DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cac and cacna1eb

DIOPT Version :9

Sequence 1:	NP_001356945.1	Gene:	cac / 32158	FlyBaseID:	FBgn0263111	Length:	2110	Species:	Drosophila melanogaster
Sequence 2:	XP_017206695.2	Gene:	cacna1eb / 567702	ZFINID:	ZDB-GENE-070705-133	Length:	2168	Species:	Danio rerio

Alignment Length:	2197	Identity:	998/2197 - (45%)
Similarity:	1241/2197 - (56%)	Gaps:	508/2197 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SLFILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFL 81
            ||||..|:|.||||.:.|||||||||.:|.||||||:||:||:||||.|||.::::|||||.||:
Zfish    50 SLFIFAENNMIRKYAKRIIEWPPFEYMILATIIANCIVLSLEQHLPGEDKTPMSKRLEKTEPYFI 114

  Fly    82 CIFCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFM-TQYPQIGPEVDLRTLRAIRVLRP 145
            .|||.||.:|::|||.|.||.|||||.||:|||.||::|.: |....:...||||||||:|||||
Zfish   115 GIFCFEAGIKLVALGFVFHKGSYLRNGWNVMDFIVVLSGILATAGSHMNIPVDLRTLRAVRVLRP 179

  Fly   146 LKLVSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCYSLED--PNKL 208
            |||||||||||:|||||||||.||||||||:.|||::|||||||||||.||.||.:..|  .|:.
Zfish   180 LKLVSGIPSLQIVLKSIIKAMVPLLQIGLLLFFAILMFAIIGLEFYSGKLHHTCLADLDILDNET 244

  Fly   209 VKEGESETPCNTDNILEKATGSFVCNNTTSMCLEKWEGPNSGITSFDNIGFAMLTVFQCITMEGW 273
            |...|.:..|......:|.|           |...|.|||.|||.||||.||:||||||||||||
Zfish   245 VDSSEVDFACGVRKCPDKYT-----------CSGSWIGPNDGITQFDNILFAVLTVFQCITMEGW 298

  Fly   274 TAILYWTNDALGSAFNWIYFVPLIVIGSFFMLNLVLGVLSGEFAKEREKVENRQEFLKLRRQQQL 338
            ||:||.||||||..:|||||:|||:|||||:|||||||||||||||||:||||:.|:|||||||:
Zfish   299 TAVLYNTNDALGPTWNWIYFIPLIIIGSFFVLNLVLGVLSGEFAKERERVENRRAFMKLRRQQQV 363

  Fly   339 ERELNGYVEWICKAEEVILAEE-RTTEEEKMHIMEARRRNAAKRKKLKSLGKSKSTDTEEEEAEE 402
            |||||||..||.:||||:|.|| :.:....:.::    :.|..:|..:..|          ..||
Zfish   364 ERELNGYRAWIDRAEEVMLQEENKNSGRSALDVL----KRATSKKNARRRG----------PGEE 414

  Fly   403 DYGDDGYLKTRSKP--------QGSCTGFWRAEKRFRFWIRHTVKTQWFYWFVIVLVFLNTVCVA 459
            .|.:...:...|:|        :|......|.|:..||.||..|||..|||.|:.||.|||:.|:
Zfish   415 KYSEISTVAGGSRPRVGMRTPRRGPAAYLRRKERMLRFSIRRMVKTDSFYWIVLSLVALNTISVS 479

  Fly   460 VEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFESSFNRFDCVVISGSIFEVIWSE 524
            :.|:.||.:||...||.||:|||||::|||:|||.||.|:||.||||.|||.||.||||||:|..
Zfish   480 IVHHNQPEWLTVIQYYTEFVFLGLFLAEMFLKMYGLGFRLYFHSSFNCFDCGVIVGSIFEVVWGF 544

  Fly   525 VKGG-SFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSIISLLFLLFLFILIFALLGMQL 588
            .:.| |||:|||||||||||||:|||||||||||:||::||:|||||||||||||::||||||||
Zfish   545 FRPGVSFGISVLRALRLLRIFKITKYWSSLRNLVVSLMSSMKSIISLLFLLFLFIVVFALLGMQL 609

  Fly   589 FGGQFNLPGGTPETNFNTFPIALLTVFQILTGEDWNEVMYQGIISQGGAQKGMIYSIYFIVLVLF 653
            |||:|.....|| |||:|||.:::||||||||||||||||.||.||||...||..|||||||.||
Zfish   610 FGGRFIFEDYTP-TNFDTFPASIMTVFQILTGEDWNEVMYNGIRSQGGVHYGMWSSIYFIVLTLF 673

  Fly   654 GNYTLLNVFLAIAVDNLANAQELTAAEEEQVEE-------------------------------- 686
            ||||||||||||||||||||||||..|||:.||
Zfish   674 GNYTLLNVFLAIAVDNLANAQELTKEEEEEEEEFFNQRYKSREFGLSERRRRPYLYRKRAIHRGR 738

  Fly   687 ----------------------------DKEKQL---------QELEK----------------- 697
                                        ::.|::         .:|.|
Zfish   739 PSPAEAEEEAAGKQAAEEQPVNAFAGRRERRKKINMSVWEQRANQLRKRRQMASREVLFGGPTED 803

  Fly   698 -------------------------------------------------EMEALQADGV------ 707
                                                             |.|.|...|:
Zfish   804 QDTPGSDHHQQHSLSTETSPLHLPESPMSVGMPLPEPPMSITIPLPEPPESEPLSGSGLEERPSA 868

  Fly   708 ------------------------------------------------------HVENGDGAVAP 718
                                                                  ..|:|:|....
Zfish   869 NNHHANTERRHRVARKFRAAAAAGVAEGGRHKRHRHRESRTEARNAENHQQFERQAEDGEGKTEE 933

  Fly   719 SKSK---------------------------------GKKKEEEKKEEE---------------- 734
            ::||                                 |.::|::.:.:|
Zfish   934 AQSKHMMNMCDPERQIENQEECQREFVCDLTGLSQASGHQEEDQAESQEAQLLRHKEDFSTESKY 998

  Fly   735 ----------------------------------------------------------------- 734

Zfish   999 MTEVSDIENNGSYLNQDECMTETSLKRESSSQPLLEMAPMTVSFKDVEASLSDKADDDDDDDMDD 1063

  Fly   735 -----------EVTEGPKPMLPYSSMFILSPTNPIRRGAHWVVNLPYFDFFIMVVISMSSIALAA 788
                       |.:...||..| .||||....|||||..|:||.|.||:..|::||..|||||||
Zfish  1064 DDDYEDDENGGEKSTASKPERP-DSMFIFKSKNPIRRICHYVVTLRYFEMTILLVIVASSIALAA 1127

  Fly   789 EDPVRENSRRNKILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSF 853
            ||||..:|.|||:|.||||.||||||.||::|::|.|:|||.|||.|:.|||:|.:||:.|.::|
Zfish  1128 EDPVCTSSERNKVLRYFDYVFTGVFTFEMIIKMIDQGLILHDGSYFRDMWNILDFIVVVGALIAF 1192

  Fly   854 GF-DMSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFI 917
            .. ::.|::.|:::.|||||||||||||||||||:|||||||||||.|||||.||||||.||.||
Zfish  1193 ALTNLLGNNKGRDIKTIKSLRVLRVLRPLKTIKRLPKLKAVFDCVVTSLKNVFNILIVYKLFMFI 1257

  Fly   918 FSVIGVQLFNGKFFYCTDESKHTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAAAMLTL 982
            |:||.||||.||||||||.|..|..||||.|..|..|....|:  |.|:...||||||..|:|||
Zfish  1258 FAVIAVQLFKGKFFYCTDGSMGTQKECQGYYIDYGRDRKEVKK--REWRRHEFHYDNVLWALLTL 1320

  Fly   983 FAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIITFQEQG 1047
            |.|.||||||||||||:..|.||.||.:..|:||||||::||:||||||||||||||||||||||
Zfish  1321 FTVSTGEGWPQVLQHSVDVTEEDHGPSRGNRMEMSIFYVIYFVVFPFFFVNIFVALIIITFQEQG 1385

  Fly  1048 EAELQDGEIDKNQKSCIDFTIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMMLIVFNTLLL 1112
            :..:::..::||:::||||.|.|:||.||||:||.|.:|::|..|||..|||.::::|..||::|
Zfish  1386 DKMMEECNLEKNERACIDFAISAKPLTRYMPQNRQTLQYRLWHFVVSPSFEYTVLVMIALNTVVL 1450

  Fly  1113 MMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVLGSIVDALWM 1177
            ||||::....|:..||::|..||.:||:|.:|||:.||..|:|:|.|||||.|||||||.:.:..
Zfish  1451 MMKYYSAPTAYDIVLKHLNTAFTVLFSLECILKIMAFGFMNYFRDTWNIFDFITVLGSITEIVVD 1515

  Fly  1178 EFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1242
            ....|:||:.||:||||||||||||||||||||||||||||||||||||||||||||||||||||
Zfish  1516 LQSVNTINMSFLKLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLIAMLFFIYAIIGMQV 1580

  Fly  1243 FGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKACDDDAEKAP------ 1301
            ||||||.. |:.|.:||||::|...:|||||.||||:|..|||:||:||.|:.|....|
Zfish  1581 FGNIKLND-ESHINQHNNFKTFFGALMLLFRSATGESWQEIMLSCLEGKECEPDPSITPPFTSPD 1644

  Fly  1302 ---GEYCGSTLAYAYFVSFIFFCSFLMLNLFVAVIMDNFDYLTRDSSILGAHHLDEFVRIWAEYD 1363
               |  ||:..||.||||||||.||||||||||||||||:||||||||||.||||||||||.|||
Zfish  1645 HEGG--CGTDFAYFYFVSFIFFSSFLMLNLFVAVIMDNFEYLTRDSSILGPHHLDEFVRIWGEYD 1707

  Fly  1364 PNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDELRVQFTTTLFALIRENL 1428
            ..|.|:|||..||:||.:|.||||.|.|||.::|||:|:.||||:|:::.|.||:||.:|||..|
Zfish  1708 RAACGRIHYNAMYEMLTHMSPPLGLGKKCPAKIAYKRLVLMNMPVDEDMTVHFTSTLMSLIRTAL 1772

  Fly  1429 SIKM-RAPEEMDQADMELRETITNIWPLQAKKMLNLLVPPSDQLNKG-KLSVGKIYAGFLILESW 1491
            .||: |..|:..|.||||::.|:.|||..::|.|:||||    :||. .::||||||..:|::.:
Zfish  1773 EIKIARGGEDRLQLDMELQKEISFIWPHLSQKTLDLLVP----INKDTDMTVGKIYASRMIMDFF 1833

  Fly  1492 RSTRFGQLDSGMPMLELQDASRHPSQESLTGADAGHLHPGHSYMNGHRRSPSLRHNGSPLARSP- 1555
            :.::..:|   ...:|.|.|:..|    |....||                |...:|..:|.||
Zfish  1834 KQSKAKKL---RLQVEAQRAAALP----LISHSAG----------------SALTSGGFVALSPI 1875

  Fly  1556 SPRRRGHQYIHHDIGFSD--TVSNVVE-----MVKETRHPRHGNSHPRYPRGSWSASTSPARSPS 1613
            ||:....|.|......|:  ..|.|.|     :..|.|.|.|               ...||..|
Zfish  1876 SPQELLLQPITQRTDSSEDYDASQVDESGLNGVWGEDRPPEH---------------AFRARHKS 1925

  Fly  1614 PSRYGGHLSRSKRTQLPYPTYG------------TTSLCQRSRSPSPARLQEMRERDRLGYGIDM 1666
               |...:|.|::||......|            .::...||||||..|:.
Zfish  1926 ---YKAAVSHSEQTQYMEKVRGRPKEQRLLLSPKNSNSKSRSRSPSEERVH-------------- 1973

  Fly  1667 GVTHVQHSYPTLASRRAGIGRRLP-PTPSKPSTLQLKPTNINFPKLNASPTHTHHSTPHSVHS-L 1729
            |||            |.|.....| |:.|:.||    |:.    |...|.|.| .|.||..:| |
Zfish  1974 GVT------------RQGNSSESPVPSTSESST----PSG----KRRLSQTST-CSRPHISYSPL 2017

  Fly  1730 PHHRDLLRDPRDMYYSSRERERD----------------RERLRDRD-RDRDRDRLH-EYDLRYE 1776
            ..|......|.:   ::.|.|.|                .:...|:| |.|.:::.| |.|   |
Zfish  2018 VSHTQSSSQPTN---NNEEDEEDDPAVQQMLGCCSTALWDDSAEDQDARARQQEKSHFEVD---E 2076

  Fly  1777 YRDRERELYERERD---REREVERERLEYIAPLSFEQALA--MGRTGRVLPS 1823
            :.......|..|..   :|.|...:....:..|:||.|:|  :||...|..|
Zfish  2077 FLGSSVRRYPSESFLALQEEEHSPDSATAMETLTFEAAVATSLGRANTVSAS 2128

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cac	NP_001356945.1	Ion_trans	37..324	CDD:334124	189/289 (65%)
		Ion_trans	441..677	CDD:334124	171/236 (72%)
		Ion_trans	769..1050	CDD:334124	185/281 (66%)
		Ion_trans	1094..1345	CDD:334124	165/259 (64%)
		GPHH	1346..1416	CDD:339854	44/69 (64%)
		Ca_chan_IQ	1418..1492	CDD:337190	34/75 (45%)
cacna1eb	XP_017206695.2	Ion_trans	70..349	CDD:306908	189/289 (65%)
		Ion_trans	463..698	CDD:306908	172/235 (73%)
		Ion_trans	1108..1387	CDD:306908	185/280 (66%)
		Ion_trans	1432..1689	CDD:306908	165/259 (64%)
		GPHH	1690..1760	CDD:318993	44/69 (64%)
		Ca_chan_IQ	1762..1836	CDD:312334	34/77 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	391	1.000	Domainoid score	I748
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1778	1.000	Inparanoid score	I66
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D172471at2759
OrthoFinder	1	1.000	-	-		FOG0000179
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100303
Panther	1	1.100	-	-	O	PTHR45628
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X841
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	11	10.830