DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and Cacna1i

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_038935723.1 Gene:Cacna1i / 56827 RGDID:68944 Length:2226 Species:Rattus norvegicus


Alignment Length:2280 Identity:555/2280 - (24%)
Similarity:895/2280 - (39%) Gaps:679/2280 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 PKKEENP----PGGGPTSLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGG 64
            |.:..||    |...|.:.|.|.:....|.:...::..|.||...:|.|:.|||.|.:  :.|..
  Rat    39 PLEGTNPDVPHPDLAPVAFFCLRQTTSPRNWCIKMVCNPWFECVSMLVILLNCVTLGM--YQPCD 101

  Fly    65 DKTVLAQK---LEKTEAYFLCIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYP 126
            |...|:.:   |:..:.:....|.:|..||::||| :..|..||.:.||.:|||:|:.| |.:|.
  Rat   102 DMECLSDRCKILQVFDDFIFIFFAMEMVLKMVALG-IFGKKCYLGDTWNRLDFFIVMAG-MVEYS 164

  Fly   127 QIGPEVDLRTLRAIRVLRPLKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFY 191
            .....::|..:|.:|||||||.::.:||:::::..::..:..|..:.||..|...||.|||::.:
  Rat   165 LDLQNINLSAIRTVRVLRPLKAINRVPSMRILVNLLLDTLPMLGNVLLLCFFVFFIFGIIGVQLW 229

  Fly   192 SGALHKTCY-----------------------------SLEDPNKL--------VKEGESETPCN 219
            :|.|...|:                             ||...|.:        :||...|...:
  Rat   230 AGLLRNRCFLEENFTIQGDVALPPYYQPEEDDEMPFICSLTGDNGIMGCHEIPPLKEQGRECCLS 294

  Fly   220 TDNILEKATG------SFVC---NNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTA 275
            .|::.:...|      |.:|   |...::|......|:.|..:|||||:|.:.:||.||:|||..
  Rat   295 KDDVYDFGAGRQDLNASGLCVNWNRYYNVCRTGNANPHKGAINFDNIGYAWIVIFQVITLEGWVE 359

  Fly   276 ILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFA--KERE---KVENRQEFLKLRRQ 335
            |:|:..|| .|.:|:|||:.||::|||||:||.|.|::.:|:  |:||   .:|.||.:|.....
  Rat   360 IMYYVMDA-HSFYNFIYFILLIIVGSFFMINLCLVVIATQFSETKQREHRLMLEQRQRYLSSSTV 423

  Fly   336 QQLERELNGYVE---WIC----KAE---------------------------------------- 353
            .......:.|.|   ::|    ||:                                        
  Rat   424 ASYAEPGDCYEEIFQYVCHILRKAKRRALGLYQALQNRRQAMGPGTPAPAKPGPHAKEPSHCKLC 488

  Fly   354 -----------------EVILAEERTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEE--- 398
                             ..|||.:.::.....|  ||.||.:       .||   |||:.:|   
  Rat   489 PRHSPLDPTPHTLVQPISAILASDPSSCPHCQH--EAGRRPS-------GLG---STDSGQEGSG 541

  Fly   399 ---EAEEDYGDDGYLKTRSKPQGS---------------------CTGFWRAEKRFRFWIRHTVK 439
               .||.:...||       ||.|                     |...|| |.|.:  :|..|.
  Rat   542 SGGSAEAEANGDG-------PQSSEDGVSSDLGKEEEQEDGAARLCGDVWR-ETRAK--LRGIVD 596

  Fly   440 TQWFYWFVIVLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESS 504
            :::|...:::.:.:|||.:.:||:.||..||..|.....:|..:|..||.:|:.|.|...|..:.
  Rat   597 SKYFNRGIMMAILVNTVSMGIEHHEQPEELTNILEICNVVFTSMFALEMILKLAAFGLFDYLRNP 661

  Fly   505 FNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIIS 569
            :|.||.:::..||:|:: .:..|   ||||||..||||:.|:.::..:||..::.|:.:|.::.:
  Rat   662 YNIFDSIIVIISIWEIV-GQADG---GLSVLRTFRLLRVLKLVRFMPALRRQLVVLMKTMDNVAT 722

  Fly   570 LLFLLFLFILIFALLGMQLFGGQFNLPGGTPET-----NFNTFPIALLTVFQILTGEDWNEVMYQ 629
            ...||.|||.||::|||.:||.:|:|...|.:|     ||::...|::|||||||.||||.|:|.
  Rat   723 FCMLLMLFIFIFSILGMHIFGCKFSLRTDTGDTVPDRKNFDSLLWAIVTVFQILTQEDWNVVLYN 787

  Fly   630 GIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEKQLQE 694
            |:     |......|:||:.|:.||||.|.|:.:||.|:..  ..|..|......|:.....|:|
  Rat   788 GM-----ASTTPWASLYFVALMTFGNYVLFNLLVAILVEGF--QAEGDANRSYSDEDQSSSNLEE 845

  Fly   695 LEKEME-------------------------------------------ALQADGVHV------- 709
            .:|..|                                           :||.|.|.|       
  Rat   846 FDKLPEGLDNSRDLKLCPIPMTPNGHLDPSLPLGAHLGPAGTMGTAPRLSLQPDPVLVALDSRKS 910

  Fly   710 ---------------------------------------------------------ENGDGAV- 716
                                                                     |.|...| 
  Rat   911 SVMSLGRMSYDQRSLSSSRSSYYGPWGRSGTWASRRSSWNSLKHKPPSAEHESLLSGEGGGSCVR 975

  Fly   717 --------APSKS---------------------------------------------------- 721
                    ||:::                                                    
  Rat   976 ACEGAREEAPTRTAPLHAPHTHHAHHGPHLAHRHRHHRRTLSLDTRDSVDLGELVPVVGAHSRAA 1040

  Fly   722 ---------------------------------KGKKKEE---------------EKKEEEEVTE 738
                                             :|:.:||               .|.:..||.|
  Rat  1041 WRGAGQAPGHEDCNGRMPNIAKDVFTKMDDCRDRGEDEEEIDYTLCFRVRKMIDVYKPDWCEVRE 1105

  Fly   739 GPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAAEDP-VRENSRRNKIL 802
            .       .|:::.||.|..|.....::....||:.::..|.::.|.:|.|.| :...|.....|
  Rat  1106 D-------WSVYLFSPENKFRILCQTIIAHKLFDYVVLAFIFLNCITIALERPQIEAGSTERIFL 1163

  Fly   803 NYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFDMSGSSAGQNLS 867
            ...:|.||.:|..||.||:|.||:.....:|||..||::|..:|..:.:.....::.:...:.|.
  Rat  1164 TVSNYIFTAIFVGEMTLKVVSLGLYFGEQAYLRSSWNVLDGFLVFVSIIDIVVSVASAGGAKILG 1228

  Fly   868 TIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVIGVQLFNGKFFY 932
            .::.||:||.||||:.|.|.|.||.|.:.:::|||.:.||:::...|..||.::|||||.|||::
  Rat  1229 VLRVLRLLRTLRPLRVISRAPGLKLVVETLISSLKPIGNIVLICCAFFIIFGILGVQLFKGKFYH 1293

  Fly   933 C--TDESKHTS-AECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTLFAVQTGEGWPQV 994
            |  .|....|: ::|..:.::              |....:::||:..|:::||.:.:.:||..:
  Rat  1294 CLGVDTRNITNRSDCVAANYR--------------WVHHKYNFDNLGQALMSLFVLASKDGWVNI 1344

  Fly   995 LQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITF---QEQGEAELQDGEI 1056
            :.:.:.|...|:.|:.|....|.:::|.:.::..||.:|:||.:::..|   ::..|||    |.
  Rat  1345 MYNGLDAVAVDQQPVTNHNPWMLLYFISFLLIVSFFVLNMFVGVVVENFHKCRQHQEAE----EA 1405

  Fly  1057 DKNQKSCIDFTIGARPLERYMPKNRNTFKYKVW---RIVV-----STPFEYFIMMLIVFNTLLLM 1113
            .:.::..:      |.||:...|.:....|..:   |:::     |...:.||..:|..|.:.:.
  Rat  1406 RRREEKRL------RRLEKKRRKAQRLPYYATYCPTRLLIHSMCTSHYLDIFITFIICLNVVTMS 1464

  Fly  1114 MKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWME 1178
            ::::||....|.:|||.|..||.:|.:|.|||::.||::.||||.||..||..||.|::.....|
  Rat  1465 LEHYNQPTSLETALKYCNYMFTTVFVLEAVLKLVAFGLRRFFKDRWNQLDLAIVLLSVMGITLEE 1529

  Fly  1179 FGSNS---IN---VGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAI 1237
            ...|:   ||   :..:|:.|.||::|||:....:|.||.|.||:...:..:.||..:||||||.
  Rat  1530 IEINAALPINPTIIRIMRVLRIARVLKLLKMATGMRALLDTVVQALPQVGNLGLLFMLLFFIYAA 1594

  Fly  1238 IGMQVFGNIKLGTVEN---SITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEK 1299
            :|:::||.:.... ||   .::||..|::|....:.||:.:||:.|..||...|:.  |..|...
  Rat  1595 LGVELFGKLVCND-ENPCEGMSRHATFENFGMAFLTLFQVSTGDNWNGIMKDTLRD--CTHDERS 1656

  Fly  1300 APGEYCGSTLAYA---YFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAE 1361
                 |.|:|.:.   |||||:....|:::|:.|||:|.:.|...::                |:
  Rat  1657 -----CLSSLQFVSPLYFVSFVLTAQFVLINVVVAVLMKHLDDSNKE----------------AQ 1700

  Fly  1362 YDPNATGKIHYTEMYDMLKNMDP---------PLGFGNKCPN----------------------- 1394
            .|.....:|.    .:|...:.|         |......||.                       
  Rat  1701 EDAEMDAEIE----LEMAHGLGPCPGPCPGPCPCPCPCPCPGPRLPTSSPGAPGRGSGGAGAGGD 1761

  Fly  1395 ------RLAYKK------LIRMNMPLDDELRVQFTTTLFALIRENLSIKM----RAPEEMDQADM 1443
                  |..|..      |..:::.:.|.|..:.|      |.:|||..:    .:|:...:...
  Rat  1762 TESHLCRHCYSPAQETLWLDSVSLIIKDSLEGELT------IIDNLSGSVFHHYASPDGCGKCHH 1820

  Fly  1444 ELRETITNIWPLQAKKMLNLLVPPSDQLNKG---KLSVGKIYAGFLILESWRSTRFGQLDSGMPM 1505
            :.:|     .|: |::....|..||.::.:|   .|.|.........|.|.||:.....|.    
  Rat  1821 DKQE-----GPV-AQRSRPRLPHPSPRVTRGHHLPLQVQLAETEAFSLNSDRSSSILLGDD---- 1875

  Fly  1506 LELQDASRHPS--QESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSPS---------PRR 1559
            |.|:|.:..|.  :||     .|.|.|......|............|::..|.         |..
  Rat  1876 LSLEDPTACPQGPKES-----KGELEPPEPMQAGDLDECFFPFASEPVSTGPESLLCEMGAIPFN 1935

  Fly  1560 RGHQYIHHDIG------FS-DTVSNVVEMVKETRHP---------RHGNSHPRYPR----GSWSA 1604
            ....::.|:..      || |..|.:::|..|..||         ..|.|....|:    |||::
  Rat  1936 PVQSWLKHESSQAPQSPFSPDGSSPLLQMPAEFFHPAVSASQKGQEPGMSAGTLPKIALQGSWAS 2000

  Fly  1605 STSP---------------ARSPSPSRYGGH----------LSRSKR------TQLPYPTYGTTS 1638
            ..||               :...|||...|.          ||.|.|      .|:|.|      
  Rat  2001 LRSPSVNCTLLRQATVSDASLDASPSSSAGSLQTTLEDSLTLSDSPRRALGPPVQVPGP------ 2059

  Fly  1639 LCQRSRSPSPARLQEMRERDRL--------------GYGIDMGVTHVQHSYPTLASRRAGIGRR- 1688
              :.|.||:..|...:|.|...              |.....|.||.....|:....|.|.|.. 
  Rat  2060 --RASLSPATRRRLSLRGRGLFSLRGLRAHQRSHSSGGSTSPGCTHHDSMDPSDEEGRGGAGGGG 2122

  Fly  1689 -------------------LPPTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHSLPHHRD 1734
                               ||||...|.....:..| :...|.|.|     ..|.|..|.   |.
  Rat  2123 AGSEHSETLSSLSLTSLFCLPPTLPPPGLTPARKFN-STSSLAAGP-----GRPGSTVSA---RG 2178

  Fly  1735 LLRDP 1739
            |:|.|
  Rat  2179 LVRSP 2183

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 106/340 (31%)
Ion_trans 441..677 CDD:334124 89/240 (37%)
Ion_trans 769..1050 CDD:334124 83/287 (29%)
Ion_trans 1094..1345 CDD:334124 91/262 (35%)
GPHH 1346..1416 CDD:339854 13/113 (12%)
Ca_chan_IQ 1418..1492 CDD:337190 16/80 (20%)
Cacna1iXP_038935723.1 Ion_trans 76..407 CDD:395416 105/335 (31%)
Ion_trans 597..824 CDD:395416 88/237 (37%)
Ion_trans 1128..1400 CDD:395416 82/285 (29%)
Ion_trans 1445..1700 CDD:395416 91/278 (33%)
PHA03307 1833..>2066 CDD:223039 54/249 (22%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D172471at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
22.010

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