNGLPELPQEPVNS 1867

  Fly  1514 HP-------SQESLTG----------------------------------------------ADA 1525
            .|       ||..:|.                                              :|.
Zfish  1868 LPPEVGMNESQSWVTSRAQEMCQKSVPENWNPDRPYPDDHHDSRHNPQTVEMREFGPVGDGYSDT 1932

  Fly  1526 GHLHPGHSYMNGHRRSPSL----------RH-----------NGSPLARSPS------------- 1556
            ...||    |.||.|:.|:          ||           :.||:.||.|             
Zfish  1933 EPYHP----MEGHGRTISMPRLSADNQRRRHRPRGSNLSTITDTSPMRRSTSSLVHGRSGRGVRL 1993

  Fly  1557 -----------------PRRRGH------------------QYIHHDIGFSDTVSNVVE------ 1580
                             ||||..                  :|...|.|....:|...:      
Zfish  1994 DDYSLERVVSEEGHRHAPRRRDRDRDRDRDRSHRTSERSLARYTDADTGLGTDLSTTTQSGDLPP 2058

  Fly  1581 --------MVKETRHPRHGNSH---------------PRYPRG----SWSASTSPAR-------- 1610
                    ..|:.||..|.:.|               .|:|:.    .||.|.|..|        
Zfish  2059 KERERERGRAKDRRHHHHHHHHHGSVDKDRYSHERDYHRHPQDRSDRQWSRSPSEGRGHRQGSSS 2123

  Fly  1611 ---SPSPSRYGGHLSRSKRTQLPYPTYGTTSLCQRSRSPSPARLQEMRERDRLGYGIDMGVTHVQ 1672
               ||.||..|....|..|.|||          |...:|.|                     ||.
Zfish  2124 VSGSPVPSTSGTSTPRRGRRQLP----------QTPSTPRP---------------------HVT 2157

  Fly  1673 HSYPTLASRRAGIGRRLPPTPSKPSTLQLKPTNINF-PKLNASPTH---THHSTPHSVHSLPHHR 1733
            :| |.:         |.||..|........|:..|| |..:..|.|   :.|::||.  ..|.| 
Zfish  2158 YS-PAV---------RKPPYGSPGQGRLRSPSPRNFSPPGHEPPYHRPPSRHASPHP--GSPRH- 2209

  Fly  1734 DLLRDPRDMYYSSRERERDRERLRDRDRDRDRDRLHEYDLRYEYRDRERELYERERDREREVERE 1798
               ..||...::|....|       ..|....|.|          :.:...|||:.:.||..|  
Zfish  2210 ---ASPRSPRHTSPRSPR-------HGRWGPPDSL----------EGDGTFYERDYEYERHHE-- 2252

  Fly  1799 RLEYIAPLSFEQALAMG-------------RTGRVLPSP----VLNGFK---------------- 1830
                  |.::||:|:.|             ||.|..|.|    :.||::                
Zfish  2253 ------PPAYEQSLSQGNPHPHSHPHPRSPRTARHGPQPHPRRMPNGYRSSSPSPHRRGPHPGPH 2311

  Fly  1831 -------PKSGLNPRHSDSDEEDWC 1848
                   |:.||:.::|::||:|||
Zfish  2312 RPPHGRGPRKGLHEQYSETDEDDWC 2336

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 185/286 (65%)
Ion_trans 441..677 CDD:334124 189/236 (80%)
Ion_trans 769..1050 CDD:334124 191/282 (68%)
Ion_trans 1094..1345 CDD:334124 169/250 (68%)
GPHH 1346..1416 CDD:339854 43/69 (62%)
Ca_chan_IQ 1418..1492 CDD:337190 32/74 (43%)
cacna1abXP_021335317.1 Ion_trans 91..360 CDD:306908 185/286 (65%)
Ion_trans 465..703 CDD:306908 190/237 (80%)
Ion_trans 1099..1335 CDD:306908 154/236 (65%)
Ion_trans 1425..1672 CDD:306908 169/250 (68%)
GPHH 1673..1743 CDD:318993 43/69 (62%)
Ca_chan_IQ 1745..1820 CDD:312334 33/76 (43%)
Herpes_ICP4_C 1841..>2243 CDD:332854 82/469 (17%)
PAT1 <2144..2300 CDD:330585 50/227 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 391 1.000 Domainoid score I748
eggNOG 1 0.900 - - E1_KOG2301
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 1778 1.000 Inparanoid score I66
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 1 1.000 - - FOG0000179
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100303
Panther 1 1.100 - - O PTHR45628
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X841
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
ZFIN 1 1.500 - -
1212.330

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