DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment cac and scn4ab

DIOPT Version :9

Sequence 1:NP_001356945.1 Gene:cac / 32158 FlyBaseID:FBgn0263111 Length:2110 Species:Drosophila melanogaster
Sequence 2:XP_005171642.1 Gene:scn4ab / 564977 ZFINID:ZDB-GENE-051201-1 Length:1835 Species:Danio rerio


Alignment Length:1804 Identity:481/1804 - (26%)
Similarity:801/1804 - (44%) Gaps:436/1804 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 FILTEDNPIRKYTRFIIEWPPFEYAVLLTIIANCVVLALEEHLPGGDKTVLAQKLEKTEAYFLCI 83
            :.|:..||:|:....|:....|...::|||:.|||.:|:.:. ||..|.:        |..|..|
Zfish   163 YCLSPFNPVRRAAIRILIHSLFSLVIMLTILTNCVFMAMSDP-PGWSKIL--------EYVFTGI 218

  Fly    84 FCVEASLKILALGLVLHKHSYLRNIWNIMDFFVVVTGFMTQYPQIGPEVDLRTLRAIRVLRPLKL 148
            :..||.:|:|:.|..:...::||:.||.:||.|:...::|::..:|   ::..||..||||.||.
Zfish   219 YTFEAMVKVLSRGFCIGDFTFLRDPWNWLDFMVISMAYLTEFVDLG---NISALRTFRVLRALKT 280

  Fly   149 VSGIPSLQVVLKSIIKAMAPLLQIGLLVLFAIVIFAIIGLEFYSGALHKTCY------------- 200
            ::.||.|:.::.::|:::..|..:.:|.:|.:.:||:|||:.:.|.|.:.|.             
Zfish   281 ITVIPGLKTIVGALIQSVKKLADVMILTVFCLSVFALIGLQLFMGNLRQKCVLWPPVGWYSDNLT 345

  Fly   201 ---------------SLEDPNKLVKEGES--ETPCNTDNILEKATGSFVCNNTTS--------MC 240
                           |..|..|.:...|:  ..|...|.:        ||.|::.        :|
Zfish   346 VLSNYTDINGNGTANSTFDYQKYINSEENYYYVPGQMDPL--------VCGNSSDAGLCPEGYIC 402

  Fly   241 LEKWEGPNSGITSFDNIGFAMLTVFQCITMEGWTAILYWTNDALGSAFNWIYFVPLIVIGSFFML 305
            |:....||.|.||:||.|:|.|.:|:.:|.:.|..:...|..|.|..: .|:||.:|.:|||:::
Zfish   403 LKAGRNPNYGYTSYDNFGWAFLALFRLMTQDFWENLFQLTLRAAGKTY-MIFFVVIIFLGSFYLI 466

  Fly   306 NLVLGVLSGEFAKEREKVENRQEFLKLRRQQQLERELNGYVEWICKAEEVILAEERTTEEEKMHI 370
            ||:|.|::..:|::                                 .|...||.:..|||...|
Zfish   467 NLILAVVAMAYAEQ---------------------------------NEATAAEAKEKEEEYAKI 498

  Fly   371 MEARRRNAAKRKKL-----KSLGKSKSTDTEEEEAEEDYGDDGY-LKTRSKPQGS---------- 419
            ||..::.|.::..:     .||...|..|  .::.:.||  ||. ||..||..||          
Zfish   499 MEQLKKQAEQKNGMVNGSKTSLSSKKKGD--NDQMQSDY--DGIALKPLSKSNGSKGNINYLEVP 559

  Fly   420 --------------------------CTGFWRAEKRFRF------------WIRHTVKTQWFYWF 446
                                      |...|     ::|            |::.   .:..|.|
Zfish   560 DSQIRKPSVVSAVESALDAQEDIERPCPPGW-----YKFADIFLKWDCCIPWVKF---KRIVYLF 616

  Fly   447 VI---------VLVFLNTVCVAVEHYGQPSFLTEFLYYAEFIFLGLFMSEMFIKMYALGPRIYFE 502
            |:         :.:.||||.:|:|||.....:.|.|.....:|.|:|.:||.:|:.||.|..||:
Zfish   617 VMDPFVDLGITLCIVLNTVFMAMEHYPMSVHVEEVLAIGNLVFTGIFAAEMVLKLIALDPYYYFQ 681

  Fly   503 SSFNRFDCVVISGSIFEVIWSEVKGGSFGLSVLRALRLLRIFKVTKYWSSLRNLVISLLNSMRSI 567
            ..:|.||.::::.|:.|::.::|:    ||||||:.||:|:||:.|.|.:|..|:..:.||:.::
Zfish   682 VGWNIFDSIIVTMSLVELMLADVE----GLSVLRSFRLMRVFKLAKSWPTLNMLIKIIGNSVGAL 742

  Fly   568 ISLLFLLFLFILIFALLGMQLFGGQF-------NLPGGTPETNFNTFPIALLTVFQILTGEDWNE 625
            .:|..:|.:.:.|||::||||||..:       :.....|..:...|..|.|.:|::|.|| |.|
Zfish   743 GNLTLVLAIIVFIFAVVGMQLFGKSYTDSVCKISSDCELPRWHMADFFHAFLIIFRVLCGE-WIE 806

  Fly   626 VMYQGIISQGGAQKGMIYSIYFIVLVLFGNYTLLNVFLAIAVDNLANAQELTAAEEEQVEEDKEK 690
            .|:..:...|   :||...::.:|:|: ||..:||:|||:.:.:. :...|:|:     ::|.|.
Zfish   807 TMWDCMEVAG---QGMCIIVFMMVMVI-GNLVVLNLFLALLLSSF-SGDNLSAS-----DDDGEN 861

  Fly   691 QLQ-------------------------ELEKEMEALQADG------------------VHVENG 712
            .||                         .|:.:.|..:.:|                  |.:.||
Zfish   862 NLQIAISRITRGIDWIKAFVNKHVRQCLNLKPKEEGAKVNGEGDAKMNAIMNSSSSMVKVPIANG 926

  Fly   713 D-------GAVAPSKSKG-----KKK-----------------EEEKKEEEEVTEGPKPMLPYSS 748
            :       |:......:|     |||                 |:..:||||....|:..  |:.
Zfish   927 ESDDDDGNGSSEDEDDEGRDINMKKKNGDESSTCSTVDKPPEVEDLVEEEEEDLTSPEDC--YTE 989

  Fly   749 MFILSPTNPIRR------------GAHW---------VVNLPYFDFFIMVVISMSSIALAAEDPV 792
                   |.|||            |..|         :|...||:.||:.:|.:||.|||.||..
Zfish   990 -------NCIRRCPCLDLDVSQGKGKAWWNFRKTCFAIVEHSYFETFIIFMILLSSGALAFEDIY 1047

  Fly   793 RENSRRNK-ILNYFDYAFTGVFTIEMLLKIVDLGVILHPGSYLREFWNIMDAVVVICAAVSFGFD 856
            .|..|..| ||.|.|..||.||.:|||||.|..|..:    |....|..:|.::|..:.:|...:
Zfish  1048 IEQRRMIKIILEYADQVFTYVFVVEMLLKWVAYGFKV----YFTNAWCWLDFLIVDVSLISLTAN 1108

  Fly   857 MSGSSAGQNLSTIKSLRVLRVLRPLKTIKRVPKLKAVFDCVVNSLKNVVNILIVYILFQFIFSVI 921
            :.|.|   .|..|||||.||.||||:.:.|...::.|.:.:|.::.::.|:|:|.::|..|||::
Zfish  1109 ILGYS---ELGAIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIFNVLLVCLIFWLIFSIM 1170

  Fly   922 GVQLFNGKFFYCTDESK---------HTSAECQGSYFKYEEDELLPKQELRVWKPRAFHYDNVAA 977
            ||.||.|||:||.:|:.         :...:|      ||..|..|  |:| |.....::|||..
Zfish  1171 GVNLFAGKFYYCFNETSEEVFDHNVVNNKTDC------YELMEFHP--EVR-WMNGKINFDNVGM 1226

  Fly   978 AMLTLFAVQTGEGWPQVLQHSMAATYEDRGPIQNFRIEMSIFYIVYFIVFPFFFVNIFVALIIIT 1042
            ..|.|..|.|.:||..::..::.:...:..|:....:.|.|:::::.|...||.:|:|:.:||..
Zfish  1227 GYLALLQVATFKGWMDIMYSAVDSRAIESQPVYEANLYMYIYFVIFIIFGSFFTLNLFIGVIIDN 1291

  Fly  1043 FQEQGEAELQDGEI--DKNQKSCIDF--TIGARPLERYMPKNRNTFKYKVWRIVVSTPFEYFIMM 1103
            |.:| :|:|...:|  .:.||...:.  .:|::..::.:|:..|..:..|:..|....|:.|||:
Zfish  1292 FNQQ-KAKLGGTDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPTNCCQGLVFDFVTQQFFDIFIMV 1355

  Fly  1104 LIVFNTLLLMMKYHNQGDMYEKSLKYINMGFTGMFSVETVLKIIGFGVKNFFKDPWNIFDLITVL 1168
            :|..|.:.:|::..:|....|:.|.|||..|..:|:.|.||||..... ::|...|||||.:.|:
Zfish  1356 MICLNMVTMMVETDDQSAEIEEILFYINFAFIILFTGECVLKITALRY-HYFSIGWNIFDFVVVI 1419

  Fly  1169 GSIV-----DALWMEFGSNSINVGFLRLFRAARLIKLLRQGYTIRILLWTFVQSFKALPYVCLLI 1228
            .||:     |.:...|.|.:: ...:||.|..|:::|:|....||.||:..:.|..||..:.||:
Zfish  1420 LSILGIGLADLIEKYFVSPTL-FRVIRLARIGRVLRLIRGAKGIRTLLFALMMSLPALFNIGLLL 1483

  Fly  1229 AMLFFIYAIIGMQVFGNIKLGTVENSITRHNNFQSFIQGVMLLFRCATGEAWPNIMLACLKGKA- 1292
            .::.||::|.||..|..:|   .|..|....||::|...::.:|...|...|..::...|.... 
Zfish  1484 FLIMFIFSIFGMSNFAYVK---KEVGIDDMMNFETFGNSIICMFMITTSAGWDGLLAPILNSPPD 1545

  Fly  1293 CDDDAEKAPGE----YCGSTLAYAYFVSFIFFCSFLML------NLFVAVIMDNFDYLTRDSS-I 1346
            ||.|.:. ||.    .||:..     |..:||||::::      |:::|:|::||:..|.:|| .
Zfish  1546 CDPDVDN-PGSTTRGNCGNAA-----VGIVFFCSYIVMSFLVVVNMYIAIILENFNVATEESSDP 1604

  Fly  1347 LGAHHLDEFVRIWAEYDPNATGKIHYTEMYDMLKNMDPPLGFGNKCPNRLAYKKLIRMNMPLDDE 1411
            |.....:.|...|.::||.|:..|.|..:.:....:..||....  ||.|   |||.|::|:...
Zfish  1605 LCEDDFEMFYETWEKFDPTASQFIDYNRLSEFCDTLKDPLRIPK--PNTL---KLITMDIPMVTG 1664

  Fly  1412 LRVQFTTTLFALIRENLSIKMRAPEEMD--QADMELR-----------ETITNIWPLQAKK---- 1459
            .::.....|.||..|.|.    ..::||  :|.||.:           |.||:  .|:.|:    
Zfish  1665 DKIHCLDLLLALTGEVLG----GSDQMDGMKATMEEKFMANNPSKASYEPITS--TLKRKQEEVA 1723

  Fly  1460 -----------MLNLLVPPSDQLNKGKL-----------SVGKIYAGFLILESWRS--------- 1493
                       :|...|..:..:.:.|.           .||      :|.|:.||         
Zfish  1724 ASTIQRAYRSHILKRCVKQASYMYRDKTGSKKPTGEAPEKVG------MIAENMRSLYGDQAVED 1782

  Fly  1494 -------------TRFGQLDSGMPMLELQ-DASRH----PSQESLTGAD 1524
                         |:||   :..|.:::| |...|    |..||.|.||
Zfish  1783 DHPVGCSFSQHGKTQFG---AKRPPVKVQSDVVLHSAPFPVPESSTAAD 1828

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cacNP_001356945.1 Ion_trans 37..324 CDD:334124 90/324 (28%)
Ion_trans 441..677 CDD:334124 81/251 (32%)
Ion_trans 769..1050 CDD:334124 98/290 (34%)
Ion_trans 1094..1345 CDD:334124 81/266 (30%)
GPHH 1346..1416 CDD:339854 18/69 (26%)
Ca_chan_IQ 1418..1492 CDD:337190 22/112 (20%)
scn4abXP_005171642.1 Ion_trans 199..481 CDD:278921 83/335 (25%)
Ion_trans 637..832 CDD:278921 67/203 (33%)
Na_trans_assoc 858..1018 CDD:284034 28/168 (17%)
Ion_trans 1041..1298 CDD:278921 90/273 (33%)
Na_channel_gate 1290..1342 CDD:240441 11/52 (21%)
Ion_trans 1364..1602 CDD:278921 75/248 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.910

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